CN105709081A - Pharmaceutical composition used for treating infectious rhinitis of chicken, applications thereof, and feed - Google Patents
Pharmaceutical composition used for treating infectious rhinitis of chicken, applications thereof, and feed Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition used for treating infectious rhinitis of chicken, applications thereof, and a feed, and belongs to the field of veterinary drug. The pharmaceutical composition is capable of improving immunity of animals, and is used for preventing and treating infectious rhinitis of chicken. The compound traditional Chinese medicine pharmaceutical composition is prepared from following active ingredients: herba centipedae, radix platycodonis, propolis, radix angelicae, rhizoma fagopyri dibotryis, flos chrysanthemi, fructus viticis, andrographis paniculata, rhizoma phragmitis, and liquorice. The compound traditional Chinese medicine pharmaceutical composition can be added into the feed directly so as to prevent and treat infectious rhinitis of chicken, and can also be prepared into granule, tablet, oral liquid, and injection for treatment of infectious rhinitis of chicken. The compound traditional Chinese medicine pharmaceutical composition is excellent in drug effect, is convenient to use, is natural, is low in toxicity, is safe, and is friendly to the environment; effect is achieved quickly; and a preparation method is simple.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition treating infectious coryza of chicken, its application and feedstuff, this medicine can strengthen animal body immunity, is used for preventing and treating infectious coryza of chicken disease, belongs to field of veterinary.
Background technology
Infectious coryza of chicken is a kind of Acute Respiratory infectious disease caused by Haemohpilus paragallinaram.This disease is with nasal sinuses inflammation, sneeze, rhinorrhea, facial edema and conjunctivitis for principal character, for one of the multiple disease in chicken farm.This disease Epidemic Scope is extensive, and the chicken at any age all can infect.Mixed group feeding is supported, and ventilates poor, sultry in hen house, abnormal smells from the patient greatly or the factor such as hen house cold wet chicken group can be promoted seriously to fall ill because resistance decline.This disease can cause Growing Chicken undergrowth, laying hen to lay eggs and be decreased obviously and the increase of superseded chicken number after occurring, and easily causes secondary infection, carrys out huge economic loss to poultry industrial belt.
In recent years, along with people's concern to food safety, and western medicine is easily generated the problem of drug resistance and residual, and herbal medicine obtains to be paid close attention to and application greatly.Herbal medicine is as the green veterinary drug of pure natural, environmental protection, containing multiple beneficial composition, and good effect and be not likely to produce drug resistance, become the necessary trend of veterinary drug industry development, the herbal medicine therefore developing effectively preventing infectious coryza of chicken sick is significant.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition treating infectious coryza of chicken, its application and feedstuff, this medicine can strengthen animal body immunity, and preventing and treating infectious coryza of chicken is sick.The active component of this herbal mixture pharmaceutical composition is made up of Herba Centipedae, Radix Platycodonis, propolis, the Radix Angelicae Dahuricae, Rhizoma Fagopyri Dibotryis, Flos Chrysanthemi, Fructus Viticis, Herba Andrographis, Rhizoma Phragmitis, Radix Glycyrrhizae, and it is effective, low toxicity noresidue, environmental protection.
Another object of the present invention is to provide the preparation method and its usage of this herbal mixture pharmaceutical composition.
It is an object of the invention to be achieved through the following technical solutions:
The present invention provides a kind of herbal mixture pharmaceutical composition, and it contains active component, and described active component is made up of Herba Centipedae, Radix Platycodonis, propolis, the Radix Angelicae Dahuricae, Rhizoma Fagopyri Dibotryis, Flos Chrysanthemi, Fructus Viticis, Herba Andrographis, Rhizoma Phragmitis, Radix Glycyrrhizae.
Wherein, described active component is made up of the component of following weight parts: Herba Centipedae 10-50 part, Radix Platycodonis 15-45 part, propolis 10-50 part, Radix Angelicae Dahuricae 10-45 part, Rhizoma Fagopyri Dibotryis 5-30 part, Flos Chrysanthemi 5-30 part, Fructus Viticis 5-25 part, Herba Andrographis 5-30 part, Rhizoma Phragmitis 4-20 part, Radix Glycyrrhizae 3-20 part.
