CN1724019A

CN1724019A - Medicine for relieving-cough and asthma

Info

Publication number: CN1724019A
Application number: CN 200510019055
Authority: CN
Inventors: 陈学锋
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-07-04
Filing date: 2005-07-04
Publication date: 2006-01-25
Anticipated expiration: 2025-07-04
Also published as: CN100356944C

Abstract

A Chinese medicine for treating cough and asthma with high curative effect is prepared from 7 Chinese-medicinal materials including ephedra, bitter apricot kernel, gypsum, liquorice root, etc.

Description

A kind of medicine with relieving cough and asthma function

Technical field

The invention belongs to drug world with relieving cough and asthma function.

Background technology

Coughing, panting is clinical common sympton, can cause by flu, bronchitis etc. are sick, men and women, old and young no matter, all can fall ill throughout the year, the patient is numerous, especially easily send out when season or the weather conversion with old person, ill have symptoms such as bottleneck throat pruritus, discomfort, rough abundant expectoration, hypopnea often, has a strong impact on rests, lives.At present, though it is many to treat the medicine of this type of disease clinically, curative effect is not fully up to expectations.Doctor trained in Western medicine adopts expelling phlegm drugs symptomatic treatments such as antitussive medicine such as codeine and ammonium chloride to symptoms such as coughing, pant, though can accomplish temporary transient controlling symptoms, the essential antibacterials such as using antibiotic that merge are to reach the healing purpose.And antibiotic abuse can cause more serious consequence, the also unsuitable life-time service antibiotic therapy of the cough that some chronic bronchitis causes.Chinese medicine has more deep understanding to the pathology pathogenesis of coughing, panting, having than remarkable advantages aspect its treatment, but also not have at present discovery on curative effect and market all than the kind of tool advantage, if can be on the basis of theory of Chinese medical science, give full play to the advantage of Chinese medicine, develop the medicine of better efficacy, can obtain good social and economic benefit.

MAXINGSHIGAN TANG is the eliminating evil classics recipe of lung qi dispersing, by ancient Chinese medicine doctor is praised highly." Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases, 48 of a part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels pieces of writing " day: " breath of breathing with cough is short, tells rare saliva, full and rapid pulse, it is right that aphonia due to larynegeal disease is to be hot drink greater than a left side, MAXINGSHIGAN TANG master it "." Records of Tradition Chinese and Western Medicine in Combination " said: " use of MAXINGSHIGAN TANG is very wide, and all suffered diseases caused by exogenous pathogenic factor are done to breathe heavily to cough, and the headache tooth is painful, and two mumps are painful, and its cause of disease is because the affection due to external wind and heat person, all available it "." epidemic febrile disease commentary " day: " we go the hot of Ramulus Cinnamomi with Ephedrae Decoction, and the suffering of reusing Gypsum Fibrosum is cold, diaphoresis with drugs pungent in flavor and warm in nature agent one is become and be hot cool clear dispersing prescription.

Typical case's prescription of this side is:

Four liang in Herba Ephedrae removes 50 in joint (6 gram) Semen Armeniacae Amarum, and two liang in peeling point (9 gram) Radix Glycyrrhizae is processed (3 gram)

Half jin in Gypsum Fibrosum, broken, brocade is wrapped up in (24 gram)

Fang Zhongyong Herba Ephedrae, Semen Armeniacae Amarum should be relievingd asthma by lung, close the Gypsum Fibrosum removing heat from QI system with drugs of pungent flavor and cold nature and expel the heat-evil; More numb Fructus Pruni a surname sends out in last, Radix Glycyrrhizae coordinate in, four medicines share, power is specially imitated element, it had not both had the cold and cool Fu Zhiyu of holding back, and increased the effect of lung qi dispersing heat clearing away, was the good side that heat is stopped up lung qi.Though MAXINGSHIGAN TANG lung qi dispersing function is strong, its sending down the abnormal ascending QI, expectorant effect are still not enough, if can remedy this deficiency, will be beneficial to rehabilitation of patients widely.

