CN114470073A - Radix tetrastigme fried carbon powder agent for treating digestive tract ulcer - Google Patents
Radix tetrastigme fried carbon powder agent for treating digestive tract ulcer Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract
The invention discloses radix tetrastigme fried carbon powder for treating peptic ulcer, belonging to the technical field of preparation methods of lianas medicaments; the method comprises the following steps: s1, taking fresh radix tetrastigme root tuber, cleaning, removing impurities, cutting into blocks, drying until the water content is below 20%, and screening out scraps for later use; s2, preparing fried and carbonized radix tetrastigme powder; s3, preparing radix tetrastigme root tuber powder; s4, mixing the fried carbon radix tetrastigme carbon powder and radix tetrastigme root tuber powder according to a ratio of 4:1 to obtain radix tetrastigme fried carbon mixed powder for treating ulcer; in addition, the invention also discloses a use method of the radix tetrastigme fried carbon powder for treating the peptic ulcer; the invention effectively solves the problem that the medicine for applying the medicine effect of the radix tetrastigme and treating the digestive tract ulcer disease is lacked at present.
Description
Technical Field
The invention relates to the technical field of a preparation method of a herbal medicine, and particularly relates to radix tetrastigme fried carbon powder for treating peptic ulcer.
Background
The peptic ulcer is a common disease occurring in gastrointestinal tract, can occur in test tube, stomach, duodenum and other parts, has complex etiology and long course of disease, comprises symptomatic bleeding treatment, operative treatment, interventional treatment and proton pump inhibitor in the current treatment mode, mainly comprises antacid, anticholinergic drug, H2 receptor antagonist or omeprazole and the like in the treatment mode, is carried out by combining with gastrointestinal mucosa protective drug, but needs to be taken for a long time due to the complex etiology of inducing ulcer, and the chemical drugs have side effects. In recent years, better effect and development are achieved in the traditional Chinese medicine treatment of gastric ulcer, and rich biological medicine resources and extensive and profound traditional Chinese medicine provide better choices for treating gastrointestinal ulcer.
Radix tetrastigme (Tetrastigma hemsleyanum) is a precious medicinal material under forest, and is a perennial evergreen herbaceous vine of the genus Millettia of the family Vitaceae. And (3) synonymy: stone monkey, stone cliff, trifoliate flatstem, filigree pendula, golden wire pendant calabash, golden thread pendant potato, tiger, fructus seu radix leiae leicae, stone breaking pearl, native meridian pill, trifoliate orange, little flatstem, Yinling Zi, etc. The radix tetrastigme has great medicinal value, all plants can be used as medicines, and meanwhile, toxicological studies show that the whole plant of the radix tetrastigme is nontoxic and has great medical value, and has effects on resisting tumors, improving immunity and resisting infection.
The radix tetrastigme is used as a traditional Chinese medicinal material, has the potential of homology of medicine and food due to the advantage of no toxic or side effect, and has certain values on tumor, inflammation resistance and infection resistance due to root tuber or whole grass. Animal experiment research shows that the blood immunity index of mice fed with the radix tetrastigme alcohol extract is superior to that of a control group, the tumor size of nude mice treated by the radix tetrastigme wall-breaking powder in a tumor forming experiment is limited, and the tumor forming time is prolonged, so that the nude mice have a good effect on resisting tumors, and in addition, the radix tetrastigme tea and other foods and health care products of the radix tetrastigme are sold on the market, so that the market reaction is good, and the radix tetrastigme alcohol extract has good acceptance in the public consumption market; meanwhile, early animal experiments and cell phenotype experiments show that the radix tetrastigme has great medicinal value in the aspects of improving immunity, resisting tumor and infection; the micro-ecology of the intestinal tract is improved, and the radix tetrastigme tea beverage and powder are orally taken, so that the gastrointestinal tract peristalsis function is improved, the gastrointestinal tract rhythmic peristalsis is maintained, and the problems of constipation and the like are solved; meanwhile, researches show that the radix tetrastigme powder, the spray and the ointment have a strong promoting function on the healing of skin trauma. The research in recent years shows that the basic effect of improving the immunity of the organism by taking the radix tetrastigme; researches show that the radix tetrastigme can improve the regeneration capacity of tissue epithelium, and the fried carbonized radix tetrastigme also has the hemostatic function and the ulcer repairing capacity by combining the basic concept of 'carbon deposit and hemostasis by frying in traditional Chinese medicine'.
The radix tetrastigme has the functions of promoting wound healing and epithelial regeneration, meanwhile, the carbonized particles can effectively stop bleeding, the acid-base environment of the ulcer surface can be improved through the adsorption function of the activated carbon in a local microenvironment, harmful bacteria and heavy metal ions are adsorbed, and the basic function of the ulcer healing surface can be adjusted. The study invents a radix tetrastigme fried carbon powder with the effect of treating gastrointestinal ulcer based on fried carbon radix tetrastigme.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: provides radix tetrastigme fried carbon powder for treating peptic ulcer, and solves the problem that the prior medicament for applying the medicament effect of the radix tetrastigme and treating the peptic ulcer is lacked.
