CN104351610B - A kind of health care oral liquid and preparation method for inhibiting alcohol absorption, promoting alcohol metabolism - Google Patents
A kind of health care oral liquid and preparation method for inhibiting alcohol absorption, promoting alcohol metabolism Download PDFInfo
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- CN104351610B CN104351610B CN201410578558.8A CN201410578558A CN104351610B CN 104351610 B CN104351610 B CN 104351610B CN 201410578558 A CN201410578558 A CN 201410578558A CN 104351610 B CN104351610 B CN 104351610B
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 95
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- 230000004060 metabolic process Effects 0.000 title claims abstract description 18
- 230000036541 health Effects 0.000 title claims abstract description 17
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- 230000001737 promoting effect Effects 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 230000002401 inhibitory effect Effects 0.000 title claims abstract description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A kind of health care oral liquid and preparation method for inhibiting alcohol absorption, promoting alcohol metabolism, belong to health food, including Long Ya Aralia wood, Radix Polygalae, hoveniae semoveniae semen, pueraria lobata, mulberry fruit, broccoli, hawthorn 4, the water extract of fructus amomi mixture and honey, chitosan, oligofructose, pure water.Preparation method includes: to extract raw material and feedstock processing, water refluxing extraction, 3 concentrations, alcohol precipitation, pure water dilution, the dissolution of sugar-type sweetener, original liquid and the mixing of sugar-type sweetener, filtering, dispenses, obtains finished product.The positive effect of the present invention is: using Aralia mandshurica as monarch drug in a prescription; it is equipped with pueraria lobata, hawthorn, fructus amomi, Radix Polygalae, mulberry fruit; form the synergistic effect of multicomponent multiple target point, combination of long drives and drop shots; using natural products prescription from preventing ethyl alcohol from absorbing; decomposing alcohol protects liver, protects injury of the reduction alcohol to body in the mechanism of three aspect of stomach; the curative effect relieved the effect of alcohol is played, relieved the effect of alcohol, had significant breakthrough in health-care effect and safety and improve.
Description
Technical field
The invention belongs to field of health care products, and in particular to one kind is able to suppress alcohol absorption and promotes alcohol metabolism, liver protection shield
The oral liquor for sobering from wine of stomach.
Background technique
Wine is the most common medium in social activity instantly, and long-term excessive consumption of alcohol can cause acute gastritis or even stomach goes out
Blood, alcohol are apparent to the damage of stomach lining.Liver is the important armour of human body, it generates in the metabolism of people, bile,
Removing toxic substances, blood coagulation, immune, heat generate and the adjusting of water and electrolyte in play very important effect, and long-term alcohol meeting
Cause alcoholic liver injury.A series of diseases such as liver damage caused by alcoholic liver injury refers to due to Excess free enthalpy alcohol
Become, often shows as alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis.It is detrimental to health.Many in recent years
Person has done a lot of research work in protection stomach lining field.American-European, Japan's Medicament for Alcoholism salable is mostly excitant, analgesic, dimension
The compositions such as raw element and minerals, can only respite be still drank after a night caused symptom, liver caused by alcohol and gastric injury are had no
Preventive and therapeutic effect.Existing liver-protecting and alcoholism-relieving class health food is inhibiting alcohol absorption, is promoting alcohol metabolism protection gastric mucosa, anti-before this
Only the effect of hepatic injury is not obvious, and still needs to be further increased.
Summary of the invention
The object of the present invention is to provide a kind of inhibition alcohol absorption, the health care oral liquid for promoting alcohol metabolism and preparation sides
Method, overcome alcohol-neutralize healthy product in the prior art inhibit alcohol absorption, promote alcohol metabolism, shield stomach liver protective effect it is inaccurate
Deficiency.
