CN104940258A - Traditional Chinese medicine extractive composition with gastric mucosa protecting function - Google Patents
Traditional Chinese medicine extractive composition with gastric mucosa protecting function Download PDFInfo
- Publication number
- CN104940258A CN104940258A CN201510321250.XA CN201510321250A CN104940258A CN 104940258 A CN104940258 A CN 104940258A CN 201510321250 A CN201510321250 A CN 201510321250A CN 104940258 A CN104940258 A CN 104940258A
- Authority
- CN
- China
- Prior art keywords
- extract
- chinese medicine
- pers
- bull
- fructus amomi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a traditional Chinese medicine extractive composition with a gastric mucosa protecting function. The traditional Chinese medicine extractive composition comprises the following components in parts by weight: 10-90 parts of a hericium erinaceus extractive, 10-90 parts of a centella extractive and 10-90 parts of a fructus amomi extractive. The traditional Chinese medicine extractive composition has a stronger protective effect on gastric mucosa damage, and under the same dosage, the traditional Chinese medicine extractive composition has the better function of protecting the gastric mucosa than a single extractive.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine extract combination with protection gastric mucosa function.
Background technology
Gastric mucosa disease is modal a kind of disease in many gastropathy, and clinical manifestation is stomachache, pantothenic acid, belch, noisy, vomiting or chronic middle Upper abdominal pain after the meal, can have melena and hematemesis time serious.Along with social life tempo increase and huge operating pressure, people's diet is irregular, does not drink not eat or crapulent situation frequently has generation.The simultaneously dietary habit of people, pica, the reasons such as the pungent and excessive drinking of surfeit are all cause the major incentive of mucosal lesion.According to statistics, U.S. gastrointestinal disease sickness rate male is 10%, and women is 5%, and Japan is 5-10%, and Germany is 12.3%.China's gastrointestinal disease average attack rate is 11.43%.Gastric mucosa chronic inflammation pathological changes, sickness rate ranks first in various gastropathy.At present, China's Patients with Chronic Gastritis accounts for the 80-90% of outpatient service gastroscopy patient.Medical expert is found by a large amount of investigation in recent years, people between 20 to 40 years old, the gastric mucosa of 47% is only had to compare compared with normal, but this period that period, labour force was the most prosperous and the most powerful just, the impact that it brings to the mankind is well imagined, so gastric mucosa disease will become one of 21 century subject matter of facing of human health.
The medicine of the treatment gastric mucosa injury occurred in the market has proton pump inhibitor (omeprazole etc.), antacid (sodium bicarbonate etc.), gastric mucosa protectant (bismuth potassium citrate etc.) and anti-helicobacter pylori medicine etc.Most of gastrointestinal disease patient selects chemotherapy, but for the impaired gastrointestinal disease of gastrointestinal mucosa, chemicals is except the effect having disease therapy, general also can stimulating gastrointestinal road, make originally impaired gastrointestinal mucosa impaired further, side effect is large, and long-time use is easy to the balance destroying body, aggravate disease, also likely cause growing of other diseases.
In view of Chinese medicine or natural drug effect gentleer, drug effect multiformity and the less feature of side effect, it more and more receives the concern of people in prevention and therapy gastric mucosa injury and related gastrointestinal tract diseases thereof compared with chemicals.In Chinese medicine selected by the present invention, Hericium erinaceus (Bull. Ex Fr.) Pers., property is flat, sweet in the mouth, and sharp the five internal organs are aid digestion; There is stomach invigorating, tonify deficiency, anticancer, effect of kidney tonifying essence.Modern pharmacology research shows, Hericium Erinaceus Polysaccharide can improve the content of SOD, CAT and MAD in mice serum, has cytoprotective, the function of immunomodulating and suppression helicobacter pylori, thus play the protective effects on gastric mucosa.Herba Centellae, sweet in the mouth, pungent, cool in nature, heat-clearing and toxic substances removing, removing heat from blood expelling summer-heat; There is promotion wound healing, stop scar hyperplasia, effect of anti-gastric-ulcer.Modern pharmacology research shows, asiaticoside can strengthen gastric mucosal barrier, increase fibroblast growth factor (FGF) Promote cell's growth, reduce the damaging action of free radical, suppress the synthesis of NO, reduce the activity of peroxidase, thus reach the effect of anti-gastric-ulcer, and do not affect pepsic secretion.Fructus Amomi, property is pungent, and temperature, returns spleen, stomach, kidney channel, has in circulation of qi promoting tune, stomach function regulating, the merit of being amusing.Modern pharmacology research shows, Fructus Amomi extract can increase mucus on gastric wall, promotes the release of Gastric Mucosal Cells synthesis and prostaglandin; increase gastric mucosa phospholipid and aminohexose; gastric acid secretion inhibiting, reduces mda content in mucous membrane tissue, thus reaches the function of protection gastric mucosa.Wherein Hericium erinaceus (Bull. Ex Fr.) Pers. and Fructus Amomi and other Chinese medicine share to treat gastropathy and have relevant report (CN102961667A and CN104115965A), and the related application of Herba Centellae is relatively less.