In order to solve the problems, the invention provides the following technical scheme:
a radix Apioris Fortunei parched carbon powder for the treatment of digestive tract ulcer; it comprises the following steps:
s1, taking fresh radix tetrastigme root tuber, cleaning, removing impurities, cutting into blocks, drying until the water content is below 20%, and screening out scraps for later use;
s2, preparing fried and carbonized radix tetrastigme powder: taking river sand, cleaning until clear water is thoroughly discharged, filtering the river sand by a coarse screen, and keeping sand grains with the diameter of less than 5mm for later use; placing river sand grains in a frying container, frying with strong fire until the temperature of the sand grains reaches above 80 deg.C, placing radix Apioris Fortunei blocks, continuously frying until the surface is brown, quickly taking out, and sieving to remove sand grains; cooling the screened fried radix tetrastigme to room temperature, and pouring the cooled radix tetrastigme into a frying container for re-frying for 2-3 times; crushing the re-fried radix tetrastigme, and sieving with a 200-mesh sieve to obtain fried carbonized radix tetrastigme powder;
s3, preparing radix tetrastigme root tuber powder: directly pulverizing dried radix Apioris Fortunei root tuber, and sieving with 200 mesh sieve to obtain radix Apioris Fortunei powder root tuber;
s4, mixing the carbon-fried radix tetrastigme carbon powder obtained in the step S2 with the radix tetrastigme tuber powder obtained in the step S3 according to a ratio of 4:1, and obtaining the radix tetrastigme carbon-fried mixed powder for treating the ulcer.
Preferably, in step S2, the radix tetrastigme is placed in a container containing dry ice for processing when the fried radix tetrastigme is cooled.
The invention also discloses a use method of the radix tetrastigme fried carbon powder for treating the peptic ulcer, and the radix tetrastigme fried carbon mixed powder can be used as powder medicine, or prepared into tablets, or packaged into capsules.
The invention has the beneficial effects that:
the invention provides radix tetrastigme fried carbon powder for treating peptic ulcer, which is prepared by taking root tuber of radix tetrastigme as a processing raw material, slicing and drying the processed raw material, putting prepared clean river sand grains into a pot, frying the processed raw material with strong fire, crushing the fried raw material after frying, and mixing the crushed raw material without frying to obtain the radix tetrastigme fried carbon powder.
Drawings
FIG. 1 is a diagram showing the state of the stomach after the rat was dissected on day 5 in the example;
FIG. 2 is a diagram illustrating the stomach of a rat dissected by the model 12h according to the present embodiment;
FIG. 3 is a schematic diagram showing the mucous membrane of the stomach of a blank group of normal rats in this example;
FIG. 4 is a pathological HE section of the gastric mucosa of a blank group of normal rats in this example;
FIG. 5 is a pathological HE section of edematous gastric mucosa from an ulcerated rat in this example;
FIG. 6 is a view of a pathological HE section of the gastric mucosa with a missing ulcer surface in this example;
FIG. 7 is a pathological HE section of the mucous membrane of the stomach of a control rat in this example;
FIG. 8 is a pathological HE section of the mucous membrane of the stomach in the state of the rat in the restoration stage in the experimental group of this example;
FIG. 9 is a pathological HE slice of the normal blank gastric mucosa of this example.
Detailed Description
The invention will be further described with reference to specific examples:
example 1:
the embodiment provides radix tetrastigme fried carbon powder for treating peptic ulcer; s1, taking fresh radix tetrastigme root tuber, cleaning, removing impurities, cutting into blocks, drying until the water content is below 20%, and screening out scraps for later use;
s2, preparing fried and carbonized radix tetrastigme powder: taking river sand, cleaning until clear water is thoroughly discharged, filtering the river sand by a coarse screen, and keeping sand grains with the diameter of less than 5mm for later use; placing river sand grains in a frying container, frying with strong fire until the temperature of the sand grains reaches above 80 deg.C, placing radix Apioris Fortunei blocks, continuously frying until the surface is brown, quickly taking out, and sieving to remove sand grains; cooling the screened fried radix tetrastigme to room temperature, and pouring the cooled radix tetrastigme into a frying container for re-frying for 2-3 times; crushing the re-fried radix tetrastigme, and sieving with a 200-mesh sieve to obtain fried carbonized radix tetrastigme powder;
s3, preparing radix tetrastigme root tuber powder: directly pulverizing dried radix Apioris Fortunei root tuber, and sieving with 200 mesh sieve to obtain radix Apioris Fortunei powder root tuber;
s4, mixing the carbon-fried radix tetrastigme carbon powder obtained in the step S2 with the radix tetrastigme tuber powder obtained in the step S3 according to a ratio of 4:1, and obtaining the radix tetrastigme carbon-fried mixed powder for treating the gastric ulcer.
In step S2, the roasted radix tetrastigme is placed in a container containing dry ice for processing when being cooled.
The invention also discloses a use method of the radix tetrastigme fried carbon powder for treating the peptic ulcer, and the radix tetrastigme fried carbon mixed powder can be used as powder medicine, or prepared into tablets, or packaged into capsules.
