CN105726590A - Chinese herbal medicine preparation with functions of reducing alcohol absorption and protecting liver - Google Patents
Chinese herbal medicine preparation with functions of reducing alcohol absorption and protecting liver Download PDFInfo
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- CN105726590A CN105726590A CN201610174363.6A CN201610174363A CN105726590A CN 105726590 A CN105726590 A CN 105726590A CN 201610174363 A CN201610174363 A CN 201610174363A CN 105726590 A CN105726590 A CN 105726590A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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Abstract
The invention discloses a Chinese herbal medicine preparation with the functions of reducing alcohol absorption and protecting the liver. The Chinese herbal medicine preparation is prepared from the following raw materials in parts by weight: 200 parts of betula albo-sinensis Burk bark and 20-40 parts of glucose, wherein the betula albo-sinensis Burk bark is the full-layer bark or the extract of a betulaceae betula plant betula albo-sinensis Burk or betula platyphylla Suk. The Chinese herbal medicine preparation is prepared by adopting pure traditional Chinese medicines, does not have harmful substances or toxic or side effects, is simple in formula and preparation process, has reliable curative effects, is low in production cost, has the functions of reducing alcohol absorption, inhibiting thirst after drinking and protecting the liver and gastric mucosa and has the characteristic of low price.
Description
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to a kind of minimizing liver-protective Chinese herbal and crude drugs preparations of alcohol absorption.
Background technology
Drink, in various social activities, the most most common or obligato a kind of mode, " When drinking with a bosom friend, a thousand cups will still be too little ", because of
, often there is insobriety, drunk phenomenon in this, and excessive drinking has become one of subject matter of harm human health.Drank
Degree, drunk, health will be caused greatly infringement.Such as: fatty liver, gastric ulcer, gastrorrhagia, peripheral neuropathy, big
Cerebral cortex atrophy, muscular degeneration of heart, intellectual deterioration etc..Pre-preventing drunkenness or relieve the effect of alcohol, first considers how to reduce ethanol at human body
Absorption, next to that the liver protecting, reduce and absorb both the liver protecting and complement each other indispensable.At present, there is no clinically and control
Treat the specific drug of alcoholic liver disease.Western medicine protects the liver and accelerates to drain to obtain method for main employing of relieving the effect of alcohol, such as injection or mouth now
Take glucose, mannitol etc.；Chinese medicine many employings strong tea, vinegar, Radix Puerariae, Flos puerariae lobatae, Japanese raisintree fruit, Fructus Schisandrae Chinensis, Radix Glycyrrhizae etc. are relieved the effect of alcohol, but only
It is mitigation symptoms, does not all reach preferable effect.
Having research and inquirement belulinic acid Betulinic acid to study the possible liver protection effect of alcoholic liver injury, prompting belulinic acid Betulinic acid can be preventative
Repair the effect of alcoholic hepatic injury sero-enzyme, and there is the stability of potential repair cell film.But how to reduce the suction of ethanol
Receive and then have no any report.
Summary of the invention
The technical problem to be solved is for above-mentioned the deficiencies in the prior art, it is provided that a kind of ethanol that reduces is inhaled
Receive liver-protective Chinese herbal and crude drugs preparations.
For solving above-mentioned technical problem, the technical solution used in the present invention is: a kind of minimizing alcohol absorption is liver-protective
Chinese herbal and crude drugs preparations, it is characterised in that be made up of the raw material of following weight portion: Cortex Betulae Luminiferae 100 parts, glucose 10～20 parts；Described
Cortex Betulae Luminiferae is the red birch of Betula plant (Betula albo-sinensis Burk) or Betula platyphylla Suk. (Betula platyphylla
Suk.) holostrome bark.
Above-mentioned a kind of raw material reducing the liver-protective Chinese herbal and crude drugs preparations of alcohol absorption can be that Cortex Betulae Luminiferae extract is (total
Composition or monomer), it is characterised in that be made up of the raw material of following weight portion: Cortex Betulae Luminiferae extract 100 parts, glucose 100～
200 parts.
