CN103977227A - Feed for preventing and treating swine vesicular disease, traditional Chinese medicine composition and preparation method of feed - Google Patents

Abstract

The invention discloses feed for preventing and treating swine vesicular disease, a traditional Chinese medicine composition and a preparation method of the feed. The feed comprises a basic feed, a trace element additive and a traditional Chinese medicine additive. The traditional Chinese medicine additive comprises schizonepeta, mint, lithospermum, radix bupleuri, fructus forsythiae, cimicifugae foetidae, radix scrophulariae, radix puerariae, duckweeds, gypsum rubrum, golden cypress, radices trichosanthis, radix angelicae, manis pentadactyla, dayflower, rhizoma anemarrhenae, coptis chinensis, cortex dictamni, radix sophorae flavescentis, adder-wort, wild buckwheat, buttercup, sea hare ova, wrightia leaves and lychnis coronata. The feed disclosed by the invention has the beneficial effects that by adding the traditional Chinese medicine additive, the feed has the effects of dispelling the wind and relieving exterior syndrome, clearing heat-fire, detoxifying, protecting gastric mucosa and enhancing the immunity of swine, the swine vesicular disease is not easy to relapse after treatment, and the feed is low in cost.

Description

A kind of for preventing and treating feedstuff, Chinese medicine composition and the preparation method of SVD

Technical field

The present invention relates to technical field of animal, particularly a kind of for preventing and treating feedstuff, Chinese medicine composition and the preparation method of SVD.

Background technology

SVD, claims again swine vesicular disease, is a kind of acute, the hot contagious disease that the virus by enterovirus genus causes.There is vesicle around in the hoof, oral cavity, nose and the sow nipple that it is characterized in that disease pig.This disease is found in 1966 first, is a kind of newer infectious disease of pig.

Symptom

What first observe is that in swinery, indivedual pigs walk lamely.On hard ground, walk more obvious, and normal back of a bow walking, there is pain reaction, or crouch and do not rise, the pig that physique is larger is more obvious.The body temperature 2-4 ℃ that generally rises.Damage generally occurs between coronet portion, frog, may be single hoof morbidity, also may all fall ill by many hoof.There is blister and ulceration in skin, and can expand to hoof bottom, and what have is loosening with coffin, even shelling.Blister and Secondary cases ulcer also may occur on asoscope portion, oral epithelium, tongue and nipple.There is constitutional blister in general contact infection, within 5-6 days, occurs Secondary cases blister through the incubation period of 2-4 days.Inoculation can be fallen ill within 2 days.Pig can return to normal condition in general 3 weeks.It is very large that sickness rate breaks out a difference in difference, and what have is no more than 10%, but also have reach 100%.Mortality rate is generally very low.Nursing sow is carried out to experimental infection, and the M & M of the piglet of its nurture is all very high.The pig that has the infected pigs of clinical symptom and be in contact with it all can produce the neutralizing antibody of high titre, and at least can maintain 4 months.

2～4 days incubation periods, what have extends to 7～8 days.Sick just fervescence to 40～42 ℃, between coronet, toe, heel occurs that one or several Semen Glycines is to the large vesicle of silkworm, vesicle merges and expands then, is full of vesicle liquid, after 1～2 day, the vesicle formation ulcer of breaking, corium exposes, and color is scarlet.Because hoof suffers damage, walking lamely appears in sick pig walking.Some case, because secondary antibacterial infects, local suppuration, can cause coffin to come off, and can not stand.In hoof generation vesicle, there is vesicle around at nose, oral cavity and sow nipple in the sick pig having.Generally through about l0 days can spontaneous recovery, but newborn piglet can cause death.After hydroa occurs, approximately have 2% pig center of origin nerve problems, performance is to preshoot, and circus movement, with nose friction pig house apparatus, has tonic spasm sometimes.Clinical symptoms can be divided into classic form, mild and recessive type.

Classic form

Main manifestations is that the toe of disease pig is, the coronet of attached toe and nose dish, tongue, lip and sow nipple generation vesicle.Early symptom is the pale swelling of epithelium, in cutin and the skin junction of coronet, first sees, and after 36～48h, vesicle is obviously protruded, and the inside is full of vesicle liquid, breaks very soon, but sometimes maintains a couple of days.Vesicle forms ulcer after breaking, and corium exposes, and color is scarlet.When pathological changes is serious, coffin comes off.The pathological changes portion of part pig forms suppurative ulcer because secondary antibacterial infects.Because hoof suffers damage, hoof has pain to occur walking lamely.Some pigs are dog sitting posture or couch undergroundly, and severe patient is creeped with knee.Fervescence to 40～42 ℃, vesicle break after temperature decline to normal.Sick pig spirit is depressed, loss of appetite or stop eating.In the ordinary course of things, as infected patient without concurrent other, do not cause death, newborn piglet can cause death.Sick pig rehabilitation is very fast, and the last recovering 2 weeks, wound surface can be completely recovered, and as coffin comes off, after the long duration, could recover.After sick SVD occurs, approximately have 2% pig center of origin nerve problems, performance, to preshoot, circus movement, rubs, stings and gnaw pig house apparatus with nose, and tonic spasm, appears in Rotation of eyeball sometimes.

Mild

Only see that vesicle appears in the sick pig of minority, propagate slowly, symptom is slight, is often not easy to be discovered.

Recessive type

Reveal any symptoms not after infection, but infected pigs can discharge virus, and susceptible pig is had to very large danger.

Blister damage is the most typical and representative pathological change of SVD.The outward appearance of blister damage and the equal indifference of damage of microexamination and FMD.Other pathological changes such as brain injury etc. are atypism all.It is generally acknowledged that infection is mainly through two approach, the one, from the place of polluting, by there being the skin of wound directly to invade epithelial tissue, the virus after propagation arrives other predisposing infection areas by blood circulation and produces pathological changes.Another approach is that per os enters digestive tract, by digestive tract epithelium and mucosa, invades virus, is recycled to and reaches predisposing infection area, thereby the pathological changes such as blister damage and apyetous encephalomyelitis occur through blood.

At hoof, nose dish, lip, lingual surface, sometimes at breast, there is vesicle in characteristic pathological changes.Indivedual cases have strip ecchymosis at endocardium, and other organs is without visible pathological change.Histology is changed to non-purulent meningitis and encephalomyelitis pathological changes, and brain middle part pathological changes is serious compared with back.Meninges is containing large amount lymphocyte, and blood vessel embedding limit is obvious, and majority is reticular tissue cell, and minority is lymphocyte and eosinophil.Ectocinerea and white matter are found softening focus.