Health care oral liquid of the invention includes 40~200 parts by weight of Long Ya Aralia wood, 40~150 parts by weight of Radix Polygalae, hoveniae semoveniae semen
40~300 parts by weight, 40~70 parts by weight of pueraria lobata, 20~100 parts by weight of mulberry fruit, 30~200 parts by weight of broccoli, hawthorn 40~
200 parts by weight, 10~100 parts by weight of water extract and honey of 30~200 parts by weight Chinese medicine mixture of fructus amomi, chitosan 10
~100 parts by weight, 10~50 parts by weight of oligofructose, 800~1000 parts by weight of pure water.
Further to improve the mouthfeel of oral solution and extend the shelf life, further include in prescription of the invention citric acid 0.6~
0.9 parts by weight, 0.2~0.3 parts by weight of potassium sorbate, 0.14~0.17 parts by weight of Aspartame.
Health care oral liquid raw material optimum amount ratio of the invention are as follows: 120 parts by weight of Long Ya Aralia wood, 100 parts by weight of Radix Polygalae,
160 parts by weight of hoveniae semoveniae semen, 50 parts by weight of pueraria lobata, 60 parts by weight of mulberry fruit, 110 parts by weight of broccoli, 120 parts by weight of hawthorn, fructus amomi
110 parts by weight, 60 parts by weight of honey, 60 parts by weight of chitosan, 30 parts by weight of oligofructose.
The preparation method of health care oral liquid of the invention the following steps are included:
1, raw material and feedstock processing are extracted
Taken Aralia mandshurica, pueraria lobata, hawthorn, fructus amomi, Radix Polygalae, mulberry fruit, broccoli are cleaned spare；By taken hoveniae semoveniae semen powder
It is mixed after broken with Aralia mandshurica, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli；
2, water mentions
Mixture is put into gauze bag and is put into Chinese medicine extracting tank, 7-12 times of the injecting material mixture in extractor
Water, continuous circumfluence extraction 1.5-2.5 hours, after extraction, by extractor mixtures of materials be separated by solid-liquid separation, discharge for the first time
Extracting solution is spare；Again in extractor 7-9 times of injecting material mixture water, carry out second and extract, extraction time 1.5-2.5
Hour, after second extracts, the mixtures of materials in extractor is separated by solid-liquid separation, second of extracting solution is discharged, and is mentioned for the first time
Liquid is taken to merge.
3, it is concentrated
Step 2 gained extracting solution is first passed through into filter filtering, is concentrated after removing impurity, density 1.05~1.16 is made and soaks
Cream.
4, alcohol precipitation
Medicinal extract obtained in step 3 is transferred in settling tank, adds 2~3ml concentration to be 95% second by every 1g medicinal extract
Ethanol water is added in the case where being slowly stirred for the ratio of alcohol solution, takes supernatant within static 24 hours；
5, the supernatant liquid filtering for obtaining step 4 evaporates into no alcohol taste, adds the pure water dilution that step 1 is taken, system
Obtain original liquid；
6, the dissolution of sugar-type sweetener
By honey, chitosan, oligofructose, citric acid, potassium sorbate, Aspartame, mixing plus the dissolution of a small amount of water, stirring
10~30 minutes, solution filtering was spare；
7, solution made from the resulting original liquid of step 5 and step 6 is uniformly mixed, is filtered, packing obtains the mouth that relieves the effect of alcohol
Take liquid product.
