CN105168787B - Chinese medicine composition and preparation method thereof for improving pig immunity - Google Patents

Chinese medicine composition and preparation method thereof for improving pig immunity Download PDF

Info

Publication number
CN105168787B
CN105168787B CN201510673162.6A CN201510673162A CN105168787B CN 105168787 B CN105168787 B CN 105168787B CN 201510673162 A CN201510673162 A CN 201510673162A CN 105168787 B CN105168787 B CN 105168787B
Authority
CN
China
Prior art keywords
parts
pig
chinese medicine
radix
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201510673162.6A
Other languages
Chinese (zh)
Other versions
CN105168787A (en
Inventor
杜雄伟
李叶
邹民发
王玉山
梁军
陈朝喜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dalian Minzu University
Original Assignee
Dalian Nationalities University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dalian Nationalities University filed Critical Dalian Nationalities University
Priority to CN201510673162.6A priority Critical patent/CN105168787B/en
Publication of CN105168787A publication Critical patent/CN105168787A/en
Application granted granted Critical
Publication of CN105168787B publication Critical patent/CN105168787B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides a kind of Chinese medicine compositions and preparation method thereof for improving pig immunity, are related to veterinary medicament field.Sea Aster 6-10 parts of present invention selection, 2~8 parts of honey-fried FLOS FARFARAE, 2~6 parts of Radix Codonopsis, 2~6 parts of honeysuckle and 3~6 parts of Paris polyphylla are used as monarch drug in a prescription, using 3~8 parts of rhizoma corydalis, 2~6 parts of radix glycyrrhizae preparata, 3~6 parts of Radix Paeoniae Alba, 0.1~0.5 part of Vacuum-dried powder of cobra gall as ministerial drug, the above nine tastes medicine is combined, it is clearing heat and detoxicating, adjust the body's immunity of pig.The present invention has the targetedly mutual matched of Chinese medicine according to the physilogical characteristics of pig, by various, learns from other's strong points to offset one's weaknesses, cooperates with mutually, have clearing heat-fire, dampness elimination and in, anti-inflammatory, antibiosis and antiviral functions;Have effects that good diseases prevention, disease-resistant, growth promotion, and have no toxic side effect and medicament residue, effectively improves pig immunity.

