CN113041308B - A Chinese medicinal composition with anti-inflammatory and toxic materials clearing away effects, and its preparation method - Google Patents
A Chinese medicinal composition with anti-inflammatory and toxic materials clearing away effects, and its preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses a traditional Chinese medicine composition for diminishing inflammation and detoxifying and a processing method thereof, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for diminishing inflammation and detoxifying comprises the following components: common andrographis herb, Indian stringbush root, loquat flower, raw pinellia tuber and sunflower disc. The loquat flower, the raw pinellia tuber and the sunflower disc are further added for compounding, the proper medicine proportion is adjusted, the medicine effect is obviously improved, the preparation method is simple, the complex extraction process is avoided, the preparation is convenient, and the application prospect is good.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for diminishing inflammation and detoxifying and a processing method thereof.
Background
The Chuanwang antiphlogistic tablet and Chuanwang antiphlogistic capsule are prepared with andrographis herb and Indian stringbush root and have the functions of diminishing inflammation and detoxicating, and are mainly used for treating phlegm heat cough and asthma, abdominal pain, acute and chronic tonsillitis, laryngopharyngitis, pneumonia, acute gastroenteritis and acute bacillary dysentery with the symptoms. The andrographis paniculata is a plant of the genus andrographis of the family acanthaceae, the main components of the andrographis paniculata include lactone, sterol, flavone, alkaloid and the like, the andrographis paniculata is bitter in taste, cold in nature, heart-returning, lung, large intestine and bladder channels, the andrographis paniculata has the effects of clearing heat and removing toxicity, cooling blood and reducing swelling, and the andrographis paniculata is clinically and commonly used for treating various infectious diseases such as cold, tonsillitis, bronchitis, acute bacillary dysentery, gastroenteritis and the like. Wikstroemia indica (L.) Link is a plant of Thymelaeaceae, and its main ingredients include wikstromol, hydroxygenkwanin, daphnetin, arctigenin, wikstromol, rosinol, beta-sitosterol, polysaccharides, acidic resin, volatile oil, saponin, etc. Indian stringbush root is cold in nature, bitter in taste, slightly pungent and toxic, enters lung and liver channels, has the functions of clearing heat and removing toxicity, and removing blood stasis and removing water, and is widely used for treating bronchitis, pneumonia, parotitis, lymphadenitis, rheumatalgia, ascites due to advanced schistosomiasis, sore, furuncle, carbuncle and the like.
Chinese patent application 201210249861.4 discloses a preparation method of an anti-inflammatory and detoxifying traditional Chinese medicine composition, which comprises the following steps: 1) pulverizing herba Andrographitis into coarse powder, feeding into a five-stage dynamic countercurrent extraction device, extracting with 75-95% ethanol at 65-85 deg.C for 30-90min at 4-10ml/g for each stage, mixing extractive solutions, and filtering to obtain filtrate I; 2) putting Wikstroemia indica into a dynamic countercurrent extraction device with a five-section type extraction pipe section, wherein the water consumption is 6-10ml/g, the extraction temperature is 90-100 ℃, the extraction time of each section is 30-50min, combining water extract, and filtering to obtain filtrate II; 3) respectively concentrating the filtrate I obtained in the step 1) and the filtrate II obtained in the step 2) into clear paste, combining, and drying under reduced pressure to obtain dry paste, or combining, concentrating, and drying under reduced pressure to obtain dry paste; adding or not adding pharmaceutically acceptable auxiliary materials to obtain the traditional Chinese medicine composition. The method adopts dynamic countercurrent extraction, reduces solvent consumption, lowers extraction temperature, greatly shortens extraction time and improves extraction efficiency.
Chinese patent application 201510668610.3 discloses an anti-inflammatory and detoxifying preparation, which is mainly tablets, calculated according to the weight components, andrographis paniculata 1100-. Meanwhile, a specific extraction method and a quality detection method aiming at single components are provided. The antiphlogistic and detoxifying preparation provided by the invention has obvious curative effects on phlegm-heat cough and asthma, acute and chronic tonsillitis, sphagitis, pneumonia, abdominal pain, diarrhea, vomiting, acute gastroenteritis and acute bacillary dysentery.
