CN103251698A - Puerarin beverage with effects of dispelling alcoholism, protecting liver and protecting stomach and preparation method thereof - Google Patents
Puerarin beverage with effects of dispelling alcoholism, protecting liver and protecting stomach and preparation method thereof Download PDFInfo
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- CN103251698A CN103251698A CN2013101793044A CN201310179304A CN103251698A CN 103251698 A CN103251698 A CN 103251698A CN 2013101793044 A CN2013101793044 A CN 2013101793044A CN 201310179304 A CN201310179304 A CN 201310179304A CN 103251698 A CN103251698 A CN 103251698A
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Abstract
The invention discloses healthcare functional beverage, and in particular relates to puerarin beverage with effects of dispelling the alcoholism, protecting the liver and protecting the stomach. The puerarin beverage is prepared by extracting the following raw materials in part by weight: 50-85 parts of puerarin, 15-35 parts of turnjujube, 10-20 parts of artichoke and 5-15 parts of cuttlebone. The formula of the puerarin beverage is scientific and rational, an extracting technology is advanced, and all effective components are from purely natural plants and marine extracts; the effects of dispelling the alcoholism, protecting the liver and protecting the stomach are outstanding; and side effects are avoided. The invention also provides a preparation method of the puerarin beverage.
Description
Technical field
The invention belongs to function drink liquid, specifically is a kind of Radix Puerariae drink liquid and method for making thereof with sobering-up, liver-protecting and stomach-protecting efficacies.
Background technology
Wine is movable necessary such as people's contacts, celebration, dinner party.No matter be that relatives and friends get together, or the contact on the business field, all be unable to do without and drink.Spirits culture is of long standing and well established in China.Responsible drinking can play the effect of relaxing muscles and tendons to promote blood circulation, appetite stimulator, allaying tiredness, and can play medicinal effect to some disease.If but excessive consumption of alcohol or be addicted to drink for a long time, not only can serious harm healthy, also can bring out multiple disease, gently then cause headache, dizziness, feel sick, drunk symptom such as vomiting, heavy then cause seriously liver, gastric injury such as alcoholism, fatty liver, liver cirrhosis and gastric ulcer.
China's excessive drinking in recent years and alcoholism number are increasing, have badly influenced people's healthy and family, social stablizing.According to data, global alcohol consumption is also in rising trend, and the beverage that contains ethanol is increasing, and drinking has become the important topic of medical circle further investigation with the relation of health.Studies have shown that: the ethanol that per os is taken in is mainly absorbed rapidly at upper part of small intestine, and the ethanol that absorbs back about 95% is catabolic by liver, so liver is the victim of ethanol maximum.Under the situation that does not have protection, an excessive consumption of alcohol is equivalent to once light-duty hepatitis.The ability of liver decomposing alcohol varies with each individual, and the capacity for liquor that the normal person decomposes a whole night is: 2～3 liang of Chinese liquor, and 2 bottles of medicated beer, 2 glasss of whiskeys surpass this limit and just can damage liver.Well imagine concerning those frequent heavy drinkings or the people that is addicted to drink, how serious ethanol will have to the injury that liver and health cause.
Therefore development has the product of sobering-up, liver-protecting and stomach-protecting efficacies, particularly develops instant, does not have the dispelling alcohol and protection of liver and stomach function drink liquid of any side effect significant again.At present solution alcohol product on the market is many based on relieving alcoholic intoxication or alleviate drunk degree, and the product of really accomplishing to relieve the effect of alcohol, protect the liver and protect stomach does not almost have.
Summary of the invention
The purpose of this invention is to provide a kind of Radix Puerariae drink liquid with sobering-up, liver-protecting and stomach-protecting efficacies, also comprise method for making in addition, this prescription is scientific and reasonable, active constituent content is high and it is fast to absorb, the Antialcoholic liver-protecting effect is remarkable.
Technical scheme of the present invention is achieved in that a kind of Radix Puerariae drink liquid with sobering-up, liver-protecting and stomach-protecting efficacies, in parts by weight, is mainly made by following raw material:
Radix Puerariae 50-85
Semen Hoveniae (Fructus Hoveniae) 15-35
Yang Thistle 10-20
Endoconcha Sepiae 5-15.
Further, described Radix Puerariae drink liquid also contains the vitamin of 0.2-1.0 part.Wherein, vitamin is one or more in vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, VB11 or the vitamin B12.
