CN106265831A - One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof - Google Patents
One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof Download PDFInfo
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- CN106265831A CN106265831A CN201510337006.2A CN201510337006A CN106265831A CN 106265831 A CN106265831 A CN 106265831A CN 201510337006 A CN201510337006 A CN 201510337006A CN 106265831 A CN106265831 A CN 106265831A
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Abstract
The present invention relates to a kind of treat laryngopharynx swelling and pain disease rapid disintegrate, the Chinese medicine preparation Flos Lonicerae Herba Pileae Scriptae dispersible tablet of the most uniformly dissolution, its component is Herba Sarcandrae extract 20%-35%, Flos Lonicerae extract 10%-18%, Mentholum 0.06%-0.3%, guar gum 5%-10%, Vivastar20%-36%, crosslinked polyethylene Topiramate Los oxazolidinone 10%-16%, glucose 15%-30%, gross weight is 100%.The feature of said preparation preparation technology is with Flos Lonicerae, Chinese medicinal material of sarcandra glaber as primary raw material, and it decocts extracting solution clear filtrate vacuum-concentrcted and becomes extractum, adds Mentholum liquid, guar gum, Vivastar, crosslinked polyethylene Topiramate Los oxazolidinone, glucose and 50-60% alcohol dampening agent, make granule, the method such as cold drying, tabletting makes tablet, rapidly, bioavailability is high for this disintegration of tablet, dissolution, and stability is high, curative effect is rapid, is better than like product.
Description
Technical field
The present invention relates to a kind of for treating laryngopharynx swelling and pain Chinese medicine preparation Flos Lonicerae Herba Pileae Scriptae dispersible tablet and preparation method thereof.
Background technology
Laryngopharynx swelling and pain is usually the performance of pharyngitis, and the traditional Chinese medical science claims sore throat, swallows the pass into stomach, and larynx is the door of lung, and it is easy that the heresy of diseases caused by exogenous pathogenic factor enters lung
Hindering larynx, throat is the ground that evil malicious good leaching is stayed for a long time." Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases " is said " being subject on pathogenic warmth, attacking the lung first ", and first throat is felt on occupying
By exopathogen.
Laryngopharynx swelling and pain is common upper respiratory disease, and particularly when anemopyretic cold, throat is easier to get angry and swells and ache, Western medicine and in
Medicine may serve to treat laryngopharynx swelling and pain, takes Western medicine instant effect, but generally with side effect, Chinese medicine is free from side effects substantially,
But curative effect is slow.
For many years, medical personal is exploring the faster Traditional Chinese medicinal prescription of curative effect always, provides curative effect rapid for swelling throat pain clinic,
Effect is notable, the new Chinese medicine formulation disperses sheet that side effect is little.
Dispersible tablet means that meeting the rapid disintegrate of water forms the tablet novel form of homogenous suspension, have good dispersing state, disintegration time short,
Drug-eluting is rapid, absorb the features such as fast (blood vessel abundant by tongue absorbs rapidly), bioavailability height, taking convenience.
Summary of the invention
It is an object of the invention to provide a kind of therapeutic effect prescription for the treatment of laryngopharynx swelling and pain both fast and sound and preparation method thereof.Motherland
Medical science is thought, primary disease can be because of impression heresy poison, and calentura is so that cloudy liquid consume, deficiency of YIN of both the lung and kidney, body fluid cannot flow upwards, and pharynx mistake is moistened foster, upper bright
In pharynx, sending out is pharyngopathy, claims " sore throat " (laryngopharynx swelling and pain), and method for the treatment of is then with heat-clearing and toxic substances removing, promoting blood circulation and detumescence, wind-expelling pain-stopping.Root
According to theory of Chinese medical science and rule for the treatment of prescription, prescription composition characteristic is: Flos Lonicerae sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.There is heat clearing away solution
Poison, dispelling wind and heat pathogens effect.Skin ulcer, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is treated for carbuncle.Chemistry becomes
Dividing and mainly have volatile oil, chlorogenic acid, iridoid, flavone and saponins compound, pharmacological research shows, Flos Lonicerae has anti-
Bacterium, antiviral, antipyretic, antioxidation isoreactivity.
