CN101297941A - Combined Chinese and western medicine sustained-release agent for preventing and treating rabbit coccidiosis and preparation method thereof - Google Patents
Combined Chinese and western medicine sustained-release agent for preventing and treating rabbit coccidiosis and preparation method thereof Download PDFInfo
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- CN101297941A CN101297941A CNA2008100287896A CN200810028789A CN101297941A CN 101297941 A CN101297941 A CN 101297941A CN A2008100287896 A CNA2008100287896 A CN A2008100287896A CN 200810028789 A CN200810028789 A CN 200810028789A CN 101297941 A CN101297941 A CN 101297941A
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Abstract
The invention discloses a retarder combining Chinese medicines and western medicines and used for preventing and curing the rabbit coccidiosis and a preparation method thereof, pertaining to the technical field of prevention and cure with the drug of poultry and livestock parasite. The retarder comprises ingredients with portions by weight: 2 to 5 portions of antifeverile dichroa root, 3 to 6 portions of abrotanum, 2 to 5 portions of sophora flavescens, 1 to 3 portions of pulsatilla chinensis, 1 to 3 portions of radix bupleuri, 1 to 3 portions of rhizoma imperatae, 1 to 3 portions of liquoric root, 0.01 to 0.05 portions of diclazuril, 8 to 10 portions of porous starch and 0.001 to 0.003 portions of chitosan. The ingredients are prepared by the steps of soaking in ethanol and Soxhlet extraction, followed by soaking in water and Soxhlet extraction, mixing, absorption and combination of extract and diclazuril as well as porous starch and chitosan, and regulation of medicinal powder quality, etc. The results from the experiments show that the egg reduction rate for the rabbit coccidiosis is 99.2 percent; in addition, the retarder of the invention is mainly applied to the prevention and cure of the rabbit coccidiosis.
Description
Technical field
The invention belongs to fowl poultry parasite medicine Prevention Technique field, relate to a kind of control rabbit coccidiosis Chinese medicine and western medicine combined sustained-release agent and preparation method thereof.
Background technology
Rabbit coccidiosis is the parasitic disease that is caused by protozoon, is one of the most serious parasitic disease of the common harm of rabbit.It is reported young rabbit infection rate up to more than 90%, and mortality rate is near 60%.Bibliographical information rabbit coccidiosis surpasses 16 kinds, and wherein except that the Si Shi Eimeria colonized in the hepatobiliary epithelial cell, all the other colonized in the intestinal mucosa epithelial cell.The risk factor of primary disease is generally visible peristalsis visible intestinal peristalsis, liver type and mixed type and infects.So far, the main means of control rabbit coccidiosis still depend on the chemical prevention of anticoccidial, and for example Salinomycin, Diclazuril, the spirit of killing, hundred balls are clear etc.The life-time service of coccidiostat, coccidiosis has produced unavoidable serious problems to medicine.Fact proved, commercially available any control rabbit coccidiosis medicine all can cause the drug resistance of coccidiosis in use for some time at present, make prevention effect significantly reduce, even lost efficacy, even it is also of no avail to improve drug level, it is intravital residual at the rabbit machine to have increased medicine on the contrary, has a strong impact on rabbit meat safety, directly is detrimental to health after being eaten by the people.
It is little that Chinese herb prevention rabbit coccidiosis has toxic and side effects, and drug residue is low, is difficult for producing advantages such as drug resistance.Fact proved that many Chinese medicines have certain preventive and therapeutic effect to the rabbit coccidiosis.Trace it to its cause, pharmaceutically active ingredient complexity in may being, form compound recipe after composition more complicated, the rabbit coccidiosis produces in fact very difficulty of drug resistance simultaneously to numerous compositions simultaneously, simultaneously can also the enhancing body resistance, the promotion body growth.Therefore, exploitation Chinese herb prevention rabbit coccidiosis has wide prospect.
But present most of anticoccidial Chinese medicines adopt powder that comminuting methods make even shred with bright product or dry product and feed, and middle pharmaceutically active ingredient leaching velocity is slow, in case the rabbit group is broken out acute coccidiosis, influences its therapeutic effect; Need pass through the oral way administration and adopt Chinese medicine to fry in shallow oil potus, when the hare infection coccidiosis is serious, loss of appetite, the oral administration difficulty need gavage, and prevention effect is affected, the speed of growth of the rabbit that slowed down simultaneously.
