CN104706728A - Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof - Google Patents
Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a combinatorial medicament used for treating piglet intestinal infection. The combinatorial medicament used for treating piglet intestinal infection is prepared from the following medicinal raw materials in parts by weight: 10-30 parts of agastache rugosus, 5-25 parts of realgar, 10-50 parts of pericarpium granati, 5-30 parts of cinnamon, 5-30 parts of snow mountain vanilla, 10-50 parts of poria peel and 0.05-0.01 part of antiseptic. The invention provides a uniform medicinal composition, swarm of piglet intestinal infection can be avoided, powder and other oral preparations which are prepared from raw materials in parts by weight have a rapid and effective effect for treating the piglet intestinal infection, and the piglet intestinal infection can be treated in 2-3 days. The invention also provides a preparation method and application of the combinatorial medicament used for treating the piglet intestinal infection, rational medication can be guided, waste caused by drug abuse can be avoided and unnecessary toxic or side effect can not be produced.
Description
Technical field
The invention belongs to veterinary drug clinical practice field, more particularly, the present invention relates to one and be used for the treatment of intestine of young pigs infection medicine and preparation method thereof.
Background technology
In recent years, piglet diarrhea has become the key factor affecting piglet survival ratio, has a strong impact on the economic benefit of China's pig industry.The cause of disease of piglet diarrhea can be caused to have multiple, wherein escherichia coli, swine dysentery spirillum, Porcine epidemic diarrhea virus (PEDV) and transmissible gastro-enteritis virus (TGEV), coccidiosis five kinds of cause of diseases be most commonly encountered diseases because of and feeding and management cause.At present, to the treatment of piglet diarrhea mainly through giving antimicrobial drug as sick in quinolones ring husky star, enrofloxacin, gentamycin, oxytetracycline, ceftiofur sodium, colistin sulfate or add atropinic medicine, better to bacillary bacillary dysentery disease curative effect, but to other cause of disease poor effect, and severe drug side effect is produced to piglet, cause its growth retardation, even death.Or adopt the mode of vaccinate to carry out immunity; as carried out the immunity of PED-TGE dyad inactivated vaccine and bacillus coli vaccine inoculation when antenatal 35 days of sow and 21 days; the control action well caught to intestine of young pigs was once played in vaccine injection; but As time goes on, new strain constantly occurs; the protective rate of vaccine is general lower; sickness rate improves year after year, wayward, and vaccine injection cost is also higher.In view of foregoing description, urgently there is a kind of production cost low, use simple, evident in efficacy, and the appearance being used for the treatment of the Chinese medicine composition that intestine of young pigs infects had no side effect.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and defect, and the advantage will illustrated at least is below provided.
Of the present invention also have an object to be to provide a kind of composition of medicine being used for the treatment of intestine of young pigs and infecting, it can treat the outburst of piglet jumpbogroup intestinal infection disease fast and effectively, avoid unnecessary economic loss, and each medicinal ingredient is all Common Chinese Herbs in composition of medicine, price is low, is easy to obtain and preparation.
A further object of the invention be to provide a kind of by micronizing or decoct with the method for pharmaceutical compositions, to make each medicinal ingredient in composition of medicine give full play to its drug effect, so as to obtain drug effect be used for the treatment of significantly intestine of young pigs infect composition of medicine.
A further object of the invention is to provide the rational administrated method for composition of medicine of the present invention, rational use of drug, to control disease fast and accurately and the waste not causing overdose to use to cause and stimulation body develop immunity to drugs or produce unnecessary toxic and side effects.
In a word, the present invention instructs, and according to clinical symptoms and the pathological change of diarrhoea, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, is reached the object of effectively this disease of control by approach such as Chinese medicine invigorating the spleen for eliminating dampness, astringing to arrest diarrhea, heat-clearing and toxic substances removing.
In order to realize according to these objects of the present invention and other advantage, provide a kind of composition of medicine being used for the treatment of intestine of young pigs and infecting, comprise the crude drug of following parts by weight: Herba Pogostemonis 10-30 part, Realgar 5-25 part, Pericarpium Granati 10-50 part, Cortex Cinnamomi 5-30 part, Bi book box 5-30 part and Cortex Sclerotii Poriae 10 ~ 50 parts, wherein, Herba Pogostemonis removing dampness by means of aromatics and middle emesis, promoting qi circulation, resolving food retention; The removing toxic substances of Realgar dampness, antibacterial, parasite killing, antiviral; Pericarpium Granati relieving diarrhea with astringents, hemostasis; Cortex Cinnamomi Bi book box mends supporing yang, the warming spleen and stomach for dispelling cold of fire, therapeutic method to keep the adverse QI flowing downwards pain relieving, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; All medicines share, bowel relieving heat, warming the spleen stomach function regulating, relieving dysentery with astringents.