Method and dosage: 10~20ml is taken orally before drinking or after drinking
The present invention is that have the function of anti-inflammatory, clearing away summerheat, the stomach function regulating that helps digestion, strengthen immunity and anti-cancer based on: Aralia mandshurica
Effect is applied in the drug of the diseases such as treatment diabetes, arthritis, myocardial infarction, gastric ulcer, neurasthenia.Experiment card
Real, the Aralia mandshurica mixing bark saponin(e by extraction has the function of that very strong inhibition ethyl alcohol absorbs.It is extracted from Radix Polygalae
Saponin(e plays the role of very strong inhibition ethyl alcohol and absorbs.Contain a large amount of glucose, organic acid in hoveniae semoveniae semen, human body can be expanded
Blood volume, and can relieving alcoholism, therefore play the role of tranquilizing the mind of sobering up.Hoveniae semoveniae semen contains large quantity of moisture, glucose, organic salt, lipid
Substance has and promotes urine excretion, accelerates intestines peristalsis, and energy smoothening secretion promotes ethyl alcohol to exclude external.Pueraria lobata can be effectively short of money
Liver caused by anti-alcohol and lipid peroxidation in testis damage, pueraria lobata contain daidzin, it can decompose acetaldehyde toxicity, can prevent wine
Essence inhibits the decrease of function to brain；It can inhibit absorption of the stomach to alcohol, promote the metabolism and excretion of alcohol in blood.The U.S.
People achieves good curative effect in the clinical research with kudzu root flavone treatment alcoholism.Mulberry fruit is cold in nature sweet in flavor, the popular feeling, liver,
Kidney channel has nourishing yin and supplementing blood, relax bowel and defecation, and the effect relieved the effect of alcohol.It is recorded in Compendium of Material Medica and " calls it and smash juice drink, energy
Solve alcohol intoxication ".Broccoli, which has, to be promoted to protect liver into ethanol decomposition, has curative effect of relieving the effect of alcohol well.Hawthorn appetite-stimulating and indigestion-relieving,
Change stagnant disperse accumulation, promoting blood circulation to remove blood stasis, resolving sputum promoting the circulation of qi.For carnivorous stagnant product, a lump in the abdomen causing distension and pain, abdominal distension feeling of fullness, stasis blocking abdominal pain, phlegm retention, diarrhea,
Discharging fresh blood stool protects stomach lining, abdominal distension caused by alleviating after drinking.The ventilating of fructus amomi energy, stomach strengthening and digestion promoting function, can play
The effect of protecting stomach lining.Chitosan is also known as chitosan, is nature uniquely existing alkaline polysaccharide.Have to cell affine
Property, liver function can be strengthened, hence it is evident that accelerate the metabolism of alcohol, the generation of acetic acid can be accelerated, reduce the concentration of acetaldehyde, make second
Aldehyde is handled in time, and acetic acid is opposite to be reduced, and prevents the formation of fatty liver and cirrhosis.It crosses and acts on forming colloidal fluid with gastric acid,
It is attached on stomach wall and forms protective film, prevent the stimulation and damage to stomach lining such as dehydrated alcohol and gastric acid, and can promote damage
The reparation of injury.The use of chitosan is the big significant innovative point of this product one.Oligofructose, which has, adjusts functions of intestines and stomach, defaecation
The effect of improving intestinal flora.The effect of easy stomach of honey tonifying spleen, laxation defaecation, slow middle analgesic, removing toxic substances.With previous materials, with not
Same effective substance has very specific protection stomach lining from different action target spot and approach, prevents and treats the work of alcoholic liver injury
With.
The positive effect of the present invention is: according to theory of traditional Chinese medical science, by repetition test, screening, with the dragon of civil conventional Chinese medicine
Ya Aralia wood is monarch drug in a prescription, is equipped with pueraria lobata, hawthorn, fructus amomi, Radix Polygalae, mulberry fruit, forms multicomponent multiple target point, the collaboration of combination of long drives and drop shots is made
With, using natural products prescription from preventing ethyl alcohol from absorbing, decomposing alcohol protection liver, three aspect of protection stomach mechanism on reduce wine
Injury of the essence to body, plays the curative effect relieved the effect of alcohol, and relieves the effect of alcohol, has significant breakthrough in health-care effect and safety and improve.
The technique that water extract-alcohol precipitation is taken in production method of the invention reduces impurity, substantially increases effective component master's
Content reduces dose.
Compliance test result example.
1, experimental method
1.1 experimental groups and stomach-filling
It tests and sets blank control group, model control group, test sample group (point high and low dose group), totally 4 groups.Every group of mouse
It is 18, totally 72 mouse.The stomach-filling amount of mouse recommends dosage to calculate according to the human body of each extract.