At present, the extraction process of the Chuanwang antiphlogistic tablet is further optimized, and the aim is to shorten the extraction time, improve the extraction efficiency and the like. In view of the fact that research is not carried out on the synergistic anti-inflammatory effect of the traditional Chinese medicine tablet formula, the applicant searches for a pharmaceutical composition with better anti-inflammatory and detoxifying effects, screens a plurality of components through a large amount of formula exploration, and can further carry out synergistic compounding on the basis of the effects of the common andrographis herb and the Indian stringbush root to improve the anti-inflammatory and detoxifying effects.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for diminishing inflammation and detoxifying and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows:
on one hand, the invention provides a traditional Chinese medicine composition for diminishing inflammation and detoxifying, which comprises the following components: common andrographis herb, Indian stringbush root, loquat flower, raw pinellia tuber and sunflower disc.
Preferably, the weight ratio of the Indian stringbush root, the raw pinellia tuber and the sunflower disc is 160-: 10-15: 7-10, more preferably 170:13: 8.
Preferably, the traditional Chinese medicine composition for diminishing inflammation and detoxifying comprises the following components in parts by weight: 70-110 parts of common andrographis herb, 150 parts of Indian stringbush root, 200 parts of loquat flower, 10-30 parts of raw pinellia tuber and 5-15 parts of sunflower disc.
Further preferably, the traditional Chinese medicine composition for diminishing inflammation and detoxifying comprises the following components in parts by weight: 80-100 parts of common andrographis herb, 190 parts of Indian stringbush root 160-sand grass, 15-25 parts of loquat flower, 10-15 parts of raw pinellia tuber and 7-10 parts of sunflower disc.
Most preferably, the traditional Chinese medicine composition for diminishing inflammation and detoxifying comprises the following components in parts by weight: 85 parts of common andrographis herb, 170 parts of Indian stringbush root, 20 parts of loquat flower, 13 parts of raw pinellia tuber and 8 parts of sunflower disc.
In another aspect, the invention provides a processing method of the anti-inflammatory and detoxifying traditional Chinese medicine composition, which comprises the following steps:
(1) pulverizing herba Andrographitis, flos Eriobotryae, and sunflower disc into coarse powder, adding 5-7 times of solvent, hot soaking for 1.5-4 hr to obtain extractive solution, standing, filtering, recovering ethanol until no ethanol smell exists, and concentrating to obtain fluid extract with relative density of 1.20-1.30;
(2) and (2) adding water into the Indian stringbush root and the raw pinellia tuber according to the formula dosage, decocting twice, wherein the adding amount of the first time is 3-4 times, the adding amount of the second time is 2-4 times, each time of decocting is 4-6 hours, merging decoction, filtering, merging filtrate and clear paste obtained in the step (1), concentrating into thick paste with the relative density of 1.35-1.40, drying, and crushing into fine powder of 100 meshes and 120 meshes to obtain the medicine.
Preferably, in the step (1), the solvent is ethanol and n-butanol which are mixed according to a volume ratio of 2-4:1, and more preferably 3: 1.
Preferably, in step (1), the temperature of the solvent is 70 to 90 ℃, and more preferably 85 ℃.
Preferably, in step (2), the drying temperature is 40 to 50 ℃, and more preferably 45 ℃.
The invention has the beneficial effects that:
(1) the processing method has the advantages of advanced process, simple method and easy operation;
(2) the traditional Chinese medicine composition disclosed by the invention is added with auxiliary components and reasonably proportioned, realizes a synergistic interaction effect and has excellent anti-inflammatory and detoxifying effects.
Detailed Description
The present invention will be further explained with reference to specific examples in order to make the technical means, the technical features, the technical objectives and the effects of the present invention easier to understand, but the following examples are only preferred embodiments of the present invention, and not all embodiments of the present invention. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative efforts belong to the protection scope of the present invention. In the following examples, unless otherwise specified, all the procedures used were conventional, all the equipment used were conventional, and all the starting materials used were commercially available.
Examples 1 to 7
The formulations of examples 1-7 are shown in Table 1, below:
table 1.
Examples 1-7 were all processed according to the following procedure:
(1) pulverizing herba Andrographitis, flos Eriobotryae, and sunflower disc into coarse powder, adding 6 times of solvent, hot-soaking for 3 hr to obtain extractive solution, standing, filtering, recovering ethanol until no alcohol smell is produced, and concentrating to obtain fluid extract with relative density of 1.20-1.30;
(2) and (2) adding water into the Indian stringbush root and the raw pinellia tuber according to the formula dosage, decocting twice, wherein the adding amount of the first time is 3.5 times, the adding amount of the second time is 2 times, decocting for 5 hours each time, combining decoction liquids, filtering, combining filtrate with the clear paste obtained in the step (1), concentrating into thick paste with the relative density of 1.35-1.40, drying at 45 ℃, and crushing into fine powder of 100 meshes to obtain the composition product.