Summary of the invention

The technical problem to be solved in the present invention is a kind of increase sending down the abnormal ascending QI, expectorant effect are provided on the MAXINGSHIGAN TANG basis and carry and take all cough suppressing panting calming medicine easily.

The present invention solves the problems of the technologies described above with following technical scheme:

The medicine material weight portion is:

Herba Ephedrae 5-30 part Semen Armeniacae Amarum 5-30 part Gypsum Fibrosum 10-50 part Semen Lepidii (Semen Descurainiae) 5-20 part

Radix Platycodonis 1-15 part Radix Peucedani 1-15 part Radix Glycyrrhizae 1-20 part

The medicine of producing with method of the present invention, continued the effect of MAXINGSHIGAN TANG lung qi dispersing, and sending down the abnormal ascending QI, expectorant effect have been strengthened greatly, clinically be widely used in various respiratory system diseases, the treatment of comprise cough, panting etc., and taking dose is little, the relieving cough and asthma effect is remarkable, production technology is simple, and moderate cost is beneficial to consumer and takes.

The specific embodiment

Medicine with relieving cough and asthma function of the present invention, raw material is formed by classics recipe Maxingshigan Tonga flavor.For remedying MAXINGSHIGAN TANG sending down the abnormal ascending QI, the imperfect shortcoming of expectorant effect, add Semen Lepidii (Semen Descurainiae) eliminating pathogen from the lung for relieving asthma, the line water detumescence of usefulness, Radix Platycodonis dispelling phlegm and relieving sore-throat, Radix Peucedani loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm make the power of full side's lowering the adverse-rising QI and dispelling phlegm stronger.

To Semen Lepidii (Semen Descurainiae), Radix Platycodonis, the Radix Peucedani that adds flavor, its drug effect also obtains the consistent of pharmacy circle and admits:

Semen Lepidii (Semen Descurainiae) is the dry mature seed of crucifer Lepidium sativum L. Lepidium apetalum Willd. or descurainia sophia (l.) webb ex prantl Descurainiasophia (L.) Webb ex prantl.Hot, bitter, Great Cold.Return lung, urinary bladder channel." Chinese pharmacopoeia version in 2005 is carried " eliminating pathogen from the lung for relieving asthma, line water detumescence.Be used for sputum and stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium ... ".

Radix Platycodonis is the dry root of campanulaceae Platycodon grandiflouorum Platycodon grandiflorum (Jacq.) A.DC..Bitter, hot, flat.Return lung meridian." Chinese pharmacopoeia version in 2005 carries that " lung qi dispersing, sore-throat relieving eliminate the phlegm, evacuation of pus.Be used for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness ... ".

Radix Peucedani is the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum Maxim..Bitter, hot, be slightly cold.Return lung meridian." Chinese pharmacopoeia version in 2005 is carried " the wind heat clearing away of loosing, lowering the adverse-rising QI to resolve phlegm.Be used for cough due to pathogenic wind-heat's abundant expectoration, the expectorant dyspnea of heat type is full, and it is yellow thick to cough up phlegm.……”。It eliminates the phlegm and renders a service by force, and action time is quite long.

Simultaneously, consider cough, the patient that pants is because of throat, esophagus discomfort, swallow general solid preparation and have difficulty, so the first-selected syrup of dosage form, syrup is taken easily, mouthfeel is good, take the rear section medicine and can directly act on or residue in throat, esophagus, onset is rapid, can comparatively fast alleviate the bottleneck throat malaise symptoms, and the medical material of respectively distinguishing the flavor of among the we mainly contains compositions such as alkaloids, flavonoid, saponins, these composition good water solubility, stable in properties, syrup helps the performance of drug effect.In addition, we can also make dosage forms such as soft extract, mixture, capsule, tablet, granule, pill.

