JPH072648B2 - Method of manufacturing herbal medicine extract - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of use] The present invention relates to a method for producing a Chinese herbal medicine extract in the pharmaceutical industry.

[Prior Art] Since ancient times, crude drugs have been used as Kampo medicines, and their Kampo prescriptions have been described in many classics (injury theory, Jin's summary, etc.) as an accumulation of many years of experience. However, according to the classics, the decoction, in which the herbal medicine is cut each time and decocted with water to extract the ingredients in the herbal medicine, is not only difficult to take due to its unique medicinal odor and taste, but also a lot of labor and time. Takes.

Currently, in the field of ethical drugs and the like, Chinese herbal medicine extracts that do not require the above-mentioned work and are easy to take are used, and for the sick, from the aspects of storage, portability, and ease of administration. It is very convenient. This herbal medicine extract is usually prepared by extracting a crude herb that has been cut with water or alcohol, and then directly or concentrating the extract and drying it to obtain a herbal medicine powder, which is a suitable excipient (lactose, corn starch, starch, etc.). Are added and mixed to obtain various dosage forms (tablets, capsules, powders, fine granules, granules, etc.).

[Problems to be Solved by the Invention] Originally, when a drug is orally administered to a living body, it is absorbed by being disintegrated in the body and exerts a medicinal effect. Therefore, the administered drug disintegrates in the body. Without it, the intended purpose as a drug cannot be achieved.

The Chinese herbal medicine extract obtained as described above cannot be said to be sufficiently satisfactory in terms of disintegration. Therefore, the present invention solves the problem of producing a Chinese herbal medicine extract having good disintegration.

[Means for Solving Problems] The inventors of the present invention have conducted diligent research in search of a method for producing a herbal medicine extract having good disintegration. As a result, the Chinese medicine is extracted with an extraction solvent, and the extract or its concentrate is concentrated. Amylase is added to the solution to react, and the powder obtained by drying the reaction solution is used as it is, or one selected from sugars, starches, dextrins, silicic acid compounds, celluloses and natural gums, or The inventors have found that a mixture of more excipients can be used to obtain a Chinese herbal medicine extract of various dosage forms, and a Chinese herbal medicine extract with good disintegration can be obtained, and the present invention has been completed.

Hereinafter, the present invention will be described in detail.

The herbal medicines used in the present invention include not only the herbal medicines referred to in traditional Chinese medicine but also so-called herbal medicines or herbal preparations comprising one or a mixture of two or more herbal medicines. Specific examples of Kampo medicines are described in the guide for general Kampo prescriptions (supervised by the Pharmaceutical Affairs Bureau of the Ministry of Health and Welfare, published by Yakuji Jikhosha, 4th edition, 6th edition, January 8, 1983) and Tsumura medical herbal preparations [general catalog]. Kampo prescriptions can be given, and more specifically, Kakkonto, Kakkonto Kagawa ▲ Kyu ▼ Ginseng, Keishikakakuyakudaioto, Anchusan, Hachimijiogan, Saiko Keishito, Saiko Keishi Ginsengto, Hangeshashinto. ,
Goreisan, Keishikashutsuyu, Shoseiryuto, Tokishakuyakusan, Kami Shoyosan, Keishibukuryogan, Keishikaryukoshashayu, Maoyu, Kibomi, Tokishikushi Kago 耱 萸 Ginger hot water, Reikei Shukanyu, Keishiyu, Juzen Daihoyu, Gagejurenzyu, ▲ Well ▼ Seijinyu, Sokei Ketsuto,
Yokukansan, Seijohofuto, Keishikashakuyakuto, Tokokujokito, Hofutsushosan, Gozumisan, Konkanzoto, Megamisan, Kososan, Keishininjinto, Yokukansanka Chen skin half summer, bruise, Kokenchuto, Tokiyu, Onkeito, Goshisha-Kinki-maru, Sairei-to, Gyorei-to, Keirei-in-Gohan-Natsukoboku-to, Kaya-Chin-Goreisan, etc. Can be mentioned. In addition, specific examples of herbal medicines include the original color Japanese and Chinese medicine encyclopedia (first volume, second volume, Tsuneo Wreck, published by Hoikusha Co., Ltd. April 1, 1980) and the 10th revised Japanese Pharmacopoeia [Supervised by the Japanese Official Book Association, published by Hirokawa Shoten. (P.863 to p.1278)].