In the step (1), the solvent is ethanol and n-butanol which are mixed according to the volume ratio of 3:1, and the temperature is 85 ℃.
Comparative examples 1 to 4
Unlike example 1, the formulations of comparative examples 1 to 4 are shown in Table 2, and the rest are the same.
Table 2.
Comparative example 5
In contrast to example 1, the process step (1) is carried out in the presence of ethanol, the solvent being identical to the remainder.
Result detection
1. Test of drug action in inflammation
The experimental subject is ICR mouse, male, and the weight is 18-22 g. Randomly dividing mice into a drug group, a comparative example group and a blank control group according to body weight, wherein the drug group comprises an experimental group 1, an experimental group 2, an experimental group 3, an experimental group 4, an experimental group 5, an experimental group 6 and an experimental group 7, and 10 mice in each group are respectively administered with the composition products prepared in examples 1-7; the comparative example components were comparative group 1, comparative group 2, comparative group 3, comparative group 4 and comparative example 5, 10 of which were administered with the composition products prepared in comparative examples 1 to 5, respectively; each group was orally administered, the blank control group was administered with the same volume of distilled water, the administration volume was 30ml/kg once a day, and the administration dose was 0.5g/kg, the blank control group was administered with the same volume of physiological saline once a day, and the administration was continued for 3 days, and 1 hour after the last administration, 0.03ml of xylene was applied to both sides of the right ear of each mouse, and the mouse was sacrificed after 1 hour, and the left and right ear pieces were weighed with a punch having a diameter of 8mm, and the difference in weight between the two ear pieces was taken as the degree of inflammatory swelling, and the results are shown in table 3.
Table 3.
| Group of | Weight difference of two ears (mg) |
| Blank control group | 17.11±1.98 |
| Experimental group 1 | 9.89±2.38** |
| Experimental group 2 | 10.63±0.77** |
| Experimental group 3 | 10.58±2.14** |
| Experimental group 4 | 11.07±1.68** |
| Experimental group 5 | 10.92±2.60** |
| Experimental group 6 | 11.34±2.55** |
| Experimental group 7 | 11.28±1.04** |
| Comparative group 1 | 12.63±3.24* |
| Comparative group 2 | 13.36±2.97* |
| Comparative group 3 | 13.79±3.18* |
| Comparative group 4 | 14.35±1.33* |
| Comparative group 5 | 10.36±2.91** |
Note: p <0.05, P <0.01, compared to the blank control group
It can be seen that compared with comparative examples 1-5, the composition products prepared in the examples of the present invention can significantly inhibit the mouse edema caused by xylene (P <0.01), and have good inhibitory effect on the inflammatory reaction of the body.
2. Gastroenteritis drug effect test
The experimental subject is ICR mouse, male, and the weight is 18-22 g. Randomly dividing mice into a drug group, a comparative example group and a blank control group according to body weight, wherein the drug group comprises an experimental group 1, an experimental group 2, an experimental group 3, an experimental group 4, an experimental group 5, an experimental group 6 and an experimental group 7, and 10 mice in each group are respectively administered with the composition products prepared in examples 1-7; the comparative example components were comparative group 1, comparative group 2, comparative group 3, comparative group 4 and comparative example 5, 10 of which were administered with the composition products prepared in comparative examples 1 to 5, respectively; each group was orally administered, and the blank control group was administered with the same volume of distilled water, 30ml/kg once a day, at a dose of 1g/kg, and the blank control group was administered with an equal volume of physiological saline. Half an hour after administration, the groups were gavaged with senna leaf decoction (administration dose of 1g/kg, administration volume of 30ml/kg), mice were placed in a metabolism cage, filter paper was placed under the net, and the diarrhea latency and the number of loose stools in 5 hours were recorded and calculated for each group of mice. The results are shown in Table 4.
