CN1634265A - Glabrous sarcandra herbal dispersible tablet and its preparing process - Google Patents
Glabrous sarcandra herbal dispersible tablet and its preparing process Download PDFInfo
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- CN1634265A CN1634265A CN 200410040994 CN200410040994A CN1634265A CN 1634265 A CN1634265 A CN 1634265A CN 200410040994 CN200410040994 CN 200410040994 CN 200410040994 A CN200410040994 A CN 200410040994A CN 1634265 A CN1634265 A CN 1634265A
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- silica gel
- herba sarcandrae
- sweet taste
- dispersible tablet
- centautin
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Abstract
The invention discloses a glabrous sarcandra herbal dispersible tablet and its preparing process, which comprises chopping, charging eight times weight of water for grilling, merging the grilling liquid, filtering and decompressing, concentrating into thick grease with a relative density of 1.25-1.30, vacuum drying the thick grease, comminuting and passing 80-180 mesh sieve, passing crystalline cellulose 193.5g, cross bonding polyvinylpyrrolidone 125g, sweet taste chrysanthemum extract 31.25g, sweet orange essence 6.25g, miropowdered silica gel 12.5g, and magnesium stearic acid 6.25g through 60-150 mesh sieve, mixing homogeneously, pelleting and compacting.
Description
Technical field: the present invention relates to improvement dosage form of a kind of Herba Sarcandrae tablet and preparation method thereof, relate in particular to a kind of Sarcandra glaber dispersant tablets and preparation method thereof.
Background technology: ZHONGJIEFENG PIAN has heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds.Be mainly used in pneumonia, appendicitis, cellulitis etc. and belong to the hyperactivity of toxic heat patient, cancer is also had certain auxiliary curative effect.At present, widely used Herba Sarcandrae tablet ubiquity disintegrate, absorb many defectives such as slow; In addition, complicated process of preparation needs through granulation, tabletting, coating multiple working procedure.
Summary of the invention: in order to overcome the deficiencies in the prior art, the present invention aims to provide that a kind of release is rapid, bioavailability is high, the simple ZHONGJIEFENG PIAN improvement of preparation technology dosage form and preparation method thereof.
Technical scheme of the present invention is made by the raw material of following consumption; Principal agent: Herba Sarcandrae 3125g, adjuvant: adhesive 50～300g, disintegrating agent 50～500g, sweet taste centautin 10～50g, orange flavor 1～10g and micropowder silica gel 1～20g and magnesium stearate 1～10g; Described adhesive is any one or the two or more mixing in Celluloasun Microcrystallisatum, calcium hydrogen phosphate, hypromellose or the polyvinylpyrrolidone, and described disintegrating agent is any one or the two or more mixing in crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose or the methacrylic acid.
This dispersible tablet is made by Herba Sarcandrae 3125g, Celluloasun Microcrystallisatum 193.5g, crospolyvinylpyrrolidone 125g, sweet taste centautin 31.25g, orange flavor 6.25g, micropowder silica gel 12.5g and magnesium stearate 6.25g, makes 1000 altogether.
The preparation method of this dispersible tablet is: with the Herba Sarcandrae chopping, the decocting that adds 8 times of weight boils three times, each 1 hour; Collecting decoction, with the decocting liquid after filtering temperature be 60～80 ℃, vacuum be-0.06～-be evaporated to relative density under the condition of 0.08MPa and be 1.25～1.30 thick paste, the measurement temperature is 60 ℃; With this thick paste temperature be 70～80 ℃, vacuum be-0.06～-condition of 0.08MPa under vacuum drying, it is standby to pulverize 80～180 mesh sieves; Described adjuvant is crossed 60～150 mesh sieves respectively, with compression molding behind the standby arcandra twig and leaf mix homogeneously, promptly.
Compared with the prior art, Sarcandra glaber dispersant tablets disintegrate provided by the present invention is rapid, can remedy former dosage form and absorb not enough slowly; Simultaneously,, can cover the poor taste of medicine, be easy to the patient and take owing to added correctivess such as sweet taste centautin, orange flavor.In addition, Sarcandra glaber dispersant tablets preparation technology provided by the present invention owing to omitted multiple working procedures such as granulation, coating, greatly reduces production cost.
The specific embodiment: the invention will be further described below in conjunction with specific embodiment:
Embodiment 1, principal agent: Herba Sarcandrae 3125g, adjuvant: Celluloasun Microcrystallisatum 193.5g, crospolyvinylpyrrolidone 125g, sweet taste centautin 31.25g, orange flavor 6.25g, micropowder silica gel 12.5g and magnesium stearate 6.25g.