As the extraction solvent for Chinese herbs, for example, water or an ethanol aqueous solution having an ethanol concentration of 25% or less can be mentioned. It may be extracted hot or cold, and particularly 90-90% with water.
The method of hot extraction at 100 ° C. is preferred.

Concentration of the extract is generally performed under reduced pressure. Specifically, vacuum concentration is performed under the conditions of a vacuum degree of 30 to 760 mmHg and an evaporation temperature of 100 ° C. or less, preferably 30 to 50 ° C.

Next, amylase is added to the extract obtained as described above or its concentrate. When adding amylase, any means may be used as long as amylase is added to the extract or its concentrated solution so that it is uniformly dispersed. As the amylase, α-amylase, β-amylase, saccharified amylase and the like can be used,
Specific examples of α-amylase include α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) and krystase (manufactured by Daiwa Kasei)
And the like, and specific examples of thermostable α-amylase include neospitase PG (manufactured by Nagase & Co., Ltd.), spitase
CP-3 (made by Nagase & Co., Ltd.) etc. are mentioned. As a specific example of β-amylase, "β-amylase # 1500"
(Manufactured by Nagase & Co., Ltd.), Biozyme M (manufactured by Amano Pharmaceuticals)
And the like. Specific examples of the saccharified amylase include glucozyme (manufactured by Nagase & Co., Ltd.) and glucozyme XL-128.
(Made by Nagase & Co., Ltd.) and the like.

The amount of amylase added is 0.001% or more, especially 0.00% or less, based on the weight of starch contained in the extract or the concentrate thereof.
05% to 0.1% is preferable.

Next, the reaction temperature for reacting amylase is α-
When using amylase 30-40 ℃, when using thermostable α-amylase 60-70 ℃ is preferred, when using β-amylase 50-60 ℃, when using saccharified amylase 30-60 C is preferred. The pH of the reaction solution is 3-8,
Since 6 to 8 is particularly preferable, it is preferable to add an alkali such as calcium carbonate, calcium hydroxide, sodium carbonate, sodium hydroxide or the like to adjust the pH as necessary.
The reaction time depends on the amount of alkali added or the reaction temperature, but is completed in about 1 to 12 hours. At this time, if the reaction is carried out while stirring using a stirring device ordinarily used,
More effective.

Then, the reaction solution is dried as it is or after being concentrated.
The reaction liquid can be concentrated in the same manner as the above-mentioned concentration of the extraction liquid. The reaction solution or its concentrated solution is dried by a suitable drying method such as a spray drying method, a vacuum drying method or a freeze-drying method generally used to obtain a powder, that is, a Chinese herb extract powder. For example, in the case of spray drying method, 60-300 ℃
The atomizer sprays the reaction solution or its concentrated solution into the hot air flow in the drying chamber kept at a high temperature, and the solvent is instantaneously evaporated to dry. In the case of the reduced pressure drying method, the reaction solution is sufficiently concentrated under reduced pressure and dried under reduced pressure of 760 mmHg or less at 5 to 100 ° C. In the freeze-drying method, the reaction solution or its concentrated solution is cooled to −80 to 0 ° C. to be frozen, and the solvent is directly sublimated in a vacuum state of 1 mmHg or less to dry.

The Chinese herb extract powder thus obtained may be directly made into various dosage forms (tablets, capsules, powders, fine granules, granules), or mixed with an appropriate excipient to obtain various dosage forms. (Tablets, capsules, powders, fine granules, granules).

Mixing of Chinese herb extract powder and excipients is achieved by ordinary powder mixing using a mixer, etc., and the specific mixing ratio is based on the total weight of Chinese herbal extract powder and excipients. The agent weight is 0.1 to 95%, preferably 5 to 50%.

Specific examples of saccharide excipients include mannitol, sucrose, sorbitol, glucose, fructose, maltose, lactose and the like, and specific examples of starch excipients include corn starch, soluble starch, carboxymethyl starch and the like, Specific examples of the dextrin excipient include dextrin, cyclodextrin, etc., and specific examples of the silicic acid compound excipient include porous silicic anhydride, ultrafine silicic anhydride, and the like. Specific examples of the shaping agent include crystalline cellulose, carboxymethyl cellulose, carboxymethyl cellulose calcium salt, carboxymethyl cellulose sodium salt, and the like, and specific examples of the natural gums excipient include tragacanth gum, gum arabic, and the like.