Table 4.
| Group of | Latent period of diarrhea (min) | Number of loose stool |
| Blank control group | 92.54±10.91 | 5.64±1.38 |
| Experimental group 1 | 172.47±20.61** | 4.11±0.33** |
| Experimental group 2 | 165.84±17.36** | 4.26±1.74* |
| Experimental group 3 | 166.15±8.61** | 4.25±1.69* |
| Experimental group 4 | 154.07±12.95** | 4.39±0.97* |
| Experiment ofGroup 5 | 150.35±31.64** | 4.34±0.60* |
| Experimental group 6 | 134.82±18.34** | 4.68±1.58* |
| Experimental group 7 | 138.56±10.67** | 4.65±1.21* |
| Comparative group 1 | 127.60±27.36* | 4.71±0.97* |
| Comparative group 2 | 118.16±16.47* | 4.89±2.27* |
| Comparative group 3 | 116.21±22.78* | 4.90±1.73* |
| Comparative group 4 | 113.78±26.70* | 4.94±1.02* |
| Comparative group 5 | 166.49±23.49* | 4.10±1.46* |
Note: p <0.05, P <0.01, compared to the blank control group
It can be seen that the composition products prepared in the examples of the present invention all have significantly fewer loose stool spots (P <0.05), prolonged diarrhea latency (P <0.01), and demonstrated a good amount of inhibition of the body's gastroenteritis response, compared to comparative examples 1-5.
The present invention is not limited to the above-described preferred embodiments, but rather, the present invention is to be construed broadly and cover all modifications, equivalents, and improvements falling within the spirit and scope of the present invention.
Claims (9)
1. A traditional Chinese medicine composition for diminishing inflammation and detoxifying is characterized by comprising the following components: 70-110 parts of common andrographis herb, 150 parts of Indian stringbush root, 200 parts of loquat flower, 10-30 parts of raw pinellia tuber and 5-15 parts of sunflower disc.
2. The anti-inflammatory and detoxifying traditional Chinese medicine composition as claimed in claim 1, wherein the weight ratio of Indian stringbush root, unprocessed rhizoma pinelliae and sunflower disc is 160-190: 10-15: 7-10.
3. The anti-inflammatory and detoxifying traditional Chinese medicine composition as claimed in claim 2, wherein the weight ratio of the Indian stringbush root, the raw pinellia ternate and the sunflower disc is 170:13: 8.
4. The anti-inflammatory and detoxifying traditional Chinese medicine composition as claimed in claim 1, wherein the composition comprises the following components: 80-100 parts of common andrographis herb, 190 parts of Indian stringbush root 160-sand grass, 15-25 parts of loquat flower, 10-15 parts of raw pinellia tuber and 7-10 parts of sunflower disc.
5. The anti-inflammatory and detoxifying traditional Chinese medicine composition as claimed in claim 1, wherein the composition comprises the following components: 85 parts of common andrographis herb, 170 parts of Indian stringbush root, 20 parts of loquat flower, 13 parts of raw pinellia tuber and 8 parts of sunflower disc.
6. The method for processing the anti-inflammatory and antidotal traditional Chinese medicine composition as claimed in any one of claims 1 to 5, which comprises the following steps:
(1) pulverizing herba Andrographitis, flos Eriobotryae, and sunflower disc into coarse powder, adding 5-7 times of solvent, hot soaking for 1.5-4 hr to obtain extractive solution, standing, filtering, recovering ethanol until no ethanol smell exists, and concentrating to obtain fluid extract with relative density of 1.20-1.30;
(2) and (2) adding water into the Indian stringbush root and the raw pinellia tuber according to the formula dosage, decocting twice, wherein the adding amount of the first time is 3-4 times, the adding amount of the second time is 2-4 times, each time of decocting is 4-6 hours, merging decoction, filtering, merging filtrate and clear paste obtained in the step (1), concentrating into thick paste with the relative density of 1.35-1.40, drying, and crushing into fine powder of 100 meshes and 120 meshes to obtain the medicine.
7. The process according to claim 6, wherein in step (1), the solvent is ethanol and n-butanol mixed in a volume ratio of 2-4: 1.
8. The process of claim 6, wherein in step (1), the solvent temperature is 70-90 ℃.
9. The process of claim 6, wherein in step (2), the drying temperature is 40-50 ℃.
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| CN1824071A (en) * | 2005-12-27 | 2006-08-30 | 江西青春康源制药有限公司 | Antiinflammatory toxin resolving capsule and its preparation method |
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