The primary raw material weight portion of this cough suppressing panting calming medicine is:

If need product is made syrup or mixture, its preparation method is: get Semen Armeniacae Amarum and add the water distillation and produce bitter almond water; Medicinal residues and all the other Six-elements decoct with water, and collecting decoction filters, and leaves standstill, and gets supernatant concentration, adds an amount of sucrose and medical additive, boil to make dissolving, filter, and put coldly, add above-mentioned bitter almond water, and it is an amount of to add water, stirs evenly, promptly.

If in the time of product need being made capsule, tablet, granule, pill, its processing technology can be: get above-mentioned seven flavor medicine material and decoct with water, collecting decoction filters, and concentrates, and drying is pulverized, and adds the starch figuration.

Do pharmacodynamics test, acute toxicity test, long term toxicity test with the syrup that embodiment in the present specification 1 produces, result of the test is as follows:

1. Pharmacodynamic test of active extract

Zoopery is the result show, the mortality rate of this product after to mouse infection staphylococcus aureus, Hemolytic streptococcus and klepsiella pneumoniae all demonstrates the certain protection effect; On Carrageenan causes mice pedal swelling inflammation and the granuloma induced by implantation of cotton pellets chronic inflammatory disease also has the obvious suppression effect; Have tangible prolongation effect the incubation period that ammonia is caused mouse cough, and can obviously suppress its cough number of times, and also have tangible prolongation effect the incubation period that citric acid is sprayed to the guinea pig cough, and can obviously suppress its cough number of times; The phenol red secretion test of mice shows that also it has tangible resolve phlegm effect.In addition histamine is caused that the contraction of guinea pig bronchial spasm also demonstrates certain inhibitory action.

Above result of the test shows that this product has relieving cough and resolving phlegm, relievings asthma, antiinflammatory, antianaphylactic effect.

2. acute toxicity test

Irritating stomach in the mice 24 hours gives this syrup and reaches 158.55g crude drug/kg (be equivalent to the clinical consumption 42.3g of people crude drug/60kg 225 times), do not see that it has anomalous effects to situations such as mice activity, defecation and psychoreactions, weight of mice is not seen yet influential, during the administration and viewing duration also do not have animal dead.Therefore, think that this syrup acute toxicity is lower.

3. long term toxicity test

Getting the Wistar rat is test group.Each rats in test groups gives respectively that dosage is 42.3,21.2, this syrup of 10.6g crude drug/kg (be equivalent to the people approximately respectively and intended 60,30,15 times of consumption in clinical day), continuously 4 weeks of gastric infusion, carries out the research of this syrup long term toxicity.Result of the test shows that this syrup high dose group (60 times), middle dosage group (30 times) and low dose group (15 times) each observation index and blank group relatively there is no tangible abnormal change.

Long term toxicity test is the result show, this product is safe by using the clinical dosage of drafting, route of administration and the course of treatment.

The investigation of product clinical efficacy

1. case choice criteria

1.1 tcm syndrome diagnostic criteria

Primary symptom: cough with copious phlegm, breathe hard and pant.

Inferior disease: itching throat or pain, chest pain, wheezing, nasal obstruction, watery nasal discharge, floating and tense pulse or cunning.

Possess one of above primary symptom, 2 of inferior diseases, can make the TCM Syndrome Type diagnosis.

1.2 the standard of including in

1. meet above-mentioned TCM Syndrome Type diagnostic criteria person.

2. the age is 18-65 year person.

1.3 exclusion standard

1.3.1 do not meet above-mentioned tcm diagnosis standard person.

Though, have one of following situation person simultaneously 1.3.2 meet above-mentioned differential diagnosis in tcm standard:

1. the age is at under-18s, or the over-65s person.

2. have and obviously hold concurrently the folder card or merge the card person.

3. suckling, gestation or the women who is just preparing gestation.

4. allergic constitution reaches multiple drug allergy person.