Herba Sarcandrae, bitter in the mouth, pungent, property is put down, GUIXIN, Liver Channel.There is an anti-inflammation, expelling wind and removing dampness, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing,
Anti-platelet aggregation effect.Main containing sesquiterpene, flavone, Ingredients Such As Coumarin, pharmacology activity research shows that it has antitumor, resists
Bacterium antiinflammatory, suppression influenza virus, protect the liver and suppress the effect such as thrombocytopenia.
Mentholum, is mostly purified by natural raw peppermint oil and produces, and external is used for local analgesia, the most overworked, headache, dizziness, mosquito
Bite；Collunarium is used for nasal obstruction of catching cold, and sucks or sprays for pharyngolaryngitis.Pharmacological research have antipruritic, pain relieving, anticorrosion, stimulation,
Anesthesia, refrigerant and antiinflammatory action.
Prescription modern science and technology method, extract active ingredients of medicinal materials, extract is made pharmaceutical preparation, have dispel the wind antipyretic, sore-throat relieving
Analgesic efficacy, for pharyngolaryngitis, throat is dry to burn, and swells and ache, the treatment of hoarseness disease.
Embodiment
According to the traditional Chinese medical science principles of formulating prescriptions, with Herba Sarcandrae as monarch drug, with Flos Lonicerae as ministerial drug, form prescription with Mentholum for adjuvant,
Using modern science and technology method, carry out extracts active ingredients, separation, purification, extracting solution cryoconcentration becomes fluid extract, adds the most auxiliary
Material, is configured to preparation.
Preparation technology of preparing step is as follows:
1, take Herba Sarcandrae, clean, be cut into broken section, put into boiling 2 times in multi-function extractor, add water 10 times for the first time,
Boiling 1.5 hours, add water 8 times the 2nd time, boil 1.5 hours, 2 times decoction liquor merge filtration, and clear filtrate vacuum decompression is dense
It is reduced to the extractum I that concentrated solution relative density is 1.20-1.30 (80 DEG C), standby.
2, extracting honeysuckle, cleans, and puts into boiling 2 times in multi-function extractor, adds water 10 times for the first time, boil 1 little
Time, add water 7 times the 2nd time, boil 1 hour, 2 times decoction liquor merge filtration, and clear filtrate vacuum-concentrcted is to concentrating liquid phase
It is the extractum II of 1.20-1.30 (80 DEG C) to density, standby.
3, dispensing, pelletize, be dried
(1) take the Mentholum of recipe quantity, dissolve in right amount with ethanol completely, under agitation add in 50% glucose solution, stir
Mix the most standby.
(2) extractum I and extractum II is thrown in wet mixing pelletizer, stir
(3) weigh that guar gum fine powder (cross 100 mesh sieves) is appropriate, Vivastar fine powder (crossing 100 mesh sieves) is appropriate, crosslinking
(PVPP fine powder (crossing 100 mesh sieves) is appropriate, glucose fine powder (crossing 100 mesh sieves) is appropriate, puts into mixed for polyethylene Topiramate Los oxazolidinone
In conjunction machine, stir, standby.
(4) under agitation, (1) is sprayed into mix homogeneously in (2), adds (3) compound, mix homogeneously, spray
Being spilled into 50-60% ethanol and make wetting agent in right amount, stir, make rounding single-size with 30 mesh sieves, at 50 DEG C, vacuum is done
Dry, with 30 mesh sieve granulate, standby.
4, total mixed, tabletting
3 (4) dry granules are put in mixer, adds lubricant (magnesium stearate) in right amount, be sufficiently mixed uniformly, in 35%-50%
Under relative humidity, it is molded into the tablet of every 0.5g specification in a state of excitement with 12mm, quality standard: gained tablet is in water in 1min
Disintegrate completely, the complete dissolution of 1.5min.Qualified timely subpackage.
