CN104351610A - Health-care oral liquid for inhibiting alcohol absorption and promoting alcohol metabolism and preparation method thereof - Google Patents
Health-care oral liquid for inhibiting alcohol absorption and promoting alcohol metabolism and preparation method thereof Download PDFInfo
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- CN104351610A CN104351610A CN201410578558.8A CN201410578558A CN104351610A CN 104351610 A CN104351610 A CN 104351610A CN 201410578558 A CN201410578558 A CN 201410578558A CN 104351610 A CN104351610 A CN 104351610A
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- alcohol
- oral liquid
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- water
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 93
- 239000007788 liquid Substances 0.000 title claims abstract description 48
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 17
- 230000004060 metabolic process Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 230000001737 promoting effect Effects 0.000 title abstract description 6
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000284 extract Substances 0.000 claims abstract description 47
- 239000000203 mixture Substances 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
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- 238000002156 mixing Methods 0.000 claims abstract description 4
- 238000001556 precipitation Methods 0.000 claims abstract description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
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- 238000009472 formulation Methods 0.000 abstract 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 abstract 1
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- ZQSIJRDFPHDXIC-UHFFFAOYSA-N Daidzein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 1
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses health-care oral liquid for inhibiting alcohol absorption and promoting alcohol metabolism and a preparation method thereof, and belongs to health-care food. The health-care oral liquid comprises a water extract of a mixture of cortex araltae, polygala tenuifolia, turnjujube, kudzu vine root, mulberry, broccoli, hawthorn and fructus amomi, and honey, chitosan, fructo-oligosaccharide and purified water. The preparation method comprises the following steps: extracting and treating raw materials, performing water reflux extraction, concentrating, performing alcohol precipitation, diluting by using purified water, dissolving a sugar-type sweetener, mixing herbal raw liquid and the sugar-type sweetener, filtering, and subpackaging to obtain a final product. The health-care oral liquid has the beneficial effects as follows: with the cortex araltae as a monarch drug, and in combination with the kudzu vine root, the hawthorn, the fructus amomi, the polygala tenuifolia and the mulberry, a multi-component multi-target and length-coordination synergistic effect is achieved; through a formulation of natural components, the health-care oral liquid can reduce harms of alcohol to a human body from three mechanisms of preventing the alcohol absorption, decomposing the alcohol to protect the liver, and protecting the stomach, thus achieving an alcoholism eliminating effect; the alcoholism eliminating effect, the health-care effect and the safety of the health-care oral liquid are significantly broken through and improved.
Description
Technical field
The invention belongs to field of health care products, be specifically related to a kind of oral liquor for sobering from wine that alcohol absorption can be suppressed to promote alcohol metabolism, liver-protecting and stomach-protecting.
Background technology
Wine, instantly modal medium in social activity, long-term excessive consumption of alcohol can cause acute gastritis, even gastrorrhagia, and the damage of alcohol to stomach lining is apparent.Liver is the armour that body weight for humans is wanted, and it produces at the metabolism of people, bile generation, removing toxic substances, blood coagulation, immunity, heat and all plays very important effect in water and electrolytical adjustment, and long-term alcohol can cause alcoholic liver injury.Alcoholic liver injury refers to a series of pathologies such as the liver damage caused due to Excess free enthalpy alcohol, often shows as alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis.Be detrimental to health.Many scholars have done a large amount of research work in protection stomach lining field in recent years.American-European, Japanese Medicament for Alcoholism salable mostly is the compositions such as excitant, anodyne, vitamin and mineral matter, and can only to be still drank after a night the symptom caused by respite, the liver caused for alcohol and gastric injury there is no preventive and therapeutic effect.Before this existing liver-protecting and alcoholism-relieving class health food at suppression alcohol absorption, promote alcohol metabolism protection gastric mucosa, prevent the effect of hepatic injury and not obvious, still need to be improved further.
