KR101687558B1 - A composition containing natural materials extract as an active ingredient for treatment of constipation, and manufacturing method of the same - Google Patents
A composition containing natural materials extract as an active ingredient for treatment of constipation, and manufacturing method of the same Download PDFInfo
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- KR101687558B1 KR101687558B1 KR1020160097064A KR20160097064A KR101687558B1 KR 101687558 B1 KR101687558 B1 KR 101687558B1 KR 1020160097064 A KR1020160097064 A KR 1020160097064A KR 20160097064 A KR20160097064 A KR 20160097064A KR 101687558 B1 KR101687558 B1 KR 101687558B1
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- constipation
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
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Abstract
Description
본 발명은 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법에 관한 것으로, 상세하게는 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물을 추출, 농축, 분말 단계를 거쳐, 과립제, 산제, 환제로 제조함으로써, 변비 및 숙변 개선에 효과가 있는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법에 관한 것이다.The present invention relates to a composition for improving constipation and aspiration, which comprises extracts of natural materials as an active ingredient, and a method for preparing the composition. More specifically, the present invention relates to a composition for improving constipation and cautiousness, A composition for improving constipation and cushioning comprising an extract of a natural material which is effective for improving constipation and sloblemia by preparing a granular material, a powder and a pesticide through a step of extraction, ≪ / RTI >
현대 사회는 생활수준이 향상되고 사회생활이 다양해지면서, 식생활의 서구화 및 인스턴트의 섭취로 열량의 섭취는 늘어난 반면, 섬유소 섭취의 감소와 스트레스의 증가, 운동량의 저하로 인해 변비가 있거나, 비만해지는 인구가 늘어나고 있다. 더욱이, 불규칙한 식사, 대기오염, 식품에 함유된 농약이나 중금속의 섭취, 항생제의 과다복용, 지나친 음주 등으로 인하여 독성이 인체에 축적되는 것을 피할 수 없게 되었다.In modern society, as the level of living has improved and social life has diversified, the consumption of calories through westernization and instant ingestion of diet has been increased, while the consumption of calories has increased due to decrease of fiber consumption, increase of stress, constipation due to decrease of exercise, Is increasing. Furthermore, accumulation of toxic substances in the human body can not be avoided due to irregular eating, air pollution, ingestion of pesticides or heavy metals in food, overdose of antibiotics, and excessive drinking.
사람이 음식을 섭취하게 되면, 영양성분은 인체의 기관에 의해 흡수되고 영양성분이 빠진 음식물은 보통 12~72시간 후에 대변의 형태로 배설되는 것이 일반적이다. 그러나 상기의 대변이 어떠한 이유로 배설되지 못하고, 장안에 오랜시간 머물게 되는 것을 변비라고 한다. When a person eats food, the nutrients are absorbed by the body's organs and the nutrient-free food is usually excreted in the form of feces after 12 to 72 hours. However, constipation refers to constipation which can not be excreted for any reason, and which is to remain in the intestine for a long time.
변비는 다양한 기전에 의해 발생할 수 있는데, 다른 질환에 의한 이차성 변비와 원인 질환이 뚜렷하지 않은 기능성 변비로 구분할 수 있다. 이 중 기능성 변비는 대변의 대장 통과 시간이 지연되거나, 대변의 대장 통과 시간은 정상이나 직장으로부터 대변 배출이 어려운 경우이다. 이차성 변비는 당뇨병, 갑상선 기능 저하증 등의 전신질환, 기질적인 병변, 변비를 유발하는 약제의 복용, 우울증 또는 식이장애 등의 정신적인 질환 등의 질환에 의해 발생된다. 변비의 치료는 발병기전에 맞게 치료하는 것이 중요한데, 대장암과 같은 기질적인 질환이나 정신적인 질환이 있을 경우에는 원인 질환의 치료가 우선이며, 기능성 변비의 경우, 생활습관 개선과 식이요법으로 정상적인 배변을 유도하는 것이 우선된다.Constipation can be caused by a variety of mechanisms, including secondary constipation caused by other diseases and functional constipation that can not distinguish the cause disease. Functional constipation is delayed in the transit time of the large bowel, or the colon transit time of the bowel is normal, or it is difficult to discharge the bowel from the rectum. Secondary constipation is caused by diseases such as systemic diseases such as diabetes, hypothyroidism, organic lesions, taking drugs that cause constipation, depression or dietary disorders. It is important to treat the constipation according to the pathogenesis. Treatment of the causative disease is priority when there is a mild disease such as colorectal cancer or mental disease. In the case of functional constipation, normal bowel movement . ≪ / RTI >
변비가 생기면 대장의 기능이 떨어지면서 수분이 과다하게 제거되어 음식 찌거기 등의 노폐물과 대변의 독성 물질이 배출되지 못하고, 신진대사가 제대로 이루어지지 않아 장에 대변이 오래 머물게 되어 숙변이 나타난다.When constipation occurs, the function of the large intestine is deteriorated, excess water is removed, and toxic substances such as food wastes and feces are not discharged, and the metabolism is not properly performed, so that the bowel becomes long and stool appears.
체내에는 평균 5 내지 10 kg의 숙변이 있는데, 숙변은 대장의 주름이나 게실에 담겨 썩으면서 대장의 기능을 약화시키고, 유독가스를 발생한다. 장에 가득찬 유독가스는 혈액을 타고 뇌로 들어가 뇌 기능을 어지럽혀 두통이 일으킬 뿐 아니라, 자궁, 방광, 전립선 등의 장기를 압박하여 혈액순환에 영향을 주어 충혈과 염증을 일으킨다. 또한, 유독가스로 인해 체내 산소와 영양소 흡수가 약화되어 피부 발진이 나타나며, 유독가스로 장이 팽창하여 불쾌감, 어깨결림, 요통 및 숙변에 의한 체중 증가 등의 증상이 나타나고, 여성은 생리통이 심해지면서 생리혈의 색깔이 검게 변하거나, 불규칙한 생리주기, 냉증이 나타나기도 한다. 이러한 이유로 변비를 개선할 수 있는 기능성 식품 개발하는 연구가 이루어지고 있다.The body has an average of 5 to 10 kg of succulence. Succubus is contained in the wrinkles and diverticulum of the large intestine, rotting it, weakening the function of the large intestine, and generating toxic gas. Poisonous gas filled in the bowel gets into the brain through the blood and disturbs the brain function, causing headaches, as well as pressure on the organs such as the uterus, bladder, and prostate, affecting blood circulation, causing redness and inflammation. In addition, due to the toxic gas, absorption of oxygen and nutrients in the body is weakened and skin rash appears. The toxic gas expands to cause symptoms such as discomfort, shoulder stiffness, back pain and weight gain due to succulence, The color of the color changes, irregular menstrual cycles, and may appear cold. For these reasons, studies are under way to develop functional foods that can improve constipation.
변비를 개선할 수 있는 식품과 관련된 종래기술로는 대한민국 등록특허공보 제10-1174723호가 있는데, 상기 종래기술은 청국장 30 내지 70중량%와 생콩 30 내지 70중량%와 이루어진 생콩 청국장 조성물 및 이를 유효성분으로 함유하는 변비 개선용 건강식품 조성물에 관한 것으로, 생콩 청국장 조성물은 생콩과 청국장을 결합시킴으로써, 생콩과 청국장이 각각의 효능 및 변비 개선의 효과를 나타내는 것이다. 상기 종래기술은 변비 개선의 효과가 있지만, 청국장에 발생하는 특유의 냄새로 인해 섭취가 용이하지 않은 문제점이 있다.Korean Patent Registration No. 10-1174723 discloses a conventional art relating to food that can improve constipation. In the prior art, the soybean chungkukjang composition comprising 30 to 70% by weight of chungkukjang and 30 to 70% The present invention relates to a health food composition for improving constipation, wherein the soybean chongkookjang composition combines soybean and chonggukjang so that soybean and chungkukjang each exhibit the effect of improving the efficacy and constipation. The above-mentioned prior art has an effect of improving constipation, but has a problem that ingestion is difficult due to the characteristic odor generated in the cheonggukjang.