Example 2:
referring to the drawings, this example prepares an alcoholic animal model of rat gastric ulcer and performs utility evaluation using the mixed powder of radix tetrastigme and charcoal-fried obtained in example 1; the specific experimental procedures are referenced as follows:
1. preparation of rat gastric ulcer model. Taking 60 rats with half each sex, randomly dividing into 3 groups, wherein each group comprises 20 rats, namely a control group, an experimental group and a blank group, diet prohibition is performed for 24 hours, the experimental group and the control group are filled with stomach alcohol according to 1.5ml/100g of body weight to manufacture an acute gastric ulcer model, the blank group is filled with physiological saline, and the experiment is performed after 12 hours;
2. grouping into a control group, an experimental group and a blank group; wherein the control group and blank group are fed with normal feed and drinking water; an experimental group uses the radix tetrastigme fried carbon powder obtained in the example 1 to prepare an additive feed for feeding, normal drinking water is carried out, the general anatomical condition of the stomach is observed on 0, 1, 2, 3, 4 and 5 days, an HE staining section is prepared, and the gastric ulcer repairing condition is observed.
3, analysis of experimental results:
(1) and (5) carrying out feed consumption statistics. Recording the weight of the rat, weighing the same feed amount according to the weight proportion, and counting the feed consumption condition, wherein the result shows that the feed consumption of the blank group is obviously higher than that of the experimental group and the control group; the feed consumption of the experimental group is obviously higher than that of the control group (all rats are randomly raised in cages, 2 rats are raised per cage); about 5 days, the feed consumption of the experimental group is not different from that of the blank group, and is obviously different from that of the control group; the stomach of the molded rat is generally shown in figure 1; in fig. 1, numbers 1-3 are experimental groups, 7-9 are control groups, 4-6 are blank groups, 3 patients in each group are observed for molding, and it can be seen that the control group and the experimental group have more food residues, the stomach fundus is inflated and swollen, and a blood sample is presented;
(2) dissection and pathology. Anatomical display shows that after the model is built for 12 hours, the ulcer surfaces of rats in the control group and the experimental group are in a severe ulcer state, and mucous membranes fall off, and particularly, refer to fig. 2; pathological HE section shows that mucosa of the ulcer surface is shed, inflammatory cells are infiltrated, a slight edema zone appears on the stomach basement and the muscle layer as shown in figures 5 and 6, and the blank group presents normal stomach section pathology as shown in figure 4; after 3 days, the experimental group showed the basic characteristics of ulcer in healing phase, the cases showed a decrease in myocyte edema, the cases showed ulcer in repairing phase locally, and the feces were blackish, as shown in fig. 8; after 4 days, the mucous membrane is basically repaired and the normal gastric mucous membrane state is presented.
The results of the independent evaluation test of the radix tetrastigme fried carbon mixed powder show that the radix tetrastigme fried carbon mixed powder has a good repairing effect on the gastric ulcer of a rat molded by alcohol.
Claims (3)
1. A radix tetrastigme fried carbon powder for treating peptic ulcer is characterized in that: it comprises the following steps:
s1, taking fresh radix tetrastigme root tuber, cleaning, removing impurities, cutting into blocks, drying until the water content is below 20%, and screening out scraps for later use;
s2, preparing fried and carbonized radix tetrastigme powder: taking river sand, cleaning until clear water is thoroughly discharged, filtering the river sand by a coarse screen, and keeping sand grains with the diameter of less than 5mm for later use; placing river sand grains in a frying container, frying with strong fire until the temperature of the sand grains reaches above 80 deg.C, placing radix Apioris Fortunei blocks, continuously frying until the surface is brown, quickly taking out, and sieving to remove sand grains; cooling the screened fried radix tetrastigme to room temperature, and pouring the cooled radix tetrastigme into a frying container for re-frying for 2-3 times; crushing the re-fried radix tetrastigme, and sieving with a 200-mesh sieve to obtain fried carbonized radix tetrastigme powder;
s3, preparing radix tetrastigme root tuber powder: directly pulverizing dried radix Apioris Fortunei root tuber, and sieving with 200 mesh sieve to obtain radix Apioris Fortunei powder root tuber;
s4, mixing the carbon-fried radix tetrastigme carbon powder obtained in the step S2 with the radix tetrastigme tuber powder obtained in the step S3 according to a ratio of 4:1, and obtaining the radix tetrastigme carbon-fried mixed powder for treating the ulcer.
2. The radix tetrastigme fried carbon powder for treating the peptic ulcer as claimed in claim 1, wherein: in step S2, the roasted radix tetrastigme is placed in a container containing dry ice for processing when being cooled.
3. The use of the radix tetrastigme fried carbon powder for treating the peptic ulcer as claimed in any one of claims 1 to 2, wherein: the radix Apioris Fortunei parched carbon mixed powder can be used as powder, or made into tablet, or packaged into capsule.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908464A (en) * | 2012-10-30 | 2013-02-06 | 丽水市莲都区绿谷三叶青珍稀植物研究所 | Radix tetrastigme micro powder and preparation method and application thereof |
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