CN110897162A - Stomach-protecting composition and preparation method and application thereof - Google Patents
Stomach-protecting composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN110897162A CN110897162A CN201911175689.0A CN201911175689A CN110897162A CN 110897162 A CN110897162 A CN 110897162A CN 201911175689 A CN201911175689 A CN 201911175689A CN 110897162 A CN110897162 A CN 110897162A
- Authority
- CN
- China
- Prior art keywords
- parts
- stomach
- protecting
- composition
- gastric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 210000001156 gastric mucosa Anatomy 0.000 claims abstract description 28
- 241000233866 Fungi Species 0.000 claims abstract description 27
- 240000000588 Hericium erinaceus Species 0.000 claims abstract description 24
- 235000007328 Hericium erinaceus Nutrition 0.000 claims abstract description 24
- 230000002633 protecting effect Effects 0.000 claims abstract description 22
- 241001149422 Ganoderma applanatum Species 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 15
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 15
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 15
- 239000011425 bamboo Substances 0.000 claims abstract description 15
- 241000123113 Phellinus igniarius Species 0.000 claims abstract description 10
- 241000264877 Hippospongia communis Species 0.000 claims abstract description 4
- 210000002784 stomach Anatomy 0.000 claims description 20
- 235000013305 food Nutrition 0.000 claims description 19
- 241001330002 Bambuseae Species 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 230000002496 gastric effect Effects 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 235000013402 health food Nutrition 0.000 claims description 4
- 241000589902 Leptospira Species 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 235000003599 food sweetener Nutrition 0.000 claims description 3
- 239000007902 hard capsule Substances 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 239000003765 sweetening agent Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000004067 bulking agent Substances 0.000 claims description 2
- 239000007884 disintegrant Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 241000221020 Hevea Species 0.000 claims 1
- 229920003211 cis-1,4-polyisoprene Polymers 0.000 claims 1
- 230000002178 gastroprotective effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract description 17
- 201000005917 gastric ulcer Diseases 0.000 abstract description 15
- 241000700159 Rattus Species 0.000 abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 244000082204 Phyllostachys viridis Species 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 description 13
- 231100000397 ulcer Toxicity 0.000 description 12
- 230000006378 damage Effects 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 208000007882 Gastritis Diseases 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 230000001681 protective effect Effects 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 235000014347 soups Nutrition 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 230000027119 gastric acid secretion Effects 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000007126 Codonopsis pilosula Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 241000221781 Hypocreaceae Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 2
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241000173529 Aconitum napellus Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- 206010055000 Bromhidrosis Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001166994 Kummerowia striata Species 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010034038 Parotitis Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241001149558 Trichoderma virens Species 0.000 description 1
- 241000256618 Trichogramma Species 0.000 description 1
- 241000001727 Tropicoporus linteus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000009858 acid secretion Effects 0.000 description 1
- 229940023019 aconite Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000002318 cardia Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 235000021222 fish soup Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 235000020997 lean meat Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004682 mucosal barrier function Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000005982 spleen dysfunction Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000005985 stomach dysfunction Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 235000021147 sweet food Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a stomach-protecting composition and a preparation method and application thereof, wherein the stomach-protecting composition is prepared from the following raw materials in parts by weight: 30-50 parts of hericium erinaceus; 10-20 parts of bamboo fungi; 3-5 parts of radix tetrastigme; 10-20 parts of crude honeycomb fungus; 10-15 parts of Ganoderma applanatum; 20-30 parts of phellinus igniarius. The components of the stomach-protecting composition have outstanding synergistic effect for protecting gastric mucosa, and experimental results show that the stomach-protecting composition has good protection effect on gastric ulcer of rats caused by ethanol.
Description
Technical Field
The invention relates to a stomach-protecting composition and a preparation method and application thereof.
Background
The entire inner surface of the stomach is covered with a layer of mucosal tissue that secretes the mucus, which forms the stomach-a mucosal barrier that protects the stomach tissue. The stomach is mainly subjected to rotten and cooked food, and the main reasons for stomach mucosa damage are two types: firstly, the symptoms of improper diet, hunger and satiety, or overeating, fat and sweet food, indigestion, qi obstruction, spleen dysfunction and stomach dysfunction are caused; the other is caused by worry, anger, liver-qi disorder and transverse adversity invading stomach. The injury of gastric mucosa will cause gastritis, gastric ulcer and other diseases.