Preferably, wherein, described crude drug with parts by weight respectively: Herba Pogostemonis 15-30 part, Realgar 10-20 part, Pericarpium Granati 15-35 part, Cortex Cinnamomi 10-25 part, Bi book box 10-25 part and Cortex Sclerotii Poriae 15 ~ 35 parts.
Preferably, wherein, described crude drug with parts by weight respectively: Herba Pogostemonis 20-30 part, Realgar 15-20 part, Pericarpium Granati 20-30 part, Cortex Cinnamomi 15-25 part, Bi book box 15-20 part and Cortex Sclerotii Poriae 20 ~ 30 parts.
In above-mentioned each scheme, use Herba Pogostemonis, Realgar, Pericarpium Granati, Cortex Cinnamomi, Bi book box and Cortex Sclerotii Poriae to carry out reasonable compatibility, toxic and side effects is little, noresidue, is natural Chinese medicine raw material, use safety.
Preferably, wherein, the dosage form of described composition of medicine is powder.This kind of method improves the quality of Chinese medicine, improves the utilization rate of Chinese medicine, and in use, micro-powder of Chinese herbs rapid dispersion suspending in water, for being taken after mixing with liquid with drinking water, effectively can solve drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
Preferably, wherein, described powder is the superfine powder that particle diameter is less than 10 microns.
Wherein, the preparation method of described powder: each crude drug is made 80-200 object powder after mixing, nanon ball-mill is used to make superfine powder in described powder again, superfine communication technique refers to and to combine with Chinese medicine theory, by Raw medicine, Chinese medicine extract, Chinese medicine preparation, the micronizations such as Chinese medicine formula, directly the cell of Raw medicine is smashed, due to plant amedica, the active ingredient of animal drugs is mainly distributed in cell and intercellular substance, based in cell, therefore be called breaking comminution process for the purpose of Raw medicine cell " cellular level pulverizing " of Chinese medicine, the micro-powder of Chinese herbs adopting cellular level pulverizing method to obtain is called " cell grade micro-powder of Chinese herbs ", the Chinese medicine made based on cell grade micro-powder of Chinese herbs is called " cell grade ultrafine Chinese herb ", is called for short " ultrafine Chinese herb ", effective solves drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
Preferably, wherein, also comprise pharmaceutically acceptable adjuvant, be prepared into any one oral formulations.
For preventing and treating a preparation method for the composition of medicine that animal intestine of young pigs infects, it is characterized in that, comprise the following steps:
Step one, described crude drug to be dried, and mix according to each parts by weight of composition of medicine described in claim 1, for subsequent use;
Step 2, add drinking water and boil extraction three times, each 1.5h, merge three medicinal liquids, filter, obtaining filtrate reduced in volume to the volume ratio of crude drug and once concentration medicinal liquid is 1: 1;
Step 3, add in described once concentration medicinal liquid 95% ethanol, leave standstill 24h at 4 DEG C, filter, gained filtrate recycling ethanol obtains secondary concentration medicinal liquid, backward described secondary concentration medicinal liquid in add pure water standardize solution, adjust pH is 5.0-7.0;
Step 4, in the described secondary concentration medicinal liquid after standardize solution, add other acceptable adjuvants, be prepared into any one oral formulations, wherein, oral formulations comprises oral liquid, granule, powder, tablet, capsule or pre-mixing agent etc.There is provided multiple and feed mode, select for pig farm, improve its universal applicability.
Be used for the treatment of a purposes for the composition of medicine that intestine of young pigs infects, it is characterized in that, be used for the treatment of intestine of young pigs and infect; Its using method is as follows:
Employing powder is treated, and consumption is 2g/ head, every day 1 time, is used in conjunction 2-3 days;
Adopt oral liquid treatment, secondary concentration medicinal liquid is prepared into oral liquid, and for gavaging, gavaging consumption is 4ml/ head (being equivalent to crude drug in whole 2 grams), every day 1 time, is used in conjunction 2-3 days.
In such scheme, illustrate the most simple and effective using method and the using dosage of two kinds of primary formulation, provide a theoretical reference to the use of other preparations.