Summary of the invention
The object of this invention is to provide and a kind ofly suppress alcohol absorption, promote the health care oral liquid of alcohol metabolism and preparation method, overcome alcohol-neutralize healthy product of the prior art suppressing alcohol absorption, promote alcohol metabolism, protect the inapt deficiency of stomach liver protective effect.
Health care oral liquid of the present invention comprises Long Ya Aralia wood 40 ~ 200 weight portion, polygala root 40 ~ 150 weight portion, hoveniae semoveniae semen 40 ~ 300 weight portion, the root of kudzu vine 40 ~ 70 weight portion, mulberry fruit 20 ~ 100 weight portion, broccoli 30 ~ 200 weight portion, hawthorn 40 ~ 200 weight portion, the water extract of fructus amomi 30 ~ 200 weight portion Chinese medicine mixture and honey 10 ~ 100 weight portion, shitosan 10 ~ 100 weight portion, FOS 10 ~ 50 weight portion, pure water 800 ~ 1000 weight portion.
For improving the mouthfeel of oral liquid further and extending the shelf life, in prescription of the present invention, also comprise citric acid 0.6 ~ 0.9 weight portion, potassium sorbate 0.2 ~ 0.3 weight portion, Aspartame 0.14 ~ 0.17 weight portion.
Health care oral liquid raw material optimum amount ratio of the present invention is: Long Ya Aralia wood 120 weight portions, polygala root 100 weight portion, hoveniae semoveniae semen 160 weight portion, the root of kudzu vine 50 weight portion, mulberry fruit 60 weight portion, broccoli 110 weight portion, hawthorn 120 weight portion, fructus amomi 110 weight portion, honey 60 weight portion, shitosan 60 weight portion, FOS 30 weight portion.
The preparation method of health care oral liquid of the present invention comprises the following steps:
1, raw material and Feedstock treating is extracted
Got Aralia mandshurica, the root of kudzu vine, hawthorn, fructus amomi, polygala root, mulberry fruit, broccoli are cleaned for subsequent use; Mix with Aralia mandshurica, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli after got hoveniae semoveniae semen is pulverized;
2, water extraction
Mixture is put into gauze bag and puts into Chinese medicine extracting tank, injecting material mixture 7-12 water doubly in extractor, continuous circumfluence extraction 1.5-2.5 hour, after extraction, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge first time extract is for subsequent use; Again toward the water of injecting material mixture 7-9 in extractor times, carry out second time and extract, extraction time 1.5-2.5 hour, after second time is extracted, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge extract for the second time, merge with first time extract.
3, concentrated
Step 2 gained extract is first filtered, concentrated after removing impurity, obtained density 1.05 ~ 1.16 medicinal extract.
4, alcohol precipitation
Medicinal extract obtained in step 3 is transferred in settling tank, adds in every 1g medicinal extract the ratio that 2 ~ 3ml concentration is the ethanol water of 95%, adding ethanol water when slowly stirring, within static 24 hours, getting supernatant;
5, supernatant liquid filtering step 4 obtained, evaporates into without alcohol taste, then adds the pure water dilution that step 1 gets, obtained original liquid;
6, the dissolving of sugar-type sweetener
Honey, shitosan, FOS, citric acid, potassium sorbate, Aspartame, mixing are added a small amount of water-soluble solution, stirs 10 ~ 30 minutes, solution filters for subsequent use;
7, mixed by the solution that the original liquid of step 5 gained and step 6 obtain, filter, packing, obtains described oral liquor for sobering from wine product.