Summary of the invention
The present invention is directed to the deficiency that the gastrointestinal tract mucous impaired Drug therapy of current gastroenteropathy exists, in conjunction with the advantage of Chinese medicine uniqueness in gastrotherapy, provide a kind of Chinese medicine extract combination with protection gastric mucosa function.
For realizing above object, the present invention adopts following technical scheme:
A kind of Chinese medicine extract combination with protection gastric mucosa function, is characterized in that comprising following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10-90 part, Herba Centellae extract 10-90 part.
Above-mentioned Chinese medicine extract combination, can also comprise Fructus Amomi extract 10-90 part.
Above-mentioned Chinese medicine extract combination, preferably comprises following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 20-90 part, Herba Centellae extract 10-50 part, Fructus Amomi extract 10-50 part.
Preferably comprise following weight portion further: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 30-50 part, Herba Centellae extract 30-50 part, Fructus Amomi extract 10-20 part, more preferably following weight portion is comprised: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 45 parts, Herba Centellae extract 45 parts, Fructus Amomi extract 10 parts.
Or, preferably comprise following weight portion further: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 70-90 part, Herba Centellae extract 10-20 part, Fructus Amomi extract 10-20 part, more preferably comprise following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 80 parts, Herba Centellae extract 10 parts, Fructus Amomi extract 10 parts.
Or, preferably comprise following weight portion further: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 30-50 part, Herba Centellae extract 10-20 part, Fructus Amomi extract 30-50 part, more preferably comprise following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 45 parts, Herba Centellae extract 10 parts, Fructus Amomi extract 45 parts.
Present invention also offers the application that above-mentioned Chinese medicine extract is combined in preparation prevention or treats in gastropathy medicine or health product.
Above-mentioned gastropathy is the disease relevant with mucosal lesion, comprises acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, polyp of stomach, gastric calculus, the innocent and malignant tumour of stomach, prolapse of gastric mucosa, acute gastric dilatation or pyloric obstruction etc.
Chinese medicine extract combination of the present invention can be used alone, and also can combinationally use with other medicines or functional food.Preferably, can adopt oral form, as tablet or electuary, effective dose is 10-1000mg/kg/d, and can be used for single drug or the drug combination treatment of relevant disease, is the scope that those skilled in the art can understand.
Results of animal shows, compared with single extract, Chinese medicine extract combination of the present invention has good gastric mucosal protective effect, particularly Chinese medicine extract is combined as: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 80 parts, Herba Centellae extract 10 parts, during Fructus Amomi extract 10 parts, to gastric ulcer, there is the strongest inhibitory action, Chinese medicine extract is combined as: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 45 parts, Herba Centellae extract 45 parts, during Fructus Amomi extract 10 parts, or Hericium erinaceus (Bull. Ex Fr.) Pers. extract 45 parts, Herba Centellae extract 10 parts, during Fructus Amomi extract 45 parts, to gastric ulcer, there is the strongest inhibitory action, ulcer inhibition rate will far above the arbitrary single extract of Isodose.
In recent years, the food of medicine-food two-purpose relaxes with its property of medicine, not easily produce drug resistance, be applicable to the features such as long-term taking, more and more deeply by the favor of consumers in general.Therefore, the present invention is with the food extracts of medicine-food two-purpose for raw material, and reasonable compatibility, works in coordination with and play a role, and can be good at the effect playing protection gastric mucosa.