Further, described active component is made up of the component of following weight parts: Herba Centipedae 15-45 part, Radix Platycodonis 10-40 part, propolis 15-45 part, Radix Angelicae Dahuricae 15-40 part, Rhizoma Fagopyri Dibotryis 9-25 part, Flos Chrysanthemi 8-25 part, Fructus Viticis 7-20 part, Herba Andrographis 8-25 part, Rhizoma Phragmitis 6-15 part, Radix Glycyrrhizae 5-15 part.
Further, described active component is made up of the component of following weight parts: Herba Centipedae 18-40 part, Radix Platycodonis 17-40 part, propolis 18-40 part, Radix Angelicae Dahuricae 16-40 part, Rhizoma Fagopyri Dibotryis 10-20 part, Flos Chrysanthemi 10-20 part, Fructus Viticis 8-18 part, Herba Andrographis 8-20 part, Rhizoma Phragmitis 7-12 part, Radix Glycyrrhizae 5-13 part.
Wherein, described herbal mixture pharmaceutical composition can be made into powder, granule, tablet, oral liquid or injection.
The preparation method that present invention also offers this herbal mixture pharmaceutical composition, comprises the steps:
1) weigh each raw material by weight, pulverize, sieve after add 6 ~ 12 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 ~ 5 times amount 80% ~ 95% ethanol staticly settle 12h, filtration；
2) pulverizing after propolis freezing, 1:3 ~ 1:6 adds 80% ~ 95% soak with ethanol 3 ~ 4 days in proportion, stirs every day 2 ~ 3 times, after standing 1 ~ 2 day, filters；
3) above-mentioned two filtrates being merged, be concentrated into extractum shape, corresponding dosage form made by the corresponding pharmaceutically acceptable carrier of dried addition or adjuvant.
The present invention also provides for described herbal mixture pharmaceutical composition and strengthens cultivated animals immunity of organisms, the application in the medicine that preventing and treating infectious coryza of chicken is sick in preparation.
The herbal mixture pharmaceutical composition of the present invention can be directly appended in feedstuff, and therefore, the present invention also provides for the feedstuff containing described herbal mixture pharmaceutical composition.
The herbal mixture pharmaceutical composition of the present invention, it can be used for preparation and strengthens animal body immunity, the medicine of preventing and treating infectious coryza of chicken disease aspect.Dialectical according to Chinese veterinarian, infectious coryza of chicken belongs to epidemic febrile disease category, and chicken body immunity is attacked by wind and cold, wind heat lowly repeatedly again, and lung meridian is hot and suffocating, and clear respectful not normal, air flue is unclear, and nose key defeats, and body fluid is stopped up stagnant, with the passing of time turns to turbid tears, grows stream as ill in deep pool.Or the heresy of wind and cold, wind heat, directly encroach on Naohu, cause brain solid, and ooze ill etc. under turbid tears.The traditional Chinese medical science is thought, lung opening at nose, and the functional disorder of cacorhinia and lung has direct relation, exopathogenic factor wind and cold heat-damp in summer dryness-fire to be the extrinsic factor fallen ill, and exopathogenic factor is fallen ill by endogenous cause of ill.Therefore should determine that lung qi dispersing is sensible, temperature compensation lung qi, drop clearly stomach-fire, let out clearly liver and gall, Yin-nourishing and body fluid promoting, the gas that raising lung is defended is the rule for the treatment of.In side, Herba Centipedae clearing the nasal passage, Radix Platycodonis lung qi dispersing evacuation of pus, propolis anti-inflammation lifting immunity, the sensible pain relieving of the Radix Angelicae Dahuricae are all principal agent；Rhizoma Fagopyri Dibotryis heat-clearing and toxic substances removing, Flos Chrysanthemi heat clearing away suppressing the hyperactive liver, Fructus Viticis be the profit head, Herba Andrographis reducing swelling and alleviating pain clearly, for accessory drugs；Rhizoma Phragmitis clearing away heat and promoting production of body fluid, for adjuvant drug；Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, invigorating the spleen and replenishing QI, removing toxic substances, for making medicine.All medicine compatibilities, make lung qi a surname smooth, sensible detumescence, then exterior syndrome solution.
The advantage of the herbal mixture pharmaceutical composition of the present invention and having the beneficial effects that:
1) the herbal mixture pharmaceutical composition of the present invention is to administer opinion prescription according to herbal medicine syndrome differentiation of formulas opinion, evident in efficacy, instant effect.