This shows that Chinese medicine and Western medicine respectively have pluses and minuses at the control rabbit coccidiosis, Chinese medicine and western medicine is in conjunction with being one of direction of rabbit coccidiosis control from now on.
Above-mentioned composite premix compound for rabbits also contains iodide and selenium-containing compound.
Summary of the invention
The objective of the invention is to deficiency at existing Chinese medicine and western medicine control rabbit coccidiosis technology, provide a kind of and can significantly reduce the Western medicine consumption, suitably increase the Chinese herbal medicine consumption, a large amount of control drug doses that reduce, delaying coccidiosis develops immunity to drugs, prolong effective control time, reach safe and effective prevention and the Chinese medicine and western medicine combined sustained-release agent for the treatment of rabbit coccidiosis, be applicable to the feed mixing administration.Another object of the present invention provides the preparation method of this Chinese medicine and western medicine combined sustained-release agent.
Chinese herbal medicine of the present invention partly selects Radix Dichroae, Artemisia annua L., Radix Sophorae Flavescentis, the Radix Pulsatillae, Radix Bupleuri, Rhizoma Imperatae, Radix Glycyrrhizae to make up.Wherein Radix Dichroae, Artemisia annua L., Radix Sophorae Flavescentis, in contained alkaloid be the main component of anticoccidial; The Radix Pulsatillae, Radix Bupleuri have the effect of heat-clearing and toxic substances removing, anti-inflammation; Rhizoma Imperatae has anastalsis, as the accessory drugs of coccidiosis.But the medicine of above-mentioned seven kinds of existing worms of killing of medicine has the medicine of human body immunity improving power again, and they unite use, and collaborative mutually playing a role realized treating both the principal and secondary aspects of a disease.
Western medicine of the present invention is selected Diclazuril.Diclazuril is a kind of anticoccidial drug of new and effective low toxicity.It disturbs the division of coccidiosis nucleic acid, makes the coccidiosis body expand and serious cavitation owing to endoplasmic reticulum in the stage of development, has stronger killing action.
The present invention is achieved through the following technical solutions.
Control rabbit coccidiosis Chinese medicine and western medicine combined sustained-release agent, the component of this slow releasing agent and the weight portion of each component are: 2～5 parts of Radix Dichroaes, 3～6 parts of Artemisia annua L., 2～5 parts of Radix Sophorae Flavescentiss, 1～3 part of the Radix Pulsatillae, 1～3 part of Radix Bupleuri, 1～3 part of Rhizoma Imperatae, 1～3 part in Radix Glycyrrhizae, 0.01～0.05 part of Diclazuril, 8～10 parts of porous-starchs, 0.001～0.003 part of chitosan
The optimization component prescription of this slow releasing agent is: 3 parts of Radix Dichroaes, 4 parts of Artemisia annua L., 3 parts of Radix Sophorae Flavescentiss, 2 parts of the Radix Pulsatillaes, 2 parts of Radix Bupleuri, 2 parts of Rhizoma Imperataes, 1 part in Radix Glycyrrhizae, 0.025 part of Diclazuril, 4 parts of porous-starchs, 0.002 part of chitosan.
The preparation method of control rabbit coccidiosis Chinese medicine and western medicine combined sustained-release agent is undertaken by following machining process.
(1) take by weighing herbal raw material medicine Radix Dichroae, Artemisia annua L., Radix Sophorae Flavescentis, the Radix Pulsatillae, Radix Bupleuri, Rhizoma Imperatae, Radix Glycyrrhizae by prescription, 50 ℃ of oven dry down, pulverize respectively, mix, standby.
(2) with step (1) mixed powder, add 90% soak with ethanol 1～2 day, add amount of alcohol for not having powder 10～15cm, being placed in the Chinese medicine extraction jar 80 ℃ of condensing refluxes extracted 2～3 hours, separate ethanol extract, ethanol is reclaimed in distilling under reduced pressure, the black extracting solution.
(3) with the medicinal residues of step (2) behind ethanol extraction, adding distil water soaked 1～2 day, amount of water was not for having powder 10～15cm, being placed in the Chinese medicine extraction jar 100 ℃ of condensing refluxes extracted 2～3 hours, separate aqueous extract, combining step (2) extracting solution, evaporation and concentration is to half of mixeding liquid volume, and is standby.