Instructions about how to take medicine and consumption: oral 10 ~ 20ml before drinking or after drinking
The present invention has anti-inflammatory, clearing away summerheat based on: Aralia mandshurica, helps digestion and stomach function, develop immunitypty and protective effect on cancer risk, applies to some extent in the medicine of the diseases such as treatment diabetes, arthritis, myocardial infarction, gastric ulcer, neurasthenia.Experiment confirms, the Aralia mandshurica mixing bark saponin(e through extracting has the effect that very strong suppression ethanol absorbs.The effect that the saponin(e extracted from polygala root has very strong suppression ethanol to absorb.Containing a large amount of glucose, organic acid in hoveniae semoveniae semen, the blood volume of human body can be expanded, again can relieving alcoholism, therefore have the effect of sobering up and calming the nerves.Smoothening secretion hoveniae semoveniae semen contains large quantity of moisture, glucose, organic salt, lipid material, has promotion urine drains, accelerates intestines peristalsis energy smoothening secretion and promotes that ethanol eliminating is external.The root of kudzu vine can the liver that causes of antagonism alcohol and lipid peroxidation in testis infringement effectively, and the root of kudzu vine is containing daidzin, and it can decompose acetaldehyde toxicity, can stop alcohol weakening brain inhibit feature; Stomach can be suppressed the absorption of alcohol, promote metabolism and the excretion of alcohol in blood.American is treating in crapulent clinical research with kudzu root flavone, achieves good curative effect.Mulberry fruit taste cold in nature is sweet, the popular feeling, liver, kidney channel, has nourishing yin and supplementing blood, relaxes bowel, and the effect of relieving the effect of alcohol.Record in Compendium of Material Medica " call it and smash juice drink, can alcohol intoxication be separated ".Broccoli has and promotes into ethanol decomposition, and protection liver, has curative effect of well relieving the effect of alcohol.Hawthorn appetite-stimulating indigestion-relieving, change stagnant long-pending, the promoting blood circulation to remove blood stasis of disappearing, promoting the circulation of qi of reducing phlegm.For meat stagnant long-pending, a lump in the abdomen causing distension and pain, abdominal distension ruffian full, stasis blocking stomachache, phlegm and retained fluid, have loose bowels, discharging fresh blood stool, protection stomach lining, the abdominal distension that alleviation causes after drinking.During the promoting the circulation of qi of fructus amomi energy is wide, the function of stomach strengthening and digestion promoting, effect of protection stomach lining can be played.Shitosan, also known as chitosan, is the alkaline polysaccharide that nature uniquely exists.Have compatibility to cell, can strengthen liver function, obviously accelerate the metabolism of alcohol, can accelerate the generation of acetic acid, reduce the concentration of acetaldehyde, make acetaldehyde be able to timely process, acetic acid reduces relatively, prevents the formation of fatty liver and cirrhosis.Cross and form colloidal fluid with hydrochloric acid in gastric juice effect, be attached on coat of the stomach and form diaphragm, prevent absolute ethyl alcohol and hydrochloric acid in gastric juice etc. to the stimulation of stomach lining and damage, and the reparation of injury region can be promoted.The use of shitosan is the large significant innovative point of this product one.FOS has adjustment functions of intestines and stomach, and defaecation improves effect of gut flora.Effect of the easy stomach of honey tonifying spleen, laxation defaecation, slow middle pain relieving, removing toxic substances.By previous materials, there is very clear and definite protection stomach lining with different effective substances from different action target spots and approach, the effect of control alcoholic liver injury,
Good effect of the present invention is: according to theory of traditional Chinese medical science; through repetition test, screening; with the Aralia mandshurica of conventional Chinese medicine among the people for monarch drug in a prescription; be equipped with the root of kudzu vine, hawthorn, fructus amomi, polygala root, mulberry fruit; form the synergy of multicomponent Mutiple Targets, combination of long drives and drop shots; natural products prescription is utilized to absorb from preventing ethanol; the mechanism of decomposing alcohol protection liver, protection stomach three aspect reduces the injury of alcohol to body; play the curative effect of relieving the effect of alcohol, relieve the effect of alcohol, health-care effect and security have and breaks through and improve significantly.
Take the technique of water extract-alcohol precipitation in production method of the present invention, reduce impurity, substantially increase the content of active ingredient master, reduce dose.