1. low dose group: 10 times of human body recommended amounts, i.e. liver-protecting and stomach-protecting oral liquor for sobering from wine；
2. high dose group: 30 times of human body recommended amounts, i.e. liver-protecting and stomach-protecting oral liquor for sobering from wine；
It is suitably concentrated after weighing liver-protecting and alcoholism-relieving oral solution according to the requirement of zoopery, continuous gavage given the test agent 30 days,
Blank control group, model control group are with the distilled water stomach-filling of equivalent.
1.2. the protective effect of chemical damage caused by alcohol is studied
After continuous gavage given the test agent 30 days, 50% ethyl alcohol (dehydrated alcohol dilution) stomach-filling model control group is taken, by real sample
Product group, stomach-filling amount are 14ml/kg, and blank control group is not necessarily to stomach-filling ethyl alcohol.Fasting 8-9h posterior orbit takes blood, survey serum GSH, MDA,
TG index.
Liver homogenate: taking liver after taking blood, and 4 DEG C of normal saline flushing is pre-chilled, filter paper is blotted.Liver is weighed to weigh about
Physiological saline is added in 1: 9 ratio in 0.1g, and 10% homogenate, 4000r/min4 DEG C of centrifugation are made in ice bath.Supernatant is taken,
Survey hepatic tissue GSH, MDA, TG index.
1.3 statistical method
The variance analysis of mean comparison is carried out between each group and data are handled, and is statisticallyd analyze using Huaxi Medical Univ
Software PEMS3.1 " Chinese medicine encyclopedia Medical Statistics " software (secondary offering on the 18th of August in 2006) is to experiment
Data in the process are for statistical analysis.
2, experimental result
The influence of 2.1 pairs of mice serums and liver GSH
Influence (mg/L) of the table 1 to mice serum and liver GSH
| Group | Serum TG content | Liver TG content |
| Blank control group | 1.08 | 0.72 |
| Model control group | 1.57 | 1.07 |
| Low dosage control group | 1.19 | O.98 |
| High dose control group | 1.11 | 0.87 |
* P < 0.05VS model control group * * P < 0.01VS model control group
△ P < 0.05VS blank control group △ △ P < 0.01VS blank control group
Learnt by statistical analysis: high dose group relative model control group serum, liver TG all have significant difference (P
< 0.05) show that high dose tool is significantly reduced the effect of the content of the intracorporal triglycerides of mouse, it prompts it to have and mitigates
Liver fat accumulation, liver-protective effect.
Experiment sets 3 dosage groups i.e. 0.2,0.4,1.2g/kg.kw, is respectively equivalent to 5,10,30 times of human body recommended amounts.
50 rats are randomly divided into water control group, starch control group and basic, normal, high 3 tested material groups by weight.Animal stomach-filling tested material
15d.Fasting 48h before dissecting, stomach-filling dehydrated alcohol 1ml/ only, is put to death each group after 1h again after experiment terminates same day stomach-filling tested material 1h
Animal takes stomach, fixes 20min with 2% formalin, cuts off along greater curvature, cleans content, measures stomach lining bleeding, ulcer
Area.
As a result:
Oral solution 14d, mucosal lesion area, starch control group and water pair are given in influence of the oral solution to mucosal lesion
Compare according to group, no significant difference (P > 0.05)；0.2,0.4,1.2g/kg.bw group is significantly lower than starch control group and water
Control group, difference are statistically significant (P < 0.01).
It is shown in Table 2:
Table 2 is a kind of to be inhibited alcohol absorption, promotes influence (x ± s) of the health care oral liquid of alcohol metabolism to mucosal lesion
Note: P < 0.01 * * (compared with water control group)
This test use dehydrated alcohol injury rats stomach lining method, observe one kind can decomposing alcohol, prevent alcohol absorption
Protective effect of the oral liquor for sobering from wine of liver-protecting and stomach-protecting to stomach lining.