Preventing the damage of the gastric mucosa, protecting the gastric mucosa and being more expensive than 'nourishing', and proper dietary content and good dietary habits are important measures for preventing and treating the damage of the gastric mucosa. The diet, which has a strong stimulation to the gastric mucosa, should be restricted and the gastric function should be regulated by reducing or increasing the secretion of gastric acid by the diet. Generally, the gastric mucosa is used as a protective film of the stomach of a human body, which is not only beneficial to digestion, but also can play a good role in protection. The protection of the gastric mucosa can be realized by daily diet. For patients with hypogastric acid secretion or deficiency, food such as concentrated fish soup, chicken soup, and mushroom soup containing nitrogen-rich extract can be administered to stimulate gastric acid secretion. Patients with excessive gastric acid secretion should avoid the above raw juice thick soup, the use of lean meat, fish, chicken, lotus root starch, light tea, various sweet cooked fruits, thick rice soup, rice porridge, etc. which are removed from the raw soup after cooking, to reduce gastric acid secretion, and eat fresh milk, soybean milk, and dried steamed bread with alkali to neutralize gastric acid.
At present, the medicines clinically used for treating more serious gastric mucosa injury are mainly anti-inflammatory and analgesic medicines, and the medicines can only relieve stomachache, cannot give consideration to acute and chronic diseases, and treat the symptoms but not the root cause.
Chinese patent document CN104840510A discloses a composition for protecting gastric mucosa, the active ingredients of the composition are prepared from the following raw materials in parts by weight: 55-85 parts of hericium erinaceus, 44-131 parts of poria cocos, 37-83 parts of astragalus membranaceus and 36-93 parts of codonopsis pilosula.
Chinese patent document CN110115356A discloses a composition for enhancing immunity and protecting gastric mucosa, which comprises, by weight, 160 parts of hericium erinaceus extract 140-.
Chinese patent document CN105561132A discloses a traditional Chinese medicine composition with the function of protecting gastric mucosa, which is prepared from the following raw materials: 1000-2500 parts of hericium erinaceus, 150-500 parts of codonopsis pilosula, 100-400 parts of bighead atractylodes rhizome, 100-400 parts of rhizoma bletillae and 50-300 parts of fructus amomi.
The final effect of the composition formula has certain function of protecting gastric mucosa. However, the synergy between the individual components is not obvious or significant.
Disclosure of Invention
In view of the above, the present invention aims to provide a stomach protecting composition with outstanding synergistic effect between components for protecting gastric mucosa, and a preparation method and applications thereof.
The adopted technical scheme is as follows:
in a first aspect, the stomach-protecting composition is prepared from the following raw materials in parts by weight:
30-50 parts of hericium erinaceus;
10-20 parts of bamboo fungi;
3-5 parts of radix tetrastigme;
10-20 parts of crude honeycomb fungus;
10-15 parts of Ganoderma applanatum;
20-30 parts of phellinus igniarius.
And (3) hericium erinaceus: sweet and neutral in nature, enter spleen and stomach meridians. Has anticancer, spleen invigorating, stomach nourishing, tranquilizing, antiinflammatory, blood sugar lowering, and blood lipid reducing effects. It can be used for treating asthenia, dyspepsia, insomnia, gastric ulcer, chronic gastritis, and digestive tract tumor. The anti-ulcer effect is mainly proved by a pepsin inhibition adsorption experiment, and the action mechanism of the hericium erinaceus for treating gastric ulcer is proved. The hericium erinaceus is used as a main component for protecting gastric mucosa in the formula of the stomach-protecting composition.
Bamboo fungus: the name of the traditional Chinese medicine. Is a stroma of Hypocrea virens (Hypocreaceae) of Hypocreaceae. Distributed in Sichuan, Yunnan, Tibet, etc. Has the effects of clearing away heat and toxic materials. Can be used for treating pharyngolaryngitis, tonsillitis, parotitis, gastritis, gastric ulcer, nephritis, and innominate toxic swelling. The bamboo fungus also has the function of protecting gastric mucosa in the formula of the stomach-protecting composition, and can be synergically used with hericium erinaceus to protect the gastric mucosa.