이러한 문제점을 개선한 종래기술로는 대한민국 등록특허공보 제10-1584632호가 있는데, 상기 종래기술은 배변 활동을 향상시키고 변비를 완화시킬 수 있는 커피 조성물에 관한 것으로서, 보다 상세하게는 커피와 함께 유산균 및 락티톨을 함께 포함하여 배변이 원활하게 이루어지게 하며, 변비 예방 및 완화 효과를 제공할 수 있어 기호식품인 커피를 즐기면서 건강 증진에도 도움이 되는 커피 조성물에 관한 것이다. 상기 종래기술은 유산균에 의해 변비가 개선되는 효과가 있지만, 커피에 함유된 카페인의 섭취로 수면장애가 발생할 수 있다.Korean Patent Registration No. 10-1584632 discloses a coffee composition which improves bowel activity and alleviates constipation. More specifically, the present invention relates to a coffee composition, The present invention relates to a coffee composition which can prevent defecation and alleviate constipation and facilitate healthy eating while enjoying coffee as a favorite food. The above-mentioned prior art has an effect of improving constipation by lactic acid bacteria, but the ingestion of caffeine contained in coffee may cause a sleep disorder.
상기와 같은 종래 기술의 문제점을 해결하기 위하여, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 조성물을 제공하는 목적이 있다.In order to solve the problems of the prior art as described above, the present invention provides a natural material extract which is extracted from a natural material blend consisting of a cellulosic material, an underwear, a seaweed, a bag, a Baekbokryeong, a presbytery, And to provide a composition comprising the same.
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 제공하는 목적이 있다. The present invention also relates to a composition for improving constipation and aspiration comprising an extract of a natural material extracted from a combination of natural materials made of a combination of natural materials made of a cellulosic material, an undergarment, seaweed, packing, Baekbokryeong, And a manufacturing method thereof.
아울러, 상기 제조방법으로 과립제, 산제, 환제를 제조하여 사용자가 손쉽게 복용하도록 편의성을 제공하는 목적이 있다.In addition, it is an object of the present invention to provide a granule, a powder, and a pill to be easily taken by a user.
본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물을 제공한다. The present invention provides a composition for improving constipation and aspiration, which comprises an extract of a natural material extracted from a natural material combination consisting of a cellulosic material, an underwear, a seaweed, a packing, a white ginseng, a presbyopia, a flax, a crust, .
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물이 변비 및 숙변을 개선하는 효과를 제공한다.In addition, the present invention provides the effect of improving natural constipation and succulence by extracting natural materials extracted from a natural material combination made of a cell material, an underwear, a seaweed, a bag, a white goblet, a presbytery,
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1)와 상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2)와 상기 천연재료 배합물을 건조하고 분말화하여 천연재료 분말을 제조하는 단계(B1)와 상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(C1);로 이루어진 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 제공한다. The present invention also relates to a method of extracting a natural material from a natural material combination comprising a natural material combination consisting of a carbonaceous material, an underwear, a seaweed, a bag, a white robe, a presbytery, (A2) of concentrating a natural material extract of a natural material concentrate to obtain a natural material concentrate, (Bl) a step (Bl) of drying and pulverizing the natural material mixture to produce a natural material powder, And a step (C1) of mixing the natural material powder of step (B1) to prepare granules, powders and pills, and a method for producing a composition for improving constipation and cramping comprising an extract of a natural material as an active ingredient.
또한, 본 발명은 상기 제조방법으로 제조된 과립제, 산제, 환제를 제공한다.In addition, the present invention provides granules, powders, and pills made by the above-described method.
상기와 같이 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물을 제공하는 효과를 있다. As described above, the present invention provides a composition for improving constipation and aspiration comprising an extract of a natural material extracted from a natural material combination consisting of a cellulosic material, an underwear, a seaweed, a packing, a Baekwolryeong, a presbytery, .
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물이 변비 및 숙변을 개선하는 효과를 가진다.Further, the present invention has the effect of improving constipation and succulence by extracting natural materials extracted from a natural material combination made of a cell material, an underwear, a seaweed, a packing, a baekwolryeong, a presbyoptera, a filament, a crustacean, a liquorice, a flaxseed and a mint.
또한, 본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 제공하는 효과를 가진다.Further, the present invention relates to a composition for improving constipation and aspiration, which comprises extracting a natural material from a natural material mixture consisting of a cellulosic material, an underwear, a seaweed, a packing, a Baekbokbok, a presbyopia, The present invention has the effect of providing a method.
아울러, 상기 제조방법으로 과립제, 산제, 환제를 제조하여 사용자가 손쉽게 복용하도록 하는 편의성을 가진다.In addition, the granules, powders, and pills can be manufactured by the above-described manufacturing method, and the user can conveniently take the granules.
도 1은 본 발명에 따른 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법을 보여주는 순서도이다.1 is a flowchart showing a method of preparing a composition for improving constipation and cramping using an extract of a natural material according to the present invention as an active ingredient.
이하, 본 발명의 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법을 상세하게 설명한다.Hereinafter, the composition for improving constipation and cramping and the method of producing the composition for improving constipation and cushioning using the natural material extract of the present invention as an effective ingredient will be described in detail.
우선 본 발명의 조성물에 대해 설명한다.First, the composition of the present invention will be described.
본 발명의 조성물은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물인 것을 특징으로 한다.The composition of the present invention is a composition for improving constipation and aspiration comprising an extract of a natural material extracted from a natural material mixture composed of a natural material consisting of a cellulosic material, an underwear, a seaweed, a packing, a white nectarine, a suture, a filament, a crust, .
또한, 본 발명의 일 실시예에 따른 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물은, 총 중량대비 차전자피 15 내지 45 중량%, 내복자 1 내지 10 중량%, 해조 5 내지 30 중량%, 곤포 5 내지 30 중량%, 백복령 1 내지 7 중량%, 노회 5 내지 20 중량%, 지실 1 내지 7 중량%, 지각 1 내지 10 중량%, 백출 1 내지 7 중량%, 아마인 1 내지 7 중량% 및 마인 1 내지 7중량%으로 이루어진 천연재료 배합물로부터 추출한 천연재료 추출물을 함유하는 것을 특징으로 한다.The composition for improving constipation and aspiration according to one embodiment of the present invention comprises 15 to 45% by weight of the total weight of the composition, 1 to 10% by weight of the underpants, 5 to 30% by weight of the seaweed, From 1 to 7% by weight of linseed, from 1 to 7% by weight of linseed, from 1 to 7% by weight of linseed, from 5 to 20% by weight of linseed, from 1 to 7% And 1 to 7% by weight of a natural material extracted from a natural material combination.