Then, granules, fine granules, powders by subjecting the Chinese herbal extract powder obtained as described above or a mixture of the Chinese herbal extract powder and excipients to operations such as granulation, sizing, and tableting as necessary. , Into capsules, tablets, etc. to make Chinese herbal extract. In this case, if desired, lubricants and binders usually used in preparations may be added. The granulation method includes a general dry granulation method and a wet granulation method, and the dry granulation method is preferable.

[Effects of the Invention] The effects of the present invention are as follows.

The Chinese medicine extract obtained according to the present invention has good disintegration property.

Experimental examples showing that the Chinese medicine extract obtained according to the present invention has good disintegration are as follows.

Experimental Example 1. Performed in the same manner as described in Example 1 below, except that the step of adding α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) to the extract and reacting was not performed in Example 1 below. As a result, one tablet was 286 mg of Shosaikoto tablets.

The disintegration time of the Shosaikoto tablets produced as described above and the Shosaikoto tablets produced in Example 1 below was measured by the disintegration test method of the 10th revised Japanese Pharmacopoeia. That is, the lower end of a glass tube with an inner diameter of 22 mm opened at both ends is closed with a mesh with a mesh of 2.0 mm, one sample tablet is placed on the mesh, and this glass tube is soaked in distilled water and moved up and down Disintegration time was defined as the end of disintegration when no residue was observed. As a result, the disintegration time of Shosaikoto tablets produced in Experimental Example 1 was 50.4.
On the other hand, the Shosaikoto tablet produced in Example 1 described later disintegrated in 9.2 minutes and quickly eluted the components.

Experimental Example 2. Performed in the same manner as described in Example 2 below, except that the step of adding α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) to the extract and reacting was not performed in Example 2 described below. As a result, one tablet was 290 mg of Shigyakusan tablet.

In the disintegration test described in Experimental Example 1, the disintegration time of the Shigyakusan tablet produced as described above was 63.5 minutes, whereas the Shiyakusan tablet produced in Example 2 described later disintegrated in 12.5 minutes. The components were quickly eluted.

Experimental Example 3. Obtained in the same manner as described in Example 2 below, except that the step of adding α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) to the extract and reacting was not carried out in Example 2 below. The dried extract powder is compacted, crushed, classified and the diameter is 1.
185mm ~ 0.356mm Shigyakusan granules were obtained.

The disintegration time of the Shigyakusan granules produced as described above and the Shigyakusan granules produced in Example 3 below were measured by the disintegration test method of the 10th revised Japanese Pharmacopoeia. That is, inner diameter 12 mm,
Open the mesh on the top and bottom of a 20 mm long plastic auxiliary cylinder.
Block with a 0.42 mm net and put 0.4 g of Shigyakusan granules in this auxiliary cylinder.
When 1 g was put, and this auxiliary cylinder was further fixed to the lower part of the glass tube used in the disintegration test of the tablet described in Experimental Example 1, soaked in distilled water and moved up and down, and no residue was observed in the auxiliary cylinder. Was set as the end of the collapse and the time was set as the collapse time. As a result, while the disintegration time of the Shigyakusan granule produced in Experimental Example 3 was 16 minutes,
The Shigyakusan granule produced in Example 3 described later disintegrated in 2 minutes and quickly eluted the components.

Experimental Example 4. The same procedure as described in Example 4 below was performed except that the step of adding spitase CP-3 (manufactured by Nagase & Co., Ltd.) to the concentrated liquid and reacting was not performed in Example 4 below. 1
Rikkunshito tablets with a tablet of 250 mg were obtained.

In the disintegration test described in Experimental Example 1, the disintegration time of the Rikkunshito tablet produced as described above was 116.2 minutes, whereas the Rikkunshito tablet produced in Example 4 described later disintegrated in 15.3 minutes. The components were quickly eluted.

Experimental Example 5. In Example 5, which will be described later, the α-amylase “MAXA
Except for not carrying out the step of adding and reacting "MYL P5000" (manufactured by Gist-Brocades), the same procedure as described in Example 5 below was carried out to obtain a 300 mg Hangeshashinto tablet.

In the disintegration test described in Experimental Example 1, the disintegration time of Hangeshashinto tablets produced as described above was 84 minutes, while
The Hangeshashinto tablet produced in Example 5, which will be described later, disintegrated in 18 minutes and rapidly eluted the components.

