CN113230305A - Isatis root granules and preparation method thereof - Google Patents
Isatis root granules and preparation method thereof Download PDFInfo
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- CN113230305A CN113230305A CN202110333545.4A CN202110333545A CN113230305A CN 113230305 A CN113230305 A CN 113230305A CN 202110333545 A CN202110333545 A CN 202110333545A CN 113230305 A CN113230305 A CN 113230305A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses an isatis root granule which is mainly prepared from the following raw materials in parts by weight: 500-800 parts of isatis root composite extract and 10-40 parts of adhesive. Decocting radix Isatidis and Glycyrrhrizae radix for 2 times, performing supercritical extraction to obtain extract, and adding adhesive to dry plasmid. The invention has the advantages that: the adhesive is selected from starch slurry, sodium carboxymethylcellulose and gelatin solution, so that the internal binding power of the granules can be improved, the powder condition is greatly improved, and the eating is not influenced; the effective components can be efficiently extracted by decoction and supercritical extraction; the radix isatidis and the liquorice are extracted at the same time, so that the active ingredients can be fully and uniformly mixed.
Description
Technical Field
The invention relates to the technical field of medicine preparation, in particular to preparation of isatis root granules.
Background
Is dried root of Isatissinindigoticafort. belonging to family Brassicaceae. Has the effects of clearing away heat and toxic materials, cooling blood, and relieving sore throat. Mainly treats exogenous fever, early warm disease, swollen and sore throat, warm poison and macula, mumps, erysipelas, carbuncle and sore toxin. The existing radix isatidis granule electuary is convenient to carry and eat, but most radix isatidis granules are easy to crush, a large amount of radix isatidis granules are changed into powder during production and are removed to cause waste, and the radix isatidis granules are easy to scatter away due to the fact that the granules are changed into powder when a bag is opened for taking with water, so that the radix isatidis granule electuary is difficult to avoid and waste. And the extraction efficiency of the effective components of the existing isatis root extraction process is not high enough. Therefore, it is necessary to develop a radix isatidis granule and a preparation method thereof, which can avoid the friable granules and can efficiently extract effective components.
Disclosure of Invention
The invention aims to provide isatis root granules and a preparation method thereof, and aims to solve the problems that the granules are easy to crush and the extraction of effective components is not high enough.
In order to achieve the purpose, the invention adopts the following technical scheme:
a radix isatidis granule is mainly prepared from the following raw materials in parts by weight: 500-800 parts of isatis root composite extract and 10-40 parts of adhesive.
Further, the isatis root composite extract comprises, by weight, 600-700 parts of isatis root composite extract and 20-40 parts of adhesive.
Further, the isatis root compound extract is obtained by extracting isatis root and liquorice together.
Further, the weight ratio of the isatis root to the liquorice is 50: 1.
further, the adhesive is selected from starch slurry, sodium carboxymethyl cellulose, and gelatin solution.
A method for preparing isatis root granules comprises the following steps:
(1) slicing radix Isatidis and Glycyrrhrizae radix, placing in a medicinal tank, decocting in water for 2 times, mixing decoctions, and keeping residue;
(2) concentrating the decoction;
(3) placing the residue in supercritical extraction kettle, performing supercritical extraction at 70-80 deg.C under 50-80MPa and 40-65g/min of carbon dioxide flow rate, adding entrainer 5-8 wt% of carbon dioxide, extracting for 1-6 hr, at 50-65 deg.C under 40-50MPa for 0.5-1 hr;
(4) mixing the liquid medicines obtained in the step (2) and the step (3), adding an adhesive, and stirring at 50-60 ℃;
(5) drying and granulating;
(6) and (6) packaging a finished product.
Preferably, the first and second electrodes are formed of a metal,
the decocting temperature in the step (1) is 95-100 ℃, and the decocting time is 1.5-2 h.
Preferably, the first and second electrodes are formed of a metal,
the entrainer is ethanol.