상기 차전자피는 차전자의 껍질을 분쇄하여 식용에 적합하도록 만든 것을 말하며, 식이섬유, 비타민 A, C, K를 함유하고 있고, 특히, 아로비노-자일란-다당류(arobino-xylan-polysaccharide)를 다량 함유하여 수분 보유량이 뛰어나다. 차전자피의 식이섬유는 수분을 흡수하여 변의 부피를 늘리고, 장을 자극하여 배변에 도움을 주며, 차전자피의 식이섬유 일일 섭취량이 3.9g 이상이면 배변활동이 원활해지고, 5.5g 이상이면 혈중 콜레스테롤 농도를 낮추는데 도움을 주는 것으로 보고되고 있다. The present invention relates to a method for producing a microbicidal composition which comprises crushing the skin of a tea beverage and making it suitable for edible use, and contains dietary fiber, vitamins A, C and K and particularly a large amount of arobino-xylan-polysaccharide So that it has excellent moisture retention. Dietary fiber of the cardiopulmonary diet absorbs water to increase the volume of the stool, stimulates the bowel to help defecation, and when the dietary fiber intake per day of the dietary fiber is 3.9 g or more, the bowel activity becomes smooth, and when the amount is 5.5 g or more, the blood cholesterol concentration is lowered It is reported to be helpful.
본 발명의 차전자피는 일 실시예의 조성물 중 총 중량대비 15 내지 45 중량%인 것이 바람직하다. 상기 차전피의 함량이 15 중량% 미만인 경우, 차전자피의 식이섬유 함량이 부족하여 배변활동을 도움을 주지 못하며, 45 중량% 초과인 경우, 차전자피의 식이섬유에 의한 장의 자극이 과하여, 설사, 복통, 두통 등을 일으킬 수 있으므로 바람직하지 않다.The particulate material of the present invention is preferably 15 to 45% by weight based on the total weight of the composition of one embodiment. If the content of the secondary blood is less than 15% by weight, the dietary fiber content of the primary cell can not be sufficient to defecate, and if it exceeds 45% by weight, irritation of the intestinal tract by the dietary fiber of the secondary cell is excessive, And the like.
상기 내복자는 십자화과에 속하는 무(Raphanus sativus Linne)의 씨를 말하며, 나복자라고도 한다. 내복자는 위산의 분비를 촉진시켜 음식물 소화를 돕고 체한 것을 내려가게 하는 효능이 있어, 복부팽만, 담의 제거, 변비 및 설사에 효과가 있다. 내복자의 섭취시, 비위가 약하거나 체력이 저하된 사람에게는 위에 과한 자극을 줄 수 있어 주의가 필요하다. 근래에는 내복자에 항균물질이 들어 있어 포도상구균, 대장균 및 피부진균의 억제작용, 혈압저하 작용 및 항암작용도 나타내는 것으로 보고되고 있으며, 특히, 내복자의 설포라판(sulforaphan)은 조리한 음식물에서 나올 수 있는 돌연변이원성 물질인 헤테로사이클릭아민(heterocyclic amine)에 대해서 강력한 항돌연변이 활성을 가진다고 보고되고 있다. The underwear refers to seeds of radish (Raphanus sativus Linne) belonging to the cruciferous family, and is also referred to as an abortus. The underwear has the effect of promoting the secretion of stomach acid to help digest food and lower the stomach, which is effective for abdominal distension, removal of feces, constipation and diarrhea. When ingesting underwear, it is necessary to be careful because it can give excessive irritation to people with weak or poor physical strength. In recent years, antibacterial substances are contained in the underwear, and thus they have been reported to be used for inhibiting staphylococci, E. coli and skin fungi, for lowering blood pressure and for anticancer activity. Especially, Has a strong antimutagenic activity against the heterocyclic amine as a source material.
본 발명의 내복자는 일실시예의 조성물 중 총 중량대비 1 내지 10 중량%인 것이 바람직하다. 상기 내복자의 함량이 1 중량% 미만인 경우, 함량 부족으로 내복자의 효과가 미비하여 음식물의 소화, 변비 개선에 도움이 되지 않고, 10 중량% 초과인 경우, 과도한 위산 분비 촉진으로 위장장애를 유발할 수 있으므로 바람직하지 않다.The undercoat of the present invention is preferably 1 to 10% by weight based on the total weight of the composition of one embodiment. If the content of the underpants is less than 1 wt%, the effect of the underpants is insufficient due to insufficient content, which does not contribute to improvement of digestion and constipation of the food, and if it exceeds 10 wt%, excessive gastric acid secretion promotion may cause gastrointestinal disorder It is not preferable.
상기 해조는 해마조과에 속하는 톳(Hijikia fusiforme Okamura) 또는 알쏭이모자반(Sargassum pallidum C. Agardh)의 전조이다. 해조에는 식이섬유가 많아 장운동을 자극하여 배변효과가 있고, 특히, 식이섬유의 일종인 알긴산은 중금속을 체외로 배출시키는 효과가 있다. 또한, 해조에 함유된 칼륨, 요오드, 칼슘 등 무기염류는 혈관의 변성을 막으며, 콜레스테롤을 낮추고, 혈액순환을 원활하게 하여 고지혈증 개선에 도움이 된다. 해조에는 요오드 성분이 풍부해 갑상선 질환을 개선하는데 도움이 된다. 해조에는 무기비소가 포함되어 있고, 특히 톳에는 다른 해조류보다 무기비소가 다량 함유되어 있으며, 무기비소를 다량 섭취시에는 체내에 축적되어 중독증상이 나타날 수 있다고 알려져있다.The seaweed is a precursor of the Hijikia fusiforme Okamura or Sargassum pallidum C. Agardh belonging to the hippocampus. Seaweed contains a lot of dietary fiber to stimulate the intestinal tract and has a defecation effect. In particular, alginic acid, which is a kind of dietary fiber, has an effect of discharging heavy metals to the outside of the body. In addition, inorganic salts such as potassium, iodine, and calcium contained in the seaweed block blood vessel degeneration, lower cholesterol, and facilitate blood circulation, thereby helping to improve hyperlipemia. Seaweed is rich in iodine and helps improve thyroid disease. The seaweed contains inorganic arsenic, and in particular, it has a higher content of inorganic arsenic than other seaweeds. It is known that when a large amount of inorganic arsenic is ingested, it accumulates in the body and may cause poisoning symptoms.
본 발명의 해조는 일 실시예의 조성물 중 총 중량대비 5 내지 30 중량%인 것이 바람직하지 않다. 상기 해조의 함량이 5 중량% 미만인 경우, 해조에 의한 배변 및 중금속 배출의 효과가 미비하고, 30 중량% 초과인 경우, 해조의 무기비소를 다량 섭취하게 될 수 있으므로 바람직하지 않다.The seaweed of the present invention is not preferred to be 5 to 30% by weight based on the total weight of the composition of one embodiment. When the content of the seaweed is less than 5% by weight, the effect of defecation and heavy metal discharge by the seaweed is insufficient. When the content of the seaweed exceeds 30% by weight, inorganic arsenic in the seaweed may be ingested in large amounts.