Description

Chinese medicine composition and preparation method thereof for improving pig immunity
Technical field
The present invention relates to veterinary medicament fields, in particular to for improving Chinese medicine composition and its preparation side of pig immunity Method.
Background technique
In recent years, with the rapid development of China's animal husbandry, ecological pig cultivation also becomes the mainstay of animal husbandry product One of, still, since pig immunity is low and the propagation pig epidemic disease of epidemic virus is on the rise, such as " highly pathogenic blue ear Disease ", " swine enzootic pneumonia ", " porcine pseudorabies " etc. have all seriously affected pig breeding or growth, heavy then lead to pig death, and this kind of Disease can be infected by contact or air borne, and therefore, high mortality and high infectious rate bring serious economy to pig farm Loss.However, antibiotics Western medicine or chemical synthetic drug are still the first choice for preventing various diseases at present, it is usually logical It crosses for medicament to be added in feed addictive and carries out feeding, the treatment with the emergence of antibody-resistant bacterium, to communicable disease Worse and worse, and these medicaments cause residual of the chemicals in pork and products thereof to effect, give public health and food Safety brings great damage, and the food consumption trend of " high-quality, the low medicine residual, green non-pollution " pursued with people is disagreed Back.The consumption that livestock products will meet people requires just to have to look for a kind of safe production model,
Chinese herbal medicine is current research direction as feed addictive.But current Chinese herbal feed additive is mainly The Chinese medicine for the different formulations that different communicable diseases are prepared, although Chinese medicine makes moderate progress on medicament residue, still One of the reason of the defects of that there are the courses for the treatment of is long, slow effect, above-mentioned communicable disease occurs is exactly caused by the hypoimmunity of pig, And for illness early period to improve the Chinese materia medica preparation based on pig immunity more there is not yet relevant report.
Summary of the invention
To solve the deficiencies in the prior art, inventor by studying repeatedly, and testing repeatedly by clinical test by the present invention Card has finally found the Chinese medicine composition of the raising pig immunity of more preferable curative effect, so as to complete the present invention.
The object of the present invention is to provide the Chinese medicine compositions for improving pig immunity.
There is provided the preparation methods of the Chinese medicine composition for another object of the present invention.
Medicament selection aster, honey-fried FLOS FARFARAE, Radix Codonopsis, honeysuckle and Paris polyphylla of the present invention are combined, and will be made after these pharmaceutical compositions Each efficacy of drugs generates synergistic effect, so as to effectively improve pig immunity, mentioned especially for the immunity of piglet It is high more significant.Wherein, select Radix Codonopsis since its nature and flavor is sweet, it is mild-natured;Returns spleen, lung channel;Matter moistens gas and has strengthening the spleen and tonifying the lung, benefit Gas nourishes blood and promotes the production of body fluid cures mainly weakness of the spleen and the stomach, anorexia and loose stool, fatigue and weakness, and the deficiency syndrome of the lung is breathed with cough, and shortness of breath, spontaneous perspiration, blood deficiency chlorosis is thirsty, increases Strong passive protective physical fitness reduces blood pressure, blood-nourishing, tonifying middle-Jiao and Qi.Select aster and be because its nature and flavor is pungent, bitter, tepor, temperature without heat, Respiratory tract secretion can be dramatically increased by embellishing but not dry and including aster saponin, Quercetin, therefore have eliminating the phlegm, antitussive effect, and can be excited Cardiac muscle, and have diuresis, it is clearing heat and detoxicating.Selecting honey-fried FLOS FARFARAE is to enter lung channel gas point, because its property is pungent sweet gentle gentle with temperature It is not hot, pungent without dry, sweet without with the characteristics of stagnant.It selects honeysuckle cold in nature sweet in flavor, there is the effect of clearing heat and detoxicating, cool bloodization is become silted up, it is main Control affection of exogenous wind-heat, seasonal febrile diseases from the beginning of, sore serious case of furuncle, red and swollen heat pain, passing stool with pus and blood.Paris polyphylla cold nature, bitter control pathopyretic ulcer.This four The effect of taste medicine helps Radix Codonopsis to improve immunity altogether.
To reach better curative effect, the traditional chinese medicine composition of the invention is also combined with rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba, Vacuum-dried powder of cobra gall. Rhizoma corydalis nature and flavor: pungent;It is bitter;Temperature, main kidney qi, promoting blood circulation, sharp gas, analgesic;Rhizoma corydalis has good analgesic effect, can treat a variety of cancers Disease;Radix glycyrrhizae preparata primary efficacy is and middle emergency, moistening lung are detoxified, coordinating the drug actions of a prescription;It is usually used in weakness of the spleen and the stomach, fatigue and weakness, it is aroused in interest Throb with fear, knotted pulse, detachable son poison.Radix glycyrrhizae preparata contains a variety of chemical components such as glycyrrhizin, enoxolone, licorice polysaccharide, has Body's