The ratio of above-mentioned raw materials is: Herba Sarcandrae extract 20%-35%, Flos Lonicerae extract 10%-18%, Mentholum 0.1%-0.6%,
Guar gum 5%-10%, Vivastar20%-36%, crosslinked polyethylene Topiramate Los oxazolidinone 10%-16%, glucose 15%-30%, gross weight
100%.
Product formulation Flos Lonicerae Herba Pileae Scriptae dispersible tablet of the present invention carries out 40 example laryngopharynx swelling and pain through the second Affiliated Hospital of Guangxi University of Chinese Medicine
(sore throat, acute hoarseness) clinical trial, in river, matched group Jiangxi, the FUFANG CAOSHANHU HANPIAN of pharmaceutical manufacturing treats 20 example swelling throats
Bitterly (sore throat, acute hoarseness) as a result, acute pharyngitis due to wind-heat treatment group and acute hoarseness treatment group are fully recovered 15 examples, cure rate 37.5%, always
Effective percentage 92.5%, matched group cures 6 examples, cure rate 30%, matched group total effective rate 70%.Clinical disease is obviously improved,
Front and back integration has significance (P ＜ 0.05) or very significant (P ＜ 0.01) meaning.Do not find any side effect.
Model case 1,5 certain, female, 23 years old, live Guangxi College of Education, on November 11st, 2013 go to a doctor.Main suit's pharyngalgia
Three days, disease saw pharyngalgia when swallowing, and dry pharynx is scorching hot more very, and dry pharynx is scorching hot, generates heat 37.5 DEG C, pharyngeal hyperemia II degree, red tongue, tongue
BOHUANG, floating and rapid pulse, examine as acute pharyngitis, card genus anemopyretic sore throat.Give Flos Lonicerae Herba Pileae Scriptae dispersible tablet to treat, each 2,
Every day 5 times, within the 1st day, without heating, pharyngalgia, dry pharynx are scorching hot and hyperemia alleviates, and the 3rd day dry pharynx burning sensation and pharyngalgia disappear, pharynx
Portion is without hyperemia.Efficacy evaluation: recovery from illness.
Example 2, land ××, female, 30 years old, Guangxi University teacher, because of pharyngalgia one day, goes to a doctor on November 24th, 2013, examines
See: pharyngeal pain, the scorching hot discomfort of dry pharynx, generate heat 37.5 DEG C, red tongue, white and thin fur, floating and rapid pulse, pharyngeal congestion (+++),
Examine as acute inflammation of the throat (anemopyretic), Western medicine diagnose: acute pharyngitis.Give Flos Lonicerae Herba Pileae Scriptae dispersible tablet, each 2, every day 5
Secondary, to take medicine the 1st day, dry pharynx is scorching hot, pharyngalgia substantially alleviates, and takes medicine the 3rd day, pharyngalgia, the scorching hot disappearance of dry pharynx, without heating,
Pharyngeal inspection (one), efficacy evaluation: recovery from illness.
Comparison medicine FUFANG CAOSHANHU HANPIAN cures case curative effect situation, and after taking medicine the 2nd day, dry pharynx is scorching hot, pharyngalgia substantially alleviates,
Take medicine the 5th day, the scorching hot disappearance of pharyngalgia, dry pharynx.Drug effect is more significantly slower than Flos Lonicerae Herba Pileae Scriptae dispersible tablet effect.
Detailed description of the invention:
Below in conjunction with embodiment, the invention will be further elaborated.Following example are only used for the purpose of citing and are not intended to this
Bright.
Embodiment 1
Crude drug uses Chinese medicinal material of sarcandra glaber 500g Chinese medicine honeysuckle 207g Mentholum 2.2g guar gum fine powder 39g
Vivastar fine powder 144.0g crosslinked polyethylene Topiramate Los oxazolidinone (PVPP fine powder 64g glucose fine powder 147g
Preparation method
1, take broken section of clean Herba Sarcandrae, decoct 2 times, add water 10 times the 1st time, decoct 1.5 hours, add water 8 times the 2nd time,
Decocting 1.5 hours, merge 2 decoction liquor and filter, clear filtrate vacuum-concentrcted to concentrated solution relative density is 1.20-1.30
The extractum I of (80 DEG C), standby.