3 dosage groups can significantly reduce dehydrated alcohol to the damaged area of stomach lining, because in oral solution as the result is shown
Effective component in conjunction with chitosan to stomach lining have good protective effect.
Specific embodiment
Embodiment 1
1,40 parts by weight of Long Ya Aralia wood, 150 parts by weight of Radix Polygalae, 40 parts by weight of hoveniae semoveniae semen, 70 parts by weight of pueraria lobata, 20 weight of mulberry fruit
Measure part, 200 parts by weight of broccoli, 40 parts by weight of hawthorn, 200 parts by weight of fructus amomi, 10 parts by weight of honey, 100 parts by weight of chitosan,
10 parts by weight of oligofructose, 800 parts by weight of pure water, 0.6 parts by weight of citric acid, 0.3 parts by weight of potassium sorbate, Aspartame
0.14 parts by weight.
2, it will first be cleaned after Long Ya Aralia wood, hoveniae semoveniae semen, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli weighing standby
With；It is blue with clean Long Ya Aralia wood, hoveniae semoveniae semen, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, west after hoveniae semoveniae semen weighing is crushed
Flower is mixed to get mixtures of materials, and then mixed material is put into gauze bag and is put into Chinese medicine extracting tank；
3,12 times of injecting material mixture of the water in extractor for the first time, first time continuous circumfluence extraction 1.5 hours,
After primary extraction, the mixtures of materials in extractor is separated by solid-liquid separation, discharge first time extracting solution is spare；Again in extractor
After second is extracted, the material in extractor is mixed for the water of secondary 7 times of mixtures of materials of injection, second of extraction 2.5 hours
Object is separated by solid-liquid separation, and second of extracting solution combined extract is discharged.
4, first time extracting solution in step 3 and second of extracting solution are merged, first passes through filter filtering, removes impurity, so
After recycle ethyl alcohol, be made 1.05 medicinal extract of density；
5, medicinal extract obtained in step 4 is transferred in settling tank, it is water-soluble that ethyl alcohol is added in the case where being slowly stirred
Liquid, ethanol water concentration 90~95%, additional amount are that every 1g medicinal extract adds 3ml ethanol water, static 24 hours, take supernatant
Liquid；
6, supernatant obtained is filtered, volatilize ethyl alcohol, adds taken pure water dilution, obtains original liquid
7, oligofructose, chitosan oligosaccharide, citric acid, honey, potassium sorbate, Aspartame are mixed after being dissolved with a small amount of water,
It insulated and stirred 30 minutes, filters spare；
8 filter sweetener soln obtained in step 7 and the resulting original liquid of step 6 after mixing, and packing must press down
Preparing alcohol absorbs, promotes the health care oral liquid of alcohol metabolism
Embodiment 2
1,200 parts by weight of Qu Ya Aralia wood, 40 parts by weight of Radix Polygalae, 300 parts by weight of hoveniae semoveniae semen, 40 parts by weight of pueraria lobata, mulberry fruit 100
Parts by weight, 30 parts by weight of broccoli, 200 parts by weight of hawthorn, 30 parts by weight of fructus amomi, honey, 100 parts by weight, 10 weight of chitosan
Part, 50 parts by weight of oligofructose, 1000 parts by weight of pure water, 0.9 parts by weight of citric acid, 0.2 parts by weight of potassium sorbate, A Siba
0.17 parts by weight of sweet tea.