The promotion wound healing that the present invention has in conjunction with Herba Centellae, stop scar hyperplasia, effect of anti-gastric-ulcer, with Hericium erinaceus (Bull. Ex Fr.) Pers. and Fructus Amomi use in conjunction, has significant synergistic therapeutic effect to gastric ulcer.
Invent described Hericium erinaceus (Bull. Ex Fr.) Pers. extract, Herba Centellae extract, Fructus Amomi extract can adopt and prepare with the following method, but not limit by this fixing means.Equal polarity or character similar Extraction solvent or solvent the visual extracting method for this reason of combination in the equivalent way of agents useful for same and extracting method.
The preparation of Hericium erinaceus (Bull. Ex Fr.) Pers. extract:
Get the crude Hericium be up to the standards, removing impurity, cleans, and pulverizes, puts in multi-function extractor, add 8 times amount water soaking 0.5h, boils and extracts 2h, extracting liquid filtering, and medicinal residues add 7 times amount water boils and extract 1.5h.Extracting solution 200 order filters, and merges extracted twice filtrate, and concentrated to outer circulation concentrator, vacuum degree control is 0.04-0.08MPa, and temperature is 60-80 DEG C, is concentrated into proportion 1.10-1.14.Concentrated solution carries out centrifugal, centrifugal liquid add that maltodextrin amount is total solid 30%, dry to spray dryer, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 ° of C.Get spraying dry gained dried cream powder and pulverized 80 mesh sieves, after mixing 50min in gained fine powder to mixer, obtain final Hericium erinaceus (Bull. Ex Fr.) Pers. extract.This extract principal character is that Hericium Erinaceus Polysaccharide content should not be less than 44%.
The preparation of Herba Centellae extract:
Get the Herba Centellae medical material be up to the standards, be placed in multi-function extractor, add 8 times amount volume 70% ethanol and leave standstill 0.5h, reflux, extract, 2.0h, extracting liquid filtering, medicinal residues add 7 times amount 70% alcohol reflux 1.5h, extracting liquid filtering.Merge extracted twice filtrate, in single-effect external circulation concentrator, concentration and recovery ethanol, vacuum is 0.04-0.08MMPa, and temperature is 60-70 DEG C, is concentrated into without alcohol taste, and adding suitable quantity of water to relative density is 1.02-1.05.The feed liquid of having diluted is carried out column chromatography, and feed liquid upper prop flow speed control is 1.5-2.0L/min, and resin adopts model D101 macroporous adsorbent resin.Water elution (flow velocity 2.0-3.0L/min) to the fluid five colors, then carries out eluting roguing by 10% ethanol 1 times amount, and resolve by the ethanol 2-3 times amount of 60% after eluting, flow speed control is 1.2-1.5L/min.To get in ethanol desorbed solution to single-effect external circulation concentrator concentrated, reclaim ethanol, vacuum is 0.04-0.08MPa, and temperature is 60-70 DEG C, is concentrated into without alcohol taste, and adding suitable quantity of water, to be concentrated into relative density be between 1.06-1.10.Get in concentrated solution to spray dryer dry, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C.Get in spraying dry gained dried cream powder to built-in 100 order pulverizers and pulverize, get the fine powder after pulverizing and cross 100 orders, mix 50-60min in gained fine powder to mixer, mixed fine powder is as final Herba Centellae extract.This extract principal character is that Herba Centellae total glycosides (asiaticoside and asiaticoside) content should not be less than 40%.
The preparation of Fructus Amomi extract:
Get the Fructus Amomi medical material be up to the standards, removing impurity, pulverizes, is placed in multi-function extractor, adds 8 times amount water boils and extracts 1.5h, extracting liquid filtering, and medicinal residues add 6 times amount water boils and extract 1h, and extracting liquid filtering, filtrate is for subsequent use.Merge extracted twice filtrate, in outer circulation concentrator, vacuum is 0.04-0.08MPa, and temperature is 60-80 DEG C, is concentrated into proportion 1.06-1.14.Concentrated solution centrifuge, extracting centrifugal liquid is for subsequent use.Get qualified centrifugal liquid, dry to spray dryer after adding appropriate maltodextrin mix homogeneously, spray dryer inlet temperature is 180 ~ 205 DEG C, and leaving air temp is 90 ~ 105 ° of C.Get in spraying dry gained dried cream powder to built-in 80 order pulverizers and pulverize, cross 80 orders, mix 50min in gained fine powder to mixer, mixed fine powder is as final Fructus Amomi extract.This extract principal character is that Fructus Amomi polyoses content should not be less than 40% with glucose meter.