2, take clean Flos Lonicerae, put into boiling 2 times in multi-function extractor, add water 10 times the 1st time, boil 1 hour,
Degree is the extractum II of 1.20-1.30 (80 DEG C), standby.
3, take the Mentholum of recipe quantity, dissolve in right amount with ethanol completely, under agitation add in 50% glucose solution, stirring
The most standby.
4, weighing the guar gum fine powder (crossing 100 mesh sieves) of recipe quantity, Vivastar fine powder (is crossed 100 mesh sieves), is cross-linked poly-second
Alkene Topiramate Los oxazolidinone (PVPP) fine powder (crosses 100 mesh sieves), and glucose fine powder (crosses 100 mesh sieves), puts in mixer, fully stirs
Mix uniformly, standby.
5, extractum I and extractum II is thrown in wet mixing pelletizer, stir, under agitation, 3 liquid are sprayed into mixing
Mix homogeneously in machine, adds 4 compounds, mix homogeneously, is sprayed into 50-60% ethanol and makees wetting agent in right amount, stirs,
Make rounding single-size with 30 mesh sieves, be vacuum dried at 50 DEG C, with 30 mesh sieve granulate, standby.
6, take 5 dry granules, add appropriate magnesium stearate (about 0.25%), mix homogeneously, under 35%-50% relative humidity, use
12mm is molded into the tablet of every 0.5g specification in a state of excitement, detects with multi-functional disintegrate digestion instrument, and 1min in water is complete for gained tablet
Full disintegrate, the complete dissolution of 1.3min.Qualified timely subpackage.
Embodiment 2
Crude drug uses Chinese medicinal material of sarcandra glaber 490g Flos Lonicerae medical material 203g Mentholum 2.4g guar gum fine powder 36g
Vivastar fine powder 140.0g crosslinked polyethylene Topiramate Los oxazolidinone (PVPP) fine powder 70g glucose fine powder 145g
Preparation method
1, take broken section of clean Herba Sarcandrae, decoct 2 times, add water 10 times the 1st time, decoct 1.5 hours, add water 8 times the 2nd time,
Decocting 1.5 hours, merge 2 decoction liquor and filter, clear filtrate vacuum-concentrcted to concentrated solution relative density is 1.20-1.30
The extractum of (80 DEG C), obtains extractum I, standby.
2, take clean Flos Lonicerae, put into boiling 2 times in multi-function extractor, add water 10 times the 1st time, boil 1 hour,
Adding water 7 times 2nd time, boil 1 hour, 2 times decoction liquor merge filtration, and clear filtrate vacuum-concentrcted is the closeest to concentrated solution
Degree is the extractum II of 1.20-1.30 (80 DEG C), standby.
3, take the Mentholum of recipe quantity, dissolve in right amount with ethanol completely, under agitation add in 50% glucose solution, stirring
The most standby.
4, weighing the guar gum fine powder (crossing 100 mesh sieves) of recipe quantity, Vivastar fine powder (is crossed 100 mesh sieves), is cross-linked poly-second
Alkene Topiramate Los oxazolidinone (PVPP) fine powder (crosses 100 mesh sieves), and glucose fine powder (crosses 100 mesh sieves), puts in mixer, fully stirs
Mix uniformly, standby.
5, extractum I and extractum II is thrown in wet mixing pelletizer, stir, under agitation, 3 liquid are sprayed into mixing
Mix homogeneously in machine, adds 4 compounds, mix homogeneously, is sprayed into 50-60% ethanol and makees wetting agent in right amount, stirs,
Make rounding single-size with 30 mesh sieves, be vacuum dried at 50 DEG C, with 30 mesh sieve granulate, standby.