(4) with Diclazuril powder and solvent N, the N-dimethyl sulfoxine is pressed 1g (quality): 10～15mL (volume) mixed, through 50 ℃ of heating of water-bath, and is stirred to medicine and dissolves fully.
(5) Diclazuril solution (4) is added in step (3) mixed liquor, stirred 30～60 minutes.
(6) take by weighing porous-starch by prescription, add in step (5) mixed liquor and adsorb, stirred 30-60 minute.
(7) with chitosan and 5% acetum, press 1g (quality): 100～150mL (volume) mixed, be stirred to dissolving fully.
(8) chitosan solution is added in step (6) mixture, stirred 120-150 minute.Place 50 ℃ of dryings down, pulverize, the 100-120 order sieves, and by adding the method for tapioca filler, regulating and control this medicated powder quality is 170g, so that be equivalent to 1g Chinese herbal medicine crude drug and Diclazuril 0.0012～0.0018g in its every 1g medicated powder.Coating-dividing sealing obtains the combined sustained-release agent product on demand.
Beneficial effect of the present invention:
The one, the worm Western medicine Diclazuril of killing is become control rabbit coccidiosis Chinese medicine and western medicine combined sustained-release agent with seven flavor Chinese herbal medicine joint research and developments, both brought into play the fast characteristics of Western medicine speed of action, brought into play the characteristics that Chinese medicine is difficult for developing immunity to drugs again, treating both the principal and secondary aspects of a disease.Under the prerequisite that does not reduce drug effect, significantly reduce the Western medicine consumption, the Chinese herbal medicine of nontoxic by uniting, harmless, drug residue free, thereby alleviate the selection pressure to coccidiosis, help delaying coccidiosis the control medicine is developed immunity to drugs, it is intravital residual at the rabbit machine to have reduced medicine simultaneously.
The 2nd, the preparation technology advanced person of combined sustained-release agent of the present invention, Chinese herbal medicine adopt to soak the mode that combines with soxhlet extraction, and extraction effect is good.Chinese medicine and western medicine host and enclose ratio of adjuvant are reasonable, have reduced production cost.
The 3rd, combined sustained-release agent of the present invention shows that through clinical test results the oral back of this slow releasing agent mixed fodder spice is stable in the rabbit body, slowly discharges medicine, and it effectively prevents to reach more than 2 months with treatment time.In prevention, slow releasing agent mixed fodder spice oral medication 3～4 days can be received the good result of preventing rabbit coccidiosis; In treatment, this slow releasing agent mixed fodder spice oral medication 4～5 days was checked the feces coccidian oocyst on the 7th day, and rabbit is turned out cloudy fully, the average egg reduction rate 99.2% of coccidian oocyst.The multiple method symptom of no obvious coccidiosis reaches the healing purpose substantially in 2 months.
The 4th, combined sustained-release agent of the present invention is to rabbit safety, and is with low cost, helps promoting producing.Rabbit shows safety at the back well-grown of taking medicine, and wherein the Diclazuril consumption is seldom, and resources of Chinese medicinal herb is wide, and is cheap.
The specific embodiment:
Below in conjunction with specific embodiment the present invention is done nearly one description that goes on foot, but the present invention's scope required for protection is not limited to the described scope of embodiment.
Choose Radix Dichroae, Artemisia annua L., Radix Sophorae Flavescentis, the Radix Pulsatillae, Radix Bupleuri, Rhizoma Imperatae, Radix Glycyrrhizae, drying down at 50 ℃ respectively, micronizing, standby after the 200-300 order sieves.
Embodiment 1
(1) take by weighing Radix Dichroae 30g, Artemisia annua L. 40g, Radix Sophorae Flavescentis 30g, Radix Pulsatillae 20g, Radix Bupleuri 20g, Rhizoma Imperatae 20g, Radix Glycyrrhizae 1og, mix homogeneously, standby.
(2) with step (1) mixed powder, add 90% soak with ethanol, adding amount of alcohol is stainless steel cask for not having powder 15cm, container, needs airtight to prevent the ethanol volatilization.Be placed in 1 day in the Chinese medicine extraction jar, extracted 2 hours at 80 ℃ of following condensing refluxes, the centrifugalize extracting solution, ethanol is reclaimed in distilling under reduced pressure, gets the black extracting solution, and is standby.