2) the herbal mixture pharmaceutical composition of the present invention can strengthen animal body immunity, is used for preventing and treating infectious coryza of chicken disease, solves residual, side-effect problem that Western medicine produces.
3) the herbal mixture pharmaceutical composition of the present invention is pure Chinese medicinal preparation, and wide material sources are beneficial to mass prevention and mass treatment, will not produce the drug residue of harm human health.
4) the herbal mixture pharmaceutical composition of the present invention is easy to use, and production technology is simple, can be made into powder, granule, tablet, oral liquid and injection etc..
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
(1) raw material containing following weight parts is weighed:
Herba Centipedae 50 parts, Radix Platycodonis 15 parts, propolis 50 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Fagopyri Dibotryis 30 parts, Flos Chrysanthemi 5 parts, Fructus Viticis 25 parts, Herba Andrographis 5 parts, Rhizoma Phragmitis 20 parts, 20 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 12 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 2 times amount 85% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:3 adds 85% soak with ethanol 3 days in proportion, stirs 2 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into extractum shape, dry and make powder.
Embodiment 2
(1) raw material containing following weight parts is weighed:
Herba Centipedae 10 parts, Radix Platycodonis 15 parts, propolis 45 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Fagopyri Dibotryis 5 parts, Flos Chrysanthemi 20 parts, Fructus Viticis 8 parts, Herba Andrographis 20 parts, Rhizoma Phragmitis 15 parts, 5 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 6 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 3 times amount 85% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:4 adds 85% soak with ethanol 2 days in proportion, stirs 2 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into extractum shape, dry and make powder.
Embodiment 3
(1) raw material containing following weight parts is weighed:
Herba Centipedae 15 parts, Radix Platycodonis 15 parts, propolis 10 parts, the Radix Angelicae Dahuricae 45 parts, Rhizoma Fagopyri Dibotryis 25 parts, Flos Chrysanthemi 10 parts, Fructus Viticis 8 parts, Herba Andrographis 8 parts, Rhizoma Phragmitis 12 parts, 3 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 9 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 2 times amount 80% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:5 adds 80% soak with ethanol 4 days in proportion, stirs 2 every day.After standing 2 days, filter.Above-mentioned two filtrates are merged, is concentrated into extractum shape, adds appropriate soluble starch mix homogeneously, dry and make granule (every 1g is equivalent to crude drug in whole 1g).
Embodiment 4
(1) raw material containing following weight parts is weighed:
Herba Centipedae 45 parts, Radix Platycodonis 10 parts, propolis 15 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Fagopyri Dibotryis 5 parts, Flos Chrysanthemi 30 parts, Fructus Viticis 20 parts, Herba Andrographis 15 parts, Rhizoma Phragmitis 10 parts, 15 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 9 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 times amount 80% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:6 adds 80% soak with ethanol 3 days in proportion, stirs 3 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into extractum shape, adds appropriate soluble starch mix homogeneously, dry and make granule (every 1g is equivalent to crude drug in whole 1g).
Embodiment 5
(1) raw material containing following weight parts is weighed:
Herba Centipedae 10 parts, Radix Platycodonis 25 parts, propolis 12 parts, the Radix Angelicae Dahuricae 16 parts, Rhizoma Fagopyri Dibotryis 5 parts, Flos Chrysanthemi 8 parts, Fructus Viticis 7 parts, Herba Andrographis 15 parts, Rhizoma Phragmitis 4 parts, 7 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 6 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 3 times amount 90% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:4 adds 90% soak with ethanol 3 days in proportion, stirs 3 every day.After standing 2 days, filter.Above-mentioned two filtrates are merged, is concentrated into extractum shape, dry, add appropriate soluble starch and magnesium stearate, mix homogeneously tabletting, make tablet (every 1g is equivalent to crude drug in whole 1g).
Embodiment 6
(1) raw material containing following weight parts is weighed:
Herba Centipedae 30 parts, Radix Platycodonis 15 parts, propolis 25 parts, the Radix Angelicae Dahuricae 10 parts, Rhizoma Fagopyri Dibotryis 30 parts, Flos Chrysanthemi 5 parts, Fructus Viticis 30 parts, Herba Andrographis 5 parts, Rhizoma Phragmitis 6 parts, 3 parts of Radix Glycyrrhizae.