상기 곤포는 다시마목에 속한 다시마(Laminaria japonica ARESCH.)와 감태(Ecklonia kurome OKAM.)의 엽상체를 건조한 것으로, 해대라고도 한다. 곤포는 강장작용, 갑상선 기능조절작용, 항암작용, 혈압저하, 동맥경화막이작용, 약한 설사작용, 및 이뇨작용을 한다. 특히, 곤포의 요오드는 신진대사를 활발하게 하여 체내 에너지 소모를 증가시키므로 비만에 도움을 주고, 갑상선종에 효과가 있는 반면, 요오드를 지나치게 섭취하면 갑상샘 호르몬의 생성이 억제될 수 있다. 곤포의 알긴산은 콜레스테롤 수치와 혈압을 낮추는 효과, 장운동을 자극하여 배변하는 효과 및 중금속을 체외로 배출시키는 효과가 있다. 곤포에는 식이섬유가 많으므로, 설사가 잦은 사람이나 갑상선 기능항진증이 있는 사람은 섭취시 주의가 필요하다.This packing is called dried sea tangle (Laminaria japonica ARESCH.) And lobster of Ecklonia kurome OKAM. Balls have tonic action, thyroid function regulating action, anti-cancer action, blood pressure lowering, arteriosclerotic membrane action, weak diarrhea, and diuretic action. In particular, iodine in packing increases metabolism, increases energy expenditure in the body, and thus helps obesity and is effective against goiter. On the other hand, excessive intake of iodine can inhibit the production of thyroid hormone. Alginic acid in packing has effects of lowering cholesterol level and blood pressure, stimulating bowel movements and defecating and discharging heavy metals to the outside of the body. People who have frequent diarrhea or hyperthyroidism need to be careful when taking their diets because they have many dietary fiber.
본 발명의 곤포는 일실시예의 조성물 중 총 중량대비 5 내지 30 중량%인 것이 바람직하다. 상기 곤포의 함량이 5 중량% 미만인 경우, 곤포에 의한 배변 및 중금속 배출의 효과가 미비하고, 30 중량% 초과인 경우, 곤포의 요오드를 다량 섭취로 갑상샘 호르몬의 생성을 억제할 수 있으므로 바람직하지 않다.The wrapping of the present invention is preferably 5 to 30% by weight based on the total weight of the composition of one embodiment. When the content of the packing material is less than 5% by weight, the effect of defecation and heavy metal discharging is insufficient. When the packing material content is more than 30% by weight, a large amount of packing iodine is consumed to inhibit the production of thyroid hormone .
상기 백복령은 소나무 뿌리에 기생하는 균핵으로, 복령은 소나무 뿌리에 버섯균이 침투하여 혹처럼 크게 자란 것을 말린 것이다. 이 중 균핵 가운데 소나무 뿌리가 있는 것을 복신, 균핵의 피부를 복령피라고 한다. 복령은 내부의 색에 따라 담홍색인 것을 적복령이라 하고, 적복령을 절편한 다음 백색 부분만을 백복령이라고 하는데, 일반적으로 복령이란 백복령을 말한다. 백복령은 탄수화물, 수분, 칼륨, 마그네슘, 칼슘 등을 함유하고 있으며, 주성분으로는 베타 파키만, 파킴산, 에르고스테롤 등이 알려져 있다. 백복령의 일부 성분은 항암효과가 있는 것으로 보고되어 있으며, 특히, 트리테르펜 성분은 항구토, 항염증, 항피부암에 효과가 있다고 보고된 바 있다. 또한, 백복령은 이뇨작용, 이뇨작용에 의한 부종의 감소, 만성위염, 복통, 혈당강하작용, 혈허 등에 효과가 있으며, 신경과민을 해소하여 불면증에 도움을 준다. The Baekbok-ri is sclerotia parasitized on the roots of pine trees. Among them, the sclerotium in the middle of the pine roots, bacillus, sclerotin skin is called huhyeongjip. It is called Baekbokryeong, and Baekbokryeong is the white part after cutting Baekbokryeong. Baek Bok-gyeong contains carbohydrate, water, potassium, magnesium, calcium and the like. Betapak Bay, pachymic acid, ergosterol, etc. are known as main ingredients. Some components of Baek Bok Bok rehn have been reported to have anticancer effects. In particular, triterpene has been reported to be effective against sunburn, anti-inflammatory and anti-skin cancer. In addition, baekbokgyeong diuretic action, decreased edema due to diuretic, chronic gastritis, abdominal pain, hypoglycemic effect, is effective in reducing blood pressure, helps to relieve nervousness and insomnia.
본 발명의 백복령은 일 실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 백복령의 함량이 1 중량% 미만인 경우, 백복령의 이뇨작용 및 복통 완화의 효과가 미비하고, 7 중량% 초과인 경우, 이뇨작용이 심해져 탈수증상이 나타날 수 있으므로 바람직하지 않다.It is preferable that the white roots of the present invention is 1 to 7% by weight based on the total weight of the composition of one embodiment. If the content of baekbokryeong is less than 1 wt%, the diuretic effect and abdominal pain relief of baekbokryeong are insufficient, and if the content is more than 7 wt%, the diuretic effect becomes severe and dehydration symptoms may appear.
상기 노회는 백합과의 알로에속 다년생 초본이며, 맛은 쓰고 성질은 차며 간과 대장에 작용한다. 노회는 간의 열을 내려주며, 열에 의한 두통, 어지럼증, 가슴이 답답한 증상을 완화하는 효과가 있다. 또한, 노회는 열로 뭉친 변비나 습관성 변비에 효과가 있으며, 기생충을 없애는 효능이 있다. 단, 소화기가 약하고 몸이 차거나, 설사를 자주하는 사람에게는 사용을 주의해야 하며, 임신부에게는 특히 그러하다. 그외 노회의 약리작용으로는 혈당 강하, 항염작용, 항균작용, 항바이러스작용, 항종류작용, 간손상에 대한 보호작용, 상처 유합작용 등이 보고된 바 있다.The presbytery is a perennial herbaceous plant of the genus Aloe with lilies. The presbytery gives heat to the liver, and has the effect of relieving headache, dizziness, and chest tightness by heat. In addition, the presbytery is effective in constipation and habitual constipation, which is caused by heat, and has the effect of eliminating parasites. However, if you have a weak digestive system, a cold body, or diarrhea frequently, you should be careful to use it, especially for pregnant women. Other pharmacological actions of the presbytery have been reported such as hypoglycemia, anti-inflammatory action, antibacterial action, antiviral action, anti-class action, protection against liver damage, and wound healing action.
본 발명의 노회는 일실시예의 조성물 중 총 중량대비 5 내지 20 중량%인 것이 바람직하다. 상기 노회의 함량이 5 중량% 미만인 경우, 노회에 의한 사하작용와 살충작용이 미비하고, 20 중량% 초과인 경우, 노회의 쓴맛이 강해지거나, 소화기 약한 사람에게는 위장에 부담을 줄 수 있으므로 바람직하지 않다.The presbyopian of the present invention is preferably 5 to 20% by weight based on the total weight of the composition of one embodiment. If the content of the presbyopia is less than 5% by weight, the secretory action and the insecticidal action by the presbytery are insufficient, and if the content of the presbyopia is more than 20% by weight, the bitterness of the presbytery becomes strong, .
상기 지실은 탱자나무의 익지 않은 열매로, 특유의 냄새가 있고, 맛은 쓰고 시며, 성질은 차다. 지실에는 헤스페리딘, 나린진, 시네프린, 폰시린 등이 함유되어 있어, 모세혈관 강화, 콜레스테롤 수치 개선, 혈류 개선, 항알레르기, 발암억제, 식욕억제 등에 효과가 있다. 또한, 지실은 위장과 대장의 열기에 의한 설사 치료, 자궁 수축력 강화, 이뇨작용, 소화관 운동 촉진, 변비로 인한 복통에도 효과가 있는 반면, 지실을 과다섭취하면 구토가 발생할 수 있고, 부종이나 혈압상승이 나타날 수 있다.The seedling is an unripe fruit of a tangerine tree, and has a characteristic odor, flavor, and property. It contains Hesperidin, Naringin, Cinephrine, Poncein, etc. It is effective for capillary strengthening, cholesterol improvement, blood flow improvement, antiallergic, carcinogenesis inhibition and appetite suppression. In addition, it is effective for diarrhea caused by gastrointestinal and intestinal fever, strengthening of uterine contractility, diuretic action, promotion of gastrointestinal motility, and abdominal pain due to constipation. On the other hand, excessive ingestion of feces may cause vomiting, May appear.