2, it will first be cleaned after Long Ya Aralia wood, hoveniae semoveniae semen, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli weighing standby
With；It is blue with clean Long Ya Aralia wood, hoveniae semoveniae semen, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, west after hoveniae semoveniae semen weighing is crushed
Flower is mixed to get mixtures of materials, and then mixed material is put into gauze bag and is put into Chinese medicine extracting tank；
3,7 times of injecting material mixture of the water in extractor for the first time, first time continuous circumfluence extraction 2.5 hours,
After primary extraction, the mixtures of materials in extractor is separated by solid-liquid separation, discharge first time extracting solution is spare；Again in extractor
After second is extracted, the material in extractor is mixed for the water of secondary 9 times of mixtures of materials of injection, second of extraction 1.5 hours
Object is separated by solid-liquid separation, and second of extracting solution combined extract is discharged；
4, first time extracting solution in step 3 and second of extracting solution are merged, first passes through filter filtering, removes impurity, so
After be concentrated, be made medicinal extract density be 1.1g/ml medicinal extract；
5, medicinal extract obtained in step 4 is transferred in settling tank, it is water-soluble that ethyl alcohol is added in the case where being slowly stirred
Liquid, ethanol water concentration 90~95%, additional amount are that every 1g medicinal extract adds 2ml ethanol water, static 24 hours, take supernatant
Liquid；
6, supernatant obtained is filtered, volatilize ethyl alcohol, adds taken pure water dilution uniformly, obtains original liquid
7, oligofructose, chitosan oligosaccharide, citric acid, honey, potassium sorbate, Aspartame are mixed after being dissolved with a small amount of water,
It insulated and stirred 30 minutes, filters spare；
8 filter sweetener soln obtained in step 7 and the resulting original liquid of step 6 after mixing, and packing must press down
Preparing alcohol absorbs, promotes the health care oral liquid of alcohol metabolism.
Embodiment 3
1,120 parts by weight of Long Ya Aralia wood, 100 parts by weight of Radix Polygalae, 160 parts by weight of hoveniae semoveniae semen, 50 parts by weight of pueraria lobata, mulberry fruit are taken
60 parts by weight, 110 parts by weight of broccoli, 120 parts by weight of hawthorn, 110 parts by weight of fructus amomi, 60 parts by weight of honey, 60 weight of chitosan
Measure part, 30 parts by weight of oligofructose, 900 parts by weight of pure water, 0.8 parts by weight of citric acid, 0.25 parts by weight of potassium sorbate, A Si
0.15 parts by weight of Ba Tian.
2, it will first be cleaned after Long Ya Aralia wood, hoveniae semoveniae semen, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli weighing standby
With；It is blue with clean Long Ya Aralia wood, hoveniae semoveniae semen, pueraria lobata, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, west after hoveniae semoveniae semen weighing is crushed
Flower is mixed to get mixtures of materials, and then mixed material is put into gauze bag and is put into Chinese medicine extracting tank；
3,8 times of injecting material mixture of the water in extractor for the first time, first time continuous circumfluence extraction 28 hours, first
After secondary extraction, the mixtures of materials in extractor is separated by solid-liquid separation, discharge first time extracting solution is spare；Again second in extractor
The water of 8 times of secondary injecting material mixture, second of extraction 2 hours, after second is extracted, the mixtures of materials in extractor is consolidated
Liquid separation, is discharged second of extracting solution combined extract；
4, first time extracting solution in step 3 and second of extracting solution are merged, first passes through filter filtering, removes impurity, so
After be concentrated, be made medicinal extract density be 1.16g/ml medicinal extract；
5, medicinal extract obtained in step 4 is transferred in settling tank, it is water-soluble that ethyl alcohol is added in the case where being slowly stirred
Liquid, ethanol water concentration 90~95%, additional amount are that every 1g medicinal extract adds 2.5ml ethanol water, static 24 hours, take supernatant
Liquid；
6, supernatant obtained is filtered, volatilize ethyl alcohol, adds taken pure water dilution uniformly, obtains original liquid
7, oligofructose, chitosan oligosaccharide, citric acid, honey, potassium sorbate, Aspartame are mixed after being dissolved with a small amount of water,
It insulated and stirred 30 minutes, filters spare；
8 filter sweetener soln obtained in step 7 and the resulting original liquid of step 6 after mixing, and packing must press down
Preparing alcohol absorbs, promotes the health care oral liquid of alcohol metabolism.