Doctor trained in Western medicine is to prevent that primary disease from importing into the important measures of SVD preventive measure prevention primary disease at ordinary times.Therefore, when introducing pig and pig product, must strict quarantine.Carry out daily disinfection, pig house, environment, effective disinfectant for means of transport (as the solution such as hot sodium hydroxide of 5% ammonia, 10% bleaching powder, 3% formalin and 3%) are regularly sterilized.Prevent from bringing disease into Pest-or disease-free area.Epidemic-stricken area and vulnerable area will regularly be inoculated, ill pig, after vesicle is broken, cleaned with 0.1% potassium permanganate or 2% alum water, and coating gentian voiet or the sweet Shan of iodine, a few days can cure.

But Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can expelling pathogenic wind from the body surface, clearing away heat-fire, removing toxic substances, protection gastric mucosa, strengthen pig immunity, and after curing, be difficult for recurrence, cost price is cheap.Therefore, Chinese herbal medicine is aspect treatment SVD disease, and application natural goods feed additive can carry out marketing, is of great practical significance.

Summary of the invention

Technical problem to be solved by this invention is to be to provide a kind of to comprise for preventing and treating the feedstuff of the Chinese medicine composition of SVD, the feedstuff that employing contains this Chinese medicine composition can overcome the defect of prior art Chinese medicine and western medicine and Chinese medicine, to suffering from the treatment of the pig of SVD, there is expelling pathogenic wind from the body surface, clearing away heat-fire, removing toxic substances, protection gastric mucosa, strengthen pig immunity, cure rate is high, have no side effect, clinical efficacy is more remarkable, drug residue free, do not produce drug resistance, be difficult for recurrence, and can improve the immunity of organisms of ill pig, cheap, after edible this type of Carnis Sus domestica of consumer, also can play certain advantages such as health-care effect to body.

In order to realize foregoing invention object, the invention provides a kind of for preventing and treating the feedstuff of SVD, it is characterized in that, comprise normal feedstuff, trace mineral supplement and Chinese medicine additive, in described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Schizonepetae 21-48 weight portion, Herba Menthae 11-30 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Radix Bupleuri 28-42 weight portion, Fructus Forsythiae 17-35 weight portion, Rhizoma Cimicifugae 16-32 weight portion, Radix Scrophulariae 25-40 weight portion, Radix Puerariae 13-28 weight portion, Herba Spirodelae 9-20 weight portion, Mirabilitum crystallina 15-30 weight portion, Cortex Phellodendri 25-40 weight portion, Radix Trichosanthis 30-45 weight portion, Radix Angelicae Dahuricae 20-35 weight portion, Squama Manis 14-33 weight portion, Herba Commelinae 23-41 weight portion, Rhizoma Anemarrhenae 17-38 weight portion, Rhizoma Coptidis 10-24 weight portion, Cortex Dictamni 23-42 weight portion, Radix Sophorae Flavescentis 6-17 weight portion, Rhizoma Bistortae 12-26 weight portion, Rhizoma Fagopyri Dibotryis 27-45 weight portion, Herba Ranunculi Japonici 8-15 weight portion, ove Notarchi 5-13 weight portion, Folium wrightiae pubescentis 21-40 weight portion and Herba lychnidis coronatae 16-37 weight portion.

In described feedstuff, the weight fraction of each composition ratio is: normal feedstuff 100 weight portions, trace mineral supplement 0.001-0.01 weight portion, Chinese medicine additive 13-26 weight portion.

Described normal feedstuff comprises one or more mixing in bean cake, Testa Tritici, Semen Maydis.

In described normal feedstuff, each component and weight are Semen Maydis 20-40 weight portion, bean cake 45-60 weight portion, Testa Tritici 30-65 weight portion.

Described trace mineral supplement comprises one or more mixing in ferrum, manganese, zinc, copper.

In described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Schizonepetae 23-45 weight portion, Herba Menthae 14-27 weight portion, Radix Arnebiae (Radix Lithospermi) 7-14 weight portion, Radix Bupleuri 34-42 weight portion, Fructus Forsythiae 17-30 weight portion, Rhizoma Cimicifugae 16-28 weight portion, Radix Scrophulariae 27-37 weight portion, Radix Puerariae 13-23 weight portion, Herba Spirodelae 9-18 weight portion, Mirabilitum crystallina 18-28 weight portion, Cortex Phellodendri 25-34 weight portion, Radix Trichosanthis 30-37 weight portion, Radix Angelicae Dahuricae 20-30 weight portion, Squama Manis 15-26 weight portion, Herba Commelinae 25-35 weight portion, Rhizoma Anemarrhenae 17-32 weight portion, Rhizoma Coptidis 10-20 weight portion, Cortex Dictamni 23-34 weight portion, Radix Sophorae Flavescentis 9-17 weight portion, Rhizoma Bistortae 12-23 weight portion, Rhizoma Fagopyri Dibotryis 27-39 weight portion, Herba Ranunculi Japonici 8-13 weight portion, ove Notarchi 5-10 weight portion, Folium wrightiae pubescentis 21-31 weight portion and Herba lychnidis coronatae 17-32 weight portion.

It is a kind of for preventing and treating the preparation method of the feedstuff of SVD that the present invention also provides, and comprises the following steps:

The first step, is ground into 90-160 object powder by normal feedstuff composition;

Second step, each component in described Chinese medicine additive is mixed in proportion, carry out charcoal and fry 50-80 minute, adding subsequently with respect to mixture quality 6-9 determining alcohol is doubly 78-94% alcoholic solution, heating and refluxing extraction 1.0-2.5 hour, obtain the first extracting solution, filter, obtain the first filtrate, it is 75-96 alcoholic solution that filtering residue adds with respect to its quality 4-8 determining alcohol doubly again, heating and refluxing extraction 1.0-2.0 hour, obtain the second extracting solution, filter, obtain the second filtrate, filtrate is merged, concentrating under reduced pressure is removed ethanol, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 300-420 order, obtain pulverous described Chinese medicine additive,

The 3rd step, the Chinese medicine additive that the normal feedstuff that the first step is obtained, second step obtain, trace mineral supplement drop in mixer and mix, send in modem and pass into the steam modulation 10-14 minute of 102-113 ℃, then at the temperature of 103-121 ℃, enter extruding puffing granulator and granulate;

The 4th step, the pellet after granulating is cooling, obtain described pig feed.