본 발명의 지실은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 지실의 함량이 1 중량% 미만인 경우, 지실에 의한 이뇨작용와 소화관 운동 촉진작용이 미비하고, 7 중량% 초과인 경우, 신맛이 강해지고, 구토나 부종, 혈압상승을 유발할 수 있으므로 바람직하지 않다.The fuselage of the present invention is preferably 1 to 7% by weight based on the total weight of the composition of one embodiment. When the content of the fibrillar is less than 1% by weight, diuretic action by the fibril and action of stimulating the movement of the digestive tract are insufficient, and when it is more than 7% by weight, the sour taste becomes strong and vomiting, edema and blood pressure may be increased.
상기 지각은 광귤나무 또는 그 재배변종의 과실로, 우리나라에서는 탱자나무의 성숙한 열매를 말한다. 지각은 지실과 효능이 같으며, 네오헤스페리딘, 나린진, 비타민 C 등이 함유되어 있다. 지각은 지실보다 작용이 완만하며, 기가 퍼지지 못하고 한곳에 모여있어 가슴과 배가 답답할 때, 음식이 정체되었거나, 변비로 인한 복통 등에 사용된다. 또한, 지각은 장운동을 촉진하며, 건위소화작용으로 소화장애에도 효과가 있으나, 혈압상승 및 위의 연동운동을 촉진하는 효과도 있으므로 위장이 약한 사람은 섭취를 주의하는 것이 좋다.The crust is the fruit of the coconut tree or cultivated varieties, and the mature fruit of the coconut tree in our country. The crust has the same efficacy as zeaxan and contains neohesperidin, naringin, and vitamin C. The crust is slower than that of the wrist, and when the chest and the stomach are tight, the food is stagnant or used for constipation due to constipation. In addition, the crust promotes intestinal motility, and is effective in the digestive disorders due to the digestion of the key, but it also has the effect of promoting blood pressure rise and stomach motion, so it is better to pay attention to ingestion of people with weak stomach.
본 발명의 지각은 일실시예의 조성물 중 총 중량대비 1 내지 10 중량%인 것이 바람직하다. 상기 지각의 함량이 1 중량% 미만인 경우, 장운동의 촉진하는 효과가 미비하고, 10 중량% 초과인 경우, 과도한 위의 연동운동으로 배탈을 일으킬 수 있으므로 바람직하지 않다.The crust of the present invention is preferably 1 to 10% by weight based on the total weight of the composition of one embodiment. If the content of the crust is less than 1% by weight, the effect of accelerating the intestinal motility is insufficient. If the crustal content is more than 10% by weight, excessive stomatal motion may result in stomach upsetting.
상기 백출은 국화과에 속하는 삽주 또는 백출의 뿌리줄기로서 그대로 또는 주피를 제거한 것이며, 삽주라고도 한다. 백출에는 아트락틸롤, 아트락틸론, 비타민 A 등이 함유되어 있고, 맛은 달고 맵고 쓰며, 따뜻한 성질을 가지고 있다. 백출은 비장과 위장을 튼튼하게 하고, 비장을 안정시켜 체기를 물리치는 효능이 있고, 신장의 기능장애로 인한 빈뇨증, 어지럼증에 효과가 있으며, 설사, 황달, 부종, 두통 및 과식 등에도 효과가 있다. 단, 백출을 장기간 복용하면 체내의 진액이 부족하게 되므로, 체내에 수분이 부족하여 열이 있거나, 진액이 부족하여 갈증이 많은 사람은 복용시 주의하여야 한다.The red pepper is either a roots of leaves or leaves belonging to the Asteraceae, or they are also called leaves. It contains artactylol, art lactilol, and vitamin A, and it has a sweet, spicy, warm character. It is effective in stabilizing the spleen and stomach, stabilizing the spleen and defeating the stomach, effective in the idiopathic disorder caused by renal dysfunction, dizziness, diarrhea, jaundice, edema, headache and overeating . However, long-term intake of white liquor becomes insufficient in the body's essence, so if there is a lack of water in the body and fever, or lack of lavender and thirst, take caution when taking.
본 발명의 백출은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 백출의 함량이 1 중량% 미만인 경우, 백출의 함량이 부족하여 비장과 위장을 튼튼하게 하는 효과가 미비하고, 7 중량% 초과인 경우, 백출에 의한 이뇨작용이 심해질 수 있으므로 바람직하지 않다.The amount of the present invention is preferably 1 to 7% by weight based on the total weight of the composition of one embodiment. If the content of the extract is less than 1% by weight, the effect of making the spleen and the stomach intact is insufficient because the content of the extract is insufficient. If the content is more than 7% by weight, the diuretic effect due to exfoliation may be increased.
상기 마인은 뽕나무과에 속하는 삼의 씨를 말하며, 저실, 마자인, 화마인이라고도 한다. 마인은 특이한 냄새가 나고, 맛은 달며, 비장과 위, 대장에 작용한다. 마인에는 올레인산, 리놀렌산, 레시틴, 콜린 등이 함유되어 있으며, 비위를 튼튼하게 하는 효과가 있다. 또한 마인은 장점막의 자극으로 점액질의 분비를 촉진하고 연동운동을 촉진하여 배변이 원활하도록 하며, 갈증을 그치게 하고, 혈액순환을 활발히 하여 어혈을 풀어주는 효과도 있다. 마인은 과량을 쓰면 구토, 설사 증상이 나타나며, 이것이 경과되면 마비작용으로 이행되므로, 사용시 주의하여야 한다.The above-mentioned Mein refers to the seed of Sam's family belonging to the family Phalaenopsis, and is also referred to as the family, Maazine, and Famein. Mine has an unusual smell, flavor, sweetness, and acts on the spleen, stomach, and large intestine. Mine contains oleic acid, linolenic acid, lecithin, choline and so on. In addition, Mine stimulates the mucous secretion by stimulating the mucous membrane, promotes peristalsis, facilitates the defecation, stops thirst, and releases blood by circulating blood. If you use excessive amount of Mine, symptoms of vomiting and diarrhea appear, and this will pass into the paralysis action, so caution should be used.
본 발명의 마인은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 마인의 함량이 1 중량% 미만인 경우, 마인의 함량이 부족하여 비장과 위장을 튼튼하게 하는 효과 및 사하작용이 미비하고, 7 중량% 초과인 경우, 구토, 설사 등이 나타날 수 있으므로 바람직하지 않다.It is preferable that the main ingredient of the present invention is 1 to 7% by weight based on the total weight of the composition of one embodiment. If the content of the main ingredient is less than 1% by weight, the content of the main ingredient is insufficient to strengthen the spleen and the stomach, and the subcutaneous effect is insufficient. When the content of the main ingredient exceeds 7% by weight, vomiting and diarrhea may occur .
