CN1969922B - Compound pharmaceutical composition and preparation process thereof - Google Patents
Compound pharmaceutical composition and preparation process thereof Download PDFInfo
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- CN1969922B CN1969922B CN2005101045551A CN200510104555A CN1969922B CN 1969922 B CN1969922 B CN 1969922B CN 2005101045551 A CN2005101045551 A CN 2005101045551A CN 200510104555 A CN200510104555 A CN 200510104555A CN 1969922 B CN1969922 B CN 1969922B
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- Prior art keywords
- radix isatidis
- pharmaceutically acceptable
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- injection
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Group | Number of animals (only) | Dosage (mg/kg) | Liver index (g/100g) | Spleen index (g/100g) |
The blank group | 10 | - | 6.26±1.02 | 0.631±0.145 |
CCl 4Matched group | 10 | 10 | 8.42±0.67 ** | 0.732±0.080 ** |
The Radix Isatidis extract group | 10 | 30 | 7.53±0.75 *# | 0.690±0.043 *# |
The monoammonium glycyrrhizinate group | 10 | 30 | 7.34±0.74 *# | 0.701±0.056 *# |
BG composite injection group (low dosage) | 10 | 10 | 6.72±0.82 ##&△ | 0.651±0.053 ##&△ |
BG composite injection group (middle dosage) | 10 | 20 | 6.64±0.74 ##&△ | 0.642±0.048 ##&△ |
BG composite injection group (high dose) | 10 | 30 | 6.49±0.80 ##&△ | 0.635±0.057 ##&△ |
Group | Dosage (mg/kg) | DHBV-DNA titre before the treatment | Treatment back 7d DHBV-DNA titre | Treatment back 14d DHBV-DNA titre | 3d DHBV-DNA titre after the drug withdrawal |
The blank group | - | 1.62±0.06 | 1.61±0.03 | 1.61±0.04 | 1.64±0.03 |
Positive controls | 50 | 1.65±0.04 | 0.78±0.14 **&& | 0.80?±0.12 **&& | 1.63±0.02 |
The Radix Isatidis extract group | 15 | 1.59±0.03 | 1.33±0.08 *& | 1.32±0.06 *& | 1.40±0.02 *& |
The diammonium glycyrrhizinate group | 15 | 1.62±0.06 | 1.32±0.10 *& | 1.29±0.08 *& | 1.36±0.07 *& |
BG composite injection group (low dosage) | 5 | 1.58±0.05 | 1.15±0.12 *& | 0.99±0.09 **&&#△ | 1.10±0.11 *& |
BG composite injection group (middle dosage) | 10 | 1.60±0.02 | 1.03±0.15 **&&#△ | 0.92±0.11 **&&#△ | 1.01±0.08 **&&#△ |
BG composite injection group (high dose) | 15 | 1.62±0.03 | 0.93±0.16 **&&#△ | 0.82±0.12 **&&#△ | 0.96±0.10 **&&#△ |
Lot number | Total nitrogen content (%) | Yield (%) |
1 | 15.67 | 1.54 |
2 | 16.13 | 1.31 |
3 | 16.51 | 1.34 |
On average | 16.10 | 1.40 |
Claims (4)
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CN1969922B true CN1969922B (en) | 2012-04-18 |
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赵云燕.甘草酸对板兰根抗内毒素活性的影响.《基层中药杂志》.2001,第15卷(第6期),第21-22页. * |
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