immunity, antitumor and analgesic effect is adjusted in anti-inflammatory and anti-allergy action.Radix Paeoniae Alba is cool in nature, bitter acid, micro- It is cold, there is replenishing blood and soft liver, calming the liver and relieving pain;Contagious yin and other effects, be suitable for fever due to yin deficiency, irregular menstruation, chest and abdomen pain over the hypochondriac region, Four limbs contractions is anxious, diarrhea dysentery abdominal pain, spontaneous sweating, metrorrhagia and metrostaxis, with inferior disease;Radix Paeoniae Alba decoction can inhibit shigella dysenteriae, streptococcus pneumonia, big Enterobacteria, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc..Snake gall, nature and flavor sweetness and bitterness is cold, return heart liver stomach meridian, heat-clearing and damp-drying drug, Desinsection improving eyesight.Above each medicine, radix glycyrrhizae preparata, Radix Paeoniae Alba and Vacuum-dried powder of cobra gall focus on the effect of anti-inflammatory and antibacterial and detoxicating, and rhizoma corydalis focuses on assistant system The cold and cool disadvantage of all medicines, but can priming reach hole key skin thoroughly, the above nine tastes medicine is combined, it is clearing heat and detoxicating, help principal drug assistance jointly Adjust body's immunity.Above all medicines play jointly clearing heat and detoxicating, dampness elimination and in, antibiosis and antiviral functions.
The dosage of each component of Chinese medicine composition of the invention is also to carry out largely groping to summarize to obtain by inventor, Dosage of each component can have good curative effect within the scope of following weight parts:
6-10 parts of aster, 2~8 parts of honey-fried FLOS FARFARAE, 2~6 parts of Radix Codonopsis, 2~6 parts of honeysuckle and 3~6 parts of Paris polyphylla.
Preferably, 8 parts of aster, 6.5 parts of honey-fried FLOS FARFARAE, 5.5 parts of Radix Codonopsis, 4 parts of honeysuckle and 4.5 parts of Paris polyphylla.
Drug dosage of each component of the present invention can also be 6-10 parts of aster, 2~8 parts of honey-fried FLOS FARFARAE, 2~6 parts of Radix Codonopsis, honeysuckle 2 ~6 parts, 3~6 parts of Paris polyphylla, 3~8 parts of rhizoma corydalis, 2~6 parts of radix glycyrrhizae preparata, 3~6 parts of Radix Paeoniae Alba, 0.1~0.5 part of Vacuum-dried powder of cobra gall.
Preferably, 8 parts of aster, 6.5 parts of honey-fried FLOS FARFARAE, 5.5 parts of Radix Codonopsis, 4 parts of honeysuckle, 4.5 parts of Paris polyphylla, 6.5 parts of rhizoma corydalis, toast 4.5 parts of Radix Glycyrrhizae, 5 parts of Radix Paeoniae Alba, 0.2 part of Vacuum-dried powder of cobra gall.
Heretofore described Vacuum-dried powder of cobra gall be it is various have the snake gall of poisonous snake and nonpoisonous snake it is dry after be developed into powder.Such as white flower Snake Vacuum-dried powder of cobra gall.
The present composition can be prepared using the conventional method of Chinese materia medica preparation, such as these bulk pharmaceutical chemicals can be ground into powder End is uniformly mixed and powder is made;Can the decocting together in addition to Vacuum-dried powder of cobra gall by these bulk pharmaceutical chemicals, decocting liquid is then concentrated.In order to make Each bulk pharmaceutical chemicals give full play to drug effect, have preferably carried out ethyl alcohol extraction to aster in formula and honeysuckle, but these are not used in limitation originally The protection scope of invention.
Preferably, the traditional chinese medicine composition of the invention the preparation method is as follows:
Include the following steps:
(1) 6-10 parts of bulk pharmaceutical chemicals aster, 2~8 parts of honey-fried FLOS FARFARAE, 2~6 parts of Radix Codonopsis, 2~6 parts of honeysuckle and Paris polyphylla 3~6 are weighed Part, impurity elimination is dried, spare;
(2) water is added to decoct twice, often in 90~100 DEG C the honey-fried FLOS FARFARAE of the weight proportion, Radix Codonopsis and three taste medicine of Paris polyphylla Secondary amount of water is advisable with not crossing powder, merges decocting liquid twice, filters to get filtrate I, is condensed into the medicinal extract that specific gravity is 1.2~1.25, Add 90~95% ethyl alcohol of mass concentration to carry out alcohol precipitation, recycle ethyl alcohol and is concentrated, it is dry at 45~50 DEG C, dry extract I is made;
(3) 90%~95% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, Extracting solution is recycled into ethyl alcohol, it is dry at 45~50 DEG C, dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, the Chinese medicine composition is made.
As also contained rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba and Vacuum-dried powder of cobra gall, preparation method in fruit component are as follows:
(1) weigh 6-10 parts of each bulk pharmaceutical chemicals aster, 2~8 parts of honey-fried FLOS FARFARAE, 2~6 parts of Radix Codonopsis, 2~6 parts of honeysuckle, Paris polyphylla 3~ 6,3~8 parts of rhizoma corydalis, 2~6 parts of radix glycyrrhizae preparata, 3~6 parts of Radix Paeoniae Alba and 0.1~0.5 part of Vacuum-dried powder of cobra gall, impurity elimination is dried, spare;
(2) by the honey-fried FLOS FARFARAE of the weight ratio, Radix Codonopsis, Paris polyphylla, rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba Six-element medicine add water in 90~ 100 DEG C decoct twice, and each amount of water is advisable with not crossing powder, merges decocting liquid twice, filter to get filtrate I, and being condensed into specific gravity is 1.2~1.25 medicinal extract adds 90%~95% ethyl alcohol of mass concentration to carry out alcohol precipitation, recycles ethyl alcohol and is concentrated, at 45~50 DEG C It is dry, dry extract I is made;