It is a kind of for preventing and treating the Chinese medicine composition of SVD that the present invention also provides, in Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Schizonepetae 21-48 weight portion, Herba Menthae 11-30 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Radix Bupleuri 28-42 weight portion, Fructus Forsythiae 17-35 weight portion, Rhizoma Cimicifugae 16-32 weight portion, Radix Scrophulariae 25-40 weight portion, Radix Puerariae 13-28 weight portion, Herba Spirodelae 9-20 weight portion, Mirabilitum crystallina 15-30 weight portion, Cortex Phellodendri 25-40 weight portion, Radix Trichosanthis 30-45 weight portion, Radix Angelicae Dahuricae 20-35 weight portion, Squama Manis 14-33 weight portion, Herba Commelinae 23-41 weight portion, Rhizoma Anemarrhenae 17-38 weight portion, Rhizoma Coptidis 10-24 weight portion, Cortex Dictamni 23-42 weight portion, Radix Sophorae Flavescentis 6-17 weight portion, Rhizoma Bistortae 12-26 weight portion, Rhizoma Fagopyri Dibotryis 27-45 weight portion, Herba Ranunculi Japonici 8-15 weight portion, ove Notarchi 5-13 weight portion, Folium wrightiae pubescentis 21-40 weight portion and Herba lychnidis coronatae 16-37 weight portion.。

The preparation method of described Chinese medicine composition composition powders comprises:

The first step, each component in described Chinese medicine composition is mixed in proportion, and input pulverizer is pulverized or directly chopping, packs into and decocts in container, add suitable quantity of water to make its submergence medical material, soak after 10-25 minute, be heated to seethe with excitement after 40-70 minute, separated fried liquid, medicinal residues again add water and decoct 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;

Second step, after filtrate is cooling, adding with respect to liquid weight 1-2 determining alcohol doubly after concentrated is 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes its precipitation, after getting its supernatant liquid filtering next day, obtain filtrate, the ethanol that precipitate is 50-60% with determining alcohol is cleaned, and collects washing liquid and merges with filtrate, decompression is regained after ethanol, and dislocation lets cool place, standing 0.5-1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste;

The 3rd step: paste is put into spray dryer dry, guarantee that inlet temperature is at 180 ℃-200 ℃, 70 ℃-90 ℃ of leaving air temps, are ground into 300 order-400 orders subsequently, obtain Powdered Chinese medicine composition.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: by adding Chinese medicine additive; can expelling pathogenic wind from the body surface, clearing away heat-fire, removing toxic substances, protection gastric mucosa, strengthen pig immunity, cure rate is high; have no side effect; clinical efficacy is more remarkable, and drug residue free does not produce drug resistance; be difficult for recurrence; and can improve the immunity of organisms of ill pig, cheap, after edible this type of Carnis Sus domestica of consumer, also can play certain advantages such as health-care effect to body.

The specific embodiment

The invention provides a kind of for preventing and treating the feedstuff of SVD, comprise normal feedstuff, trace mineral supplement and Chinese medicine additive, described Chinese medicine additive comprises: Herba Schizonepetae, Herba Menthae, Radix Arnebiae (Radix Lithospermi), Radix Bupleuri, Fructus Forsythiae, Rhizoma Cimicifugae, Radix Scrophulariae, Radix Puerariae, Herba Spirodelae, Mirabilitum crystallina, Cortex Phellodendri, Radix Trichosanthis, the Radix Angelicae Dahuricae, Squama Manis, Herba Commelinae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Bistortae, Rhizoma Fagopyri Dibotryis, Herba Ranunculi Japonici, ove Notarchi, Folium wrightiae pubescentis and Herba lychnidis coronatae.

In Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Schizonepetae 21-48 weight portion, Herba Menthae 11-30 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Radix Bupleuri 28-42 weight portion, Fructus Forsythiae 17-35 weight portion, Rhizoma Cimicifugae 16-32 weight portion, Radix Scrophulariae 25-40 weight portion, Radix Puerariae 13-28 weight portion, Herba Spirodelae 9-20 weight portion, Mirabilitum crystallina 15-30 weight portion, Cortex Phellodendri 25-40 weight portion, Radix Trichosanthis 30-45 weight portion, Radix Angelicae Dahuricae 20-35 weight portion, Squama Manis 14-33 weight portion, Herba Commelinae 23-41 weight portion, Rhizoma Anemarrhenae 17-38 weight portion, Rhizoma Coptidis 10-24 weight portion, Cortex Dictamni 23-42 weight portion, Radix Sophorae Flavescentis 6-17 weight portion, Rhizoma Bistortae 12-26 weight portion, Rhizoma Fagopyri Dibotryis 27-45 weight portion, Herba Ranunculi Japonici 8-15 weight portion, ove Notarchi 5-13 weight portion, Folium wrightiae pubescentis 21-40 weight portion and Herba lychnidis coronatae 16-37 weight portion.

Wherein, the pungent loose gas of Herba Schizonepetae is fragrant, is longer than and delivers loose wind, loose pathogen thoroughly, with Herba Menthae, Radix Arnebiae (Radix Lithospermi), Radix Bupleuri, Fructus Forsythiae compatibility; Rhizoma Cimicifugae induce sweat rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy, with Radix Scrophulariae compatibility with using; Radix Puerariae expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst; Herba Spirodelae is pungent cold, relieving the exterior syndrome by diaphoresis, and rash is antipruritic, inducing diuresis to remove edema; Mirabilitum crystallina is pungent, salty, cold, and clearing away heat-fire is used with Cortex Phellodendri compatibility is same; Radix Trichosanthis can clearing away heat-fire and detoxify, again can detumescence and apocenosis to treat skin ulcer, with the Radix Angelicae Dahuricae, Squama Manis compatibility with using; Herba Commelinae is sweet, light, cold, can clearing away heat-fire, removing toxic substances, and inducing diuresis to remove edema, with Rhizoma Anemarrhenae compatibility; Rhizoma Coptidis is bitter, cold, heat clearing and damp drying, eliminating fire and detoxication; Cortex Dictamni heat clearing and damp drying, the removing toxic substances of dispeling the wind, with Radix Sophorae Flavescentis, Fructus Forsythiae compatibility; Rhizoma Bistortae hardship is let out cold and cool, energy heat-clearing and toxic substances removing, cooling blood for hemostasis, suppressing the hyperactive liver to arrest the wind syndrome; Rhizoma Fagopyri Dibotryis heat-clearing and toxic substances removing, evacuation of pus blood stasis dispelling and Herba Ranunculi Japonici, ove Notarchi, Folium wrightiae pubescentis, Herba lychnidis coronatae compatibility.

The pharmacology of each crude drug is as follows:

Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet.Be included into lung, Liver Channel.Main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.