5. merge to have the inclination, serious primary disease persons such as brain, liver, kidney, hemopoietic system.

6. psychotic.

7. the state of an illness is critical, is difficult to definite estimator is made in the effectiveness and the safety of new drug.

2. therapeutic scheme

2.1 administrated method: oral, a 15ml, 3 times on the one.

2.2 the course of treatment: medication 7 days.

3. observation index

Observe primary symptom and time disease variation.According to light (+) of symptom, in (++), heavy (+++), primary symptom is remembered the 2-6 branch respectively, inferior disease is remembered the 1-3 branch respectively, the tongue arteries and veins that meets dialectical standard is remembered 1 fen respectively.

Symptom scalar quantization table

Symptom	Gently (+)	In (++)	Heavy (+++)
Symptom	Gently (+)	In (++)	Heavy (+++)	The cough wheezing of panting of coughing up phlegm	Daytime, interruption was coughed, not influence work is lived, and expectoration 10～50ml is accidental round the clock, does not influence that sleep or movable idol are heard or when seeing cough, deep breathing	Daytime cough or see that idol is coughed at night, still as seen expectoration～100ml pants day and night to adhere to going to work round the clock, can adhere to that still work is dispersed in	Hacking cough or paroxysm round the clock, influence work and the above failing to lie flat due to dyspnea of expectoration 100ml round the clock of having a rest, influence sleep and activity are abound with

The pharyngalgia of breathing hard nasal obstruction watery nasal discharge chest pain

Feel the dry pharynx of breathing hard, hypodynia idol nasal obstruction, do not influence with nasal respiration idol snivel chest pain slight

The activity of breathing hard aggravation pharyngalgia often has the sooner or later equal watery nasal discharge of the obstructed sense of nasal obstruction in the daytime, measures few chest pain and obviously can stand

Obviously breathe hard, the work that influences is lived to have sore throat and is very had a stuffy nose obviously, need to flow pure and impure tears with mouth breathing, it is remarkable to continue the many chest pains of amount, and influence is breathed, cough

Tongue arteries and veins: specifically describe

4. curative effect determinate standard

Clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and integration reduces more than 95%.

Produce effects: clinical symptoms, sign are obviously improved, and integration reduces between 70%～94%.

Effectively: clinical symptoms, sign all take a favorable turn, and integration reduces 30%～＜69%.

Invalid: clinical symptoms does not have obvious improvement, very then increases the weight of, and integration reduces＜30%.

Computing formula is: [integration before (integration before the treatment-treatment back integration) ÷ treatment] * 100%

Observing time window: go into preceding the 1st observation of group and collection of specimens in preceding 1 day of administration; Medication finishes the back detection and finished in 3 days.

Product curative effect survey result table

The example number	The product curative effect
	The product curative effect								Clinical recovery	％	Produce effects	％	Effectively	％	Invalid	％
	232	158	68.1	47	20.3	24	10.3	3	Clinical recovery	％	Produce effects	％	Effectively	％	Invalid	％	1.3

Embodiment 1: syrup

Prescription: Herba Ephedrae 68g Semen Armeniacae Amarum 135g Gypsum Fibrosum 335g Semen Lepidii (Semen Descurainiae) 100g

Radix Platycodonis 100g Radix Peucedani 135g Radix Glycyrrhizae 68g

Method for making: above seven flavors, Semen Armeniacae Amarum add the water distillation and produce bitter almond water 135ml; Six-elements such as medicinal residues and all the other Herba Ephedraes decoct with water secondary (adding 8 times of water gagings), and each 2 hours, collecting decoction, filter, standing over night is got the clear paste that supernatant is evaporated to relative density 1.10～1.15 (60 ℃), add sucrose 500g and sodium benzoate 3g, boil and make dissolving, filter, put cold, add above-mentioned bitter almond water, add water to 1000ml, stir evenly, promptly.