Compared with the prior art, the invention has the following advantages:
(1) the adhesive is selected from starch slurry, sodium carboxymethylcellulose and gelatin solution, so that the internal binding power of the granules can be improved, the powder condition is greatly improved, and the eating is not influenced;
(2) the effective components can be efficiently extracted by decoction and supercritical extraction;
(3) the radix isatidis and the liquorice are extracted at the same time, so that the active ingredients can be fully and uniformly mixed.
Detailed Description
The present invention will be described in detail with reference to specific embodiments, which are illustrative of the present invention and are not to be construed as limiting the present invention.
Example 1
A radix isatidis granule is mainly prepared from the following raw materials in parts by weight: 500 parts of isatis root composite extract and 20 parts of adhesive.
The radix Isatidis composite extract is obtained by extracting radix Isatidis and Glycyrrhrizae radix together. The weight ratio of the isatis root to the liquorice is 50: 1.
the adhesive is selected from starch slurry and gelatin solution.
A method for preparing isatis root granules comprises the following steps:
(1) slicing radix Isatidis and Glycyrrhrizae radix, placing in a medicinal tank, adding water, decocting at 100 deg.C for 1.5 hr for 2 times, mixing decoctions, and keeping residue;
(2) concentrating the decoction;
(3) placing the residue in a supercritical extraction kettle, performing supercritical extraction at 70 deg.C under 80MPa and 40g/min carbon dioxide flow rate, adding entrainer ethanol 8 wt% of carbon dioxide, extracting for 1.5 hr, separating at 60 deg.C under 45MPa for 1 hr;
(4) mixing the liquid medicines obtained in the step (2) and the step (3), adding an adhesive, and stirring at 60 ℃;
(5) drying and granulating;
(6) and (6) packaging a finished product.
Example 2
A radix isatidis granule is mainly prepared from the following raw materials in parts by weight: 600 parts of isatis root composite extract and 40 parts of adhesive.
The radix Isatidis composite extract is obtained by extracting radix Isatidis and Glycyrrhrizae radix together.
The weight ratio of the isatis root to the liquorice is 50: 1.
the adhesive is selected from starch slurry, sodium carboxymethylcellulose and gelatin solution.
A method for preparing isatis root granules comprises the following steps:
(1) slicing radix Isatidis and Glycyrrhrizae radix, placing in a medicinal tank, adding water, decocting at 100 deg.C for 2 hr for 2 times, mixing decoctions, and keeping residue;
(2) concentrating the decoction;
(3) placing the residue in a supercritical extraction kettle, performing supercritical extraction at 80 deg.C under 70MPa and 50g/min carbon dioxide flow rate, adding entrainer ethanol 8 wt% of carbon dioxide, extracting for 2 hr, at 65 deg.C under 50MPa for 1 hr;
(4) combining the liquid medicines obtained in the step (2) and the step (3), adding an adhesive, and stirring at 55 ℃;
(5) drying and granulating;
(6) and (6) packaging a finished product.
Example 3
A radix isatidis granule is mainly prepared from the following raw materials in parts by weight: 800 parts of isatis root composite extract and 30 parts of adhesive.
The radix Isatidis composite extract is obtained by extracting radix Isatidis and Glycyrrhrizae radix together.
The weight ratio of the isatis root to the liquorice is 50: 1.
the adhesive is selected from starch slurry, sodium carboxymethylcellulose and gelatin solution.
A method for preparing isatis root granules comprises the following steps:
(1) slicing radix Isatidis and Glycyrrhrizae radix, placing in a medicinal tank, adding water, decocting at 100 deg.C for 2 times, mixing decoctions, and keeping residue;
(2) concentrating the decoction;
(3) placing the residue in a supercritical extraction kettle, performing supercritical extraction at 80 deg.C under 50MPa and carbon dioxide flow rate of 65g/min, adding 5 wt% ethanol entrainer, extracting for 2.5 hr, separating at 65 deg.C under 40MPa for 2 hr;
(4) mixing the liquid medicines obtained in the step (2) and the step (3), adding an adhesive, and stirring at 60 ℃;
(5) drying and granulating;
(6) and (6) packaging a finished product.