The present invention at least comprises following beneficial effect:
1, the present invention selects Herba Pogostemonis, Realgar, Pericarpium Granati, Cortex Cinnamomi, Bi book box, Cortex Sclerotii Poriae, and toxic and side effects is little, noresidue, is natural Chinese medicine raw material, uses safer;
2, theoretical foundation of the present invention is Basic Theories of Chinese Medicine, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs prescription meets the feature of Chinese medicine, product through test, Be very effective; Wherein, Herba Pogostemonis removing dampness by means of aromatics and middle emesis, promoting qi circulation, resolving food retention; The removing toxic substances of Realgar dampness, antibacterial, parasite killing, antiviral, Pericarpium Granati relieving diarrhea with astringents, hemostasis; Cortex Cinnamomi Bi book box mends supporing yang, the warming spleen and stomach for dispelling cold of fire, therapeutic method to keep the adverse QI flowing downwards pain relieving, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; All medicines share, bowel relieving heat, warming the spleen stomach function regulating, relieving dysentery with astringents; Combine the feature of Chinese medicine;
3, the present invention uses modern ultrastructurepower technology, advantageously plays in the property of medicine, and using method is flexible, and clinical effectiveness is more reliably good;
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
In order to realize according to these objects of the present invention and other advantage, provide a kind of composition of medicine being used for the treatment of intestine of young pigs and infecting, comprise the crude drug of following parts by weight: Herba Pogostemonis 10-30 part, Realgar 5-25 part, Pericarpium Granati 10-50 part, Cortex Cinnamomi 5-30 part, Bi book box 5-30 part and Cortex Sclerotii Poriae 10 ~ 50 parts, wherein, Herba Pogostemonis removing dampness by means of aromatics and middle emesis, promoting qi circulation, resolving food retention; The removing toxic substances of Realgar dampness, antibacterial, parasite killing, antiviral; Pericarpium Granati relieving diarrhea with astringents, hemostasis; Cortex Cinnamomi Bi book box mends supporing yang, the warming spleen and stomach for dispelling cold of fire, therapeutic method to keep the adverse QI flowing downwards pain relieving, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; All medicines share, bowel relieving heat, warming the spleen stomach function regulating, relieving dysentery with astringents.
In another kind of example, described crude drug with parts by weight respectively: Herba Pogostemonis 15-30 part, Realgar 10-20 part, Pericarpium Granati 15-35 part, Cortex Cinnamomi 10-25 part, Bi book box 10-25 part and Cortex Sclerotii Poriae 15 ~ 35 parts.
In another kind of example, described crude drug with parts by weight respectively: Herba Pogostemonis 25 parts, Realgar 18 parts, Pericarpium Granati 15 parts, Cortex Cinnamomi 20 parts, Bi book box 17 parts and Cortex Sclerotii Poriae 25 parts.
In another kind of example, described crude drug with parts by weight respectively: Herba Pogostemonis 30 parts, Realgar 15 parts, Pericarpium Granati 20 parts, Cortex Cinnamomi 20 parts, Bi book box 20 parts, Cortex Sclerotii Poriae 20 parts.
In above-mentioned each example, use Herba Pogostemonis, Realgar, Pericarpium Granati, Cortex Cinnamomi, Bi book box and Cortex Sclerotii Poriae to carry out reasonable compatibility, toxic and side effects is little, noresidue, is natural Chinese medicine raw material, use safety.
In another kind of example, the dosage form of described composition of medicine is powder.This kind of method improves the quality of Chinese medicine, improves the utilization rate of Chinese medicine, and in use, micro-powder of Chinese herbs rapid dispersion suspending in water, for being taken after mixing with liquid with drinking water, effectively can solve drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
In another kind of example, described powder is the superfine powder that particle diameter is less than 10 microns, wherein, the preparation method of described powder is: each crude drug is made 80-200 object powder after mixing, nanon ball-mill is used to make superfine powder in described powder again, superfine communication technique refers to and to combine with Chinese medicine theory, by Raw medicine, Chinese medicine extract, Chinese medicine preparation, the micronizations such as Chinese medicine formula, directly the cell of Raw medicine is smashed, due to plant amedica, the active ingredient of animal drugs is mainly distributed in cell and intercellular substance, based in cell, therefore be called breaking comminution process for the purpose of Raw medicine cell " cellular level pulverizing " of Chinese medicine, the micro-powder of Chinese herbs adopting cellular level pulverizing method to obtain is called " cell grade micro-powder of Chinese herbs ", the Chinese medicine made based on cell grade micro-powder of Chinese herbs is called " cell grade ultrafine Chinese herb ", is called for short " ultrafine Chinese herb ", effective solves drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
In another kind of example, also comprise pharmaceutically acceptable adjuvant, be prepared into any one oral formulations.