Claims (2)
1. a kind of health care oral liquid for inhibiting alcohol absorption, promoting alcohol metabolism, it is characterized in that: by 40~200 weight of Long Ya Aralia wood
Measure part, 40~150 parts by weight of Radix Polygalae, 40~300 parts by weight of hoveniae semoveniae semen, 40~70 parts by weight of pueraria lobata, 20~100 weight of mulberry fruit
Part, 30~200 parts by weight of broccoli, 40~200 parts by weight of hawthorn, 30~200 parts by weight Chinese medicine mixture of fructus amomi water mention
Take 10~100 parts by weight of object and honey, 10~100 parts by weight of chitosan, 10~50 parts by weight of oligofructose, pure water 800~
1000 parts by weight, 0.6~0.9 parts by weight of citric acid, 0.2~0.3 parts by weight of potassium sorbate, 0.14~0.17 weight of Aspartame
Part composition；
It is described inhibit alcohol absorption, promote alcohol metabolism health care oral liquid the preparation method comprises the following steps:
(1) raw material extracts
Take 40~200 parts by weight of Aralia mandshurica, 40~150 parts by weight of Radix Polygalae, 40~300 parts by weight of hoveniae semoveniae semen, pueraria lobata 40~70
Parts by weight, 20~100 parts by weight of mulberry fruit, 30~200 parts by weight of broccoli, 40~200 parts by weight of hawthorn, 30~200 weight of fructus amomi
Measure part, 10~100 parts by weight of honey, 10~100 parts by weight of chitosan, 10~50 parts by weight of oligofructose, pure water 800~
1000 parts by weight, 0.6~0.9 parts by weight of citric acid, 0.2~0.3 parts by weight of potassium sorbate, 0.14~0.17 weight of Aspartame
Part；
(2) feedstock processing
The taken Aralia mandshurica of step (1), pueraria lobata, hawthorn, fructus amomi, Radix Polygalae, mulberry fruit, broccoli are cleaned spare；By taken trifoliate orange Dulcis
Son mixes after crushing with Aralia mandshurica, pueraria lobata, hawthorn, fructus amomi, Radix Polygalae, mulberry fruit, broccoli；
(3) water mentions
Mixture obtained by step (2) is put into gauze bag and is put into Chinese medicine extracting tank, injecting material mixes in extractor
7-12 times of object of water continuous circumfluence extraction 1.5-2.5 hours, after extraction, the mixtures of materials in extractor is separated by solid-liquid separation, row
First time extracting solution is spare out；Again in extractor 7-9 times of injecting material mixture water, carry out second and extract, when extraction
Between 1.5-2.5 hours, after second extracts, the mixtures of materials in extractor is separated by solid-liquid separation, second of extracting solution is discharged, with
First time extracting solution merges；
(4) it is concentrated
Extracting solution obtained by step (3) is first passed through into filter filtering, is concentrated after removing impurity, 1.05~1.16 medicinal extract of density is made；
(5) alcohol precipitation
Medicinal extract obtained in step (4) is transferred in settling tank, adds 2~3ml concentration to be 95% ethyl alcohol by every 1g medicinal extract
Ethanol water is added in the case where being slowly stirred for the ratio of aqueous solution, takes supernatant within static 24 hours；
(6) it dilutes
The supernatant liquid filtering that step (5) is obtained, evaporates into no alcohol taste, and the pure water for adding step (1) to be taken dilutes, raw medicine is made
Liquid；
(7) dissolution of sugar-type sweetener
Honey, chitosan, oligofructose, citric acid, potassium sorbate, Aspartame, mixing plus a small amount of water that step (1) is taken
Dissolution is stirred 10~30 minutes, and solution filtering is spare；
(8) solution made from the resulting original liquid of step (6) and step (7) is uniformly mixed, is filtered, packing obtains inhibition alcohol
Absorb, promote the health care oral liquid of alcohol metabolism.