Compliance test result example.
1, experimental technique
1.1 experiment grouping and gavages
Experiment establishes blank group, model control group, given the test agent group (point high and low dose group), totally 4 groups.Often organizing mouse is 18, totally 72 mouse.The gavage amount of mouse recommends Dosage calculation according to the human body of each extract.
1. low dose group: 10 times of human body recommended amounts, i.e. liver-protecting and stomach-protecting oral liquor for sobering from wine;
2. high dose group: 30 times of human body recommended amounts, i.e. liver-protecting and stomach-protecting oral liquor for sobering from wine;
Suitably concentrate after weighing liver-protecting and alcoholism-relieving oral liquid according to zooperal requirement, continuous gavage given the test agent 30 days, blank group, model control group are with the distilled water gavage of equivalent.
1.2. the protective effect of the chemical damage caused by alcohol is studied
Continuous gavage given the test agent, after 30 days, is got 50% ethanol (absolute ethyl alcohol dilution) gavage model control group, by real sample sets, gavage amount is 14ml/kg, and blank group is without the need to gavage ethanol.Fasting 8-9h posterior orbit gets blood, surveys serum GSH, MDA, TG index.
LH: take liver after getting blood, with the normal saline flushing of precooling 4 DEG C, filter paper blots.Take liver heavily about 0.1g, add physiological saline in the ratio of 1: 9, make the homogenate of 10% in ice bath, 4000r/min4 DEG C centrifugal.Get supernatant, survey hepatic tissue GSH, MDA, TG index.
1.3 statistical method
Carry out variance analysis that mean compares between each group and data are processed, adopting Huaxi Medical Univ statistical analysis software PEMS3.1 " Chinese medicine encyclopedia Medical Statistics " software (secondary offering on August 18th, 2006) to carry out statistical analysis to the data in experimentation.
2, experimental result
2.1 impacts on mice serum and liver GSH
Table 1 is on the impact (mg/L) of mice serum and liver GSH
| Group | Serum TG content | Liver TG content |
| Blank group | 1.08 | 0.72 |
| Model control group | 1.57 | 1.07 |
| Low dosage control group | 1.19 | O.98 |
| High dose control group | 1.11 | 0.87 |
* P < 0.05VS model control group * * P < 0.01VS model control group
△ P < 0.05VS blank group △ △ P < 0.01VS blank group
Learnt by statistical analysis: high dose group relative model control group serum, liver TG all have significant difference (P < 0.05) and show that high dose has the effect of the content of the significant triglycerides reduced in Mice Body, point out it to have and alleviate liver fat accumulation, liver-protective effect
3 dosage groups that is 0.2,0.4,1.2g/kg.kw are established in experiment, are equivalent to 5,10,30 times of human body recommended amounts respectively.50 rats are divided into water control group, starch control group and basic, normal, high 3 tested material groups at random by body weight.Fasting 48h before animal gavage tested material 15d. dissects, experiment terminates the same day only respectively organizes gavage absolute ethyl alcohol 1ml/ again after gavage tested material 1h, put to death animal after 1h, get stomach, fix 20min by 2% formalin, cut off along greater curvature, clean content, measurement stomach lining is hemorrhage, ulcer area.
Result:
The impact of oral liquid on mucosal lesion gives oral liquid 14d, mucosal lesion area, and starch control group compares with water control group, no significant difference (P>0.05); 0.2,0.4,1.2g/kg.bw group is starkly lower than starch control group and water control group, and difference all has statistical significance (P<0.01).
In table 2:
Table 2 one takes liquid to impact (x ± s) the Group Animals hemorrhage band of number (only) stomach lining of mucosal lesion and ulcer area (mm2)
Note: * * P<0.01 (comparing with water control group)
This test adopts absolute ethyl alcohol injury rats stomach lining method, observe a kind of can decomposing alcohol, prevent the protective effect of oral liquor for sobering from wine to stomach lining of alcohol absorption liver-protecting and stomach-protecting.