6, take 5 dry granules, add appropriate magnesium stearate (about 0.25%), mix homogeneously, under 35%-50% relative humidity, use
12mm is molded into the tablet of every 0.5g specification in a state of excitement, detects with multi-functional disintegrate digestion instrument, gained tablet 0.9min in water
Disintegrate completely, the complete dissolution of 1.3min.Qualified timely subpackage.
Embodiment 3
Crude drug uses Chinese medicinal material of sarcandra glaber 510g Flos Lonicerae medical material 212g Mentholum 2.5g guar gum fine powder 40g
Vivastar fine powder 150.0g crosslinked polyethylene Topiramate Los oxazolidinone (PVPP fine powder 65g glucose fine powder 135g
Preparation method
1, take broken section of clean Herba Sarcandrae, decoct 2 times, add water 10 times the 1st time, decoct 1.5 hours, add water 8 times the 2nd time,
Decocting 1.5 hours, merge 2 decoction liquor and filter, clear filtrate vacuum-concentrcted to concentrated solution relative density is 1.20-1.30
The extractum I of (80 DEG C), standby.
2, take clean Flos Lonicerae, put into boiling 2 times in multi-function extractor, add water 10 times the 1st time, boil 1 hour,
Adding water 7 times 2nd time, boil 1 hour, 2 times decoction liquor merge filtration, and clear filtrate vacuum-concentrcted is the closeest to concentrated solution
Degree is the extractum II of 1.20-1.30 (80 DEG C), standby.
3, take the Mentholum of recipe quantity, dissolve in right amount with ethanol completely, under agitation add in 50% glucose solution, stirring
The most standby.
4, weighing the guar gum fine powder (crossing 100 mesh sieves) of recipe quantity, Vivastar fine powder (is crossed 100 mesh sieves), is cross-linked poly-second
Alkene Topiramate Los oxazolidinone (PVPP) fine powder (crosses 100 mesh sieves), and glucose fine powder (crosses 100 mesh sieves), puts in mixer, fully stirs
Mix uniformly, standby.
5, extractum I and extractum II is thrown in wet mixing pelletizer, stir, under agitation, 3 liquid are sprayed into mixing
Mix homogeneously in machine, adds 4 compounds, mix homogeneously, is sprayed into 50-60% ethanol and makees wetting agent in right amount, stirs,
Make rounding single-size with 30 mesh sieves, be vacuum dried at 50 DEG C, with 30 mesh sieve granulate, standby.
6, take 5 dry granules, add appropriate magnesium stearate (about 0.25%), mix homogeneously, under 35%-50% relative humidity, use
12mm is molded into the tablet of every 0.5g specification in a state of excitement, detects with multi-functional disintegrate digestion instrument, gained tablet 0.8min in water
Disintegrate completely, the complete dissolution of 1.2min.Qualified timely subpackage.
Embodiment described above is only to be described the preferred embodiment of the present invention, not design and the model to the present invention
Enclose and be defined.
The key technology of invention formulation is pharmaceutical formulation and preparation process thereof.The preparation of the technology of the present invention gained has following spy
Point:
Invention formulation preparation method, is directly added into Mentholum liquid mode, product with Herba Sarcandrae, Flos Lonicerae extract (extractum)
Depositing under by regulation condition of storage, Mentholum is difficult to separate out, and quality stability is high；Extract extractum addition adjuvant guar gum,
Vivastar, PVPP, glucose etc. can make tablet rapid disintegrate dissolution, have excellent dispersion uniformity, disintegrate rapid, molten
Going out rapid, uniform, active component to be absorbed rapidly, improve bioavailability, make again tablet hardness moderate, storage and transport process is difficult to
The feature such as burst apart；Product quality, curative effect are better than listing like product.
Use product of the present invention, select aboundresources, local authentic medicinal herbs Herba Sarcandrae, Flos Lonicerae, for making full use of motherland doctor
Medicine treasure-house, develops new drug, has higher academic significance, to promoting scientific and technological progress, promotes that human health has positive role and has
Significantly Social benefit and economic benefit.