상기 아마인은 아마과에 속하는 아마의 잘 익은 씨로, 필수 불포화 지방산, 리그난 등을 함유하고 있으며, 호마자, 호마인이라고도 한다. 아마인의 불포화 지방산은 콜레스테롤을 감소시켜 혈액순환을 원활히 하며 혈당을 조절하는 효과가 있다. 아마인의 리그난은 활성산소에 의한 체내 세포의 노화를 억제하는 항산화 효과가 있으며, 장벽을 보호하고 중금속을 체외로 배출하는 효과가 있다. 또한, 아마인은 식이섬유소가 풍부하여 대장에 있는 숙변을 배출하고 변비를 예방하는 효과가 있다. 단, 아마인에는 독성물질이 있어 과량 섭취시에는 두통, 구토, 설사, 복통 등의 부작용이 나타난다.The flaxseed is a flaxseed of flaxseed which contains essential unsaturated fatty acids, lignans and so on. The unsaturated fatty acids in flaxseed reduce cholesterol, promote blood circulation and control blood sugar. Lignan of the flaxseed has an antioxidative effect which inhibits the aging of the body cells by the active oxygen, it has the effect of protecting the barrier and discharging the heavy metal to the outside of the body. In addition, flax fiber is abundant in the large intestine in the colon, and has the effect of preventing constipation. However, flaxseed is toxic substances, excessive intake of headache, vomiting, diarrhea, abdominal pain and side effects such as appears.
본 발명의 아마인은 일실시예의 조성물 중 총 중량대비 1 내지 7 중량%인 것이 바람직하다. 상기 아마인의 함량이 1 중량% 미만인 경우, 아마인의 함량이 부족하여 숙변 및 중금속의 배출 효과가 미비하고, 7 중량% 초과인 경우, 두통, 설사, 구토의 부작용이 나타날 수 있으므로 바람직하지 않다.The flaxen of the present invention is preferably 1 to 7% by weight based on the total weight of the composition of one embodiment. If the content of flaxine is less than 1% by weight, the effect of exhaustion of succulents and heavy metals is insufficient, and if it exceeds 7% by weight, side effects of headache, diarrhea and vomiting may occur.
상기 본 발명에 따른 변비 및 숙변 개선용 조성물은 변비를 개선하고, 숙변을 제거하는 효과를 나타내며, 변비 개선으로 인해 체내의 노폐물과 독소물질의 배출이 원활하여 해독효과를 볼 수 있으며, 숙변제거로 인한 체중감량의 효과를 볼 수 있다.The composition for improving constipation and cautiousness according to the present invention has the effect of improving constipation and eliminating succumbing. The composition of the present invention can improve the constipation and release toxins and toxins from the body, The effect of weight loss can be seen.
이하, 본 발명의 제조방법에 대한 바람직한 실시 내용은 첨부한 도면을 참조하여 설명하며, 본 발명의 제조방법은 하기 단계를 포함하는 것이 바람직하나 이에 한정되지 않는다.Hereinafter, preferred embodiments of the method of the present invention will be described with reference to the accompanying drawings. The method of manufacturing the present invention preferably includes the following steps, but not limited thereto.
본 발명은 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 아마인 및 마인으로 이루어진 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1)와 상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2)와 상기 천연재료 배합물을 건조하고 분말화하여 천연재료 분말을 제조하는 단계(B1)와 상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 과립제, 산제, 환제를 제조하는 단계(C1)를 제공한다.The present invention relates to a method of extracting a natural material from a natural material combination consisting of a natural material combination consisting of a cell material, an underwear, a seaweed, a packing, a white roe, a presbytery, (A2) a step of concentrating the material extract to produce a concentrate of natural material and (B1) drying and pulverizing the natural material blend to produce a natural material powder, and a concentrate of the natural material of step (A2) B1) to prepare a granule, a powder and a pill (C1).
상기 천연재료 배합물로부터 천연재료 추출물을 추출하는 단계(A1)에서 정제수와 식품용 알코올을 8 : 2 내지 5 : 5 중량비로 혼합한 추출 용매를 제조한다. 상기 식품용 알코올은 에탄올인 것이 바람직하다. In step (A1) of extracting the natural material extract from the natural material combination, an extraction solvent is prepared by mixing purified water and alcohol for food at a weight ratio of 8: 2 to 5: 5. The food alcohol is preferably ethanol.
상기 추출 용매는 알코올 대비 정제수의 중량비가 5 중량비 미만이면 알코올 성분이 상대적으로 늘어나, 추출 후 남은 알코올을 제거하기 위한 공정이 추가되며, 알코올 대비 정제수의 중량비가 8 중량비 초과이면 알코올 성분이 상대적으로 줄어 각각의 천연재료에서 추출물들이 균일하게 추출되지 않는 문제점이 있다.If the weight ratio of purified water to alcohol is less than 5 parts by weight, the alcohol component is relatively increased and a process for removing remaining alcohol after the extraction is added. If the weight ratio of purified water to alcohol is more than 8 parts by weight, There is a problem that the extracts are not uniformly extracted from each natural material.
우선 천연재료를 깨끗이 세척하여 배합한 후, 1,000 내지 5,000 mL의 상기 추출 용매를 넣고, 75 내지 95 ℃의 온도로 8 내지 10 시간 동안 진공상태에서 천연재료 추출물을 추출하는 단계(A1)를 수행한다.First, the natural material is thoroughly washed and blended, then 1,000 to 5,000 mL of the above extraction solvent is added, and step (A1) of extracting the natural material extract in a vacuum state at a temperature of 75 to 95 DEG C for 8 to 10 hours is performed .
상기 천연재료를 배합할 때는 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 마인 및 아마인을 포함한다.When the natural materials are blended, they include potatoes, underwear, seaweeds, wrapping, white roe, presbytery, fir, crust, liquor, mine and flaxseed.
상기 단계(A1)에서 상기 천연재료 추출물을 얻은 후, 상기 단계(A1)의 천연재료 추출물을 농축하는 단계(A2)를 수행한다. 1,000 내지 5,000 mL의 천연재료 추출물을 진공 저온 농축 방법으로 500 내지 1,000 mL의 혼합 천연재료 농축액을 제조한다. After obtaining the natural material extract in the step (A1), the step (A2) of concentrating the natural material extract of the step (A1) is carried out. 1,000 to 5,000 mL of the natural material extract is subjected to a vacuum low-temperature concentration method to prepare a concentrated natural material concentrate of 500 to 1,000 mL.
상기 진공 저온 농축 방법은 열 영향을 받는 물질이나 공기에 의해 산화되는 물질을 농축하기 위해 진공 상태에서 저온(40 내지 90 ℃)으로 하며, 이는 천연재료 약효의 손상없이 농축하는 것이다.The vacuum low-temperature concentration method is a method of concentrating a substance to be thermally influenced or oxidized by air to a low temperature (40 to 90 ° C) in a vacuum state, without concentrating the harmful effect of the natural material.
다음 단계로, 상기 천연재료를 건조하고 분말화하는 단계(B1)를 수행한다. 상기 단계(B1)에서는 천연재료를 깨끗이 세척하고 배합한 후, 건조기에서 65 내지 75 ℃의 온도로 8 내지 10 시간 동안 건조한 후, 100 내지 300 mesh의 천연재료 분말을 제조한다.As a next step, step (B1) of drying and pulverizing the natural material is carried out. In step (B1), the natural material is thoroughly cleaned and blended, dried in a drier at a temperature of 65 to 75 ° C for 8 to 10 hours, and then 100 to 300 mesh of a natural material powder is produced.
상기 천연재료를 배합할 때는 차전자피, 내복자, 해조, 곤포, 백복령, 노회, 지실, 지각, 백출, 마인 및 아마인을 포함한다.When the natural materials are blended, they include potatoes, underwear, seaweeds, wrapping, white roe, presbytery, fir, crust, liquor, mine and flaxseed.