(2) each raw material outside propolis, pulverize, sieve after add 9 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 times amount 95% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:4 adds 95% soak with ethanol 3 days in proportion, stirs 2 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into extractum shape, dry, add appropriate soluble starch and magnesium stearate, mix homogeneously tabletting, make tablet (every 1g is equivalent to crude drug in whole 1g).
Embodiment 7
(1) raw material containing following weight parts is weighed:
Herba Centipedae 10 parts, Radix Platycodonis 17 parts, propolis 15 parts, the Radix Angelicae Dahuricae 20 parts, Rhizoma Fagopyri Dibotryis 20 parts, Flos Chrysanthemi 15 parts, Fructus Viticis 18 parts, Herba Andrographis 14 parts, Rhizoma Phragmitis 9 parts, 5 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 8 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 2 times amount 85% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:4 adds 85% soak with ethanol 3 days in proportion, stirs 2 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into every 1ml and is equivalent to crude drug in whole 1g, then add suitable amount of sucrose, benzoic acid, ethyl hydroxybenzoate, make oral liquid.
Embodiment 8
(1) raw material containing following weight parts is weighed:
Herba Centipedae 40 parts, Radix Platycodonis 45 parts, propolis 30 parts, the Radix Angelicae Dahuricae 25 parts, Rhizoma Fagopyri Dibotryis 20 parts, Flos Chrysanthemi 15 parts, Fructus Viticis 10 parts, Herba Andrographis 10 parts, Rhizoma Phragmitis 7 parts, 5 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 6 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 times amount 85% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:4 adds 85% soak with ethanol 3 days in proportion, stirs 2 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into every 1ml and is equivalent to crude drug in whole 1g, then add suitable amount of sucrose, benzoic acid, ethyl hydroxybenzoate, make oral liquid.
Embodiment 9
(1) raw material containing following weight parts is weighed:
Herba Centipedae 45 parts, Radix Platycodonis 35 parts, propolis 40 parts, the Radix Angelicae Dahuricae 30 parts, Rhizoma Fagopyri Dibotryis 5 parts, Flos Chrysanthemi 5 parts, Fructus Viticis 10 parts, Herba Andrographis 15 parts, Rhizoma Phragmitis 10 parts, 8 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 12 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 times amount 85% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:5 adds 85% soak with ethanol 3 days in proportion, stirs 3 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into every 1ml and is equivalent to crude drug in whole 1g, then add appropriate preservative, make injection.
Embodiment 10
(1) raw material containing following weight parts is weighed:
Herba Centipedae 20 parts, Radix Platycodonis 30 parts, propolis 35 parts, the Radix Angelicae Dahuricae 30 parts, Fructus Viticis 5 parts, Flos Chrysanthemi 25 parts, Fructus Viticis 10 parts, Herba Andrographis 8 parts, Rhizoma Phragmitis 4 parts, 3 parts of Radix Glycyrrhizae.
(2) each raw material except propolis, pulverize, sieve after add 9 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 times amount 85% ethanol and staticly settles 12h, filtration.Pulverizing after propolis freezing, 1:4 adds 85% soak with ethanol 3 days in proportion, stirs 3 every day.After standing 1 day, filter.Above-mentioned two filtrates are merged, is concentrated into every 1ml and is equivalent to crude drug in whole 1g, then add appropriate preservative, make injection.
Test example 1
This test adopts secondary haemophilus artificial infection chicken group, observes the effect that herbal mixture pharmaceutical composition of the present invention is sick to prevention artificial challenge's infectious coryza of chicken.
Test and Selection does not inoculate blue brown 225 of the sea of infectious coryza of chicken vaccine, uniform 42 ages in days of body weight, is randomly divided into 5 groups, often group 45, every secondary haemophilus CCM6075 (Type B) bacterium solution 0.2ml(2.0 × 10 of via intranasal application instillation9CFU/ml).
Test group 1 adopts embodiment 1 to prepare；Test group 2 adopts embodiment 2 to prepare；Test group 1 ~ 2 is administered before artificial challenge 5d, and every 1kg feedstuff adds this herbal mixture pharmaceutical composition 20g mixed feeding, successive administration 5d.Drug control group, the erythromycin of 0.4%, free drink-service.Positive controls: infect, be not administered.Blank group: do not infect and be not administered, isolated rearing.Respectively group rearing conditions is all consistent for other.
Test chicken 36h after infection falls ill successively.Showing as bilateral or unilateral eyelid swelled, sneeze, open one's mouth to breathe, sick chicken often shakes the head, and frequently scratches nose rostral with pawl.Spirit is depressed, and body weight is gradually reduced.The visible flaxen incrustation of the dried nares of mucus in nose.