Herba Menthae: nature and flavor are pungent is cool.Return lung meridian, Liver Channel.For anemopyretic cold, epidemic febrile disease from the beginning of.Be used for the conjunctival congestion of having a headache, laryngopharynx swelling and pain.These product lightly float and rise floating, awakening consciousness, kind part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, the throat evacuated of merit.

Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty.GUIXIN, Liver Channel.Be mainly used in that heat in blood poison is contained, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire etc.

Radix Bupleuri: cold nature, bitter in the mouth, pungent.Return Liver Channel, gallbladder meridian.Tool depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, loose effect of fire.Expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, cold and heat deficient fever.

Fructus Forsythiae: bitter in the mouth, cold nature.GUIXIN, lung, small intestine meridian.Main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat.Having antibacterial, heart tonifying, diuresis, town the pharmacological action such as to tell, is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of symptoms such as, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.

Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature.Return lung meridian, spleen channel, large intestine channel, stomach warp.For measles, thoroughly send out smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature.Return lung, stomach, kidney channel.There is clearing away heat and cooling blood, eliminating fire and detoxication, the effect of YIN nourishing, cures mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.

Radix Puerariae: cool in nature, sweet in the mouth, pungent.Return spleen, stomach warp.Can yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.

Herba Spirodelae: pungent, cold.Return lung, small intestine meridian.Diaphoresis, dispels the wind, row water, heat clearing away, removing toxic substances.The hot carbuncle of row while controlling, macule is not saturating, wind heat pain rash, skin pruritus, edema, amenorrhea, skin ulcer tinea, erysipelas, scalds.

Mirabilitum crystallina: pungent, salty, cold.GUIXIN, stomach, kidney channel.Row calentura while curing mainly, high fever excessive thirst, laryngopharynx swelling and pain, edema, urine retention, aphtha of the mouth and tongue, carbuncle, erysipelas, scalds.

Cortex Phellodendri: cold in nature, bitter in the mouth.The effects such as tool heat clearing and damp drying, eliminating fire and detoxication, are usually used in the diseases such as damp-heat dysentery, jaundice, leucorrhea and pyretic arthralgia, pyretic stranguria.

Radix Trichosanthis: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature.Return lung, stomach, large intestine channel.Function expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, the venom contained.

Squama Manis: salty in the mouth, cold nature.Return liver, stomach warp.Blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula.

Herba Commelinae: sweet, cold, light.GUIXIN, liver,spleen,kidney, all warps of intestine and small intestine.Main cold and heat subtertian malaria, phlegm retention, fourth is swollen, and meat disease is not smooth, infantile erysipelas, the mad epilepsy of generating heat, large abdomen feeling of fullness, body face edema due to disorder of QI, hematodiarrhoea, Serpentis dog stings, the poison such as carbuncle.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature.Return lung, stomach, kidney channel.Have the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.

Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, has the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.

Cortex Dictamni: hardship, salty, cold.Return spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel.Control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy is yellow, labor is yellow etc.

Radix Sophorae Flavescentis: bitter in the mouth, cold in nature.Return liver, kidney, large intestine, small intestine meridian, bladder, heart channel, urinary bladder channel.Can heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.

Rhizoma Bistortae: hardship, cool.Return lung, liver, large intestine channel.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Control calentura infantile convulsion, tetany, tetanus, carbuncle scrofula, snake bite and insect sting.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.

Herba Ranunculi Japonici: pungent, micro-hardship, temperature.Poisonous.Return liver; Gallbladder; The heart; Stomach warp.Jaundice eliminating; Dingchuan; Preventing the attack (or recurrence) of malaria; Analgesia; Removing nebula.Cure mainly jaundice; Asthma; Malaria; Migraine; Toothache; The arthroncus of knee; Rheumatic arthritis; The raw nebula film of order; Scrofula; Carbuncle pyogenic infections from tumour or sore.

Ove Notarchi: sweet in the mouth; Salty; Cold in nature.Return lung; Kidney channel.Clearing away heat and nourishing YIN; Softening the hard mass expectorant.The main dryness of the lung is breathed with cough; Epistaxis, goiter; Scrofula.

Folium wrightiae pubescentis: sweet; Micro-hardship; Cool in nature.Expelling pathogenic wind from the body surface; Heat-clearing and toxic substances removing.Main cold, fever; Laryngopharynx swelling and pain; Acute and chronic tracheitis; Acute pyelonephritis.

Herba lychnidis coronatae: sweet; Micro-hardship; Cold in nature.Return lung; Liver Channel.Removing damp-heat; Eliminating fire and detoxication.Main cold, fever; Herpes zoster; Rheumatic arthralgia; Have loose bowels.

In feedstuff, the weight fraction of each composition ratio is: normal feedstuff 100 weight portions, trace mineral supplement 0.001-0.01 weight portion, Chinese medicine additive 13-26 weight portion.

Normal feedstuff comprises one or more mixing in bean cake, Testa Tritici, Semen Maydis.

In normal feedstuff, each component and weight are Semen Maydis 20-40 weight portion, bean cake 45-60 weight portion, Testa Tritici 30-65 weight portion.

Trace mineral supplement comprises one or more mixing in ferrum, manganese, zinc, copper.

In Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Schizonepetae 23-45 weight portion, Herba Menthae 14-27 weight portion, Radix Arnebiae (Radix Lithospermi) 7-14 weight portion, Radix Bupleuri 34-42 weight portion, Fructus Forsythiae 17-30 weight portion, Rhizoma Cimicifugae 16-28 weight portion, Radix Scrophulariae 27-37 weight portion, Radix Puerariae 13-23 weight portion, Herba Spirodelae 9-18 weight portion, Mirabilitum crystallina 18-28 weight portion, Cortex Phellodendri 25-34 weight portion, Radix Trichosanthis 30-37 weight portion, Radix Angelicae Dahuricae 20-30 weight portion, Squama Manis 15-26 weight portion, Herba Commelinae 25-35 weight portion, Rhizoma Anemarrhenae 17-32 weight portion, Rhizoma Coptidis 10-20 weight portion, Cortex Dictamni 23-34 weight portion, Radix Sophorae Flavescentis 9-17 weight portion, Rhizoma Bistortae 12-23 weight portion, Rhizoma Fagopyri Dibotryis 27-39 weight portion, Herba Ranunculi Japonici 8-13 weight portion, ove Notarchi 5-10 weight portion, Folium wrightiae pubescentis 21-31 weight portion and Herba lychnidis coronatae 17-32 weight portion.