The technical solutions provided by the embodiments of the present invention are described in detail above, and the principles and embodiments of the present invention are explained herein by using specific examples, and the descriptions of the embodiments are only used to help understanding the principles of the embodiments of the present invention; meanwhile, for a person skilled in the art, according to the embodiments of the present invention, there may be variations in the specific implementation manners and application ranges, and in summary, the content of the present description should not be construed as a limitation to the present invention.
Claims (8)
1. The isatis root granule is characterized in that:
the health-care food is mainly prepared from the following raw materials in parts by weight: 500-800 parts of isatis root composite extract and 10-40 parts of adhesive.
2. The isatis root granules according to claim 1, wherein:
the isatis root composite extract comprises, by weight, 600-700 parts of isatis root composite extract and 20-40 parts of adhesive.
3. The isatis root granules according to claim 1, wherein:
the radix Isatidis composite extract is obtained by extracting radix Isatidis and Glycyrrhrizae radix together.
4. The isatis root granules according to claim 1, wherein:
the weight ratio of the isatis root to the liquorice is 50: 1.
5. the isatis root granules according to claim 1, wherein:
the adhesive is selected from starch slurry, sodium carboxymethylcellulose and gelatin solution.
6. A method for preparing the isatis root granules as claimed in claim 1, which is characterized in that:
the method comprises the following steps:
(1) slicing radix Isatidis and Glycyrrhrizae radix, placing in a medicinal tank, decocting in water for 2 times, mixing decoctions, and keeping residue;
(2) concentrating the decoction;
(3) placing the residue in supercritical extraction kettle, performing supercritical extraction at 70-80 deg.C under 50-80MPa and 40-65g/min of carbon dioxide flow rate, adding entrainer 5-8 wt% of carbon dioxide, extracting for 1-6 hr, at 50-65 deg.C under 40-50MPa for 0.5-1 hr;
(4) mixing the liquid medicines obtained in the step (2) and the step (3), adding an adhesive, and stirring at 50-60 ℃;
(5) drying and granulating;
(6) and (6) packaging a finished product.
7. The preparation method of the isatis root granules according to claim 6, which is characterized by comprising the following steps:
the decocting temperature in the step (1) is 95-100 ℃, and the decocting time is 1.5-2 h.
8. The preparation method of the isatis root granules according to claim 6, which is characterized by comprising the following steps:
the entrainer is ethanol.
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CN202110333545.4A CN113230305A (en) | 2021-03-29 | 2021-03-29 | Isatis root granules and preparation method thereof |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1969922A (en) * | 2005-11-22 | 2007-05-30 | 黄振华 | Compound pharmaceutical composition and preparation process thereof |
CN101396382A (en) * | 2007-09-27 | 2009-04-01 | 上海市脑血管病防治研究所 | Composite isatis root orally disintegrating tablet and preparation method thereof |
CN106109573A (en) * | 2016-06-17 | 2016-11-16 | 广东和平君乐药业有限公司 | A kind of compound isatis root granules and production technology thereof |
-
2021
- 2021-03-29 CN CN202110333545.4A patent/CN113230305A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1969922A (en) * | 2005-11-22 | 2007-05-30 | 黄振华 | Compound pharmaceutical composition and preparation process thereof |
CN101396382A (en) * | 2007-09-27 | 2009-04-01 | 上海市脑血管病防治研究所 | Composite isatis root orally disintegrating tablet and preparation method thereof |
CN106109573A (en) * | 2016-06-17 | 2016-11-16 | 广东和平君乐药业有限公司 | A kind of compound isatis root granules and production technology thereof |
Non-Patent Citations (3)
Title |
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唐剑锋: "氨溴索口服液联合小儿咳喘灵颗粒辅助治疗小儿支气管肺炎的疗效观察", 《中国民康医学》 * |
杨山,等: "中西医结合治疗眼部带状疤疹28例", 《中国中西医结合杂志》 * |
黄玉兰,等: "超临界萃取板蓝根中靛玉红的工艺研究", 《黑龙江八一农垦大学学报》 * |
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