Cuing open inspection and see nasal membrane hyperemia swelling, surface is covered with a large amount of mucus, has exudate grumeleuse in hole, after become caseous necrosis thing.Visible catarrhal conjunctivitis, conjunctival congestion swelling.Face and wattle subcutaneous dropsy.Gather secretions under sick chicken socket of the eye by sterile swab, Sanguis Gallus domesticus agar plate is rule, then again using staphylococcus as " raising bacterium " intersection line on flat board, be placed in the big wide-mouth candle bottle sealing lid in 37 DEG C of cultivations, make wax candle self-extinguish.Cultivate the breeding of 24 ~ 48h visible staphylococcus periphery of bacterial colonies and have bigger translucent dewdrop sample pair haemophilus bacterium colony, grow in satellite sample.Continuous Observation 7 days, adopts PASWStatistics18.0 software that data are carried out statistical analysis, adds up the difference of each group and positive controls.
Result is in Table 1.The sickness rate of test group 1 is 48.89%；The sickness rate of test group 2 is 51.11%；The sickness rate of drug control group is 55.56%；The sickness rate of positive controls is 100.00%；Blank group is not fallen ill.The sickness rate of test group 1,2 and drug control group is substantially less than positive controls (P < 0.05).The sickness rate of test group 1,2 is lower than drug control group, but is not significantly different from (P > 0.05).
Sickness rate, mortality rate and the protective rate that table 1 is respectively organized
| Group Not | Number of animals | Morbidity number | Death toll | Sickness rate (%) | Mortality rate (%) | Protective rate (%) |
| Test group 1 | 45 | 22 | 0 | 48.89 | 0.00 | 100.00 |
| Test group 2 | 45 | 23 | 1 | 51.11 | 2.22 | 97.78 |
| Drug control group | 45 | 25 | 2 | 55.56 | 4.44 | 95.56 |
| Positive controls | 45 | 45 | 8 | 100.00 | 17.78 | 82.22 |
| Blank group | 45 | 0 | 0 | - | - | - |
Brief summary: the infection of secondary haemophilus is had protective effect by herbal mixture pharmaceutical composition of the present invention, and metainfective sickness rate is substantially less than positive controls, it was shown that herbal mixture pharmaceutical composition of the present invention can be used for the prevention that infectious coryza of chicken is sick.
Test example 2
This test adopts secondary haemophilus artificial infection chicken group, observes the herbal mixture pharmaceutical composition of the present invention therapeutic effect to artificial challenge's infectious coryza of chicken.
Test and Selection does not inoculate blue brown 150 of the sea of infectious coryza of chicken vaccine, uniform 21 ages in days of body weight, is randomly divided into 5 groups, often group 30, every secondary haemophilus CCM6075 (Type B) bacterium solution 0.1ml(2.0 × 10 of via intranasal application instillation9CFU/ml).
Test group 1 adopts embodiment 7 to prepare；Test group 2 adopts embodiment 8 to prepare, and every 1L water adds the mixed drink of this herbal mixture pharmaceutical composition 2ml, successive administration 7d.Drug control group, 0.4% erythromycin, free drink-service.Test group and medicine group when disease symptom occurs in chicken group after infection, start administration.Positive controls, is not administered after infection, isolated rearing.Blank group, does not infect and is not administered, isolated rearing.
Test chicken 24h after infection falls ill successively, initial stage non-evident sympton, and nose has thin water sample nose liquid, sneeze.Opening one's mouth to breathe, eyelid is adhered, moving difficulty.Then face inflammation, eyes swelling is shed tears, and has cheesy secretion to pile up.Cut open inspection, bacteriology checking according to clinic, artificial challenge's success can be made a definite diagnosis.Continuous Observation 7 days, adopts PASWStatistics18.0 software that data are carried out statistical analysis, adds up the difference of each group and positive controls.
Result is in Table 2.The mortality rate of test group and drug control group is substantially less than positive controls (P < 0.05).Test group is by, after drinking water administration, comparing with positive controls, and the state of an illness substantially alleviates, and spirit, appetite take a turn for the better gradually.Test group protective rate reaches more than 96.67%, higher than positive controls 83.33%(P < 0.05).