Radix tetrastigme: the radix tetrastigme is a grapevine plant, the root tuber of the radix tetrastigme is named as snake aconite, also called as the flat leaf of Japanese clover, golden silk hanging gourd and the like, the radix tetrastigme or the whole herb is used as a medicine, the radix tetrastigme is a common Chinese herbal medicine for folk, has the functions of resisting virus, resisting inflammation, easing pain, relieving heat, protecting liver and the like, has small toxic and side effects, is a plant antibiotic which can not be replaced by western medicines, and has been widely applied to resisting cancer, resisting AIDS virus and other diseases clinically. The radix tetrastigme can restore the gastrointestinal function, and is also a gastric mucosa protective agent in the formula of the stomach protecting composition, so that the radix tetrastigme and hericium erinaceus can be synergically used for protecting the gastric mucosa.
And (3) honeycombed fungi: regulate qi to alleviate pain, invigorate stomach. Primary epigastric pain; dyspepsia is caused. Can be used for treating digestive system tumor in gastrointestinal tract. The trichogramma has the stomach invigorating effect, namely the stomach mucosa is protected, so that the stomach mucosa can be protected by synergy with hericium erinaceus in the formula of the stomach protecting composition.
Ganoderma applanatum: slightly bitter and mild. Has antitumor, liver protecting, antiinflammatory, antiviral, blood sugar lowering, and blood pressure regulating effects, and can be used for treating pharyngolaryngitis, hepatitis, gastritis, gastric ulcer, esophageal cancer, nasopharyngeal carcinoma, etc. Ganoderma applanatum has functions of treating gastritis and gastric ulcer, so in the formula of the stomach-protecting composition, the Ganoderma applanatum and Hericium erinaceus can be synergistic to protect gastric mucosa.
Leptospira pellucida: inhibiting tumor, treating bromhidrosis, stopping bleeding, treating gastritis, gastric ulcer, and treating leprosy. The microporous thin-skin bacterium has the functions of treating gastritis and gastric ulcer, so that the stomach protecting composition can be synergically used with hericium erinaceus to protect gastric mucosa in the formula.
As can be seen, the 6 components have the function or effect of protecting the gastric mucosa, so that the components have outstanding synergistic effect on protecting the gastric mucosa, and no side effect is found.
Furthermore, the meshes of Hericium erinaceus, bamboo fungus, radix Apioris Fortunei, Mollungiella, Ganoderma Applanatum and Leptospira gracilis are all no less than 500 meshes.
Further, the stomach-protecting composition is prepared from the following raw materials in parts by weight:
40 parts of hericium erinaceus;
15 parts of bamboo fungus;
4 parts of radix tetrastigme;
15 parts of crude beehive fungus;
12 parts of Ganoderma applanatum;
and 25 parts of phellinus igniarius.
In a second aspect, the present invention provides a method for preparing a stomach-protecting composition, comprising the steps of:
s1, respectively crushing raw materials of hericium erinaceus, bamboo fungi, radix tetrastigme, hairy beehive fungi, ganoderma applanatum and phellinus igniarius into powder with the mesh number of more than or equal to 500 meshes.
S2, mixing the crushed raw materials in the S1 according to a ratio, and then putting the mixture into an extraction kettle for supercritical CO2 extraction, wherein a supercritical CO2 fluid is used as an extraction solvent, the extraction pressure is 40-45Mpa, the extraction temperature is 50-70 ℃, and the CO2 flow is 20-25L/h, so that an extraction liquid and residues are obtained;
s3, decocting the residue obtained in the step S2 with water for 2-4 times, each time for 1-2h, filtering, combining the filtrates, and concentrating to obtain a water extract;
s4, uniformly mixing the extract obtained in the step S2 with the water extract obtained in the step S3 to obtain the stomach-protecting composition.
In a third aspect, the invention provides application of the stomach-protecting composition in preparing food or health-care products for protecting gastric mucosa.
A food is prepared from the stomach-protecting composition of the scheme.