Embodiment 2: syrup

Prescription: Herba Ephedrae 165g Semen Armeniacae Amarum 105g Gypsum Fibrosum 250g Semen Lepidii (Semen Descurainiae) 80g

Radix Platycodonis 120g Radix Peucedani 100g Radix Glycyrrhizae 80g

Method for making: above seven flavors, Semen Armeniacae Amarum add the water distillation and produce bitter almond water 150m1; Six-elements such as medicinal residues and all the other Herba Ephedraes decoct with water secondary (adding 10 times of water gagings), and each 2 hours, collecting decoction, filter, standing over night is got the clear paste of the full relative density 1.15～1.20 of supernatant concentrating under reduced pressure (60 ℃), add sucrose 500g and sodium benzoate 3g, boil and make dissolving, filter, put cold, add above-mentioned bitter almond water, add water to 1000ml, stir evenly, promptly.

Embodiment 3: soft extract

Prescription: Herba Ephedrae 100g Semen Armeniacae Amarum 150g Gypsum Fibrosum 80g Semen Lepidii (Semen Descurainiae) 150g

Radix Platycodonis 100g Radix Peucedani 100g Radix Glycyrrhizae 80g

Method for making: above seven flavors, Herba Ephedrae, Semen Armeniacae Amarum add the water distillation and produce distillate 150ml; The five tastes such as medicinal residues and all the other Gypsum Fibrosum decoct with water secondary (adding 8 times of water gagings), and each 2 hours, collecting decoction filtered, and standing over night is got the thick paste that supernatant is evaporated to relative density 1.30～1.35 (60 ℃).Other gets sucrose 600g, makes syrup, adds above-mentioned thick paste and refined honey 60g, is concentrated in right amount, puts coldly, adds above-mentioned distillate, stirs evenly, and makes about 1000g, promptly.

Embodiment 4: mixture

Prescription: Herba Ephedrae 200g Semen Armeniacae Amarum 180g Gypsum Fibrosum 180g Semen Lepidii (Semen Descurainiae) 40g

Radix Platycodonis 30g Radix Peucedani 60g Radix Glycyrrhizae 20g

Method for making: above seven flavors, Herba Ephedrae, Semen Armeniacae Amarum add the water distillation and produce distillate 100ml; The five tastes such as medicinal residues and all the other Gypsum Fibrosum decoct with water secondary (adding 12 times of water gagings), and each 2 hours, collecting decoction, filter, standing over night is got the thick paste that supernatant is evaporated to relative density 1.28～1.32 (60 ℃), add sucrose 150g and sodium benzoate 3g, boil and make dissolving, filter, put cold, add above-mentioned distillate, add water to 1000ml, stir evenly, promptly.

Embodiment 5: tablet

Prescription: Herba Ephedrae 250g Semen Armeniacae Amarum 160g Gypsum Fibrosum 250g Semen Lepidii (Semen Descurainiae) 100g

Radix Platycodonis 50g Radix Peucedani 90g Radix Glycyrrhizae 40g

Method for making: above seven flavors, decoct with water secondary (adding 11 times of water gagings), each 1.5 hours, collecting decoction, filter, standing over night is got the thick paste that supernatant is evaporated to relative density 1.25～1.30 (60 ℃), 80 ℃ of dryings, dried cream powder is broken, granulates tabletting, every heavy 0.4 gram.

Embodiment 6: capsule

Prescription: Herba Ephedrae 150g Semen Armeniacae Amarum 180g Gypsum Fibrosum 200g Semen Lepidii (Semen Descurainiae) 100g

Radix Platycodonis 100g Radix Peucedani 70g Radix Glycyrrhizae 10g

Method for making: above seven flavors, decoct with water secondary (adding 9 times of water gagings), each 1.5 hours, collecting decoction filtered, standing over night is got the thick paste that supernatant is evaporated to relative density 1.30～1.35 (60 ℃), 80 ℃ of dryings, and dried cream powder is broken, cross 80 mesh sieves, the dress capsule, 0.5 gram/grain, promptly.