For preventing and treating a preparation method for the composition of medicine that animal intestine of young pigs infects, it is characterized in that, comprise the following steps:
Step one, described crude drug to be dried, and mix according to each parts by weight of composition of medicine described in claim 1, for subsequent use;
Step 2, add drinking water and boil extraction three times, each 1.5h, merge three medicinal liquids, filter, obtaining filtrate reduced in volume to the volume ratio of crude drug and once concentration medicinal liquid is 1: 1;
Step 3, add in described once concentration medicinal liquid 95% ethanol, leave standstill 24h at 4 DEG C, filter, gained filtrate recycling ethanol obtains secondary concentration medicinal liquid, backward described secondary concentration medicinal liquid in add pure water standardize solution, adjust pH is 5.0-7.0;
Step 4, in the described secondary concentration medicinal liquid after standardize solution, add other acceptable adjuvants, be prepared into any one oral formulations, wherein, oral formulations comprises oral liquid, granule, powder, tablet, capsule or pre-mixing agent etc.There is provided multiple and feed mode, select for pig farm, improve its universal applicability.Such as, pre-mixing agent can be used for infecting with pig feed mixing treatment intestine of young pigs, easy to use.
Be used for the treatment of a purposes for the composition of medicine that intestine of young pigs infects, it is characterized in that, be used for the treatment of intestine of young pigs and infect; Its using method is as follows:
Employing powder is treated, and consumption is 2g/ head, every day 1 time, is used in conjunction 2-3 days;
Adopt oral liquid treatment, secondary concentration medicinal liquid is prepared into oral liquid, and for gavaging, gavaging consumption is 4ml/ head, every day 1 time, is used in conjunction 2-3 days.
In such scheme, illustrate the most simple and effective using method and the using dosage of two kinds of primary formulation, provide a theoretical reference to the use of other preparations.
Inventor provides the manufacture method of several oral formulations:
1, the present invention prepares oral liquid method: by Herba Pogostemonis 10-30 part, Realgar 5-25 part, Pericarpium Granati 10-50 part, Cortex Cinnamomi 5-30 part, Bi book box 5-30 part, Cortex Sclerotii Poriae 10 ~ 50 parts.After mixing fully, add drinking water and boil extraction three times, each 1.5h, merge medicinal liquid, filter, filtrate reduced in volume to 1: 1 (crude drug: medicinal liquid), add the ethanol that weight is medicine 6 times amount 95%, leave standstill (4 DEG C) 24h, filter, filtrate recycling ethanol, adds purified water standardize solution, adjusts PH5.0-7.0, add 0.05% potassium sorbate, fill, sterilizing, to obtain final product.
2, the present invention prepares granule method:
Chinese medicine in preparation is added drinking water by oral liquid and extracts three times, each 1.5h by first-selection jointly, merges medicinal liquid, filter, filtrate reduced in volume to 1: 1 (crude drug: medicinal liquid), adds the ethanol that weight is medicine 6 times amount 95%, leave standstill (4 DEG C) 24h, filter, filtrate recycling ethanol, be evaporated to relative density 1.18 ~ 1.20, get adjuvant 3 parts, use extract spray-drying process, 60 DEG C are dried to moisture less than 5%, 10 ~ 80 mesh sieve granulate, subpackage finished product.
3, the present invention prepares method for injection: the Chinese medicine just in case study on implementation 1 jointly adds drinking water by oral liquid and extracts three times, each 1.5h, merge medicinal liquid, filter, filtrate reduced in volume to 1: 1 (crude drug: medicinal liquid), adds the ethanol that weight is medicine 6 times amount 95%, leave standstill (4 DEG C) 24h, filter, filtrate recycling ethanol, then the ethanol adding that weight is medicine 8 times amount 95%, leave standstill (4 DEG C) 24h, filter, filtrate recycling ethanol, injects and uses water standardize solution, adjust PH5.0-7.0, fill, 100 DEG C of sterilizings, to obtain final product.
4, the present invention prepares tablet method: by Herba Pogostemonis 10-30 part, Realgar 5-25 part, Pericarpium Granati 10-50 part, Cortex Cinnamomi 5-30 part, Bi book box 5-30 part, Cortex Sclerotii Poriae 10 ~ 50 parts.Fine powder is milled to respectively with Chinese medicine ultra-fine powder machine.With mixer, the medicament mixed of each component is evenly added protective agent and amylum adhesive, adopt tablet forming technique to make, 60 DEG C are dried to moisture less than 5%, bottle.