(3) 90%~95% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, Extracting solution is recycled into ethyl alcohol, it is dry at 45~50 DEG C, dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, add Vacuum-dried powder of cobra gall, the Chinese medicine group is made Close object.
Chinese medicine composition of the present invention can be added various pharmaceutical carriers required when preparing different dosage forms and be used In the Chinese materia medica preparation for improving pig immunity.Such as disintegrating agent, particle is made in Chinese medicine composition obtained by the present invention, dried starch is added, Tabletting obtains the disintegrating agent for improving pig immunity after mixing.
Chinese medicine composition of the invention, the present invention, will be various mutual with targetedly Chinese medicine according to the physilogical characteristics of pig Proportion, learn from other's strong points to offset one's weaknesses, mutually cooperate with, have clearing heat-fire, dampness elimination and in, anti-inflammatory, antibiosis and antiviral functions;With good anti- Sick, disease-resistant, growth promotion effect, and have no toxic side effect and medicament residue, effectively improve pig immunity.
Specific embodiment
The present invention is further described by the following examples, but is not used in and limits the scope of the invention.
Embodiment 1
8 parts of aster, 6.5 parts of honey-fried FLOS FARFARAE, 5.5 parts of Radix Codonopsis, 4 parts of honeysuckle and 4.5 parts of Paris polyphylla.
(1) each bulk pharmaceutical chemicals aster, honey-fried FLOS FARFARAE, Radix Codonopsis, honeysuckle and Paris polyphylla, removal is weighed to dry, it is spare;
(2) water is added to decoct twice, every time plus water in 90 DEG C the honey-fried FLOS FARFARAE of the weight proportion, Radix Codonopsis and three taste medicine of Paris polyphylla Amount is advisable with not crossing powder, merges decocting liquid twice, filters to get filtrate I, is condensed into the medicinal extract that specific gravity is 1.2, is added mass concentration 95% ethyl alcohol carries out alcohol precipitation, recycles ethyl alcohol and is concentrated, dry at 45~50 DEG C, and dry extract I is made;
(3) 95% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, will extracted Liquid recycles ethyl alcohol, dry at 45~50 DEG C, and dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, the Chinese medicine composition is made.
Gained Chinese medicine composition is added in deionized water and is dissolved, spray can be obtained using aerosol bottle packaging.
Embodiment 2
8 parts of aster, 6.5 parts of honey-fried FLOS FARFARAE, 5.5 parts of Radix Codonopsis, 4 parts of honeysuckle, 4.5 parts of Paris polyphylla, 6.5 parts of rhizoma corydalis, radix glycyrrhizae preparata 4.5 Part, 5 parts of Radix Paeoniae Alba, 0.2 part of Vacuum-dried powder of cobra gall.
(1) it is dry that each bulk pharmaceutical chemicals aster, honey-fried FLOS FARFARAE, Radix Codonopsis, honeysuckle, Paris polyphylla, rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba and snake gall are weighed Powder, it is spare;
(2) add water in 90 DEG C the honey-fried FLOS FARFARAE of the weight ratio, Radix Codonopsis, Paris polyphylla, rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba Six-element medicine It decocts twice, each amount of water is advisable with not crossing powder, merges decocting liquid twice, filters to get filtrate I, and being condensed into specific gravity is 1.2 Medicinal extract adds 95% ethyl alcohol of mass concentration to carry out alcohol precipitation, recycles ethyl alcohol and is concentrated, dry at 45~50 DEG C, and dry extract I is made;
(3) 95% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, will extracted Liquid recycles ethyl alcohol, dry at 45~50 DEG C, and dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, add Vacuum-dried powder of cobra gall, the Chinese medicine group is made Close object.Particle is made in Chinese medicine composition obtained by the present invention, dried starch is added, tabletting is obtained for improving pig immunity after mixing Disintegrating agent.
Embodiment 3
4 parts of 10 parts of aster, 6 parts of honey-fried FLOS FARFARAE, 6 parts of Radix Codonopsis, 4 parts of honeysuckle and Paris polyphylla, 8 parts of rhizoma corydalis, 2 parts of radix glycyrrhizae preparata, Radix Paeoniae Alba 3 Part, 0.5 part of Vacuum-dried powder of cobra gall.
(1) it is spare that each bulk pharmaceutical chemicals are weighed;
(2) add water in 90 DEG C the honey-fried FLOS FARFARAE of the weight ratio, Radix Codonopsis, Paris polyphylla, rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba Six-element medicine Decoct twice, each amount of water is advisable with not crossing powder, merges decocting liquid twice, filters to get filtrate I, be condensed into specific gravity be 1.2~ 1.25 medicinal extract adds 90%~95% ethyl alcohol of mass concentration to carry out alcohol precipitation, recycles ethyl alcohol and is concentrated, dry at 45~50 DEG C, Dry extract I is made;
(3) 90%~95% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, Extracting solution is recycled into ethyl alcohol, it is dry at 45~50 DEG C, dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, add Vacuum-dried powder of cobra gall, the Chinese medicine group is made Close object.
Gained Chinese medicine composition is ground into fine powder again, ethyl alcohol is added and makees binder, starch is added and makees filler, is pressed into Granule.
Embodiment 4
6 parts of 10 parts of aster, 2 parts of honey-fried FLOS FARFARAE, 2 parts of Radix Codonopsis, 2 parts of honeysuckle and Paris polyphylla, 3 parts of rhizoma corydalis, 6 parts of radix glycyrrhizae preparata, Radix Paeoniae Alba 6 Part, 0.4 part of Vacuum-dried powder of cobra gall.