Detailed description of the invention
Concrete steps of the present invention are described by the following examples, but do not limit by embodiment.
Term used in the present invention, except as otherwise noted, generally has the implication that those of ordinary skill in the art understand usually.
Below in conjunction with specific embodiment and comparable data describes in further detail the present invention.Should be understood that these embodiments just in order to demonstrate the invention, but not limit the scope of the invention by any way.
In the examples below, the various process do not described in detail and method are conventional methods as known in the art.
Below in conjunction with specific embodiment, the present invention is further described.
Embodiment 1: the preparation of Hericium erinaceus (Bull. Ex Fr.) Pers. extract, Herba Centellae extract, Fructus Amomi extract
The preparation of Hericium erinaceus (Bull. Ex Fr.) Pers. extract:
Get the crude Hericium be up to the standards, removing impurity, cleans, and pulverizes, puts in multi-function extractor, add 8 times amount water soaking 0.5h, boils and extracts 2h, extracting liquid filtering, and medicinal residues add 7 times amount water boils and extract 1.5h.Extracting solution 200 order filters, and merges extracted twice filtrate, and concentrated to outer circulation concentrator, vacuum degree control is 0.04-0.08MPa, and temperature is 60-80 DEG C, is concentrated into proportion 1.10-1.14.Concentrated solution carries out centrifugal, centrifugal liquid add that maltodextrin amount is total solid 30%, dry to spray dryer, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 ° of C.Get spraying dry gained dried cream powder and pulverized 80 mesh sieves, after mixing 50min in gained fine powder to mixer, obtain final Hericium erinaceus (Bull. Ex Fr.) Pers. extract.
The preparation of Herba Centellae extract:
Get the Herba Centellae medical material be up to the standards, be placed in multi-function extractor, add 8 times amount volume 70% ethanol and leave standstill 0.5h, reflux, extract, 2.0h, extracting liquid filtering, medicinal residues add 7 times amount 70% alcohol reflux 1.5h, extracting liquid filtering.Merge extracted twice filtrate, in single-effect external circulation concentrator, concentration and recovery ethanol, vacuum is 0.04-0.08MPa, and temperature is 60-70 DEG C, is concentrated into without alcohol taste, and adding suitable quantity of water to relative density is 1.02-1.05.The feed liquid of having diluted is carried out column chromatography, and feed liquid upper prop flow speed control is 1.5-2.0L/min, and resin adopts model D101 macroporous adsorbent resin.Water elution (flow velocity 2.0-3.0L/min) to the fluid five colors, then carries out eluting roguing by 10% ethanol 1 times amount, and resolve by the ethanol 2-3 times amount of 60% after eluting, flow speed control is 1.2-1.5L/min.To get in ethanol desorbed solution to single-effect external circulation concentrator concentrated, reclaim ethanol, vacuum is 0.04-0.08MPa, and temperature is 60-70 DEG C, is concentrated into without alcohol taste, and adding suitable quantity of water, to be concentrated into relative density be between 1.06-1.10.Get in concentrated solution to spray dryer dry, spray dryer inlet temperature is 180-205 DEG C, and leaving air temp is 90-105 DEG C.Get in spraying dry gained dried cream powder to built-in 100 order pulverizers and pulverize, get the fine powder after pulverizing and cross 100 orders, mix 50-60min in gained fine powder to mixer, mixed fine powder is as final Herba Centellae extract.