It is a kind of for preventing and treating the preparation method of the feedstuff of SVD that the present invention also provides, and comprises the following steps:

The first step, is ground into 90-160 object powder by normal feedstuff composition;

Second step, each component in described Chinese medicine additive is mixed in proportion, carry out charcoal and fry 50-80 minute, adding subsequently with respect to mixture quality 6-9 determining alcohol is doubly 78-94% alcoholic solution, heating and refluxing extraction 1.0-2.5 hour, obtain the first extracting solution, filter, obtain the first filtrate, it is 75-96 alcoholic solution that filtering residue adds with respect to its quality 4-8 determining alcohol doubly again, heating and refluxing extraction 1.0-2.0 hour, obtain the second extracting solution, filter, obtain the second filtrate, filtrate is merged, concentrating under reduced pressure is removed ethanol, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 300-420 order, obtain pulverous described Chinese medicine additive,

The 3rd step, the Chinese medicine additive that the normal feedstuff that the first step is obtained, second step obtain, trace mineral supplement drop in mixer and mix, send in modem and pass into the steam modulation 10-14 minute of 102-113 ℃, then at the temperature of 103-121 ℃, enter extruding puffing granulator and granulate;

The 4th step, the pellet after granulating is cooling, obtain described pig feed.

It is a kind of for preventing and treating the Chinese medicine composition of SVD that the present invention also provides, in Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Schizonepetae 21-48 weight portion, Herba Menthae 11-30 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Radix Bupleuri 28-42 weight portion, Fructus Forsythiae 17-35 weight portion, Rhizoma Cimicifugae 16-32 weight portion, Radix Scrophulariae 25-40 weight portion, Radix Puerariae 13-28 weight portion, Herba Spirodelae 9-20 weight portion, Mirabilitum crystallina 15-30 weight portion, Cortex Phellodendri 25-40 weight portion, Radix Trichosanthis 30-45 weight portion, Radix Angelicae Dahuricae 20-35 weight portion, Squama Manis 14-33 weight portion, Herba Commelinae 23-41 weight portion, Rhizoma Anemarrhenae 17-38 weight portion, Rhizoma Coptidis 10-24 weight portion, Cortex Dictamni 23-42 weight portion, Radix Sophorae Flavescentis 6-17 weight portion, Rhizoma Bistortae 12-26 weight portion, Rhizoma Fagopyri Dibotryis 27-45 weight portion, Herba Ranunculi Japonici 8-15 weight portion, ove Notarchi 5-13 weight portion, Folium wrightiae pubescentis 21-40 weight portion and Herba lychnidis coronatae 16-37 weight portion.。

The preparation method of Chinese medicine composition composition powders comprises:

The first step, each component in described Chinese medicine composition is mixed in proportion, and input pulverizer is pulverized or directly chopping, packs into and decocts in container, add suitable quantity of water to make its submergence medical material, soak after 10-25 minute, be heated to seethe with excitement after 40-70 minute, separated fried liquid, medicinal residues again add water and decoct 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;

Second step, after filtrate is cooling, adding with respect to liquid weight 1-2 determining alcohol doubly after concentrated is 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes its precipitation, after getting its supernatant liquid filtering next day, obtain filtrate, the ethanol that precipitate is 50-60% with determining alcohol is cleaned, and collects washing liquid and merges with filtrate, decompression is regained after ethanol, and dislocation lets cool place, standing 0.5-1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste;

The 3rd step: paste is put into spray dryer dry, guarantee that inlet temperature is at 180 ℃-200 ℃, 70 ℃-90 ℃ of leaving air temps, are ground into 300 order-400 orders subsequently, obtain Powdered Chinese medicine composition.

The toxicity test of embodiment 1 Chinese medicine composition of the present invention

Get Herba Schizonepetae 23g, Herba Menthae 27g, Radix Arnebiae (Radix Lithospermi) 7g, Radix Bupleuri 42g, Fructus Forsythiae 17g, Rhizoma Cimicifugae 16g, Radix Scrophulariae 37g, Radix Puerariae 23g, Herba Spirodelae 9g, Mirabilitum crystallina 20g, Cortex Phellodendri 25g, Radix Trichosanthis 30g, Radix Angelicae Dahuricae 20g, Squama Manis 26g, Herba Commelinae 35g, Rhizoma Anemarrhenae 17g, Rhizoma Coptidis 15g, Cortex Dictamni 23g, Radix Sophorae Flavescentis 9g, Rhizoma Bistortae 14g, Rhizoma Fagopyri Dibotryis 29g, Herba Ranunculi Japonici 13g, ove Notarchi 5g, Folium wrightiae pubescentis 31g and Herba lychnidis coronatae 17g; After mix homogeneously, pulverize, the water to adding 1400g in the mixture after pulverizing, decocts 2.5 hours, filters, and adds the water of 600g again to decoct in filtering residue 2 hours, filters, and by twice filtrate mixing, is evaporated to the decoct that crude drug concentration is 3g/ml.

Get ICR mice, body weight is at 25-30 gram, by body weight random packet, and 10 every group, male and female half and half, oral administration solution administration, dosage is only 6.0ml/.After administration, Continuous Observation is 20 days, and all mices of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

Embodiment 2 Chinese medicine composition 1 of the present invention and preparation method

Get Herba Schizonepetae 45g, Herba Menthae 14g, Radix Arnebiae (Radix Lithospermi) 14g, Radix Bupleuri 34g, Fructus Forsythiae 30g, Rhizoma Cimicifugae 28g, Radix Scrophulariae 27g, Radix Puerariae 13g, Herba Spirodelae 18g, Mirabilitum crystallina 28g, Cortex Phellodendri 34g, Radix Trichosanthis 37g, Radix Angelicae Dahuricae 30g, Squama Manis 15g, Herba Commelinae 25g, Rhizoma Anemarrhenae 32g, Rhizoma Coptidis 20g, Cortex Dictamni 34g, Radix Sophorae Flavescentis 17g, Rhizoma Bistortae 23g, Rhizoma Fagopyri Dibotryis 27-39g, Herba Ranunculi Japonici 8g, ove Notarchi 10g, Folium wrightiae pubescentis 21g and Herba lychnidis coronatae 32g; Dropping into pulverizer pulverizes, Chinese medicine composition after pulverizing is packed into and decocted in container, add suitable quantity of water to make its submergence medical material, soak after 10 minutes, be heated to seethe with excitement after 40 minutes, separated fried liquid, medicinal residues again add water and decoct 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue; After filtrate is cooling, adding the determining alcohol with respect to 2 times of liquid weights after concentrated is 86% ethanol, fully mix homogeneously, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that precipitate is 55% with determining alcohol is cleaned, and collects washing liquid and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 0.5 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste; Paste is put into spray dryer dry, guarantee that inlet temperature is at 185 ℃, 85 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain Powdered Chinese medicine composition.