A food is prepared from the stomach-protecting composition of the scheme and auxiliary materials acceptable to foods.
Further, the auxiliary materials acceptable on the food comprise one or more of flavoring agent, sweetening agent, bulking agent, coating material, lubricating agent and disintegrating agent.
Further, the food is in a dosage form selected from tablets, powders, granules, soft capsules or hard capsules.
A health product is prepared from the stomach-protecting composition and auxiliary materials acceptable for health food.
In conclusion, the stomach-protecting composition, the food and the health-care product have the outstanding function of protecting the gastric mucosa by synergistic interaction.
Drawings
FIG. 1 is a graph showing the results of the test of the protective effect (visual observation) of the model control group of example 4 on gastric ulcer in rats induced by absolute ethanol.
FIG. 2 is a graph showing the results of experiments on the protective effect (visual observation) of ranitidine hydrochloride on gastric ulcer of rats caused by absolute ethanol in example 4.
FIG. 3 is a graph of the results of a low dose group of the composition of example 4 on the protection of gastric ulcers in rats induced by absolute ethanol (visual observation).
FIG. 4 is a graph of the results of a dose group in the composition of example 4 demonstrating the protective effect (visual observation) of gastric ulcers in rats induced by absolute ethanol.
FIG. 5 is a graph showing the results of experiments conducted on the protective effect (visual observation) of the high dose group of the composition of example 4 on gastric ulcer in rats induced by absolute ethanol.
Detailed Description
The present invention is described in detail below with reference to specific examples, but the use and purpose of these exemplary embodiments are merely to exemplify the present invention, and do not set forth any limitation on the actual scope of the present invention in any form, and the scope of the present invention is not limited thereto.
Example 1
A stomach-protecting composition is prepared from the following raw materials in parts by weight:
30 parts of hericium erinaceus;
10 parts of bamboo fungus;
3 parts of radix tetrastigme;
10 parts of crude beehive fungus;
10 parts of Ganoderma applanatum;
20 parts of phellinus linteus.
The preparation method of the stomach-protecting composition comprises the following steps:
s1, respectively crushing raw materials of hericium erinaceus, bamboo fungi, radix tetrastigme, hairy beehive fungi, ganoderma applanatum and phellinus igniarius into powder with the mesh number of more than or equal to 500 meshes.
S2, mixing the crushed raw materials in the step S1Mixing, loading into extraction kettle, and supercritical CO2Extracting with supercritical CO2Fluid is extraction solvent, extraction pressure is 40-45Mpa, extraction temperature is 50-70 deg.C, and CO is added2The flow rate is 20-25L/h, and extract liquor and residue are obtained;
s3, decocting the residue obtained in the step S2 with water for 2-4 times, each time for 1-2h, filtering, combining the filtrates, and concentrating to obtain a water extract;
s4, uniformly mixing the extract obtained in the step S2 with the water extract obtained in the step S3 to obtain the stomach-protecting composition.
Example 2
Referring to example 1, the difference from example 1 is that the stomach-protecting composition of this example is prepared from the following raw materials in parts by weight:
40 parts of hericium erinaceus;
15 parts of bamboo fungus;
4 parts of radix tetrastigme;
15 parts of crude beehive fungus;
12 parts of Ganoderma applanatum;
and 25 parts of phellinus igniarius.
Example 3
Referring to example 1, the difference from example 1 is that the stomach-protecting composition of this example is prepared from the following raw materials in parts by weight:
50 parts of hericium erinaceus;
20 parts of bamboo fungus;
5 parts of radix tetrastigme;
20 parts of crude honeycomb fungus;
15 parts of Ganoderma applanatum;
and 30 parts of phellinus igniarius.
Example 4
Animal experiments:
1. animal grouping, modeling and administration
50 SD rats weighing 150-. Rats were fasted without water (about 24h) starting 1 day before the last administration and 1.5h after the last administration, and a model of acute gastric mucosal injury was prepared by gavage with 1 ml/stomach of absolute ethanol. After 1.5h, the rats were sacrificed, the abdominal cavity was opened and the pylorus and cardia were ligated, 5mL of 1% formaldehyde solution was injected into the gastric cavity, the stomach was taken out and immersed in 1% formaldehyde solution, the gastric wall was cut open along the greater curvature of the stomach after 30min, flattened, washed, and the degree of gastric mucosal injury was visually observed.