Experimental Example 6. Performed in the same manner as described in Example 6 described below, except that the step of adding α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) to the concentrated solution and performing the reaction in Example 6 described below was not performed. As a result, Daisaikoto granules having a particle size of 12 to 48 mesh were obtained.

In the disintegration test described in Experimental Example 3, the disintegration time of Daisaikoto granules produced as described above was 60 minutes or longer, whereas that of Daisaikoto granules produced in Example 6 described later was 2 minutes. And the components were quickly eluted.

Experimental Example 7. In Example 8, which will be described later, the extract was treated with "β-amylase #
Except that the step of adding 1500 "(manufactured by Nagase & Co., Ltd.) and carrying out the reaction was not carried out, the same procedure as described in Example 8 below was carried out to obtain 12 g-48 g of ginseng ginseng granules.

In the disintegration test described in Experimental Example 3, the disintegration time of the ginseng granules produced as described above was 30 minutes or longer, whereas the ginseng granules produced in Example 8 described later disintegrated in 1 minute. Then, the components were quickly eluted.

Experimental Example 8. The ginseng granules obtained in Experimental Example 7 were crushed with a crusher to give powder of 42 mesh or less and filled in No. 1 gelatin capsule (1
(450 mg in capsule) to obtain a ginseng hard capsule.

The disintegration time of the ginseng hard capsules manufactured as described above and the ginseng hard capsules manufactured in Example 9 below was measured by the disintegration test method of the 10th revised Japanese Pharmacopoeia.
That is, the lower end of a glass tube with an inner diameter of 22 mm opened at both ends is closed by a mesh with a mesh of 2.0 mm, one sample capsule is placed on the mesh, and this glass tube is used as a test solution (sodium chloride 2.0 g). PH was adjusted to 1000 ml by adding 24.0 ml of dilute hydrochloric acid and water.
Disintegration time was defined as the end of the disintegration when no residue was observed on the net by dipping it in a liquid of about 1.2).

As a result, while the disintegration time of the ginseng hard capsules produced in Experimental Example 8 was 18 minutes, the ginseng hard capsules produced in Example 9 described later disintegrated in 3 minutes and the components were rapidly eluted. .

Experimental Example 9. In Example 11, which will be described later, the concentrated solution contained "β-amylase #
1500 "(manufactured by Nagase & Co., Ltd.) was not added, and the reaction was performed in the same manner as described in Example 11 below, to give Saireito tablets each containing 300 mg.

In the disintegration test described in Experimental Example 1, the disintegration time of the Sairei-to tablets produced as described above was 61 minutes, whereas the Sairei-to tablets produced in Example 11 below was 19 minutes, and Example 12
The Sairei-to tablets prepared in 1) disintegrated in 11 minutes and the components were rapidly eluted.

[Examples] Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited thereto.

Example 1. Prescription crude drug of Shosaikoto (composed of 7 parts of Saiko, 5 parts of summer, 3 parts of yellow gogon, 3 parts of oju, 3 parts of carrot, 2 parts of licorice, 1 part of ginger) Water 10 was added and the mixture was heated and extracted at 100 ° C. After the extraction was completed, solid-liquid separation was performed while hot to obtain an extract. 80 of the extract
0 ml was collected, 10 mg of α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) was added thereto, and the mixture was reacted at 37 ° C. for 10 hours with stirring. After the reaction was completed, the reaction solution was concentrated to 200 ml and freeze-dried (freezing temperature -40 ° C, vacuum degree 0.1 mmH
(g, shelf temperature 20 ° C.) to give 144 g of dry extract powder. To 70 g of this dry extract powder, 30 g of dextrin [manufactured by Matsutani Chemical Industry Co., Ltd.] was added and mixed using a mixer to give 1 tablet.
Compression molding was carried out to obtain 286 mg of Shosaikoto tablets.

Example 2 300 kg of water was added to 30 kg of a prescription crude drug of tetra-reversed acid (composed of 5 parts of Saiko, 4 parts of peony, 2 parts of bokook and 1.5 parts of licorice), and heat extraction was performed at 100 ° C. At the time, solid-liquid separation was performed to obtain an extract. Take 20 of the extract and add 700 mg of α-amylase (manufactured by Wako Pure Chemical Industries, Ltd.) to this and incubate at 37 ℃.
The reaction was carried out with stirring for 10 hours. After completion of the reaction, the reaction solution is spray-dried (blast temperature 160 ° C, exhaust air temperature 110 ° C), approximately 3 kg
To obtain a dry extract powder. 1 piece by compressing and molding this powder
290 mg of Shigyakusan tablet was obtained.