(1) it is spare that each bulk pharmaceutical chemicals are weighed;
(2) add water in 100 DEG C the honey-fried FLOS FARFARAE of the weight ratio, Radix Codonopsis, Paris polyphylla, rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba Six-element medicine It decocts twice, each amount of water is advisable with not crossing powder, merges decocting liquid twice, filters to get filtrate I, and being condensed into specific gravity is 1.25 Medicinal extract adds 90% ethyl alcohol of mass concentration to carry out alcohol precipitation, recycles ethyl alcohol and is concentrated, dry at 45~50 DEG C, and dry extract I is made;
(3) 90% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, will extracted Liquid recycles ethyl alcohol, dry at 45~50 DEG C, and dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, add Vacuum-dried powder of cobra gall, the Chinese medicine group is made Close object.
Gained Chinese medicine composition is added to dissolve to boil in deionized water, decoction is made.
Test example 1
Dalian pig farm piglet and Adult Pig each 300 are chosen, piglet and Adult Pig are divided into test group I, test II And control group, every group 100, point circle raising, test group I carries out feeding, test group II with the traditional chinese medicine composition of the invention granule Feeding is carried out with the traditional chinese medicine composition of the invention disintegrating agent, control group is not administered, and test pig keeps environment and raising by personal management Management is consistent, takes free choice feeding and drinking-water, during test, daily disinfection is normally carried out.
Specific packet transaction is as shown in table 1.
The grouping of 1 test group of table and processing
Group Test pig's head number Dosage/mg/kg weight Processing mode
Piglets group I 100 2 Mixed drink administration
Piglets group II 100 5 Mixed drink administration
Piglet control group 100 0 It is not administered
Adult Pig test group I 100 5 Mixed drink administration
Adult Pig test group II 100 7 Mixed drink administration
Adult Pig control group 100 0 It is not administered
1, medication
Test group I takes granular preparation, and piglet dosage is 2ml/kg weight, and Adult Pig dosage is the perfusion of 5ml/kg weight The direct administered by oral gavage of device, 3 times/d, is used in conjunction 30d;Test group II takes disintegrating agent, and piglet dosage is 5ml/kg weight, and Adult Pig is used Amount is 7ml/kg weight, and 3 times/d, 30d is used in conjunction in direct administered by oral gavage after being dissolved in water.Drug control group is without any drug Processing.
2, observation index
The breath state of observation duration of medication piglet and Adult Pig breathes, the clinical settings such as diarrhea, while observing morbid pig Head number, and observe the state of an illness of sick pig whether there is or not recurrence after drug withdrawal 7d or occur dead.
3, therapeutic effect criterion
1) effective: temperature of pig body is normal, no diarrhea, and breathing is normal, no oedema, and spirit, appetite are normal;
2) improve: temperature of pig body is normal, no diarrhea, there is mild respiratory symptom, and spirit, appetite are normal;
3) invalid: there is exception in temperature of pig body, has diarrhea, there is respiratory symptom, loss of appetite, weight loss.
The analysis of 2 treatment results of table
Note: P < 0.01 * * * compared with the control group.
As seen from the experiment, the immunity of piglet and Adult Pig can be improved in the Chinese medicine composition that the present invention invents, Taking can guarantee that diarrhea do not occur in piglet and Adult Pig in two weeks, mild respiratory symptom effectively prevents pig blue-ear disease etc. Respiratory disease can suitably increase pharmaceutical quantities according to the case where pig, to reach optimum medicine efficacy.Test example 2
The piglet for mild diarrhea or respiratory symptom occur and Adult Pig each 200 are chosen, test group and control are divided into Group, every group 100, point circle raising, test group 1,2 carries out feeding with the traditional chinese medicine composition of the invention disintegrating agent, and piglet dosage is 5ml/kg weight, Adult Pig dosage are 7ml/kg weight, and 3 times/d, 30d is used in conjunction in direct administered by oral gavage after being dissolved in water;Control group 1, it 2 is not administered, test pig is kept environment consistent with feeding management, taken free choice feeding and drinking-water, experimental period by personal management Between, daily disinfection is normally carried out.
The grouping of 3 test group of table and processing
1, observation index
The breath state of observation duration of medication piglet and Adult Pig breathes, the clinical settings such as diarrhea, while observing morbid pig Head number, and observe the state of an illness of sick pig whether there is or not recurrence after drug withdrawal 7d or occur dead.
2, therapeutic effect criterion
1) effective: temperature of pig body is normal, no diarrhea, and breathing is normal, no oedema, and spirit, appetite are normal;
2) improve: temperature of pig body is normal, no diarrhea, there is mild respiratory symptom, and spirit, appetite are normal;
3) invalid: improvement standard or death is not achieved.
The analysis of 4 treatment results of table
By being tested above it is found that Chinese medicine composition of the invention is improved for the piglet of doubtful illness and Adult Pig and exempts from The effect of epidemic disease power, and can achieve effective percentage 89%, it is significant in efficacy.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art within the technical scope of the present disclosure, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (3)