Result shows 3 dosage groups all obviously can reduce the damaged area of absolute ethyl alcohol to stomach lining, because the active ingredient in oral liquid is combined with shitosan have good protective effect to stomach lining.
Detailed description of the invention
Embodiment 1
1, Long Ya Aralia wood 40 weight portions, polygala root 150 weight portion, hoveniae semoveniae semen 40 weight portion, the root of kudzu vine 70 weight portion, mulberry fruit 20 weight portion, broccoli 200 weight portion, hawthorn 40 weight portion, fructus amomi 200 weight portion, honey 10 weight portion, shitosan 100 weight portion, FOS 10 weight portion, pure water 800 weight portion, citric acid 0.6 weight portion, potassium sorbate 0.3 weight portion, Aspartame 0.14 weight portion.
2, afterwash of first Long Ya Aralia wood, hoveniae semoveniae semen, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli being weighed is for subsequent use; Hoveniae semoveniae semen is weighed after pulverizing and be mixed to get mixtures of materials with the Long Ya Aralia wood cleaned, hoveniae semoveniae semen, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli, then mixed material is put into gauze bag and put into Chinese medicine extracting tank;
3, first time is toward the water of 12 times, injecting material mixture in extractor, for the first time continuous circumfluence extraction 1.5 hours, and after first time extraction, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge first time extract is for subsequent use; The water of 7 times, second time injecting material mixture in extractor again, second time is extracted 2.5 hours, after second time is extracted, by the mixtures of materials Separation of Solid and Liquid in extractor, discharges second time extract and merges extract.
4, by extract and the merging of second time extract for the first time in step 3, be first filtered, remove impurity, then reclaim ethanol, obtained density 1.05 medicinal extract;
5, be transferred in settling tank by medicinal extract obtained in step 4, add ethanol water, ethanol water concentration 90 ~ 95% when slowly stirring, addition is that every 1g medicinal extract adds 3ml ethanol water, static 24 hours, get supernatant;
6, filter obtained supernatant, volatilization ethanol, then add got pure water dilution, obtain original liquid
7, mix FOS, chitosan oligosaccharide, citric acid, honey, potassium sorbate, Aspartame with after a small amount of water-soluble solution, insulated and stirred 30 minutes, filters for subsequent use;
Sweetener soln obtained in step 7 is mixed rear filtration with the original liquid of step 6 gained, packing by 8, must suppress alcohol absorption, promote the health care oral liquid of alcohol metabolism
Embodiment 2
1, Qu Ya Aralia wood 200 weight portions, polygala root 40 weight portion, hoveniae semoveniae semen 300 weight portion, the root of kudzu vine 40 weight portion, mulberry fruit 100 weight portion, broccoli 30 weight portion, hawthorn 200 weight portion, fructus amomi 30 weight portion, honey, 100 weight portions, shitosan 10 weight portion, FOS 50 weight portion, pure water 1000 weight portion, citric acid 0.9 weight portion, potassium sorbate 0.2 weight portion, Aspartame 0.17 weight portion.