Above-mentioned a kind of dosage form reducing the liver-protective Chinese herbal and crude drugs preparations of alcohol absorption is capsule, tablet, granule
Or oral liquid.
Described weight portion can be gram, two, jin, the weight metering unit such as kilogram, ton.
The present invention is with Betula platyphylla Suk. or red birch holostrome bark as raw medicinal material, extracts Cortex Betulae Luminiferae with soak by water or reflow of alcohol method
Effective ingredient, the liver-protective Chinese herbal and crude drugs preparations of minimizing alcohol absorption being mixed with glucose, this formulation method is normal
Rule method.
The present invention compared with prior art has the following advantages.
1, the Chinese herbal and crude drugs preparations of the present invention use the red birch of pure natural or Betula platyphylla Suk. holostrome bark be raw material extracted after and Fructus Vitis viniferae
Sugar preparation, unharmful substance, has no side effect, and formula is simple with preparation technology, curative effect is reliable, production cost is low, has reduction
Alcohol absorption, suppression the most thirsty, the liver protecting, protection gastric mucosa, cheap feature.
2, the Chinese herbal and crude drugs preparations of the present invention use the red birch of pure natural or Betula platyphylla Suk. holostrome bark be raw material extracted after extraction
Thing and glucose are prepared, and unharmful substance, have no side effect, and formula is simple with preparation technology, curative effect is reliable, production cost is low,
There is reduction alcohol absorption, suppress the most thirsty, the liver protecting, protection gastric mucosa, cheap feature.
3, the Chinese herbal and crude drugs preparations of the present invention has that curative effect is high, stability strong, the feature for the treatment of both the principal and secondary aspects of a disease, and patient does not goes out after taking
Bad of existing complication etc. are answered, and are suitable for medicine, health food listing popularization.
Detailed description of the invention
Embodiment 1: the present embodiment one reduces alcohol absorption liver-protective Chinese herbal medicine capsule agent, by following raw material system
Become: Cortex Betulae Luminiferae 100kg, glucose 10～20kg；Described Cortex Betulae Luminiferae is Betula plant red birch (Betula albo-sinensis
Or the holostrome bark of Betula platyphylla Suk. (Betula platyphylla Suk.) Burk).
The preparation method of the present embodiment capsule is:
Step one, Cortex Betulae Luminiferae is ground into the coarse powder of 5～10 mesh；
Step 2, Cortex Betulae Luminiferae boiling after crushed in step one is extracted twice, for the first time amount of water be pulverize after
8 times of Cortex Betulae Luminiferae quality, decocting time is 2 hours, and 6 times of the Cortex Betulae Luminiferae quality after amount of water is pulverizing for the second time, during decoction
Between be 1 hour, merging filtrate after filtration, be concentrated into 50 DEG C and record the thick paste that relative density is 1.30；
Step 3, thick paste described in step 2 is placed in vacuum drying tank it is vacuum dried, obtain Cortex Betulae Luminiferae dry extract；
Step 4, Cortex Betulae Luminiferae dry extract described in step 3 is mixed with glucose after be ground into 60 mesh fine powders and (or make
Grain), then described fine powder (granule) is loaded in capsule, be reduced alcohol absorption liver-protective Chinese herbal medicine capsule agent, often
Seed lac capsule 0.8g Han fine powder.
The present embodiment reduce alcohol absorption liver-protective Chinese herbal medicine capsule agent usage and dosage: one time 4～6, wine
Before or take after drinking.
Embodiment 2: the present embodiment one reduces the liver-protective Chinese medicinal herbal tablets of alcohol absorption, its preparation method and enforcement
Example 1 is essentially identical, only increases the technological process of pelletizing press sheet, every tablet weight 0.8g.