1. the preparation method for the Chinese medicine composition for improving pig immunity, characterized in that it comprises the following steps:
(1) it weighs 6~10 parts of each bulk pharmaceutical chemicals aster, 2~8 parts of honey-fried FLOS FARFARAE, 2~6 parts of Radix Codonopsis, 2~6 parts of honeysuckle, Paris polyphylla 3~6, prolong 3~8 parts of Hu rope, 2~6 parts of radix glycyrrhizae preparata, 3~6 parts of Radix Paeoniae Alba and 0.1~0.5 part of Vacuum-dried powder of cobra gall, impurity elimination is dried, spare;
(2) add water in 90~100 DEG C the honey-fried FLOS FARFARAE of the weight ratio, Radix Codonopsis, Paris polyphylla, rhizoma corydalis, radix glycyrrhizae preparata, Radix Paeoniae Alba Six-element medicine Decoct twice, each amount of water is advisable with not crossing powder, merges decocting liquid twice, filters to get filtrate I, be condensed into specific gravity be 1.2~ 1.25 medicinal extract adds 90%~95% ethyl alcohol of mass concentration to carry out alcohol precipitation, recycles ethyl alcohol and is concentrated, dry at 45~50 DEG C, Dry extract I is made;
(3) 90%~95% ethyl alcohol of mass concentration is added in the aster of the weight proportion and honeysuckle and carries out refluxing extraction, will mentioned Liquid is taken to recycle ethyl alcohol, it is dry at 45~50 DEG C, dry extract II is made;
(4) dry extract I and dry extract II are mixed, is crushed into powder, add Vacuum-dried powder of cobra gall, the Chinese traditional medicine composition is made Object.
2. according to claim 1 for improving the preparation method of the Chinese medicine composition of pig immunity, which is characterized in that each The dosage of component are as follows: 8 parts of aster, 6.5 parts of honey-fried FLOS FARFARAE, 5.5 parts of Radix Codonopsis, 4 parts of honeysuckle, 4.5 parts of Paris polyphylla, 6.5 parts of rhizoma corydalis, toast are sweet Careless 4.5 parts, 5 parts of Radix Paeoniae Alba, 0.2 part of Vacuum-dried powder of cobra gall.
3. a kind of for improving the Chinese materia medica preparation of pig immunity, which is characterized in that including claim 1 institute as active component Chinese medicine composition made from the preparation method stated and pharmaceutical carrier.
CN201510673162.6A 2015-10-16 2015-10-16 Chinese medicine composition and preparation method thereof for improving pig immunity Expired - Fee Related CN105168787B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510673162.6A CN105168787B (en) 2015-10-16 2015-10-16 Chinese medicine composition and preparation method thereof for improving pig immunity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510673162.6A CN105168787B (en) 2015-10-16 2015-10-16 Chinese medicine composition and preparation method thereof for improving pig immunity