The mortality rate of table 2 each group after infecting and protective rate
| Group Not | Number of animals (only) | Morbidity number (only) | Death toll (only) | Mortality rate (%) | Protective rate (%) |
| Test group 1 | 30 | 30 | 1 | 3.33 | 96.67 |
| Test group 2 | 30 | 30 | 0 | 0.00 | 100.00 |
| Drug control group | 30 | 30 | 1 | 3.33 | 96.67 |
| Positive controls | 30 | 30 | 5 | 16.67 | 83.33 |
| Blank group | 30 | 0 | 0 | 0.00 | - |
Brief summary: adopting this herbal mixture medicine composite for curing infectious coryza of chicken sick, protective rate is up to 100.00%.Therapeutic effect is better than positive controls, it was demonstrated that this herbal mixture pharmaceutical composition can be used for the treatment that infectious coryza of chicken is sick.
Test example 3
In mid-November, 2013, more than 3,000 Roman egghen that chicken farm, Beijing is raised occurs that sick chicken spirit is depressed, nose is shown in thin water sample shape nasal mucus, mouth breathing, sneeze, gets rid of head, bilateral or unilateral facial swelling symptom, egg production occurs being remarkably decreased phenomenon, and after 2 days, the morbidity of chicken group large area, brings tremendous influence to chicken farm.Cut open the sick chicken of inspection and see the acute catarrhal inflammation of hole and eye conjunctiva under nasal cavity, socket of the eye, it is seen that in air bag, abdominal cavity and fallopian tube, have the cheesy secretions of milk yellow.The swelling soft, hemorrhage of laying hen follicle, necrosis or atrophy.It is diagnosed as infectious coryza of chicken through laboratory inspection.Rear employing Traditional Chinese medicine composition of the present invention more than 5,000 is merely hit to what this was introduced and the laying hen drug treatment of above-mentioned disease symptom is occurred.Test point three groups, test group 1 adopts embodiment 8 to prepare；Every 1L water adds the mixed drink of this herbal mixture pharmaceutical composition 2ml, successive administration 7d；Test group 2 adopts oxytetracycline drug treatment, and concentration is 0.4%, free drink-service；Blank group does not give any medicine, normally raises.Continuing after off-test to observe 3d, test group 1 chicken group 99.66% gets well, and without recurrence, egg production is recovered.Test group 2 chicken group 99.52% gets well, and egg production is gone up.Blank group chicken group 72.12% gets well, and egg production is severely impacted.Result is in Table 3.
The curative effect of infectious coryza of chicken is added up by 3 herbal mixture pharmaceutical compositions of table
| Group Not | Number of animals (only) | Cure number (only) | Death toll (only) | Cure rate (%) |
| Test group 1 | 1790 | 1784 | 6 | 99.66 |
| Test group 2 | 1680 | 1672 | 8 | 99.52 |
| Blank group | 1370 | 988 | 52 | 72.12 |
Brief summary: this herbal mixture pharmaceutical composition can be used for treating infectious coryza of chicken, has significant therapeutic effect to the egg production of laying hen, maintains laying hen egg yield, greatly reduce loss.
Test example 4
At the beginning of 2013 12 months, the chickling morbidity of 896 22 ages in days of Zhangjiakou City Animal Raising Zone, Hebei province, disease symptom main manifestations is mouth breathing, eyelid is adhered, and dietary amount declines, and stands transfixed to the ground, moving difficulty, has thin sample nasal mucus in nose, sneeze, face are swollen, ataxia etc..It is infectious coryza of chicken after diagnosing.Chickling is divided into 2 groups, and test group 1 adopts embodiment 3 to prepare, and mixed drink administration, every 1L water adds this herbal mixture pharmaceutical composition 2g, successive administration 7d；Test group 2 is fallen ill not to be administered and is not treated；Packet isolation.In process of the test, test group 1 quantity of falling ill gradually decreases, and sick chicken symptom is relieved to disappearance, and protective rate reaches 100.00%.Whole rehabilitations through 5 ~ 7 days, administration whole process has no chicken group any untoward reaction.Result is in Table 4.