Claims

1. medicine with relieving cough and asthma function, form by classics recipe Maxingshigan Tonga flavor, it is characterized in that the weight portion of each raw medicinal material is: Herba Ephedrae 5-30 part Semen Armeniacae Amarum 5-30 part Gypsum Fibrosum 10-50 part Semen Lepidii (Semen Descurainiae) 5-20 part Radix Platycodonis 1-15 part Radix Peucedani 1-15 part Radix Glycyrrhizae 1-20 part.

2. the preparation method with medicine of relieving cough and asthma function is characterized in that the weight portion of each raw medicinal material of syrup is: Herba Ephedrae 5-30 part Semen Armeniacae Amarum 5-30 part Gypsum Fibrosum 10-50 part Semen Lepidii (Semen Descurainiae) 5-20 part Radix Platycodonis 1-15 part Radix Peucedani 1-15 part Radix Glycyrrhizae 1-20 part;

Preparation technology is that Semen Armeniacae Amarum adds water distillation and produces bitter almond water, medicinal residues and all the other Six-element medical materials decoct with water, filter, and standing over night is got the supernatant concentrating under reduced pressure and become clear paste, add sucrose and sodium benzoate, boil and make dissolving, filter, put cold, add above-mentioned bitter almond water, add water to quantitatively, stir evenly, get product.

3. the preparation method with medicine of relieving cough and asthma function is characterized in that the weight portion of each raw medicinal material of soft extract is: Herba Ephedrae 5-30 part Semen Armeniacae Amarum 5-30 part Gypsum Fibrosum 10-50 part Semen Lepidii (Semen Descurainiae) 5-20 part Radix Platycodonis 1-15 part Radix Peucedani 1-15 part Radix Glycyrrhizae 1-20 part;

Preparation technology is that Herba Ephedrae, Semen Armeniacae Amarum add water distillation and produce distillate, and medicinal residues and all the other five tastes medical materials decoct with water, filter, and standing over night is got the supernatant concentrating under reduced pressure and become thick paste; Other gets sucrose and makes syrup, adds above-mentioned thick paste and refined honey, is concentrated in right amount, puts coldly, adds above-mentioned distillate, stir evenly, and packing, packing gets product.

4. the preparation method with medicine of relieving cough and asthma function is characterized in that the weight portion of each raw medicinal material of mixture is: Herba Ephedrae 5-30 part Semen Armeniacae Amarum 5-30 part Gypsum Fibrosum 10-50 part Semen Lepidii (Semen Descurainiae) 5-20 part Radix Platycodonis 1-15 part Radix Peucedani 1-15 part Radix Glycyrrhizae 1-20 part;

Preparation technology is that Herba Ephedrae, Semen Armeniacae Amarum add water distillation and produce distillate, and medicinal residues and all the other five tastes medical materials decoct with water, filtration, standing over night, get the supernatant concentrating under reduced pressure and become thick paste, add sucrose and sodium benzoate, boil and make dissolving, filter, put coldly, add above-mentioned bitter almond water, add water to quantitatively, stir evenly, promptly.

5. preparation method with medicine of relieving cough and asthma function is characterized in that each raw medicinal material weight portion of tablet is:

Radix Platycodonis 1-15 part Radix Peucedani 1-15 part Radix Glycyrrhizae 1-20 part;

Preparation technology is that the seven flavor medicine material decocts with water, and filters, and standing over night is got the supernatant concentrating under reduced pressure and become thick paste, and drying and crushing is granulated tabletting.

6. preparation method with medicine of relieving cough and asthma function is characterized in that the weight portion of each raw medicinal material of capsule is:

Method for making: above seven flavors, decoct with water, filter, standing over night is got the supernatant concentrating under reduced pressure and is become thick paste, and drying is pulverized, sieves, the dress capsule, promptly.