Example 3 A dry extract powder obtained in the same manner as in Example 2 was consolidated,
The mixture was crushed and classified to obtain Shigyakusan granules having a diameter of 1.185 mm to 0.356 mm.

Example 4. Rikkunshiyu (4 parts of Soso, 4 parts of carrots, 4 parts of summer, 4 parts of Furei,
Consists of 2 parts of large jujube, 2 parts of crust, 2 parts of licorice and 0.5 part of ginger
To 6 kg of the prescription herbal medicine, add 90 of water and extract by heating at 100 ℃,
After the extraction was completed, solid-liquid separation was performed while hot to obtain an extract. Concentrate this extract to 15 and then collect 2 of the concentrate and add spitase CP-3 (made by Nagase & Co., Ltd.) to it.
100 mg was added and reacted at 60 ° C. for 10 hours with stirring.
After completion of the reaction, the reaction solution was spray-dried (air temperature: 150 ° C, air temperature: 100 ° C) to obtain a dry extract powder. To 95 g of this dried extract powder, 4.5 g of lactose (manufactured by Megre Co., Ltd.) and 0.5 g of magnesium stearate [manufactured by Odaira Chemical Industry Co., Ltd.] were added and mixed, and each tablet was compression molded to 250 mg and Rikkunshito A tablet was obtained.

Example 5. Hangeshashinto (half summer 5 parts, yellow ▲ goron ▼ 2.5 parts, licorice 2.5 parts,
Containing 6 kg of prescription crude drug of 2.5 parts of Ojutsu, 2.5 parts of ginseng, 1 part of Huanglian, 2.5 parts of ginger), water 60 was added and extracted by heating at 100 ° C. After completion of extraction, solid-liquid separation was performed during hot extraction. A liquid was obtained. The extract was concentrated to about 15 by a vacuum concentrator at 40 ° C. 5 of this concentrated solution was collected, 10 g of α-amylase “MAXAMYL P5000” (manufactured by Gist-Brocades) was added, and the mixture was reacted at 40 ° C. for 5 hours while stirring. After the reaction is completed, the reaction solution is spray-dried (air temperature: 150 ° C, air temperature: 90 ° C).
C.) to obtain a dry extract powder. This dry extract powder
Crystalline cellulose [trade name: Avicel PH-101, manufactured by Asahi Kasei Kogyo Co., Ltd.] 19.5 g and magnesium stearate [Ohira Chemical Industry Co., Ltd.] 0.5 g are mixed with 80 g, and one tablet is 300 mg.
It was compression-molded so as to obtain Hangeshashinto tablets.

Example 6. Daisaiko-to (composed of Saiko 6 parts, half summer 4 parts, yellow goron 3 parts, peony root 3 parts, ojutsu 3 parts, currant seeds 2 parts, ginger 1 part, and daio 1 part) 200 kg of water was added to 10 kg of the prescription crude drug, and the mixture was heated and extracted at 100 ° C. After the extraction was completed, solid-liquid separation was performed during heating to obtain an extract. The extract was concentrated to about 30 at 40 ° C using a vacuum concentrator. Ten of this concentrated solution was collected, and 0.75 g of α-amylase (Wako Pure Chemical Industries, Ltd.) dispersed in 20 ml of distilled water was added. Furthermore, the mixture was reacted at 37 ° C. for 10 hours while stirring. This liquid was spray dried (blast temperature 160 ° C., exhaust air temperature 90 ° C.) to obtain a dry extract powder. To 80 g of this dry extract powder, 15 g of lactose (manufactured by Megre) was added and mixed. To this mixture was added 50 g of a 10% hydroxypropylcellulose / ethanol solution, which was kneaded in the usual manner, extruded, dried, and sieved to give Daisaikoto granules having particles of 12 to 48 mesh.

Example 7. The granules obtained in Example 6 were pulverized with a pulverizer and sieved to obtain 32 Meshyu-150 Meshyu Daisaikoto fine granules.