4 the herbal mixture pharmaceutical compositions of the table therapeutic effect to infectious coryza of chicken
| Group Not | Number of animals (only) | Death toll (only) | Mortality rate (%) | Protective rate (%) |
| Test group 1 | 448 | 0 | 0 | 100.00 |
| Test group 2 | 448 | 51 | 11.38 | 88.62 |
Brief summary: the infective rhinitis of chickling is had therapeutic effect by this herbal mixture pharmaceutical composition.Carry out this test meanwhile, it is to be noted that protection isolation, carry out the strict sterilization of hen house and equipment, it is ensured that equilibrium at room temperature, the aggregate measures such as environment clean hygiene, therapeutic effect can be effectively accomplished.
Test example 5
On June 25th, 2013, the laying hen 6150 of chicken farm, Datong City, Shanxi Province livestock on hand 240 age in days, the Growing Chicken of 150 ages in days 4200.Chicken group occurs that disease symptom is the swelling of eyelid both sides, sneeze, and ataxia piles up a large amount of serosity secretions in nose, and dried yellowly is formed a scab.Listless, loss of appetite, laying rate of laying hen declines 50% more than, Growing Chicken weight loss, eliminates increasing number.Full group almost all falls ill.Cuing open inspection and find that sick chicken nasal cavity redness is hemorrhage, long-pending have a large amount of serosity secretions；Larynx, tunica mucosa tracheae are congested, and air bag adheres to cheesy thing.Laying hen ovarian hemorrhage, shrinkage or necrosis, gray or brown etc..Secondary hemophilus infection is confirmed as through laboratory diagnosis.Adopting embodiment 4 to prepare, every 1L water adds the mixed drink of this herbal mixture pharmaceutical composition 2g；In feedstuff, add speed simultaneously mend health, 100g spice 100kg, free choice feeding, be used in conjunction 5 ~ 7 days.Chicken group's symptom alleviates, mental restoration, and Growing Chicken weight recovery, laying hen egg yield go up.Within 5th day, epidemic situation has been substantially achieved control, it is to avoid loss.Result is in Table 5.
5 the herbal mixture pharmaceutical compositions of the table therapeutic effect to infectious coryza of chicken
| Group Not | Number of animals (only) | Morbidity number (only) | Sickness rate (%) | Death toll (only) | Mortality rate (%) | Protective rate (%) |
| Laying hen | 6150 | 6100 | 99.19 | 65 | 1.06 | 98.94 |
| Growing Chicken | 4200 | 4200 | 100 | 46 | 1.07 | 98.93 |
Brief summary: the protective rate of this disease up to 98.94%, is illustrated that this herbal mixture pharmaceutical composition can treat infectious coryza of chicken disease by this herbal mixture pharmaceutical composition.
The above is only the preferred embodiment of the present invention; it should be pointed out that, for those skilled in the art, under the premise without departing from the technology of the present invention principle; can also making some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (8)
1. a herbal mixture pharmaceutical composition, it contains active component, and described active component is made up of Herba Centipedae, Radix Platycodonis, propolis, the Radix Angelicae Dahuricae, Rhizoma Fagopyri Dibotryis, Flos Chrysanthemi, Fructus Viticis, Herba Andrographis, Rhizoma Phragmitis, Radix Glycyrrhizae.
2. herbal mixture pharmaceutical composition according to claim 1, it is characterized in that, described active component by weight, is made up of Herba Centipedae 10-50 part, Radix Platycodonis 15-45 part, propolis 10-50 part, Radix Angelicae Dahuricae 10-45 part, Rhizoma Fagopyri Dibotryis 5-30 part, Flos Chrysanthemi 5-30 part, Fructus Viticis 5-25 part, Herba Andrographis 5-30 part, Rhizoma Phragmitis 4-20 part, Radix Glycyrrhizae 3-20 part.
3. herbal mixture pharmaceutical composition according to claim 2, it is characterized in that, described active component by weight, is made up of Herba Centipedae 15-45 part, Radix Platycodonis 10-40 part, propolis 15-45 part, Radix Angelicae Dahuricae 15-40 part, Rhizoma Fagopyri Dibotryis 9-25 part, Flos Chrysanthemi 8-25 part, Fructus Viticis 7-20 part, Herba Andrographis 8-25 part, Rhizoma Phragmitis 6-15 part, Radix Glycyrrhizae 5-15 part.
4. herbal mixture pharmaceutical composition according to claim 3, it is characterized in that, described active component by weight, is made up of Herba Centipedae 18-40 part, Radix Platycodonis 17-40 part, propolis 18-40 part, Radix Angelicae Dahuricae 16-40 part, Rhizoma Fagopyri Dibotryis 10-20 part, Flos Chrysanthemi 10-20 part, Fructus Viticis 8-18 part, Herba Andrographis 8-20 part, Rhizoma Phragmitis 7-12 part, Radix Glycyrrhizae 5-13 part.