Embodiment 3 Chinese medicine composition 2 of the present invention and preparation method

Get Herba Schizonepetae 30g, Herba Menthae 20g, Radix Arnebiae (Radix Lithospermi) 10g, Radix Bupleuri 35g, Fructus Forsythiae 28g, Rhizoma Cimicifugae 26g, Radix Scrophulariae 36g, Radix Puerariae 15g, Herba Spirodelae 12g, Mirabilitum crystallina 18g, Cortex Phellodendri 29g, Radix Trichosanthis 33g, Radix Angelicae Dahuricae 27g, Squama Manis 22g, Herba Commelinae 30g, Rhizoma Anemarrhenae 19g, Rhizoma Coptidis 11g, Cortex Dictamni 27g, Radix Sophorae Flavescentis 11g, Rhizoma Bistortae 13g, Rhizoma Fagopyri Dibotryis 37g, Herba Ranunculi Japonici 12g, ove Notarchi 7g, Folium wrightiae pubescentis 23g and Herba lychnidis coronatae 24g; Dropping into pulverizer pulverizes, Chinese medicine composition after pulverizing is packed into and decocted in container, add suitable quantity of water to make its submergence medical material, soak after 19 minutes, be heated to seethe with excitement after 50 minutes, separated fried liquid, medicinal residues again add water and decoct 2 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue; After filtrate is cooling, adding the determining alcohol with respect to 1 times of liquid weight after concentrated is 90% ethanol, fully mix homogeneously, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that precipitate is 55% with determining alcohol is cleaned, and collects washing liquid and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste; Paste is put into spray dryer dry, guarantee that inlet temperature is at 200 ℃, 90 ℃ of leaving air temps, are ground into 400 orders subsequently, obtain Powdered Chinese medicine composition.

Embodiment 4 Chinese medicine composition 3 of the present invention and preparation method

Get Herba Schizonepetae 26g, Herba Menthae 16g, Radix Arnebiae (Radix Lithospermi) 13g, Radix Bupleuri 40g, Fructus Forsythiae 19g, Rhizoma Cimicifugae 19g, Radix Scrophulariae 29g, Radix Puerariae 22g, Herba Spirodelae 17g, Mirabilitum crystallina 27g, Cortex Phellodendri 33g, Radix Trichosanthis 31g, Radix Angelicae Dahuricae 22g, Squama Manis 16g, Herba Commelinae 27g, Rhizoma Anemarrhenae 31g, Rhizoma Coptidis 19g, Cortex Dictamni 32g, Radix Sophorae Flavescentis 15g, Rhizoma Bistortae 13g, Rhizoma Fagopyri Dibotryis 28g, Herba Ranunculi Japonici 9g, ove Notarchi 8g, Folium wrightiae pubescentis 30g and Herba lychnidis coronatae 31g; Dropping into pulverizer pulverizes, Chinese medicine composition after pulverizing is packed into and decocted in container, add suitable quantity of water to make its submergence medical material, soak after 25 minutes, be heated to seethe with excitement after 70 minutes, separated fried liquid, medicinal residues again add water and decoct 3, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue; After filtrate is cooling, adding the determining alcohol with respect to 2 times of liquid weights after concentrated is 80% ethanol, fully mix homogeneously, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that precipitate is 50% with determining alcohol is cleaned, and collects washing liquid and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 0.7 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste; Paste is put into spray dryer dry, guarantee that inlet temperature is at 180 ℃, 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain Powdered Chinese medicine composition.

Embodiment 5 feedstuff 1 of the present invention and preparation method

A kind of feedstuff, comprise normal feedstuff, trace mineral supplement and Chinese medicine additive, its ratio of weight and number is 100 weight portions: 0.005 weight portion: 13 weight portions, wherein in normal feedstuff, each component agent weight is bean cake 6000g, Testa Tritici 3000g, Semen Maydis 2000g, wherein, trace mineral supplement is the mixture of ferrum, manganese, zinc and copper, wherein in Chinese medicine additive, the parts by weight of each crude drug are: Herba Schizonepetae 45 weight portions, Herba Menthae 14 weight portions, Radix Arnebiae (Radix Lithospermi) 14 weight portions, Radix Bupleuri 34 weight portions, Fructus Forsythiae 30 weight portions, Rhizoma Cimicifugae 28 weight portions, Radix Scrophulariae 27 weight portions, Radix Puerariae 13 weight portions, Herba Spirodelae 18 weight portions, Mirabilitum crystallina 28 weight portions, Cortex Phellodendri 34 weight portions, Radix Trichosanthis 37 weight portions, the Radix Angelicae Dahuricae 30 weight portions, Squama Manis 15 weight portions, Herba Commelinae 25 weight portions, the Rhizoma Anemarrhenae 32 weight portions, Rhizoma Coptidis 20 weight portions, Cortex Dictamni 34 weight portions, Radix Sophorae Flavescentis 17 weight portions, Rhizoma Bistortae 23 weight portions, Rhizoma Fagopyri Dibotryis 27-39 weight portion, Herba Ranunculi Japonici 8 weight portions, ove Notarchi 10 weight portions, Folium wrightiae pubescentis 21 weight portions and Herba lychnidis coronatae 32 weight portions.

The preparation method of feedstuff is as follows:

The first step, is ground into 160 object powder by normal feedstuff composition;

Second step, each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 80 minutes, adding subsequently the determining alcohol with respect to 6 times of mixture qualities is 78% alcoholic solution, heating and refluxing extraction 2.5 hours, obtain the first extracting solution, filter, obtain the first filtrate, it is 75% alcoholic solution that filtering residue adds the determining alcohol with respect to 8 times of its quality again, heating and refluxing extraction 1.0 hours, obtain the second extracting solution, filter, obtain the second filtrate, filtrate is merged, concentrating under reduced pressure is removed ethanol, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 300 orders, obtain pulverous described Chinese medicine additive,

The 3rd step, the Chinese medicine additive that the normal feedstuff that the first step is obtained, second step obtain, trace mineral supplement drop in mixer and mix, send into the steam modulation 10 minutes that passes into 102 ℃ in modem, then at the temperature of 103 ℃, enter extruding puffing granulator and granulate;

The 4th step, the pellet after granulating is cooling, obtain described pig feed.