The preparation of Fructus Amomi extract:
Get the Fructus Amomi medical material be up to the standards, removing impurity, pulverizes, is placed in multi-function extractor, adds 8 times amount water boils and extracts 1.5h, extracting liquid filtering, and medicinal residues add 6 times amount water boils and extract 1h, and extracting liquid filtering, filtrate is for subsequent use.Merge extracted twice filtrate, in outer circulation concentrator, vacuum is 0.04-0.08MPa, and temperature is 60-80 DEG C, is concentrated into proportion 1.06-1.14.Concentrated solution centrifuge, extracting centrifugal liquid is for subsequent use.Get qualified centrifugal liquid, dry to spray dryer after adding appropriate maltodextrin mix homogeneously, spray dryer inlet temperature is 180 ~ 205 DEG C, and leaving air temp is 90 ~ 105 ° of C.Get in spraying dry gained dried cream powder to built-in 80 order pulverizers and pulverize, cross 80 orders, mix 50min in gained fine powder to mixer, mixed fine powder is as final Fructus Amomi extract
Embodiment 2:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 33 parts, Herba Centellae extract 33 parts, Fructus Amomi extract 33 parts.
Embodiment 3:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 80 parts, Herba Centellae extract 10 parts, Fructus Amomi extract 10 parts.
Embodiment 4:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10 parts, Herba Centellae extract 45 parts, Fructus Amomi extract 45 parts.
Embodiment 5:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 45 parts, Herba Centellae extract 45 parts, Fructus Amomi extract 10 parts.
Embodiment 6:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10 parts, Herba Centellae extract 80 parts, Fructus Amomi extract 10 parts.
Embodiment 7:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10 parts, Herba Centellae extract 10 parts, Fructus Amomi extract 80 parts.
Embodiment 8:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 45 parts, Herba Centellae extract 10 parts, Fructus Amomi extract 45 parts.
Embodiment 9:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 90 parts, Herba Centellae extract 10 parts.
Embodiment 10:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 50 parts, Herba Centellae extract 50 parts.
Embodiment 11:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10 parts, Herba Centellae extract 90 parts.
Embodiment 12:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 90 parts, Fructus Amomi extract 10 parts.
Embodiment 13:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 50 parts, Fructus Amomi extract 50 parts.
Embodiment 14:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10 parts, Fructus Amomi extract 90 parts.
Embodiment 15:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Herba Centellae extract 90 parts, Fructus Amomi extract 10 parts.
Embodiment 16:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Herba Centellae extract 50 parts, Fructus Amomi extract 50 parts.
Embodiment 17:
A kind of Chinese medicine extract combination with protection gastric mucosa function, containing, for example lower weight portion: Herba Centellae extract 10 parts, Fructus Amomi extract 90 parts.
Embodiment 18:
Auxiliary protection function-comparing animals experiment is had to mucosal lesion.
Experiment material: Hericium erinaceus (Bull. Ex Fr.) Pers. extract, Herba Centellae extract, Fructus Amomi extract (embodiment 1 is prepared and obtains); The extractive composition of embodiment 2-17; Formaldehyde, dehydrated alcohol, chloral hydrate, glacial acetic acid (analytical pure) is provided by Xi Long Chemical Co., Ltd.; Pure water.
Laboratory animal: SD male rat (body weight 180-220g) is provided by Qinglongshan animal feeding center, Nanjing.
Dosage choice: after taking the Hericium erinaceus (Bull. Ex Fr.) Pers. extract of respective quality, Herba Centellae extract, Fructus Amomi extract mixing respectively according to the extract combination ratio described in embodiment 2 to embodiment 17, add pure water dilution to dissolve, after abundant mixing, be made into the solution of 20mg/ml, put into the preservation of 4 DEG C, refrigerator, according to the dosed administration of rat body weight 200mg/kg.
Experimental technique: adopt indometacin acute gastric mucosal injury modelling
Get SD rat 184, be divided into 23 groups at random, often organize 8, be respectively Normal group (normal saline replacement indometacin), model control group (normal saline 5ml/kg), Hericium erinaceus (Bull. Ex Fr.) Pers. group (Hericium erinaceus (Bull. Ex Fr.) Pers. extract 200mg/kg), Fructus Amomi group (Fructus Amomi extract 200mg/kg), Herba Centellae group (Herba Centellae extract 200mg/kg) and proportion optimizing group (different ratio mixture 200mg/kg).Every day gavage extract 1 time, continuous gavage 2 weeks, after last gavage, allows rat go on a hunger strike but the 19h that feeds water, and finally gives indometacin 5mg/kg (wiring solution-forming 0.5mg/ml, gavage), makes indometacin gastric mucosa injury model.Animal is put to death after 5h, to cut open the belly ligation cardia and pylorus, get stomach in 10% formalin, to fix 20 minutes tailing edge greater gastric curvatures cut open, measure the area (being accurate to 0.01mm) of the congested or hemorrhage band of dispersivity of the strip of glandular stomach district mucosa with slide gauge, calculate ulcer inhibition rate.