The present embodiment reduce the liver-protective Chinese medicinal herbal tablets of alcohol absorption usage and dosage: one time 4～6, before wine
Or take after drinking.
Embodiment 3: the present embodiment one reduces alcohol absorption liver-protective Chinese herbal medicine granule, its preparation method and reality
Execute example 1 essentially identical, simply powder is dried through pelletizing and the technological process such as subpackage, every bag 3～5g.
The present embodiment reduce alcohol absorption liver-protective Chinese herbal medicine granule usage and dosage: one time 1 bag, before wine or
Take after drinking.
Embodiment 4: the present embodiment one reduces the liver-protective Chinese herbal medicament oral liquid of alcohol absorption, by following raw material system
Become: Cortex Betulae Luminiferae 100kg, glucose 10～20kg；Described Cortex Betulae Luminiferae is Betula plant red birch (Betula albo-sinensis
Or the holostrome bark of Betula platyphylla Suk. (Betula platyphylla Suk.) Burk).
The preparation method of the capsule of the present embodiment is:
Step one, 100kg Cortex Betulae Luminiferae is ground into the coarse powder of 5-10 mesh；
Step 2, Cortex Betulae Luminiferae boiling after crushed in step one is extracted twice, for the first time amount of water be pulverize after
8 times of Cortex Betulae Luminiferae quality, decocting time is 3 hours, and 6 times of the Cortex Betulae Luminiferae quality after amount of water is pulverizing for the second time, during decoction
Between be 2 hours, merging filtrate after filtration, be concentrated into 50 DEG C and record the thick paste that relative density is 1.30；
Step 3, thick paste described in step 2 is placed in vacuum drying tank it is vacuum dried, obtain Cortex Betulae Luminiferae dry extract；
Step 4, Cortex Betulae Luminiferae dry extract described in step 3 is mixed with glucose after be ground into 60 mesh fine powders, be subsequently adding steaming
Distilled water 100 liters, Preservative qs, heating makes it fully dissolve to obtain medicinal liquid；
Medicinal liquid in step 5, just step 4 is through technological processes such as initial filter, fine straining, fill, sterilizings so that every ml is containing medical material
1 gram, every loading amount 10ml.
A kind of usage and dosage reducing the liver-protective Chinese herbal medicament oral liquid of alcohol absorption of the present embodiment: one time 1, before wine
Or take after drinking.
Embodiment 5: the present embodiment one reduces alcohol absorption liver-protective Chinese herbal medicine capsule agent, by following raw material system
Become: Cortex Betulae Luminiferae 100kg, glucose 10～20kg；Described Cortex Betulae Luminiferae is Betula plant red birch (Betula albo-sinensis
Or the holostrome bark of Betula platyphylla Suk. (Betula platyphylla Suk.) Burk).
The preparation method of the present embodiment capsule is:
Step one, Cortex Betulae Luminiferae is ground into the coarse powder of 5-10 mesh；
Step 2, Cortex Betulae Luminiferae after crushed in step one is added mass concentration be 60～80% reflow of alcohol extract twice,
First time adds 8 times that alcohol amount is the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 2 hours, and second time adds alcohol amount and is
6 times of Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, merging filtrate after filtration, reclaims ethanol, and filtrate is dense
It is reduced to 50 DEG C and records the thick paste that relative density is 1.30；
Step 3, thick paste described in step 2 is placed in vacuum drying tank it is vacuum dried, obtain Cortex Betulae Luminiferae dry extract；
Step 4, Cortex Betulae Luminiferae dry extract described in step 3 is mixed with glucose after be ground into 60 mesh fine powders and (or make
Grain), then described fine powder (granule) is loaded in capsule, be reduced alcohol absorption liver-protective Chinese herbal medicine capsule agent, often
Seed lac capsule 0.8g Han fine powder.