Publications (2)

Publication Number Publication Date
CN105168787A CN105168787A (en) 2015-12-23
CN105168787B true CN105168787B (en) 2019-04-19

Family

ID=54891537

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510673162.6A Expired - Fee Related CN105168787B (en) 2015-10-16 2015-10-16 Chinese medicine composition and preparation method thereof for improving pig immunity

Country Status (1)

Country Link
CN (1) CN105168787B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104666524A (en) * 2013-11-29 2015-06-03 黄石市科兴机电科技有限公司 Stomach-invigorating traditional Chinese medicine for livestock

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07291872A (en) * 1994-04-26 1995-11-07 Tsumura & Co Therapeutic agent for infectious disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104666524A (en) * 2013-11-29 2015-06-03 黄石市科兴机电科技有限公司 Stomach-invigorating traditional Chinese medicine for livestock

Also Published As

Publication number Publication date
CN105168787A (en) 2015-12-23

Similar Documents

Publication Publication Date Title
CN102239972B (en) Traditional Chinese medicine feed additive used to improve immunity and resist parasitic infection of weaned piglets and preparation and use method thereof
CN102698123B (en) Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof
CN105166545A (en) Bovine compound feed and preparation method thereof
CN105168807B (en) The Chinese medicine composition and preparation method thereof for treating pig blue-ear disease
CN103961614B (en) Chinese medicine composition for treating respiratory disease and its production and use
CN106173450A (en) Improve compound feed additive and the feedstuff of pigeon immunity
CN103007111B (en) Chinese medicinal preparation for treating diarrhea of rabbits and preparation method of Chinese medicinal preparation
CN105709081A (en) Pharmaceutical composition used for treating infectious rhinitis of chicken, applications thereof, and feed
CN103960542B (en) A kind of feed for preventing and treating swine eperythrozoonosis and Chinese medicine composition
CN102552657B (en) Chinese medicinal composition used for treating Newcastle disease of chicken
CN100438902C (en) Medicine for preventing and treating infectious rhinitis of chicken
CN103599362A (en) Traditional Chinese medicine composition for treating swine enzootic pneumonia and preparation method thereof
CN105168787B (en) Chinese medicine composition and preparation method thereof for improving pig immunity
CN104547174B (en) Preparation method of the fowl with anti virus herb granule
CN103735710B (en) Traditional Chinese medicine composition for treating recessive mastitis of dairy cows and preparation method thereof
CN103566312B (en) Traditional Chinese medicine combination for treating loss of appetite of pigs
CN113350429A (en) Traditional Chinese medicine composition for preventing and treating African swine fever disease and preparation method and application thereof
CN105535720A (en) Chinese herbal medicinal composition for preventing and treating chick bronchitis, and preparation method thereof
CN104222632B (en) Feed for preventing coccidiosis of rabbits
CN103211988B (en) Pharmaceutical composition for treating porcine infectious gastrointestinal inflammations
CN105688171B (en) Feed additive for chicks and preparation method thereof
CN108125237A (en) A kind of anti-inflammatory health products of kobadrin and its preparation process
CN103690771B (en) Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof
CN106729589A (en) Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine
CN103142824B (en) Medicine for controlling swine erysipelas

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190419