2. Observation of indices
Calculating the gastric mucosa ulcer index and the ulcer inhibition rate according to Guth integral standard, and accumulating the integral according to the lengths of erosion, ulcer, bleeding and the like limited to the gastric epithelium, wherein the normal score is 0, and the punctate bleeding score is 1; linear bleeding, wherein the length is less than 1mm and is counted for 2 minutes, the length is 1-2 mm and is counted for 3 minutes, the length is 2-4 mm and is counted for 4 minutes, and the length is more than 4mm and is counted for 5 minutes; the value is doubled when the width is larger than 2mm, the values are added to be the total damage index of the animal, and the average value of each group is used as the ulcer index of the group. The ulcer inhibition rate was calculated according to the following formula: ulcer inhibition ratio (%) (ulcer index of model group-ulcer index of administration group)/ulcer index of model group × 100%.
3. Results
Compared with a model group, the gastric ulcer index of the rat in the high-dose composition group is obviously reduced (P is less than 0.001), the ethanol type gastric mucosa injury of the rat can be obviously inhibited, and the ulcer inhibition rate is 71.43%; compared with a model control group, the gastric ulcer indexes of rats in the medium and low dose groups are also reduced to a certain degree, the ulcer inhibition rates are respectively 43.68% and 54.84%, the effect is better than that of ranitidine hydrochloride capsules, and the specific results are shown in table 1 and figures 1-5.
Table 1 effect of composition on gastric mucosal ulcer index and ulcer inhibition (x ± s, n ═ 10)
Note: p <0.001 (compared to model control group)
4. Conclusion
Under the test conditions, the stomach-protecting composition of example 2 has a good protective effect on the gastric ulcer of the rats caused by ethanol.
Example 5
The stomach-protecting composition of example 2 was added with a coating material, a corrigent, a sweetener and a disintegrant to prepare a hard capsule as a food.
Example 6
The stomach-protecting composition of example 2 is added with an auxiliary material acceptable for health food to prepare a tablet as a health food.
The auxiliary materials acceptable on the health-care food are selected and added according to the auxiliary materials available for health-care food record products and the use regulations thereof (2019) published by the general office of market supervision.
The above-listed detailed description is only a specific description of a possible embodiment of the present invention, and they are not intended to limit the scope of the present invention, and equivalent embodiments or modifications made without departing from the technical spirit of the present invention should be included in the scope of the present invention.
Claims (10)
1. The stomach-protecting composition is characterized by being prepared from the following raw materials in parts by weight:
30-50 parts of hericium erinaceus;
10-20 parts of bamboo fungi;
3-5 parts of radix tetrastigme;
10-20 parts of crude honeycomb fungus;
10-15 parts of Ganoderma applanatum;
20-30 parts of phellinus igniarius.
2. The stomach-protecting composition according to claim 1, wherein the mesh number of Hericium erinaceus, bamboo fungus, Hevea hemsleyana, Golomyces lanuginosus, Ganoderma applanatum and Leptospira tenuifolia is not less than 500 meshes.
3. The stomach-protecting composition according to claim 1, which is prepared from the following raw materials in parts by weight:
40 parts of hericium erinaceus;
15 parts of bamboo fungus;
4 parts of radix tetrastigme;
15 parts of crude beehive fungus;
12 parts of Ganoderma applanatum;
and 25 parts of phellinus igniarius.
4. A process for preparing a gastroprotective composition according to any one of claims 1 to 3, characterized in that it comprises the following steps:
s1, respectively crushing raw materials of hericium erinaceus, bamboo fungi, radix tetrastigme, hairy beehive fungi, ganoderma applanatum and phellinus igniarius into powder with the mesh number of more than or equal to 500 meshes.