2. the health care oral liquid for inhibiting alcohol absorption, promoting alcohol metabolism a kind of according to claim 1, it is characterized in that: former
Expect optimum amount ratio are as follows: 120 parts by weight of Long Ya Aralia wood, 100 parts by weight of Radix Polygalae, 160 parts by weight of hoveniae semoveniae semen, 50 weight of pueraria lobata
Part, 60 parts by weight of mulberry fruit, 110 parts by weight of broccoli, 120 parts by weight of hawthorn, 110 parts by weight of fructus amomi, 60 parts by weight of honey, shell are poly-
Sugared 60 parts by weight, 30 parts by weight of oligofructose.
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| CN105726590A (en) * | 2016-03-24 | 2016-07-06 | 党学德 | Chinese herbal medicine preparation with functions of reducing alcohol absorption and protecting liver |
| KR101952648B1 (en) * | 2017-08-03 | 2019-02-27 | 국가식품클러스터지원센터 | The Inhibitory Effects of Amomum vilosum Loureiro Extracts and Composition Containing the Extract as Effective Ingredient |
| CN108652000A (en) * | 2018-03-07 | 2018-10-16 | 姜学林 | Imperial bud liver-protecting and alcoholism-relieving solid articles of a kind of compound thorn and preparation method thereof |
| CN109007213A (en) * | 2018-07-10 | 2018-12-18 | 青岛高新区尚达医药研究所 | A kind of relieving alcoholism and protecting liver sugar cube and preparation method thereof |
| CN109007808A (en) * | 2018-08-14 | 2018-12-18 | 宝健（北京）生物技术有限公司 | A kind of relieving alcoholism and protecting liver composition and the relieving alcoholism and protecting liver preparation comprising it |
| CN112262900A (en) * | 2020-09-02 | 2021-01-26 | 岳康医疗生物科技有限公司 | Formula and preparation method of instant solid beverage for sobering up and body building |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104510A (en) * | 1993-12-28 | 1995-07-05 | 龚枫砰 | Spirit companion |
| CN101011170A (en) * | 2006-11-07 | 2007-08-08 | 北京汉潮联创中药科技有限公司 | Antialcoholic plant beverage and its preparation method |
| CN102552493A (en) * | 2012-02-02 | 2012-07-11 | 贵州益佰制药股份有限公司 | Anti-inebriation drunk-preventing composition and preparation method thereof |
| CN102578671A (en) * | 2012-03-20 | 2012-07-18 | 牟一心 | Alcoholism-relieving liver-protecting botanical nutritional beverage and making method thereof |
| CN103445117A (en) * | 2013-09-16 | 2013-12-18 | 宁波市江东农茹生物科技有限公司 | Healthcare radix puerariae nutrition powder capable of preventing alcoholic liver injury |
-
2014
- 2014-10-23 CN CN201410578558.8A patent/CN104351610B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104510A (en) * | 1993-12-28 | 1995-07-05 | 龚枫砰 | Spirit companion |
| CN101011170A (en) * | 2006-11-07 | 2007-08-08 | 北京汉潮联创中药科技有限公司 | Antialcoholic plant beverage and its preparation method |
| CN102552493A (en) * | 2012-02-02 | 2012-07-11 | 贵州益佰制药股份有限公司 | Anti-inebriation drunk-preventing composition and preparation method thereof |
| CN102578671A (en) * | 2012-03-20 | 2012-07-18 | 牟一心 | Alcoholism-relieving liver-protecting botanical nutritional beverage and making method thereof |
| CN103445117A (en) * | 2013-09-16 | 2013-12-18 | 宁波市江东农茹生物科技有限公司 | Healthcare radix puerariae nutrition powder capable of preventing alcoholic liver injury |
Non-Patent Citations (1)
| Title |
|---|
| 皂苷生物活性的研究进展;王楠;《医学研究生学报》;20071231;第20卷(第2期);第211-214页 * |
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