Ulcer inhibition rate (%)=[(model control group ulcer area average-tested material group ulcer area average)/model control group ulcer area average] × 100% statistical analysis statistical result is all with average ± standard deviation ± s) represent, multiple experimental group mean compares with a matched group mean with adopting SPSS 16.0 software to carry out ANOVA analysis, with P<0.05 for there being statistical significance.
Experimental result:
Table 1: Hericium erinaceus (Bull. Ex Fr.) Pers./Herba Centellae/Fructus Amomi three compositions on the impact of experimental rat acute gastric mucosal lesion caused by indometacin (
n=8)
| Group | Dosage (mg/kg) | Ulcer index (mm 2) | Ulcer inhibition rate (%) |
| Normal group | —— | 0 | NA |
| Model control group | —— | 22.21±0.98 | NA |
| Hericium erinaceus (Bull. Ex Fr.) Pers. | 200 | 6.06±0.55 | 72.73±2.47 |
| Herba Centellae | 200 | 11.6±0.31 | 47.77±1.41 |
| Fructus Amomi | 200 | 14.65±0.15 | 34.02±0.68 |
| Embodiment 2 | 200 | 12.03±1.99 | 45.81±8.94 |
| Embodiment 3 | 200 | 0.48±0.15 | 97.83±0.68 |
| Embodiment 4 | 200 | 7.80±1.06 | 64.88±4.75 |
| Embodiment 5 | 200 | 2.99±0.63 | 86.54±2.82 |
| Embodiment 6 | 200 | 7.61±0.45 | 65.73±2.02 |
| Embodiment 7 | 200 | 4.61±0.25 | 79.23±1.17 |
| Embodiment 8 | 200 | 3.08±0.80 | 86.13±3.62 |
Above result can be found out, tested material obviously can reduce the mucosal lesion that indometacin causes, and suppresses the formation of ulcer.Embodiment 2-8 be the different ratio of Hericium erinaceus (Bull. Ex Fr.) Pers./Herba Centellae/Fructus Amomi three taste Chinese medicine to gastric mucosa injury, wherein embodiment 3 has best gastric mucosa auxiliary protection function, the strongest to ulcer inhibitory action.In embodiment 5 and 8, the ratio combination of three taste Chinese medicines also all serves obvious synergy.
Table 2: Hericium erinaceus (Bull. Ex Fr.) Pers./Herba Centellae/Fructus Amomi combination of two on the impact of experimental rat acute gastric mucosal lesion caused by indometacin (
n=8)
| Group | Dosage (mg/kg) | Ulcer index (mm 2) | Ulcer inhibition rate (%) |
| Normal group | —— | 0 | NA |
| Model control group | —— | 30.76±2.471 | NA |
| Embodiment 9 | 200 | 13.43±3.707 | 56.34±12.05 |
| Embodiment 10 | 200 | 10.65±3.767 | 65.37±12.25 |
| Embodiment 11 | 200 | 18.69±6.766 | 39.23±22.00 |
| Embodiment 12 | 200 | 17.37±3.185 | 43.54±10.35 |
| Embodiment 13 | 200 | 12.88±4.704 | 58.12±15.29 |
| Embodiment 14 | 200 | 11.81±2.054 | 50.11±17.11 |
| Embodiment 15 | 200 | 15.15±2.438 | 50.74±7.925 |
| Embodiment 16 | 200 | 18.83±3.117 | 38.79±10.13 |
| Embodiment 17 | 200 | 18.06±4.356 | 41.28±14.16 |
Above result can be found out, the therapeutic effect difference of three taste Chinese medicine combination of two and one-component is little, synergism is not obvious especially, can find out, although one-component can be used in the treatment of gastric ulcer under prior art, how improve therapeutic effect and there is no rule by combinationally using and can follow.Three taste Chinese medicines are carried out combining rear discovery compositions by the present invention can reduce mucosal lesion, suppresses the formation of ulcer.Particularly embodiment 3,5,8 has better gastric mucosa auxiliary protection function, the strongest to the inhibitory action of ulcer, has good synergistic therapeutic effect.