5. the herbal mixture pharmaceutical composition described in claim 1 ~ 4, it is characterised in that it is powder, granule, tablet, oral liquid or injection.
6. a preparation method for the herbal mixture pharmaceutical composition described in any one of claim 1 ~ 5, comprises the steps:
1) weigh each raw material by weight, pulverize, sieve after add 6 ~ 12 times amount soak by water three times, each 1.5h, merge decoction liquor, filter, filtrate is concentrated in right amount, adds 1 ~ 5 times amount 80% ~ 95% ethanol staticly settle 12h, filtration；
2) pulverizing after propolis freezing, 1:3 ~ 1:6 adds 80% ~ 95% soak with ethanol 3 ~ 4 days in proportion, stirs every day 2 ~ 3 times, after standing 1 ~ 2 day, filters；
3) above-mentioned two filtrates being merged, be concentrated into extractum shape, corresponding dosage form made by the corresponding pharmaceutically acceptable carrier of dried addition or adjuvant.
7. the herbal mixture pharmaceutical composition described in any one of claim 1 ~ 5 strengthens cultivated animals immunity of organisms, the application in the medicine that preventing and treating infectious coryza of chicken is sick in preparation.
8. contain the feedstuff of herbal mixture pharmaceutical composition described in any one of claim 1 ~ 5.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728529A (en) * | 2017-02-28 | 2017-05-31 | 铜仁市万山区令杨农牧发展有限公司 | A kind of medicine that can prevent and treat rabbit rhinitis |
| CN107373169A (en) * | 2017-07-25 | 2017-11-24 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent and treat feed of infectious coryza of chicken and preparation method thereof |
| CN110522890A (en) * | 2019-08-15 | 2019-12-03 | 广东高山动物药业有限公司 | Prevent and treat chicken rhinitis and the Chinese herbal feed additive of protozoosis and preparation method thereof |
| CN111053810A (en) * | 2020-01-13 | 2020-04-24 | 亳州市乾元生物科技有限公司 | Traditional Chinese medicine composition for treating infectious rhinitis of chicken, application, feeding method and preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370706A (en) * | 2011-10-12 | 2012-03-14 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating infectious rhinitis of chickens and preparation method thereof |
| CN103070914A (en) * | 2012-09-24 | 2013-05-01 | 吴江市精工铝字制造厂 | Traditional Chinese medicine composition for treating rhinitis and preparation method thereof |
-
2014
- 2014-12-02 CN CN201410716292.9A patent/CN105709081B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370706A (en) * | 2011-10-12 | 2012-03-14 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating infectious rhinitis of chickens and preparation method thereof |
| CN103070914A (en) * | 2012-09-24 | 2013-05-01 | 吴江市精工铝字制造厂 | Traditional Chinese medicine composition for treating rhinitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 卢天运等: "农户土种成年鸡传染性鼻炎的诊治", 《江西畜牧兽医杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728529A (en) * | 2017-02-28 | 2017-05-31 | 铜仁市万山区令杨农牧发展有限公司 | A kind of medicine that can prevent and treat rabbit rhinitis |
| CN107373169A (en) * | 2017-07-25 | 2017-11-24 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent and treat feed of infectious coryza of chicken and preparation method thereof |
| CN110522890A (en) * | 2019-08-15 | 2019-12-03 | 广东高山动物药业有限公司 | Prevent and treat chicken rhinitis and the Chinese herbal feed additive of protozoosis and preparation method thereof |
| CN110522890B (en) * | 2019-08-15 | 2021-06-11 | 广东高山动物药业有限公司 | Traditional Chinese medicine feed additive for preventing and treating rhinitis and protozoal disease of chicken and preparation method thereof |
| CN111053810A (en) * | 2020-01-13 | 2020-04-24 | 亳州市乾元生物科技有限公司 | Traditional Chinese medicine composition for treating infectious rhinitis of chicken, application, feeding method and preparation method |
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| CN105709081B (en) | 2020-10-20 |
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Effective date of registration: 20220715 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: Shaoshan Da Bei Nong Animal Pharmaceutical Co., Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: Shaoshan Dabeinong Animal Medicine Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. |