(3) with the medicinal residues of step (2) behind ethanol extraction, adding distil water soaks, amount of water was not for having powder 12, be placed in the Chinese medicine extraction jar in 1 day, extracted centrifugalize extracting solution, combining step (2) extracting solution 2 hours at 100 ℃ of following condensing refluxes, evaporation and concentration is to half of mixeding liquid volume, and is standby.
(4) Diclazuril powder 0.25g is added solvent N, among the N-dimethyl sulfoxine 3mL, is stirred to medicine under 50 ℃ of the water-baths and dissolves fully, the Diclazuril clear solution.
(5) Diclazuril solution (4) is added in step (3) mixed liquor, stirred 40 minutes.
(6) take by weighing porous-starch 90g, add in step (5) mixed liquor and adsorb, stirred 30-60 minute.
(7) chitosan 0.02g is added among the 5% acetum 3mL, be stirred to dissolving fully, get chitosan transparent solution.
(8) chitosan solution is added in step (6) mixture, stir after 120-150 minute.Place 50 ℃ of dryings down, after the pulverizing, the 100-120 order sieves.By adding the method for tapioca filler, regulating and control this medicated powder quality is 170g, so that be equivalent to 1g Chinese herbal medicine crude drug and Diclazuril 0.0015g in its every 1g medicated powder.Coating-dividing sealing obtains the combined sustained-release agent product on demand.
Embodiment 2
Present embodiment takes by weighing Radix Dichroae 25g, Artemisia annua L. 45g, Radix Sophorae Flavescentis 25g, Radix Pulsatillae 25g, Radix Bupleuri 12g, Rhizoma Imperatae 25g, Radix Glycyrrhizae 13g; Add amount of alcohol for not having powder 15cm, soak with ethanol 1 day; Water logging bubble 1 day; Diclazuril takes by weighing 0.20g, uses 2.5mL N, the dissolving of N-dimethyl sulfoxine; Porous-starch consumption 90g; Chitosan takes by weighing 0.20g, dissolves with 5% acetic acid 3mL; All the other preparation methoies, technology all are same as embodiment 1.Finally make and be equivalent to 1g Chinese herbal medicine crude drug and Diclazuril 0.0012g in every 1g medicated powder.
Embodiment 3
Present embodiment takes by weighing Radix Dichroae 32g, Artemisia annua L. 38g, Radix Sophorae Flavescentis 33g, Radix Pulsatillae 17g, Radix Bupleuri 17g, Rhizoma Imperatae 18g, Radix Glycyrrhizae 15g; Add amount of alcohol for not having powder 15cm, soak with ethanol 1 day; Water logging bubble 1 day; Diclazuril takes by weighing 0.30g, uses 3.5mL N, the dissolving of N-dimethyl sulfoxine; Porous-starch consumption 90g; Chitosan takes by weighing 0.20g, dissolves with 5% acetic acid 3mL; All the other preparation methoies, technology all are same as embodiment 1.Finally make and be equivalent to 1g Chinese herbal medicine crude drug and Diclazuril 0.0018g in every 1g medicated powder.
Controlled trial
Selection has 40 of the 35 age in days New Zealand white rabbit that coccidian oocyst gets rid of, and is divided into 4 groups immediately, 20 every group.Prevent and treat rabbit coccidiosis with 3 kinds of slow releasing agents (being called slow releasing agent 1, slow releasing agent 2, slow releasing agent 3 successively) of embodiment preparation respectively.Every rabbit 1g medicated powder of taking medicine was taken medicine 5 days.Establishing disobedience in addition compares with the medicine group.Gather rabbit feces 0,5,10,15,20,25,30,35,40,50,60 respectively, check the coccidian oocyst number, calculate egg reduction rate with saline floatation method.The results are shown in Table 1.
Table 1 slow releasing agent is to rabbit coccidiosis prevention effect controlled trial
Claims (3)
1, control rabbit coccidiosis Chinese medicine and western medicine combined sustained-release agent, it is characterized in that the component of this slow releasing agent and the weight portion of each component are: 2～5 parts of Radix Dichroaes, 3～6 parts of Artemisia annua L., 2～5 parts of Radix Sophorae Flavescentiss, 1～3 part of the Radix Pulsatillae, 1～3 part of Radix Bupleuri, 1～3 part of Rhizoma Imperatae, 1～3 part in Radix Glycyrrhizae, 0.01～0.05 part of Diclazuril, 8～10 parts of porous-starchs, 0.001～0.003 part of chitosan.