Claims (9)
1. one kind has the Chinese medicine extract combination of protection gastric mucosa function, it is characterized in that comprising following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 10-90 part, Herba Centellae extract 10-90 part.
2. Chinese medicine extract combination according to claim 1, is characterized in that also comprising: Fructus Amomi extract 10-90 part.
3. Chinese medicine extract according to claim 2 combination, is characterized in that comprising following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 20-90 part, Herba Centellae extract 10-50 part, Fructus Amomi extract 10-50 part.
4. Chinese medicine extract according to claim 3 combination, is characterized in that comprising following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 30-50 part, Herba Centellae extract 30-50 part, Fructus Amomi extract 10-20 part.
5. Chinese medicine extract according to claim 3 combination, is characterized in that comprising following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 70-90 part, Herba Centellae extract 10-20 part, Fructus Amomi extract 10-20 part.
6. Chinese medicine extract according to claim 3 combination, is characterized in that comprising following weight portion: Hericium erinaceus (Bull. Ex Fr.) Pers. extract 30-50 part, Herba Centellae extract 10-20 part, Fructus Amomi extract 30-50 part.
7. the application that Chinese medicine extract is combined in preparation prevention or treats in gastropathy medicine or health product as described in one of claim 1-6 item.
8. application according to claim 7, is characterized in that described gastropathy is the disease relevant with mucosal lesion.
9. application according to claim 8, is characterized in that described gastropathy comprises acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, polyp of stomach, gastric calculus, the innocent and malignant tumour of stomach, prolapse of gastric mucosa, acute gastric dilatation or pyloric obstruction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510321250.XA CN104940258B (en) | 2015-06-11 | 2015-06-11 | A kind of Chinese medical extract combination with protection stomach lining function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510321250.XA CN104940258B (en) | 2015-06-11 | 2015-06-11 | A kind of Chinese medical extract combination with protection stomach lining function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104940258A true CN104940258A (en) | 2015-09-30 |
| CN104940258B CN104940258B (en) | 2018-09-14 |
Family
ID=54155692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510321250.XA Expired - Fee Related CN104940258B (en) | 2015-06-11 | 2015-06-11 | A kind of Chinese medical extract combination with protection stomach lining function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104940258B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456550A (en) * | 2015-12-14 | 2016-04-06 | 北京威力格生物科技有限公司 | Compound for preventing and treating gastric mucosal damage as well as preparation method and application of compound |
| CN105832905A (en) * | 2016-04-29 | 2016-08-10 | 李佃贵 | Hot-compressing traditional Chinese medicine for treating chronic gastritis |
| CN106924640A (en) * | 2017-04-27 | 2017-07-07 | 吴林宜 | A kind of Hericium erinaceus nourishing the stomach ball and preparation method thereof |
| CN110897162A (en) * | 2019-11-26 | 2020-03-24 | 浙江省农业科学院 | Stomach-protecting composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088110A (en) * | 1993-05-10 | 1994-06-22 | 李文升 | Chinese medicine atomic powder for clearing lump in abdomen and manufacture method |
| KR20140078994A (en) * | 2012-12-18 | 2014-06-26 | 좋은먹거리영농조합법인 | Composition for Preventing or Treating Gastritis and Gastric Ulcer Comprising Opuntia Humifusa Removed Cell Wall Components |
-
2015
- 2015-06-11 CN CN201510321250.XA patent/CN104940258B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088110A (en) * | 1993-05-10 | 1994-06-22 | 李文升 | Chinese medicine atomic powder for clearing lump in abdomen and manufacture method |
| KR20140078994A (en) * | 2012-12-18 | 2014-06-26 | 좋은먹거리영농조합법인 | Composition for Preventing or Treating Gastritis and Gastric Ulcer Comprising Opuntia Humifusa Removed Cell Wall Components |