Claims (2)
1. treat a Chinese medicine preparation Flos Lonicerae Herba Pileae Scriptae dispersible tablet for laryngopharynx swelling and pain disease, it is characterized in that swollen joint
Wind extract 20%-35%, Flos Lonicerae extract 10%-18%, Mentholum 0.1%-0.6%, guar gum 5%-10%,
Vivastar20%-36%, crosslinked polyethylene Topiramate Los oxazolidinone 10%-16%, glucose fine powder 15%-30%, gross weight
Amount is 100%, makes dispersible tablet.
2. according to the preparation described in claims 1, it is characterised in that its preparation technology is: (1) gold silver
Flower, Herba Sarcandrae decoct extraction respectively, and it is 1.20-1.30 that extracting solution vacuum and low temperature respectively is concentrated into relative density
(80 DEG C) extractum；(2) extractum described in add Mentholum liquid be stirring evenly and then adding into guar gum, Vivastar,
Crosslinked polyethylene Topiramate Los oxazolidinone, glucose mixture, mix homogeneously；(3) material of mix homogeneously adds 50-60%
It is appropriate that ethanol makees wetting agent, stirs, makes rounding single-size with 30 mesh sieves, and at 50 DEG C, vacuum is done
Dry, with 30 mesh sieve granulate, mixing, add lubricant and be pressed into tablet dispersible tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510337006.2A CN106265831A (en) | 2015-06-12 | 2015-06-12 | One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510337006.2A CN106265831A (en) | 2015-06-12 | 2015-06-12 | One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof |
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| CN201510337006.2A Pending CN106265831A (en) | 2015-06-12 | 2015-06-12 | One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108982731A (en) * | 2018-06-19 | 2018-12-11 | 广西昌弘制药有限公司 | The construction method and its HPLC characteristic spectrum of honeysuckle Caoshan Hu Hanpian HPLC characteristic spectrum |
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| CN1634265A (en) * | 2004-11-03 | 2005-07-06 | 贵州海泰药业技术有限公司 | Glabrous sarcandra herbal dispersible tablet and its preparing process |
| CN1857343A (en) * | 2006-04-11 | 2006-11-08 | 徐蕾 | Chinese medicine composition for preventing and treating viral cold and throat disease and its preparing method |
| CN1939358A (en) * | 2005-09-30 | 2007-04-04 | 江西本草天工科技有限责任公司 | Sarcandra glaber dispersant tablets |
| CN101365428A (en) * | 2006-01-05 | 2009-02-11 | 生命周期药物公司 | Disintegrating loadable tablets |
| CN101879211A (en) * | 2010-07-23 | 2010-11-10 | 阙锋 | Chinese medicinal preparation for clearing heat, relieving sore-throat and stopping pain and preparation method thereof |
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2015
- 2015-06-12 CN CN201510337006.2A patent/CN106265831A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634265A (en) * | 2004-11-03 | 2005-07-06 | 贵州海泰药业技术有限公司 | Glabrous sarcandra herbal dispersible tablet and its preparing process |
| CN1939358A (en) * | 2005-09-30 | 2007-04-04 | 江西本草天工科技有限责任公司 | Sarcandra glaber dispersant tablets |
| CN101365428A (en) * | 2006-01-05 | 2009-02-11 | 生命周期药物公司 | Disintegrating loadable tablets |
| CN1857343A (en) * | 2006-04-11 | 2006-11-08 | 徐蕾 | Chinese medicine composition for preventing and treating viral cold and throat disease and its preparing method |
| CN101879211A (en) * | 2010-07-23 | 2010-11-10 | 阙锋 | Chinese medicinal preparation for clearing heat, relieving sore-throat and stopping pain and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108982731A (en) * | 2018-06-19 | 2018-12-11 | 广西昌弘制药有限公司 | The construction method and its HPLC characteristic spectrum of honeysuckle Caoshan Hu Hanpian HPLC characteristic spectrum |
| CN108982731B (en) * | 2018-06-19 | 2021-01-12 | 广西昌弘制药有限公司 | Method for constructing HPLC characteristic spectrum of sarcandra glabra buccal tablet and HPLC characteristic spectrum thereof |
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