S2, mixing the crushed raw materials in the S1 according to a ratio, and putting the mixture into an extraction kettle for supercritical CO2Extracting with supercritical CO2Fluid is extraction solvent, extraction pressure is 40-45Mpa, extraction temperature is 50-70 deg.C, and CO is added2The flow rate is 20-25L/h, and extract liquor and residue are obtained;
s3, decocting the residue obtained in the step S2 with water for 2-4 times, each time for 1-2h, filtering, combining the filtrates, and concentrating to obtain a water extract;
s4, uniformly mixing the extract obtained in the step S2 with the water extract obtained in the step S3 to obtain the stomach-protecting composition.
5. Use of the gastric care composition according to any one of claims 1 to 3 for the preparation of a food or health product for protecting gastric mucosa.
6. A food product made from the gastric care composition of any one of claims 1-3.
7. A food product made from the composition of any one of claims 1 to 3 and a food acceptable excipient.
8. The food product of claim 7, wherein the comestibly acceptable excipient comprises one or more of a flavoring agent, a sweetener, a bulking agent, a coating material, a lubricant, and a disintegrant.
9. The food product according to claim 7, wherein the food product is in a dosage form selected from the group consisting of tablets, powders, granules, soft capsules, and hard capsules.
10. A health product comprising the composition for protecting stomach of any one of claims 1 to 3 and an auxiliary acceptable in health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911175689.0A CN110897162A (en) | 2019-11-26 | 2019-11-26 | Stomach-protecting composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911175689.0A CN110897162A (en) | 2019-11-26 | 2019-11-26 | Stomach-protecting composition and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110897162A true CN110897162A (en) | 2020-03-24 |
Family
ID=69819657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911175689.0A Pending CN110897162A (en) | 2019-11-26 | 2019-11-26 | Stomach-protecting composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110897162A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956736A (en) * | 2020-08-04 | 2020-11-20 | 浙江省农业科学院 | Hypoglycemic composition mainly comprising sparassis crispa as well as preparation method and application thereof |
| CN112294936A (en) * | 2020-11-02 | 2021-02-02 | 浙江省农业科学院 | Culture medium for preparing stomach-protecting fermentation product and preparation method |
| CN114470073A (en) * | 2022-03-15 | 2022-05-13 | 朱建国 | Radix tetrastigme fried carbon powder agent for treating digestive tract ulcer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840510A (en) * | 2015-06-09 | 2015-08-19 | 天津铸源健康科技集团有限公司 | Composition used for protecting gastric mucosa and application thereof |
| CN104940258A (en) * | 2015-06-11 | 2015-09-30 | 中国药科大学 | Traditional Chinese medicine extractive composition with gastric mucosa protecting function |
| CN106071530A (en) * | 2016-06-13 | 2016-11-09 | 于汇 | Hericium erinaceus (Bull. Ex Fr.) Pers. drinks |
| CN107616398A (en) * | 2017-08-18 | 2018-01-23 | 四川岚晟生物科技有限公司 | A kind of solid beverage with nourishing stomach and spleen and preparation method thereof |
| CN109077299A (en) * | 2018-07-26 | 2018-12-25 | 黑龙江省科学院微生物研究所 | A kind of Hericium erinaceus composition and the preparation method and application thereof |
-
2019
- 2019-11-26 CN CN201911175689.0A patent/CN110897162A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840510A (en) * | 2015-06-09 | 2015-08-19 | 天津铸源健康科技集团有限公司 | Composition used for protecting gastric mucosa and application thereof |
| CN104940258A (en) * | 2015-06-11 | 2015-09-30 | 中国药科大学 | Traditional Chinese medicine extractive composition with gastric mucosa protecting function |
| CN106071530A (en) * | 2016-06-13 | 2016-11-09 | 于汇 | Hericium erinaceus (Bull. Ex Fr.) Pers. drinks |
| CN107616398A (en) * | 2017-08-18 | 2018-01-23 | 四川岚晟生物科技有限公司 | A kind of solid beverage with nourishing stomach and spleen and preparation method thereof |
| CN109077299A (en) * | 2018-07-26 | 2018-12-25 | 黑龙江省科学院微生物研究所 | A kind of Hericium erinaceus composition and the preparation method and application thereof |