Embodiment 6 feedstuff 2 of the present invention and preparation method

A kind of feedstuff, comprise normal feedstuff, trace mineral supplement and Chinese medicine additive, its ratio of weight and number is 100 weight portions: 0.008 weight portion: 26 weight portions, wherein in normal feedstuff, each component agent weight is bean cake 5500g, Testa Tritici 6500g, Semen Maydis 4000g, wherein, trace mineral supplement is the mixture of ferrum, manganese, zinc and copper, wherein in Chinese medicine additive, the parts by weight of each crude drug are: Herba Schizonepetae 30 weight portions, Herba Menthae 20 weight portions, Radix Arnebiae (Radix Lithospermi) 10 weight portions, Radix Bupleuri 35 weight portions, Fructus Forsythiae 28 weight portions, Rhizoma Cimicifugae 26 weight portions, Radix Scrophulariae 36 weight portions, Radix Puerariae 15 weight portions, Herba Spirodelae 12 weight portions, Mirabilitum crystallina 18 weight portions, Cortex Phellodendri 29 weight portions, Radix Trichosanthis 33 weight portions, the Radix Angelicae Dahuricae 27 weight portions, Squama Manis 22 weight portions, Herba Commelinae 30 weight portions, the Rhizoma Anemarrhenae 19 weight portions, Rhizoma Coptidis 11 weight portions, Cortex Dictamni 27 weight portions, Radix Sophorae Flavescentis 11 weight portions, Rhizoma Bistortae 13 weight portions, Rhizoma Fagopyri Dibotryis 37 weight portions, Herba Ranunculi Japonici 12 weight portions, ove Notarchi 7 weight portions, Folium wrightiae pubescentis 23 weight portions and Herba lychnidis coronatae 24 weight portions.

The preparation method of feedstuff is as follows:

The first step, is ground into 90 object powder by normal feedstuff composition;

Second step, each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 50 minutes, adding subsequently the determining alcohol with respect to 9 times of mixture qualities is 94% alcoholic solution, heating and refluxing extraction 1.0 hours, obtain the first extracting solution, filter, obtain the first filtrate, it is 96% alcoholic solution that filtering residue adds the determining alcohol with respect to 4 times of its quality again, heating and refluxing extraction 2.0 hours, obtain the second extracting solution, filter, obtain the second filtrate, filtrate is merged, concentrating under reduced pressure is removed ethanol, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 420 orders, obtain pulverous described Chinese medicine additive,

The 3rd step, the Chinese medicine additive that the normal feedstuff that the first step is obtained, second step obtain, trace mineral supplement drop in mixer and mix, send into the steam modulation 14 minutes that passes into 113 ℃ in modem, then at the temperature of 121 ℃, enter extruding puffing granulator and granulate;

The 4th step, the pellet after granulating is cooling, obtain described pig feed.

Embodiment 7 clinical trials

(1) for examination animal

Choose in the sick pig after make a definite diagnosis on pig farm, 3, Linyi, Shandong, choose at random 120 3 monthly ages sick pig as treatment contrast test object; Separately from pig farm, 3, Linyi, Shandong, choose at random 180 3 monthly age health pig as prevention contrast test object.

(2) pathological material of disease is taked:

Selection has classical symptom, without obvious complication, the sick pig that do not heal with medicine, take disease pig not ulceration or the just vesicle skin of ulceration, after cleaning and grinding, with normal saline, make suspension, standby.

(3) prevention contrast experiment:

180 of random choose 3 monthly age health pig are divided into 3 groups (matched group 1, matched group 2 and embodiment groups) at random; wherein; matched group 1 and matched group 2 are used respectively traditional pig feed pig of feeding; embodiment group is used the pig of feeding of the feedstuff 1 in embodiment 5, and feeding, after 14 days, carries out artificial ear root intramuscular inoculation injection pathological material of disease 4mL/ head to matched group 1 and embodiment group; after 28 days; observed and recorded is respectively organized sickness rate and the protective rate of pig, and all pigs are weighed by head, and result is as shown in table 1.

Average daily gain: formal test took every nest pig weight the same day early in the morning, every group of a few nest weighs to be added and is starting weight, off-test takes every nest pig weight on the 2nd day early in the morning, every group of a few nest weighs to be added and is last weight, utilize end heavily to deduct initial recuperation and go out weightening finish, divided by raising natural law, then divided by a number, draw

Every pig average daily gain.

Average daily ingestion amount=total feed consumption rate ÷ (raising natural law * test number)

Feedstuff-meat ratio=average daily ingestion amount ÷ average daily gain

Table 1 preventive effect synopsis

Data from table 1: the feedstuff that the present invention contains Chinese medicine composition has obvious preventive effect to SVD, but also can obviously promote pig weightening finish, there is obvious economic benefit.

(4) treatment contrast test:

The sick pig of 120 3 monthly ages of choosing is at random divided into 2 groups (treatment by Chinese herbs group, western medicine groups) at random, with different medicines, treats, wherein, treatment by Chinese herbs group is selected the Chinese medicine composition 3 of embodiment 4, and dose is 0.7g/kg every day, is used in conjunction 9 days; Western medicine group is selected the grand treasured of blue ear health+amoxicillin/hundred million of annulus, 1 time/d, uses continuously 9 days.Observed and recorded is respectively organized the cure rate of pig.Treatment by Chinese herbs group is cured 60, cure rate 100%, and western medicine group is cured 50, cure rate 83.3%.Quantity and the time result of curing are as shown in table 2.

Table 2 liang group is treated respectively 9 days quantity and time comparative examples (%) of curing afterwards

Data from table 2: Chinese medicine composition of the present invention is obviously better than western medicine group to SVD therapeutic effect, instant effect, improves cure rate.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. one kind for preventing and treating the feedstuff of SVD, it is characterized in that, comprise normal feedstuff, trace mineral supplement and Chinese medicine additive, in described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Schizonepetae 21-48 weight portion, Herba Menthae 11-30 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Radix Bupleuri 28-42 weight portion, Fructus Forsythiae 17-35 weight portion, Rhizoma Cimicifugae 16-32 weight portion, Radix Scrophulariae 25-40 weight portion, Radix Puerariae 13-28 weight portion, Herba Spirodelae 9-20 weight portion, Mirabilitum crystallina 15-30 weight portion, Cortex Phellodendri 25-40 weight portion, Radix Trichosanthis 30-45 weight portion, Radix Angelicae Dahuricae 20-35 weight portion, Squama Manis 14-33 weight portion, Herba Commelinae 23-41 weight portion, Rhizoma Anemarrhenae 17-38 weight portion, Rhizoma Coptidis 10-24 weight portion, Cortex Dictamni 23-42 weight portion, Radix Sophorae Flavescentis 6-17 weight portion, Rhizoma Bistortae 12-26 weight portion, Rhizoma Fagopyri Dibotryis 27-45 weight portion, Herba Ranunculi Japonici 8-15 weight portion, ove Notarchi 5-13 weight portion, Folium wrightiae pubescentis 21-40 weight portion and Herba lychnidis coronatae 16-37 weight portion.