2, slow releasing agent according to claim 1 is characterized in that the component of this slow releasing agent and the weight portion of each component are: 3 parts of Radix Dichroaes, 4 parts of Artemisia annua L., 3 parts of Radix Sophorae Flavescentiss, 2 parts of the Radix Pulsatillaes, 2 parts of Radix Bupleuri, 2 parts of Rhizoma Imperataes, 1 part in Radix Glycyrrhizae, 0.025 part of Diclazuril, 4 parts of porous-starchs, 0.002 part of chitosan.
3, slow releasing agent preparation method according to claim 1 is characterized in that carrying out according to the following steps:
(1) take by weighing herbal raw material medicine Radix Dichroae, Artemisia annua L., Radix Sophorae Flavescentis, the Radix Pulsatillae, Radix Bupleuri, Rhizoma Imperatae, Radix Glycyrrhizae by prescription, 50 ℃ of oven dry down, pulverize respectively, mix, standby.
(2) with step (1) mixed powder, add 90% soak with ethanol 1～2 day, add amount of alcohol for not having powder 10～15cm, being placed in the Chinese medicine extraction jar 80 ℃ of condensing refluxes extracted 2～3 hours, separate ethanol extract, ethanol is reclaimed in distilling under reduced pressure, the black extracting solution.
(3) with the medicinal residues of step (2) behind ethanol extraction, adding distil water soaked 1～2 day, amount of water was not for having powder 10～15cm, being placed in the Chinese medicine extraction jar 100 ℃ of condensing refluxes extracted 2～3 hours, separate aqueous extract, combining step (2) extracting solution, evaporation and concentration is to half of mixeding liquid volume, and is standby.
(4) with Diclazuril powder and solvent N, the N-dimethyl sulfoxine is pressed 1g (quality): 10～15mL (volume) mixed, through 50 ℃ of heating of water-bath, and is stirred to medicine and dissolves fully.
(5) Diclazuril solution (4) is added in step (3) mixed liquor, stirred 30～60 minutes.
(6) take by weighing porous-starch by prescription, add in step (5) mixed liquor and adsorb, stirred 30-60 minute.
(7) with chitosan and 5% acetum, press 1g (quality): 100～150mL (volume) mixed, be stirred to dissolving fully.
(8) chitosan solution is added in step (6) mixture, stirred 120-150 minute.Place 50 ℃ of dryings down, pulverize, the 100-120 order sieves, and by adding the method for tapioca filler, regulating and control this medicated powder quality is 170g, so that be equivalent to 1g Chinese herbal medicine crude drug and Diclazuril 0.0012～0.0018g in its every 1g medicated powder.Coating-dividing sealing obtains the combined sustained-release agent product on demand.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579697A (en) * | 2012-03-27 | 2012-07-18 | 贵州省畜牧兽医研究所 | Chinese herbal prescription for treating coccidiosis in chicken |
| CN104845736A (en) * | 2015-06-01 | 2015-08-19 | 湖北中烟工业有限责任公司 | Preparation method and application of stir-fried extractum glycyrrhizae |
| CN109394697A (en) * | 2018-11-30 | 2019-03-01 | 合肥中龙神力动物药业有限公司 | A kind of diclazuril sustained release preparation and preparation method thereof for preventing and treating chicken coccidiosis of rabbit |
-
2008
- 2008-06-16 CN CNA2008100287896A patent/CN101297941A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579697A (en) * | 2012-03-27 | 2012-07-18 | 贵州省畜牧兽医研究所 | Chinese herbal prescription for treating coccidiosis in chicken |
| CN102579697B (en) * | 2012-03-27 | 2013-07-03 | 贵州省畜牧兽医研究所 | Chinese herbal prescription for treating coccidiosis in chicken |
| CN104845736A (en) * | 2015-06-01 | 2015-08-19 | 湖北中烟工业有限责任公司 | Preparation method and application of stir-fried extractum glycyrrhizae |
| CN104845736B (en) * | 2015-06-01 | 2018-04-24 | 湖北中烟工业有限责任公司 | A kind of preparation method and application for frying extract of licorice root |
| CN109394697A (en) * | 2018-11-30 | 2019-03-01 | 合肥中龙神力动物药业有限公司 | A kind of diclazuril sustained release preparation and preparation method thereof for preventing and treating chicken coccidiosis of rabbit |
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Application publication date: 20081105 |