상기 단계(A2)에 의해 천연재료 농축액을 제조하고, 상기 단계(B1)에 의해 천연재료 분말을 제조한 후, 다음과 같이 과립제, 산제, 환제를 제조하는 단계(C1)를 수행한다.The natural material concentrate is prepared by the step (A2), the natural material powder is prepared by the step (B1), and then the step (C1) for preparing the granules, the acid agent and the pellets is carried out as follows.
상기 천연재료 농축액과 부형제(옥수수 분말)를 1 : 1 내지 4 : 1 중량비로 배합한 후 동결건조로 과립제를 제조한다. 상기 부형제는 약제에 적당한 굳기나 형상을 주기 위해서 첨가하거나, 주제(主劑)의 양이 적은 경우에 일정 중량을 주어 취급하기 쉬운 크기로 할 목적으로 첨가되는 것이다. The natural material concentrate and the excipient (corn powder) are mixed in a weight ratio of 1: 1 to 4: 1, followed by lyophilization to prepare granules. The excipient is added for imparting a suitable hardness or shape to the medicament or added for the purpose of making the medicament easy to handle by giving a certain weight when the amount of the main agent is small.
상기 천연재료 농축액이 부형제 대비 1 중량비 미만이면 변비 예방 및 개선의 효능이 나타나지 않으며, 부형제 대비 4 중량비를 초과하면 천연재료 농축액과 부형제가 서로 응집되는 것이 어려워 과립제 제조 시 문제점이 발생된다.If the concentration of the natural material concentrate is less than 1 part by weight of the excipient, the effect of preventing and improving constipation is not exhibited. If the proportion of the excipient is more than 4 parts by weight, it is difficult to agglomerate the concentrated concentrate and the excipient.
상기 천연재료 농축액과 천연재료 분말을 1 : 1 내지 4 : 1 중량비로 혼합하여 65 내지 75 ℃의 온도로 8 내지 10 시간 동안 건조한 후 100 내지 300 mesh의 산제를 제조한다.The natural material concentrate and the natural material powder are mixed at a weight ratio of 1: 1 to 4: 1 and dried at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare a powder of 100 to 300 mesh.
상기 산제 100 내지 400 g에 찹쌀 50 내지 450 g과 정제수 500 내지 1,500 mL를 더 포함하여 혼합하고, 3 내지 7 mm의 직경으로 환제를 제조한다. 50 to 450 g of glutinous rice and 500 to 1,500 mL of purified water are further added to 100 to 400 g of the powder, and the pellet is prepared to have a diameter of 3 to 7 mm.
이하, 본 발명의 제조예, 실시예 및 시험예에 의해 상세히 설명한다.Hereinafter, the production examples, examples and test examples of the present invention will be described in detail.
하기 제조예, 실시예 및 시험예는 본 발명을 예시하는 것일 뿐, 본 발명이 하기 제조예, 실시예 및 시험예에 한정되는 것은 아니다. The following Production Examples, Examples and Test Examples are merely illustrative of the present invention, and the present invention is not limited to the following Production Examples, Examples and Test Examples.
< < 제조예Manufacturing example > > 추출 용매의 제조 Preparation of extraction solvent
추출 용매는 정제수와 식품용 알코올(에탄올)을 7 : 3 중량비로 혼합하여 제조하였다.The extraction solvent was prepared by mixing purified water and alcohol for food (ethanol) at a weight ratio of 7: 3.
< < 실시예Example > > 변비 및 숙변 개선용 조성물의 제조 Preparation of compositions for improving constipation and cramping
본 발명의 변비 및 숙변 개선용 조성물의 제조는 아래와 같은 조성물의 함량으로 혼합하여 제조하였다.The compositions for improving constipation and cramping of the present invention were prepared by mixing the following compositions.
(A1) 차전자피 33 중량%, 내복자 5 중량%, 해조 10 중량%, 곤포 10 중량%, 백복령 7 중량%, 노회 10 중량%, 지실 5 중량%, 지각 5 중량%, 백출 5 중량%, 아마인 5 중량% 및 마인 5 중량%의 천연재료를 배합한 후, 상기 제조예의 추출 용매 3,000 mL를 넣고 85 내지 90 ℃의 온도로 10 시간 동안 진공상태에서 추출하여 천연재료 추출물을 제조하였다.(A1) a mixture of 33% by weight of an antimicrobial agent, 5% by weight of an underwear, 10% by weight of seaweed, 10% by weight of packing, 7% 5% by weight of phosphorus and 5% by weight of natural materials were added thereto. Then, 3,000 mL of the extraction solvent of the above preparation example was added and extracted at a temperature of 85 to 90 DEG C for 10 hours under vacuum to prepare a natural material extract.
(A2) 상기 천연재료 추출물을 얻은 후, 3,000 mL의 상기 단계(A1)의 천연재료 추출물을 진공 저온 농축 방법으로 1,000 mL로 농축하여 천연재료 농축액을 제조하였다.(A2) After obtaining the natural material extract, 3,000 mL of the natural material extract of step (A1) was concentrated to 1,000 mL by vacuum low-temperature concentration method to prepare a concentrate of natural material.
(B1) 차전자피 33 중량%, 내복자 5 중량%, 해조 10 중량%, 곤포 10 중량%, 백복령 7 중량%, 노회 10 중량%, 지실 5 중량%, 지각 5 중량%, 백출 5 중량%, 아마인 5 중량% 및 마인 5중량%의 천연재료를 깨끗이 씻은 후, 건조기에서 65 내지 75 ℃의 온도로 10 시간 동안 건조한 후 200 mesh 천연재료 분말을 제조하였다.(B1) a mixture of 33% by weight of an antimicrobial agent, 5% by weight of an underwear, 10% by weight of seaweed, 10% by weight of packing, 7% 5% by weight and 5% by weight of natural materials were cleanly washed and then dried in a drier at 65 to 75 ° C for 10 hours to prepare a 200-mesh natural material powder.
(C1) 상기 단계(A2)의 천연재료 농축액과 옥수수 분말(부형제)을 2 : 1 중량비로 배합한 후 동결건조로 과립제를 제조하고, 상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 2 : 1 중량비로 혼합하여 65 내지 75 ℃의 온도로 10 시간 동안 건조한 후 200 mesh 산제를 제조하며, 상기 산제 300 g에 찹쌀 300 g과 정제수 1,000 mL를 더 포함하여 혼합한 후 5 mm의 직경으로 환제를 제조하였다.(C1) granulating the natural material concentrate of step (A2) and corn powder (excipient) at a weight ratio of 2: 1, Were mixed at a weight ratio of 2: 1 and dried at a temperature of 65 to 75 ° C for 10 hours to prepare a 200-mesh powder. 300 g of glutinous rice and 1,000 ml of purified water were further added to 300 g of the powder, A pile of 5 mm in diameter was prepared.
< < 시험예Test Example > 변비 및 숙변 개선 효과 확인 > Check for constipation and improvement of constipation
본 발명의 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 변비 및 숙변 개선 효과를 알아보기 위하여, 평소에 변비 증상이 있는 20~40대 남녀 20명을 대상자로 선정하고, 실험군과 대조군으로 나누어 실험하였다.In order to evaluate the constipation and improvement of constipation of the composition for improving constipation and cramping using the natural material extract of the present invention as an active ingredient, 20 subjects in the 20s and 40s who had constipation symptoms were selected as the subjects, Respectively.