2, afterwash of first Long Ya Aralia wood, hoveniae semoveniae semen, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli being weighed is for subsequent use; Hoveniae semoveniae semen is weighed after pulverizing and be mixed to get mixtures of materials with the Long Ya Aralia wood cleaned, hoveniae semoveniae semen, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli, then mixed material is put into gauze bag and put into Chinese medicine extracting tank;
3, first time is toward the water of 7 times, injecting material mixture in extractor, for the first time continuous circumfluence extraction 2.5 hours, and after first time extraction, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge first time extract is for subsequent use; The water of 9 times, second time injecting material mixture in extractor again, second time is extracted 1.5 hours, after second time is extracted, by the mixtures of materials Separation of Solid and Liquid in extractor, discharges second time extract and merges extract;
4, by extract and the merging of second time extract for the first time in step 3, be first filtered, remove impurity, then concentrate, obtained medicinal extract density is the medicinal extract of 1.1g/ml;
5, be transferred in settling tank by medicinal extract obtained in step 4, add ethanol water, ethanol water concentration 90 ~ 95% when slowly stirring, addition is that every 1g medicinal extract adds 2ml ethanol water, static 24 hours, get supernatant;
6, filter obtained supernatant, volatilization ethanol, then add got pure water dilution evenly, obtain original liquid
7, mix FOS, chitosan oligosaccharide, citric acid, honey, potassium sorbate, Aspartame with after a small amount of water-soluble solution, insulated and stirred 30 minutes, filters for subsequent use;
Sweetener soln obtained in step 7 is mixed rear filtration with the original liquid of step 6 gained, packing by 8, must suppress alcohol absorption, promote the health care oral liquid of alcohol metabolism.
Embodiment 3
1, Long Ya Aralia wood 120 weight portions, polygala root 100 weight portion, hoveniae semoveniae semen 160 weight portion, the root of kudzu vine 50 weight portion, mulberry fruit 60 weight portion, broccoli 110 weight portion, hawthorn 120 weight portion, fructus amomi 110 weight portion, honey 60 weight portion, shitosan 60 weight portion, FOS 30 weight portion, pure water 900 weight portion, citric acid 0.8 weight portion, potassium sorbate 0.25 weight portion, Aspartame 0.15 weight portion is got.
2, afterwash of first Long Ya Aralia wood, hoveniae semoveniae semen, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli being weighed is for subsequent use; Hoveniae semoveniae semen is weighed after pulverizing and be mixed to get mixtures of materials with the Long Ya Aralia wood cleaned, hoveniae semoveniae semen, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli, then mixed material is put into gauze bag and put into Chinese medicine extracting tank;
3, first time is toward the water of 8 times, injecting material mixture in extractor, for the first time continuous circumfluence extraction 28 hours, and after first time extraction, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge first time extract is for subsequent use; The water of 8 times, second time injecting material mixture in extractor again, second time is extracted 2 hours, after second time is extracted, by the mixtures of materials Separation of Solid and Liquid in extractor, discharges second time extract and merges extract;
4, by extract and the merging of second time extract for the first time in step 3, be first filtered, remove impurity, then concentrate, obtained medicinal extract density is the medicinal extract of 1.16g/ml;
5, be transferred in settling tank by medicinal extract obtained in step 4, add ethanol water, ethanol water concentration 90 ~ 95% when slowly stirring, addition is that every 1g medicinal extract adds 2.5ml ethanol water, static 24 hours, get supernatant;
6, filter obtained supernatant, volatilization ethanol, then add the dilution of got pure water evenly, obtain original liquid
7, mix FOS, chitosan oligosaccharide, citric acid, honey, potassium sorbate, Aspartame with after a small amount of water-soluble solution, insulated and stirred 30 minutes, filters for subsequent use;
Sweetener soln obtained in step 7 is mixed rear filtration with the original liquid of step 6 gained, packing by 8, must suppress alcohol absorption, promote the health care oral liquid of alcohol metabolism.
Claims (4)
1. one kind is suppressed the health care oral liquid of alcohol absorption, promotion alcohol metabolism
,it is characterized in that: comprise Long Ya Aralia wood 40 ~ 200 weight portion, polygala root 40 ~ 150 weight portion, hoveniae semoveniae semen 40 ~ 300 weight portion, the root of kudzu vine 40 ~ 70 weight portion, mulberry fruit 20 ~ 100 weight portion, broccoli 30 ~ 200 weight portion, hawthorn 40 ~ 200 weight portion, the water extract of fructus amomi 30 ~ 200 weight portion Chinese medicine mixture and honey 10 ~ 100 weight portion, shitosan 10 ~ 100 weight portion, FOS 10 ~ 50 weight portion, pure water 800 ~ 1000 weight portion.