Example 8. 90 kg of water was added to 6 kg of ginseng and heat extraction was performed at 100 ° C. After the extraction was completed, solid-liquid separation was performed during heating to obtain an extract. This extract
10 was collected, 0.3 g of "β-amylase # 1500" (manufactured by Nagase & Co., Ltd.) was added and reacted at 40 ° C for 4 hours with stirring, and then concentrated to 1.5 by a vacuum concentrator.
This concentrated solution was freeze-dried to give a dry extract powder. To 80 g of the obtained powder, 20 g of dextrin was added and mixed well, followed by compression molding, crushing and sieving to obtain a ginseng granule for medicine having particles of 12 to 48 mesh.

Example 9 The ginseng granules obtained in Example 8 were crushed with a crusher to give powder of 42 mesh or less and filled in No. 1 gelatin capsule (1
(450 mg in a capsule) to obtain a ginseng hard capsule.

Example 10. Fukuryo Intake Hangekobokuyu (6 parts, 6 parts, 苯 苓, 4 parts of soy sauce,
3 parts of magnolia, 3 parts of Chen skin, 3 parts of ginseng, 2 parts of Soha, 1.5 fruit
Part, and 1 part of ginger) were added to 100 kg of 5% ethanol aqueous solution to 10 kg of a prescription crude drug, and the mixture was heated and extracted at 70 ° C. After the extraction was completed, solid-liquid separation was performed during heating to obtain an extract. The extract was concentrated to about 25 at 40 ° C by a vacuum concentrator. Take this concentrated liquid 5, add 4.5 g of saccharified amylase glucozyme (manufactured by Nagase & Co., Ltd.), and stir 5 at 50 ° C with stirring.
Reacted for hours. This liquid is spray-dried (blast temperature 150 ° C,
The exhaust air temperature was 90 ° C) to obtain a dry extract powder. To 140 g of this dried extract powder, 60 g of cornstarch [Matsutani Chemical Industry Co., Ltd.] was added and mixed well to obtain a Horei Intake Hangebokubokuto powder.

Example 11. Sairei-to (7 parts Saiko, 5 parts Sawara, 5 parts midsummer, yellow Gon 3
Part, Sosou part 3, Ojumu part 3, Borei part 3, Carrot part 3, Peipart 3
Part, licorice, 2 parts, cinnamon bark, and 1 part ginger) was added to 100 kg of water, and the mixture was heated and extracted at 100 ° C. After the extraction was completed, solid-liquid separation was performed during heating to obtain an extract. The extract was concentrated to about 20 at 40 ° C. using a vacuum concentrator. 2 of this concentrated solution are collected, and "β-amylase # 1500"
Add 3.3 g of Nagase & Co., Ltd. and stir 40
The reaction was carried out at 0 ° C for 5 hours. The reaction solution was freeze-dried (freezing temperature −40 ° C., vacuum degree 0.1 torr, shelf temperature 20 ° C.) to obtain a dry extract powder. The dried extract powder was pulverized into fine powder of 100 mesh or less and compression-molded to obtain a Saireito tablet of 300 mg per tablet.

Example 12. Two of the concentrates obtained as described in Example 11.
Was collected, 5.0 g of saccharified amylase glucozyme (manufactured by Nagase & Co., Ltd.) was added, and reacted at 40 ° C. for 5 hours while stirring. The reaction solution was freeze-dried (freezing temperature −40 ° C., vacuum degree 0.1 torr, shelf temperature 20 ° C.) to obtain a dry extract powder.
The dried extract powder was pulverized into a fine powder having a particle size of 100 mesh or less and then compression-molded to obtain a Saireito tablet of 300 mg per tablet.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Takayoshi Kimura 3010-101 Ushiku, Ushiku-cho, Inashiki-gun, Ibaraki (56) References JP-A-53-104715 (JP, A) JP-B-52-16728 (JP, B2) JP 54-6627 (JP, B2) JP 55-1027 (JP, B2) JP 59-1688 (JP, B2)

Claims (1)

[Claims] 1. A herbal medicine is extracted with an extraction solvent, amylase is added to the extract or a concentrated solution thereof to cause a reaction, and the reaction solution is dried to obtain powder as it is, or sugars, starches, dextrins. , A silicic acid compound, celluloses, natural gums, and one or more excipients selected from the mixture to prepare a herbal medicine extract of various dosage forms. Method.