실험군은 아침 및 저녁 식사 30분 전에 실시예의 조성물 4~5g을 100 mL의 물과 함께 매일 2회씩, 총 14일간 섭취하도록 하고, 상기 기간 동안 다른 변비 개선용 건강기능식품이나 약제는 섭취하지 않도록 하였다.In the experimental group, 4 to 5 g of the composition of the Example was taken twice daily with 100 mL of water for a total of 14 days before the morning and the evening, and no other health functional food or medicines for improving constipation were consumed during the period .
대조군은 아침 및 저녁 식사 30분 전에 100 mL의 물을 매일 2회씩, 총 14일간 섭취하도록 하고, 상기 기간 동안 다른 변비개선용 건강기능식품이나 약제는 섭취하지 않도록 하였다.The control group consumed 100 mL of water twice a day for a total of 14 days, 30 minutes before breakfast and dinner, during which no other health-enhancing functional food or medicines were taken.
14일 동안 섭취한 후, 실험 대상자들에게 불규칙한 배변활동의 개선, 아랫배 복통 및 불쾌감의 개선에 대한 설문조사, 체중변화를 측정하였다. 설문조사는 5점 척도법으로 진행하였으며, 매우 좋음 5 점, 좋음 4 점, 보통 3 점, 나쁨 2 점, 매우 나쁨 1 점으로 하였다. 불규칙한 배변활동의 개선에 대한 설문조사는 14일간 배변의 횟수 및 간격에 대해 점수화하였고, 체중변화는 실시예와 비교예의 조성물을 섭취하기 전후에 몸무게를 측정하여, 섭취 전후의 몸무게 차이의 평균값을 구하여 kg으로 표기하였다. 실시예와 비교예의 조성물에 대한 평가 점수는 하기 [표 1]과 같다.After 14 days of ingestion, subjects were randomly assigned to one of the following: improvement of irregular bowel movements, abdominal pain and improvement of discomfort, weight change. The survey was conducted on a 5-point scale, with 5 excellent, 4 good, 3 bad, 2 bad and 1 bad. The questionnaire for improvement of irregular bowel movements was scored for the number of bowel movements and interval for 14 days. The body weight change was measured before and after taking the composition of the examples and the comparative examples, and the average of the weight difference before and after the ingestion was obtained kg. < / RTI > The evaluation scores of the compositions of Examples and Comparative Examples are shown in Table 1 below.
상기 표 1에서 나타낸 바와 같이, 본 발명에 따른 변비 및 숙변 개선용 조성물을 섭취한 실험군은 불규칙한 배변활동, 아랫배 복통 및 불쾌감이 개선되고, 체중이 감량되는 결과를 보였으며, 대조군은 불규칙한 배변활동과 아랫배 복통 및 불쾌감, 체중감량에서 대체적으로 효과가 없었다. 이는 본 발명에 따른 변비 및 숙변 개선용 조성물이 배변활동과 변비를 개선하는 효과가 있으며, 숙변이 제거되어 체중감량의 효과를 나타내는 것을 확인할 수 있었다.As shown in Table 1, the experimental group consuming the composition for improving constipation and cautiousness according to the present invention showed irregular bowel movement, abdominal pain and discomfort, and weight loss, and the control group had irregular bowel movement Abdomen abdominal pain and discomfort, weight loss was generally ineffective. It was confirmed that the composition for improving constipation and cramping according to the present invention has an effect of improving bowel activity and constipation, and shows the effect of weight loss by eliminating the cramping.
이상, 본 발명에서 설명한 것은 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물 및 그의 제조방법을 위한 실시예에 불과한 것으로, 본 발명은 상기 실시예에 한정되는 것이 아니다. 첨부된 청구범위에서 청구하는 바와 같이 본 발명의 요지를 벗어남이 없이 당해 발명이 속하는 분야에서 통상의 지식을 가진 자라면 누구든지 다양한 변경 실시가 가능한 범위까지 본 발명의 범위에 속하는 것으로 간주 되어야 할 것이다. As described above, the present invention is not limited to the above-described embodiments, but is merely an example of a composition for improving constipation and cramping, which comprises an extract of natural materials as an active ingredient, and a method for producing the composition. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the appended claims and their equivalents. .
Claims (7)
상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2); 및
상기 단계(A2)의 천연재료 농축액과 옥수수 분말을 배합한 후 동결건조로 과립제를 제조하는 단계(C1)을 포함하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.(A1) extracting a natural material extract from a natural material combination consisting of a natural material composition consisting of a carnauba, an underwear, a seaweed, a packing, a white roe, a presbytery, a filament, a crust, a liquor, a flaxseed and a mine;
(A2) of concentrating the natural material extract of step (A1) to prepare a concentrate of natural material; And
A method for preparing a composition for improving constipation and aspiration, comprising the step of: (C1) mixing a natural material concentrate of step (A2) with corn powder and preparing a granule by freeze-drying.
상기 단계(A1)의 천연재료 추출물을 농축하여 천연재료 농축액을 제조하는 단계(A2);
상기 천연재료 배합물을 건조하고 분말화하여 천연재료 분말을 제조하는 단계(B1); 및
상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 산제, 또는 산제의 가공공정을 거친 환제를 제조하는 단계(C1)를 포함하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.(A1) extracting a natural material extract from a natural material combination consisting of a natural material composition consisting of a carnauba, an underwear, a seaweed, a packing, a white roe, a presbytery, a filament, a crust, a liquor, a flaxseed and a mine;
(A2) of concentrating the natural material extract of step (A1) to prepare a concentrate of natural material;
Drying and pulverizing said natural material blend to produce a natural material powder (Bl); And
(C1) of mixing a natural material concentrate of the step (A2) with a natural material powder of the step (B1) to prepare a poultice after a processing step of a powder or a powder, A method for preparing a composition for improving constipation and cramping.
상기 천연재료 추출물을 추출하는 단계(A1)에서 정제수와 식품용 에탄올을 8 : 2 내지 5 : 5 중량비로 혼합한 추출 용매를 사용하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.The method according to claim 2 or 3,
Wherein said extract is a mixture of purified water and ethanol for food in a weight ratio of 8: 2 to 5: 5 in step (A1) of extracting said natural material extract. ≪ / RTI >
상기 단계(A2)의 천연재료 농축액과 옥수수 분말을 1 : 1 내지 4 : 1 중량비로 배합한 후 동결건조로 과립제를 제조하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.3. The method of claim 2,
A composition for improving constipation and aspiration (hereinafter referred to as " composition for improving constipation & cushioning ") comprising, as an active ingredient, a natural material extract, which comprises blending the natural material concentrate of step (A2) and corn powder at a weight ratio of 1: 1 to 4: ≪ / RTI >
상기 단계(A2)의 천연재료 농축액과 상기 단계(B1)의 천연재료 분말을 혼합하여 65 내지 75 ℃의 온도로 건조한 후 산제를 제조하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.The method of claim 3,
Wherein the natural material extract of step (A2) is mixed with the natural material powder of step (B1) and dried at a temperature of 65 to 75 ° C to prepare a powder. A method for preparing a composition for improvement.
상기 산제에 찹쌀과 정제수를 더 포함하여 혼합한 후 3 내지 7 mm의 직경으로 환제를 제조하는 것을 특징으로 하는 천연재료 추출물을 유효성분으로 하는 변비 및 숙변 개선용 조성물의 제조방법.The method according to claim 6,
The method of manufacturing a composition for improving constipation and aspiration according to claim 1, wherein the natural agent extract is a mixture of glutinous rice and purified water.
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