2. a kind ofly according to claim 1 suppress alcohol absorption, promote the health care oral liquid of alcohol metabolism
,it is characterized in that: also comprise citric acid 0.6 ~ 0.9 weight portion, potassium sorbate 0.2 ~ 0.3 weight portion, Aspartame 0.14 ~ 0.17 weight portion.
3. one kind is suppressed the health care oral liquid of alcohol absorption, promotion alcohol metabolism
,it is characterized in that: raw material optimum amount ratio is: Long Ya Aralia wood 120 weight portions, polygala root 100 weight portion, hoveniae semoveniae semen 160 weight portion, the root of kudzu vine 50 weight portion, mulberry fruit 60 weight portion, broccoli 110 weight portion, hawthorn 120 weight portion, fructus amomi 110 weight portion, honey 60 weight portion, shitosan 60 weight portion, FOS 30 weight portion.
4. the preparation method of a health care oral liquid as claimed in claim 1 comprises the following steps:
(1) raw material extracts
Qu Aralia wood 40 ~ 200 weight portion, polygala root 40 ~ 150 weight portion, hoveniae semoveniae semen 40 ~ 300 weight portion, the root of kudzu vine 40 ~ 70 weight portion, mulberry fruit 20 ~ 100 weight portion, broccoli 30 ~ 200 weight portion, hawthorn 40 ~ 200 weight portion, fructus amomi 30 ~ 200 weight portion, honey 10 ~ 100 weight portion, shitosan 10 ~ 100 weight portion, FOS 10 ~ 50 weight portion, pure water 800 ~ 1000 weight portion, citric acid 0.6 ~ 0.9 weight portion, potassium sorbate 0.2 ~ 0.3 weight portion, Aspartame 0.14 ~ 0.17 weight portion,
(2) Feedstock treating
Step (1) Aralia mandshurica of getting, the root of kudzu vine, hawthorn, fructus amomi, polygala root, mulberry fruit, broccoli are cleaned for subsequent use; Mix with Aralia mandshurica, the root of kudzu vine, hawthorn, fructus amomi, seneca-snakeroot, mulberry fruit, broccoli after got hoveniae semoveniae semen is pulverized;
(3) water extraction
Step (2) gained mixture is put into gauze bag and puts into Chinese medicine extracting tank, injecting material mixture 7-12 water doubly in extractor, continuous circumfluence extraction 1.5-2.5 hours, after extraction, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge first time extract is for subsequent use; Again toward the water of injecting material mixture 7-9 in extractor times, carry out second time and extract, 1.5-2.5 hours extraction times, after second time is extracted, by the mixtures of materials Separation of Solid and Liquid in extractor, discharge extract for the second time, merge with first time extract;
(4) concentrated
Step (3) gained extract is first filtered, concentrated after removing impurity, obtained density 1.05 ~ 1.16 medicinal extract;
(5) alcohol precipitation
Medicinal extract obtained in step (4) is transferred in settling tank, adds in every 1g medicinal extract the ratio that 2 ~ 3ml concentration is the ethanol water of 95%, adding ethanol water when slowly stirring, within static 24 hours, getting supernatant;
(6) dilute
By the supernatant liquid filtering that step (5) obtains, evaporate into without alcohol taste, add the pure water dilution that step (1) gets, obtained original liquid;
(7) dissolving of sugar-type sweetener
Honey step (1) got, shitosan, FOS, citric acid, potassium sorbate, Aspartame, mixing add a small amount of water-soluble solution, stir 10 ~ 30 minutes, and solution filters for subsequent use;
(8) solution that the original liquid of step (6) gained and step (7) obtain mixed, filter, packing, alcohol absorption must be suppressed, promote the health care oral liquid of alcohol metabolism.
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