2. according to claim 1 for preventing and treating the feedstuff of SVD, it is characterized in that, in described feedstuff, the weight fraction of each composition ratio is: normal feedstuff 100 weight portions, trace mineral supplement 0.001-0.01 weight portion, Chinese medicine additive 13-26 weight portion.

3. according to claim 1ly for preventing and treating the feedstuff of SVD, it is characterized in that, described normal feedstuff comprises one or more mixing in bean cake, Testa Tritici, Semen Maydis.

4. according to claim 3ly for preventing and treating the feedstuff of SVD, it is characterized in that, in described normal feedstuff, each component and weight are Semen Maydis 20-40 weight portion, bean cake 45-60 weight portion, Testa Tritici 30-65 weight portion.

5. according to claim 1ly for preventing and treating the feedstuff of SVD, it is characterized in that, described trace mineral supplement comprises one or more mixing in ferrum, manganese, zinc, copper.

6. arbitrary described for preventing and treating the feedstuff of SVD according to claim 1-5, it is characterized in that, in described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Schizonepetae 23-45 weight portion, Herba Menthae 14-27 weight portion, Radix Arnebiae (Radix Lithospermi) 7-14 weight portion, Radix Bupleuri 34-42 weight portion, Fructus Forsythiae 17-30 weight portion, Rhizoma Cimicifugae 16-28 weight portion, Radix Scrophulariae 27-37 weight portion, Radix Puerariae 13-23 weight portion, Herba Spirodelae 9-18 weight portion, Mirabilitum crystallina 18-28 weight portion, Cortex Phellodendri 25-34 weight portion, Radix Trichosanthis 30-37 weight portion, Radix Angelicae Dahuricae 20-30 weight portion, Squama Manis 15-26 weight portion, Herba Commelinae 25-35 weight portion, Rhizoma Anemarrhenae 17-32 weight portion, Rhizoma Coptidis 10-20 weight portion, Cortex Dictamni 23-34 weight portion, Radix Sophorae Flavescentis 9-17 weight portion, Rhizoma Bistortae 12-23 weight portion, Rhizoma Fagopyri Dibotryis 27-39 weight portion, Herba Ranunculi Japonici 8-13 weight portion, ove Notarchi 5-10 weight portion, Folium wrightiae pubescentis 21-31 weight portion and Herba lychnidis coronatae 17-32 weight portion.

7. arbitrary described for preventing and treating the preparation method of the feedstuff of SVD according to claim 1-6, it is characterized in that, comprise the following steps:

The first step, is ground into 90-160 object powder by normal feedstuff composition;

Second step, each component in described Chinese medicine additive is mixed in proportion, carry out charcoal and fry 50-80 minute, adding subsequently with respect to mixture quality 6-9 determining alcohol is doubly 78-94% alcoholic solution, heating and refluxing extraction 1.0-2.5 hour, obtain the first extracting solution, filter, obtain the first filtrate, it is 75-96 alcoholic solution that filtering residue adds with respect to its quality 4-8 determining alcohol doubly again, heating and refluxing extraction 1.0-2.0 hour, obtain the second extracting solution, filter, obtain the second filtrate, filtrate is merged, concentrating under reduced pressure is removed ethanol, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 300-420 order, obtain pulverous described Chinese medicine additive,

The 3rd step, the Chinese medicine additive that the normal feedstuff that the first step is obtained, second step obtain, trace mineral supplement drop in mixer and mix, send in modem and pass into the steam modulation 10-14 minute of 102-113 ℃, then at the temperature of 103-121 ℃, enter extruding puffing granulator and granulate;

The 4th step, the pellet after granulating is cooling, obtain described pig feed.

8. one kind for preventing and treating the Chinese medicine composition of SVD, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Herba Schizonepetae 21-48 weight portion, Herba Menthae 11-30 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Radix Bupleuri 28-42 weight portion, Fructus Forsythiae 17-35 weight portion, Rhizoma Cimicifugae 16-32 weight portion, Radix Scrophulariae 25-40 weight portion, Radix Puerariae 13-28 weight portion, Herba Spirodelae 9-20 weight portion, Mirabilitum crystallina 15-30 weight portion, Cortex Phellodendri 25-40 weight portion, Radix Trichosanthis 30-45 weight portion, Radix Angelicae Dahuricae 20-35 weight portion, Squama Manis 14-33 weight portion, Herba Commelinae 23-41 weight portion, Rhizoma Anemarrhenae 17-38 weight portion, Rhizoma Coptidis 10-24 weight portion, Cortex Dictamni 23-42 weight portion, Radix Sophorae Flavescentis 6-17 weight portion, Rhizoma Bistortae 12-26 weight portion, Rhizoma Fagopyri Dibotryis 27-45 weight portion, Herba Ranunculi Japonici 8-15 weight portion, ove Notarchi 5-13 weight portion, Folium wrightiae pubescentis 21-40 weight portion and Herba lychnidis coronatae 16-37 weight portion.

9. according to claim 8ly for preventing and treating the Chinese medicine composition of SVD, it is characterized in that, the preparation method of described Chinese medicine composition composition powders comprises:

The first step, each component in described Chinese medicine composition is mixed in proportion, and input pulverizer is pulverized or directly chopping, packs into and decocts in container, add suitable quantity of water to make its submergence medical material, soak after 10-25 minute, be heated to seethe with excitement after 40-70 minute, separated fried liquid, medicinal residues again add water and decoct 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;

Second step, after filtrate is cooling, adding with respect to liquid weight 1-2 determining alcohol doubly after concentrated is 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes its precipitation, after getting its supernatant liquid filtering next day, obtain filtrate, the ethanol that precipitate is 50-60% with determining alcohol is cleaned, and collects washing liquid and merges with filtrate, decompression is regained after ethanol, and dislocation lets cool place, standing 0.5-1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste;

The 3rd step, puts into spray dryer by paste dry, guarantees that inlet temperature is at 180 ℃-200 ℃, and 70 ℃-90 ℃ of leaving air temps, are ground into 300 order-400 orders subsequently, obtain Powdered Chinese medicine composition.