Embodiment 2, principal agent: Herba Sarcandrae 3125g, adjuvant: Celluloasun Microcrystallisatum 50g, crospolyvinylpyrrolidone 50g, sweet taste centautin 10g, orange flavor 1g, micropowder silica gel 1g and magnesium stearate 1g.
Embodiment 3, principal agent: Herba Sarcandrae 3125g, adjuvant: Celluloasun Microcrystallisatum 300g, crospolyvinylpyrrolidone 300g, sweet taste centautin 50g, orange flavor 10g, micropowder silica gel 20g and magnesium stearate 10g.
Embodiment 4, and with Herba Sarcandrae 3125g chopping, the decocting that adds 8 times of weight boils three times, each 1 hour; Collecting decoction, the decocting liquid after filtering is evaporated to relative density under the condition that temperature is 70 ℃, vacuum for-0.07MPa be 1.28 thick paste, measuring temperature is 60 ℃; It is standby that this thick paste was pulverized 120 mesh sieves behind the vacuum drying in temperature under being 75 ℃, vacuum for the condition of-0.07MPa; With adjuvant: Celluloasun Microcrystallisatum 193.5g, crospolyvinylpyrrolidone 125g, sweet taste centautin 31.25g, orange flavor 6.25g, micropowder silica gel 12.5g and magnesium stearate 6.25g cross 120 mesh sieves respectively, then with compression molding behind itself and the described standby arcandra twig and leaf mix homogeneously, make 1000 altogether, promptly.
Claims (3)
1. Sarcandra glaber dispersant tablets, it is characterized in that: it is to be made by the raw material of following consumption; Principal agent: Herba Sarcandrae 3125g, adjuvant: adhesive 50～300g, disintegrating agent 50～500g, sweet taste centautin 10～50g, orange flavor 1～10g and micropowder silica gel 1～20g and magnesium stearate 1～10g; Described adhesive is any one or the two or more mixing in Celluloasun Microcrystallisatum, calcium hydrogen phosphate, hypromellose or the polyvinylpyrrolidone, and described disintegrating agent is any one or the two or more mixing in crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose or the methacrylic acid.
2. Sarcandra glaber dispersant tablets according to claim 1, it is characterized in that: this dispersible tablet is made by Herba Sarcandrae 3125g, Celluloasun Microcrystallisatum 193.5g, crospolyvinylpyrrolidone 125g, sweet taste centautin 31.25g, orange flavor 6.25g, micropowder silica gel 12.5g and magnesium stearate 6.25g, makes 1000 altogether.
3. Sarcandra glaber dispersant tablets agent according to claim 1 and 2 and preparation method thereof is characterized in that: with the Herba Sarcandrae chopping, the decocting that adds 8 times of weight boils three times, each 1 hour; Collecting decoction, with the decocting liquid after filtering temperature be 60～80 ℃, vacuum be-0.06～-be evaporated to relative density under the condition of 0.08MPa and be 1.25～1.30 thick paste, the measurement temperature is 60 ℃; With this thick paste temperature be 70～80 ℃, vacuum be-0.06～-condition of 0.08MPa under vacuum drying, it is standby to pulverize 80～180 mesh sieves; Described adjuvant is crossed 60～150 mesh sieves respectively, with compression molding behind the standby arcandra twig and leaf mix homogeneously, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040994 CN1634265A (en) | 2004-11-03 | 2004-11-03 | Glabrous sarcandra herbal dispersible tablet and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040994 CN1634265A (en) | 2004-11-03 | 2004-11-03 | Glabrous sarcandra herbal dispersible tablet and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1634265A true CN1634265A (en) | 2005-07-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 200410040994 Pending CN1634265A (en) | 2004-11-03 | 2004-11-03 | Glabrous sarcandra herbal dispersible tablet and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897740A (en) * | 2010-07-21 | 2010-12-01 | 江西省药物研究所 | Glabrous sarcandra herb formula particle and preparation method thereof |
| CN101664512B (en) * | 2009-09-15 | 2011-05-11 | 江西天施康中药股份有限公司 | Method for preparing traditional Chinese medicine preparation containing herba sarcandrae extracts |
| CN106265831A (en) * | 2015-06-12 | 2017-01-04 | 阙锋 | One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof |
-
2004
- 2004-11-03 CN CN 200410040994 patent/CN1634265A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664512B (en) * | 2009-09-15 | 2011-05-11 | 江西天施康中药股份有限公司 | Method for preparing traditional Chinese medicine preparation containing herba sarcandrae extracts |
| CN101897740A (en) * | 2010-07-21 | 2010-12-01 | 江西省药物研究所 | Glabrous sarcandra herb formula particle and preparation method thereof |
| CN106265831A (en) * | 2015-06-12 | 2017-01-04 | 阙锋 | One treats laryngopharynx swelling and pain Chinese medicine preparation and preparation method thereof |
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