Non-Patent Citations (3)
| Title |
|---|
| 凌关庭: "《保健食品原料手册》", 31 May 2007 * |
| 施之琪等: "积雪草总苷抗乙酸致大鼠胃溃疡的研究", 《中国实验方剂学杂志》 * |
| 龚仕明等: "《胃病患者吃什么》", 30 June 2004 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456550A (en) * | 2015-12-14 | 2016-04-06 | 北京威力格生物科技有限公司 | Compound for preventing and treating gastric mucosal damage as well as preparation method and application of compound |
| CN105456550B (en) * | 2015-12-14 | 2019-10-25 | 北京威力格生物科技有限公司 | Gastric mucosa damage prophylactic treatment compound and the preparation method and application thereof |
| CN105832905A (en) * | 2016-04-29 | 2016-08-10 | 李佃贵 | Hot-compressing traditional Chinese medicine for treating chronic gastritis |
| CN106924640A (en) * | 2017-04-27 | 2017-07-07 | 吴林宜 | A kind of Hericium erinaceus nourishing the stomach ball and preparation method thereof |
| CN110897162A (en) * | 2019-11-26 | 2020-03-24 | 浙江省农业科学院 | Stomach-protecting composition and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104940258B (en) | 2018-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102784363B (en) | Traditional Chinese medicine composition for treating pancreatic cancer and preparation method thereof | |
| CN105166544A (en) | Pig mixed feed and preparation method thereof | |
| CN104068279A (en) | Sea eel compound feed and preparation method thereof | |
| CN104940258A (en) | Traditional Chinese medicine extractive composition with gastric mucosa protecting function | |
| CN105166545A (en) | Bovine compound feed and preparation method thereof | |
| CN103721103A (en) | Medicine for treating swine erysipelas and preparation method thereof | |
| CN103689748B (en) | One has adjustment intestines and stomach function, the anti-washing drink treated constipation | |
| CN105028995A (en) | Mixed dog food and preparation method thereof | |
| KR20200081553A (en) | Composition for the prevention and improvement of Antitussive and Expectorant | |
| CN105214032A (en) | The solid dispersion tablet for the treatment of peptic ulcer | |
| CN104434950B (en) | A kind of Cortex Eucommiae targeting preparation for the treatment of colon cancer and preparation method thereof | |
| CN105214037A (en) | The solid dispersal capsule for the treatment of peptic ulcer | |
| CN103948899A (en) | Traditional Tibetan medicine for treating atrophic gastritis | |
| CN104707008B (en) | A kind of composite drug and preparation method for preventing chickens respiratory disease | |
| CN115414427B (en) | Traditional Chinese medicine composition for treating chronic skin pruritus and preparation method and application thereof | |
| KR20180112561A (en) | Composition for preventing, improving or treating fatty liver diseases, hyperlipidemia and constipation comprising Phragmitis Rhizoma and Humulus japonicus extract | |
| CN106668704A (en) | Hui-nationality traditional Chinese medicine aralia root bark granules for treating gastric cancer and preparation method thereof | |
| CN111789903A (en) | Pharmaceutical composition for treating urethral cancer and preparation method thereof | |
| CN104305196A (en) | Composition for clearing heat and cooling blood and preparation method thereof | |
| CN114699496A (en) | Traditional Chinese medicine compound, preparation method and application thereof in chicken adenofibromyositis | |
| CN115607646A (en) | Composition for treating recurrent oral ulcer and chronic pharyngolaryngitis and preparation method thereof | |
| CN106620106A (en) | Traditional Chinese medicine composition for treating diarrhea of livestock and poultry and preparation method thereof | |
| CN106668746A (en) | Hui-nationality traditional Chinese medicine rhizoma curcumae and herba sarcandrae granules for treating leukemia and preparation method thereof | |
| CN106668540A (en) | Hui nationality traditional Chinese medicine cordyceps sinensis blood cancer rehabilitation tablet and preparation method thereof | |
| CN106668536A (en) | Hui-nationality traditional Chinese medicine caterpillar fungus granules for treating leukemia and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180914 Termination date: 20190611 |