In order to effect of the present invention is described, inventor provide clinical practice experiment as follows:
In the clinical verification on several extensive pig farm.Find that suckling piglet diarrhoea gavages or be taken after mixing with liquid 4ml/ head or 2g/ head immediately, can fully recover for 2 times.Controlled trial, each field stays suckling piglet 10 nest for contrast, and matched group gavages 2% enrofloxacin oral liquid 3ml/ head, 2 times on the one, is used in conjunction 2 days; All the other diarrhoea piglets are treatment group, gavage test drug and are taken after mixing with liquid 4ml/ head or 2g/ head, every day 1 time, be used in conjunction 2 days; Statistical test group and matched group diarrhoea head number, after treatment in two days, within one week, statistics cures head number, repeatedly head number, effectively head number, invalid head number.
Criterion:
Cure: within one week, without repeatedly falling ill, piglet stool is shaped, spirit is good, and anus is clean, and suck the breast normal, fur is rich in gloss.
Repeatedly: start the 1-2 days that takes a turn for the better, there is symptom of diarrhea again.
Effective: to defecate dense thick, sucking is normal, body condition is partially thin.
Invalid or dead: piglet stool, in gruel shape, becomes thin, without god or dehydration, perianal is filthy, and anus is loose.
Experimental group: total several 6623, cures 5413,650 repeatedly, effective 560,
Effective percentage=(curing head number+effectively head number)/total head number=90.1%;
Matched group, wherein cures 835 by 1350 altogether,
Effective percentage=(curing head number+effectively head number)/total head number=62%.
Results of comparison shows, evident in efficacy, and economic benefit is given prominence to.
Although embodiment of the present invention are open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable the field of the invention completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details.
Claims (8)
1. be used for the treatment of the composition of medicine that intestine of young pigs infects, it is characterized in that, comprise the crude drug of following parts by weight: Herba Pogostemonis 10-30 part, Realgar 5-25 part, Pericarpium Granati 10-50 part, Cortex Cinnamomi 5-30 part, Bi book box 5-30 part and Cortex Sclerotii Poriae 10 ~ 50 parts.
2. be used for the treatment of as claimed in claim 1 intestine of young pigs infect composition of medicine, it is characterized in that, described crude drug with parts by weight respectively: Herba Pogostemonis 15-30 part, Realgar 10-20 part, Pericarpium Granati 15-35 part, Cortex Cinnamomi 10-25 part, Bi book box 10-25 part and Cortex Sclerotii Poriae 15 ~ 35 parts.
3. be used for the treatment of as claimed in claim 1 intestine of young pigs infect composition of medicine, it is characterized in that, described crude drug with parts by weight respectively: Herba Pogostemonis 20-30 part, Realgar 15-20 part, Pericarpium Granati 20-30 part, Cortex Cinnamomi 15-25 part, Bi book box 15-20 part and Cortex Sclerotii Poriae 20 ~ 30 parts.
4. be used for the treatment of the composition of medicine that intestine of young pigs infects as claimed in claim 1, it is characterized in that, the dosage form of described composition of medicine is powder.
5. be used for the treatment of the composition of medicine that intestine of young pigs infects as claimed in claim 4, it is characterized in that, described powder is the superfine powder that particle diameter is less than 10 microns.
6., as being used for the treatment of the pharmaceutical composition that intestine of young pigs infects as described in arbitrary in claim 1-4, it is characterized in that, also comprise pharmaceutically acceptable adjuvant, being prepared into any one oral formulations.
7. be used for the treatment of a preparation method for the composition of medicine that intestine of young pigs infects as claimed in claim 6, it is characterized in that, comprise the following steps:
Step one, described crude drug to be dried, and mix according to each parts by weight of composition of medicine described in claim 1, for subsequent use;
Step 2, add drinking water and boil extraction three times, each 1.5h, merge three medicinal liquids, filter, obtaining filtrate reduced in volume to the volume ratio of crude drug and once concentration medicinal liquid is 1:1;
Step 3, add in described once concentration medicinal liquid 95% ethanol, leave standstill 24h at 4 DEG C, filter, gained filtrate recycling ethanol obtains secondary concentration medicinal liquid, backward described secondary concentration medicinal liquid in add pure water standardize solution, adjust pH is 5.0-7.0;
Step 4, in the described secondary concentration medicinal liquid after standardize solution, add other acceptable adjuvants, be prepared into any one oral formulations.
8. as the purposes being used for the treatment of the composition of medicine that intestine of young pigs infects in claim 1-4 as described in any one, it is characterized in that, be used for the treatment of intestine of young pigs and infect, its using method is as follows:
Employing powder is treated, and consumption is 2g/ head, every day 1 time, is used in conjunction 2-3 days;
Adopt oral liquid treatment, secondary concentration medicinal liquid is prepared into oral liquid, and for gavaging, gavaging consumption is 4ml/ head, every day 1 time, is used in conjunction 2-3 days.
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Application publication date: 20150617 |