The present embodiment reduce alcohol absorption liver-protective Chinese herbal medicine capsule agent usage and dosage: one time 4～6, wine
Before or take after drinking.
Embodiment 6: the present embodiment one reduces the liver-protective Chinese medicinal herbal tablets of alcohol absorption, its preparation method and enforcement
Example 5 is essentially identical, only increases the technological process of pelletizing press sheet, every tablet weight 0.8g.
The present embodiment reduce the liver-protective Chinese medicinal herbal tablets of alcohol absorption usage and dosage: one time 4～6, before wine
Or take after drinking.
Embodiment 7: the present embodiment one reduces alcohol absorption liver-protective Chinese herbal medicine granule, its preparation method and reality
Execute example 5 essentially identical, simply powder is dried through pelletizing and the technological process such as subpackage, every bag 3～5g.
The present embodiment reduce alcohol absorption liver-protective Chinese herbal medicine granule usage and dosage: one time 1 bag, before wine or
Take after drinking.
Embodiment 8: the present embodiment one reduces the liver-protective Chinese herbal medicament oral liquid of alcohol absorption, by following raw material system
Become: Cortex Betulae Luminiferae 100kg, glucose 10～20kg；Described Cortex Betulae Luminiferae is Betula plant red birch (Betula albo-sinensis
Or the holostrome bark of Betula platyphylla Suk. (Betula platyphylla Suk.) Burk).
The preparation method of the capsule of the present embodiment is:
Step one, 100kg Cortex Betulae Luminiferae is ground into the coarse powder of 5-10 mesh；
Step 2, Cortex Betulae Luminiferae after crushed in step one is added mass concentration be 60～80% reflow of alcohol extract twice,
First time adds 8 times that alcohol amount is the Cortex Betulae Luminiferae quality after pulverizing, and reflux extracting time is 2 hours, and second time adds alcohol amount and is
6 times of Cortex Betulae Luminiferae quality after pulverizing, reflux extracting time is 1 hour, merging filtrate after filtration, reclaims ethanol, and filtrate is dense
It is reduced to 50 DEG C and records the thick paste that relative density is 1.30；
Step 3, thick paste described in step 2 is placed in vacuum drying tank it is vacuum dried, obtain Cortex Betulae Luminiferae dry extract；
Step 4, Cortex Betulae Luminiferae dry extract described in step 3 is mixed with glucose after be ground into 60 mesh fine powders, be subsequently adding steaming
Distilled water 100 liters, Preservative qs, heating makes it fully dissolve to obtain medicinal liquid；
Medicinal liquid in step 5, just step 4 is through technological processes such as initial filter, fine straining, fill, sterilizings so that every ml is containing medical material
1 gram, every loading amount 10ml.
A kind of usage and dosage reducing the liver-protective Chinese herbal medicament oral liquid of alcohol absorption of the present embodiment: one time 1～2,
Before wine or take after drinking.
Embodiment 9: the present embodiment one reduces the liver-protective Chinese herbal medicine capsule of alcohol absorption, is made up of following raw material:
Cortex Betulae Luminiferae extract 100kg, glucose 100～200kg；Described Cortex Betulae Luminiferae extract is Betula plant red birch (Betula
Albo-sinensis Burk) or the holostrome bark extraction gained of Betula platyphylla Suk. (Betula platyphylla Suk.).
The preparation method of the capsule of the present embodiment is: by Cortex Betulae Luminiferae extract and glucose co-grinding, stir,
It is dried, sterilizing, encapsulated (0.8g) and get final product.
A kind of usage and dosage reducing alcohol absorption liver-protective Chinese herbal medicine capsule agent of the present embodiment: one time 4～6,
Before wine or take after drinking.
The preparation method of the tablet of the present embodiment is: by Cortex Betulae Luminiferae extract and glucose co-grinding, stirs, goes out
Bacterium, pelletizes, is dried, tabletting (0.8g) and get final product.