Non-Patent Citations (7)
| Title |
|---|
| 吴德峰: "《食用中草药》", 30 October 2017, 上海科学技术出版社 * |
| 孙红等: "树舌多糖对大鼠胃黏膜损伤的保护作用", 《中草药》 * |
| 林海鸣等: "猴头菌抗胃溃疡作用的研究", 《中草药》 * |
| 王巧旭等: "保健食品保护胃黏膜辅助作用检验方法的建立及应用", 《现代预防医学》 * |
| 陈康林: "《药用真菌肿瘤学》", 30 June 2017, 北京：中医古籍出版社 * |
| 陈康林: "《被遗忘的灵丹妙药—野生药用真菌：陈康林野生药用真菌秘方集》", 28 February 2011, 北京：中医古籍出版社 * |
| 雷志勇等: "《菌物药治肿瘤》", 31 May 2018, 北京：中医古籍出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956736A (en) * | 2020-08-04 | 2020-11-20 | 浙江省农业科学院 | Hypoglycemic composition mainly comprising sparassis crispa as well as preparation method and application thereof |
| CN112294936A (en) * | 2020-11-02 | 2021-02-02 | 浙江省农业科学院 | Culture medium for preparing stomach-protecting fermentation product and preparation method |
| CN114470073A (en) * | 2022-03-15 | 2022-05-13 | 朱建国 | Radix tetrastigme fried carbon powder agent for treating digestive tract ulcer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102861298B (en) | Traditional Chinese medicine composition for treating chronic gastritis | |
| CN110897162A (en) | Stomach-protecting composition and preparation method and application thereof | |
| CN103520577A (en) | Medicine-and-food dual-purpose preparation for treating pneumoconiosis, clearing away lung-heat and nourishing heart and preparation method for medicine-and-food dual-purpose preparation | |
| CN106362117A (en) | Traditional Chinese medicine composition capable of dispelling alcohol effect and nourishing liver and preparation method thereof | |
| US20200147166A1 (en) | Health supplement food for promotion of hair growth, mitigation and alleviation of hair loss, regulation of blood glucose, and alleviation and relief of gastric disorder symptoms | |
| CN102205108B (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
| CN103736061A (en) | Traditional Chinese medicine composition for treating stomach distension | |
| CN112006137A (en) | Spleen-tonifying and stomach-nourishing Su-radish tea and preparation method thereof | |
| CN107095995B (en) | A pharmaceutical composition for treating gastritis and gastric ulcer, and its preparation method | |
| CN112057553A (en) | Uric acid reducing composition and preparation method and application thereof | |
| CN114949143B (en) | Traditional Chinese medicine composition with effect of treating infantile anorexia and preparation method and application thereof | |
| CN106421374A (en) | Traditional Chinese medicine composition for treating diabetes and application method thereof | |
| CN110742990A (en) | Traditional Chinese medicine composition for treating non-alcoholic simple fatty liver, preparation and application | |
| CN108721557B (en) | Traditional Chinese medicine composition with auxiliary protection function on gastric mucosa injury and preparation method and application thereof | |
| KR100204166B1 (en) | Composition for anti-stress | |
| CN104474459A (en) | Traditional Chinese medicine preparation with liver protection effect and preparation method thereof | |
| CN104825817B (en) | A kind of Chinese medicine preparation with antitumor action | |
| CN100455306C (en) | Traditional Chinese medicine preparation for treating stomach and intestinal disease and its preparation | |
| CN112807415A (en) | Spleen and stomach warming and tonifying middle-jiao tea and preparation method thereof | |
| KR101819490B1 (en) | Composition for preventing, improving or treating livedo reticularis comprising Haechungtang as effective component | |
| CN105535414A (en) | Health food composition with gastric mucosal damage auxiliary protection function | |
| CN107595952B (en) | Traditional Chinese medicine for treating infantile diarrhea and preparation method thereof | |
| CN105125789A (en) | Spleen and stomach strengthening preparation for treating stomachache and preparation method of preparation | |
| CN110585389A (en) | Medicine for treating chronic gastritis and gastric ulcer and preparation method thereof | |
| CN103736045A (en) | Traditional Chinese medicinal composition for treating superficial gastritis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200324 |
|
| RJ01 | Rejection of invention patent application after publication |