A kind of usage and dosage reducing the liver-protective Chinese medicinal herbal tablets of alcohol absorption of the present embodiment: one time 4～6, wine
Before or take after drinking.
The preparation method of the granule of the present embodiment is: by Cortex Betulae Luminiferae extract and glucose co-grinding, stir,
Sterilizing, pelletizes, and is dried, subpackage (3～5g) and get final product.
A kind of usage and dosage reducing alcohol absorption liver-protective Chinese herbal medicine capsule agent of the present embodiment: one time 1 bag, before wine
Or take after drinking.
The preparation method of the oral liquid of the present embodiment is: Cortex Betulae Luminiferae extract mixes with glucose addition distilled water, prevents
Rotten agent is appropriate, and heating makes it fully dissolve, through technological processes such as initial filter, fine straining, fill, sterilizings so that every ml is containing extract
0.1 gram, every loading amount 10ml.
A kind of usage and dosage reducing the liver-protective Chinese herbal medicament oral liquid of alcohol absorption of the present embodiment: one time 1～2,
Before wine or take after drinking.
Curative effect determinate standard: cure: without drunk symptom, without thirsty phenomenon；Effective: clinical symptom relief or thirsty phenomenon subtract
Gently；Invalid: symptom is unchanged.
General clinical data: clinical observation drunk case totally 180 example, 6 hours observing times；Treatment group 120 example, blank group
30 examples, compare 30 examples；Wherein, treatment group: take capsule 30 example of the present invention, tablet 30 example, granule 30 example, oral liquid
30 examples；Matched group 30 example all takes compound kudzu root soup (Radix Puerariae 15 grams, Japanese raisintree fruit 10 grams, 10 grams of Radix Glycyrrhizae)；Blank group is taken temperature and is opened
Water；Comparitive study result see table.
Table 1 treatment group and matched group Comparison of therapeutic:
Note: granule effect is best, it may be possible to dose-effect relationship.
As shown in table 1, clinical observation case 180 example of the present invention, wherein treatment group 120 example, matched group 30 example, blank
Organize 30 examples；Treatment group uses capsule of the present invention, tablet, granule and oral liquid, wherein takes capsule 30 example, one time 4
Grain, takes after drinking；Take tablet 30 example, one time 4, take after drinking；Take granule 30 example, one time 5 grams, take after drinking；
Take oral liquid 30 example, a 10ml, take after drinking；Matched group uses compound kudzu root soup, is decocted in water for oral dose；Blank group uses temperature to open
Water routine is taken.Treatment group compares with matched group general curative effect, and its result is: take capsule 30 example in treatment group, cures 18
Example, accounts for 60%, total effective rate 100%；Treatment group is taken tablet 30 example, cures 18 examples, account for 60%, total effective rate 100%；Control
Treatment group is taken granule 30 example, cures 28 examples, account for 91%, total effective rate 100%；Treatment group is taken oral liquid 30 example, controls
More 20 examples, account for 66%, total effective rate 100%；Matched group 30 example takes compound kudzu root soup, effective 29 examples, invalid 1 example, the most effectively
Rate 97%；Blank group 30 examples, take warm water and cure 0 example, effective 2 examples, invalid 28 examples, total effective rate 7%.Two groups are compared curative effect
There were significant differences.
Table 2 fills the impact (mg/l of 1.5h, 2.5h, 3.5h Ethanol concentration in rat blood after drinking to mice;X ± s)
Note: * * p ＜ 0.01 compared with compound kudzu root group.
As shown in table 2, mice is filled 1.5 h, 2.5 h, the impact of 3.5 h Ethanol concentration in rat bloods after drinking: by male mice
Being divided into 3 groups at random, model group only fills wine 0.2mL/20g body weight;Compound kudzu root soup group fills and the most i.e. fills each 0.2mL/ of this decoction
20g body weight;Administration group fills and the most i.e. fills 0.2mL/20mg body weight of the present invention.3 groups take respectively at 1.5 h after drinking, 2.5 h, 3.5 h
Hematometry Ethanol concentration in rat blood.Through obtaining ethanol content and statistical procedures p ＜ 0.01 in significant difference with standard curve.
Model case case 1: Wang, man, 45 years old, peasant.Often accompanying drinks reach dead drunk thirsty incomparably, the most liquor-saturated seemingly
Suffer from a serious illness one, once by other sides of relieving the effect of alcohol but poor effect.After often drink after take granule one of the present invention and wrap (5g), half an hour
After all go well, have no thirsty phenomenon.
Case 2: what certain, man, 34 years old, workman.Usually the 300ml that drinks is the most dead drunk, after before wine, respectively take this
Invention granule 1 wraps, and its capacity for liquor can increase to more than 400ml, and has no the drunk apperances such as thirsty, facial flushes, thinking etc.
Cut normal.
Claims (4)
1. one kind is reduced the liver-protective Chinese herbal and crude drugs preparations of alcohol absorption, it is characterised in that be made up of the raw material of following weight portion:
Cortex Betulae Luminiferae 100 parts, glucose 10-20 part；Described Cortex Betulae Luminiferae is Betula plant red birch (Betula albo-sinensis
Or the holostrome bark of Betula platyphylla Suk. (Betula platyphylla Suk.) Burk).
2. the raw material reducing the liver-protective Chinese herbal and crude drugs preparations of alcohol absorption can be Cortex Betulae Luminiferae extract (total composition or list
Body), it is characterised in that it is made up of the raw material of following weight portion: Cortex Betulae Luminiferae extract 100 parts, glucose 100～200 parts.
A kind of minimizing liver-protective Chinese herbal and crude drugs preparations of alcohol absorption the most according to claim 1, it is characterised in that described
The dosage form of Chinese herbal and crude drugs preparations is capsule, tablet, granule or oral liquid, and its preparation method is conventional method.
A kind of minimizing liver-protective Chinese herbal and crude drugs preparations of alcohol absorption the most according to claim 2, it is characterised in that described
The dosage form of Chinese herbal and crude drugs preparations is capsule, tablet, granule or oral liquid, and its preparation method is conventional method.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610174363.6A CN105726590A (en) | 2016-03-24 | 2016-03-24 | Chinese herbal medicine preparation with functions of reducing alcohol absorption and protecting liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610174363.6A CN105726590A (en) | 2016-03-24 | 2016-03-24 | Chinese herbal medicine preparation with functions of reducing alcohol absorption and protecting liver |
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| CN105726590A true CN105726590A (en) | 2016-07-06 |
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| CN201610174363.6A Pending CN105726590A (en) | 2016-03-24 | 2016-03-24 | Chinese herbal medicine preparation with functions of reducing alcohol absorption and protecting liver |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089760A (en) * | 2019-06-18 | 2020-12-18 | 成都医学院 | Healthy wine based on ethanol dehydrogenase inhibition |
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|---|---|---|---|---|
| CN104351610A (en) * | 2014-10-23 | 2015-02-18 | 吉林省现代中药工程研究中心有限公司 | Health-care oral liquid for inhibiting alcohol absorption and promoting alcohol metabolism and preparation method thereof |
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2016
- 2016-03-24 CN CN201610174363.6A patent/CN105726590A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104351610A (en) * | 2014-10-23 | 2015-02-18 | 吉林省现代中药工程研究中心有限公司 | Health-care oral liquid for inhibiting alcohol absorption and promoting alcohol metabolism and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 倪士峰等: "桦木属植物的药用研究", 《安徽农业科学》 * |
| 吴吴: "解酒便方知多少", 《家庭医学》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112089760A (en) * | 2019-06-18 | 2020-12-18 | 成都医学院 | Healthy wine based on ethanol dehydrogenase inhibition |
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Application publication date: 20160706 |