Method for making with Radix Puerariae drink liquid of sobering-up, liver-protecting and stomach-protecting efficacies is that step is as follows:
1) preparation Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution: take by weighing Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke and be ground into powder respectively by prescription, mix the ethanol that the back adds the 60-70% concentration of 8-10 times of weight, make ethanol extract in the supersound extraction mode, leave standstill after 24 hours and filter, filtrate decompression is distilled, concentrated and make no pure concentrated solution;
2) preparation Endoconcha Sepiae decocting extracting solution: take by weighing Endoconcha Sepiae by prescription, pulverize the deionized water that the back adds 8 times, heating decocted 1 hour, and decoction liquor is merged back standing sedimentation 24 hours, filtered then;
3) with step 1) and step 2) the gained extracting solution mixes, and adds after vitamin stirs, and distilling under reduced pressure concentrates, filters and make again.
Preferred value is further: Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke are ground into 60-100 purpose powder respectively.
Radix Puerariae drink liquid eating method of the present invention: get this drink liquid 10-15 and drip, be added in one glass of about pure water of 150 milliliters, namely drinkable after stirring evenly.If insobriety, can be in that doubling dosage be edible after drinking.
The effective ingredient of Radix Puerariae drink liquid of the present invention is all from pure natural plant and ocean elite, and wherein Radix Puerariae is the root of pulse family perennial defoliation liana Herba Gelsemii Elegantis or Radix Puerariae rattan, and cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, toxin expelling, all effects of relieving the effect of alcohol.Main component has osajin (mainly comprising puerarin, daidzein, daiazi etc.), Radix Puerariae glycoside, triterpene saponin, alkaloid and other chemical compounds, and trace element is abundant.In the effective ingredient of Radix Puerariae, of greatest concern is osajin, also is its main active.Numerous studies have shown that Radix Puerariae extract have suppress big mice ethanol absorbtivity, acceleration of alcohol metabolism, raising to the dosis tolerata of ethanol, reduce mortality rate and reduce effects such as liver injury. Radix Puerariae isoflavone can significantly reduce the rising of rat blood serum AST, ALT and HA content due to the carbon tetrachloride; alleviate hepatocellular pathologic lesion, chronic hepatic injury is had the certain protection effect.Its mechanism may with remove oxygen-derived free radicals, anti peroxidation of lipid is relevant with fibrosis.
Arithoke is a kind of natural plants with special health care; the edible history in hundreds of years is arranged the America and Europe; be rich in vegetable protein; vitamin; cinarine; the arithoke element; coffee alkyd; flavonoid isoreactivity composition; particularly its cynarin that contains can improve the vigor of liver; promote to get rid of toxin in the liver (ammonia that produces as digesting protein); promote the regeneration of liver cell; promote the secretion of bile and the digestion of fat (cholesterol in the control agent); other compositions that arithoke contains have flavonoid (Fiavonoid:Luteotin; Cynaosid; Scdymosin etc.); bitter principle (Sesquiterpenlacton; wherein 50% is Cynaropikrin), these materials have auxiliary cynarin the liver protecting and promote the function of liver toxin expelling.Normal food arithoke has treatment chronic hepatitis, cholesterol reducing and treatment dyspepsia, improve gastrointestinal function, increase bile secretion, alleviate constipation, diarrhoea, feel sick, the effect of vomiting etc.
Semen Hoveniae (Fructus Hoveniae) is the drying that has the meat fruit stem, mellow fruit or the seed of Rhamnaceae plant Semen Hoveniae (Fructus Hoveniae).Main component is hovenoside, alkaloid, flavone compound, glucose and potassium malate etc., have relieve the effect of alcohol, protect the liver, multiple efficacies such as diuresis, blood pressure lowering, antitumor.Pharmacological evaluation shows that Semen Hoveniae (Fructus Hoveniae) decocting liquid can be accelerated tangible antialcoholism actions such as alcohol metabolism, enhancing alcohol dehydrogenase activity, shortening mice relieving alcoholic intoxication time; Investigating the test of Semen Hoveniae (Fructus Hoveniae) hepatoprotective effect with the acute alcoholism mice model shows; Semen Hoveniae (Fructus Hoveniae) decocting extracting solution gastric infusion in advance can stop the mouse liver MDA due to the ethanol to raise and GSH decline; and cholesterol, the glyceric acid three ester that can resist due to the ethanol increase; point out it to the protective effect of ethanol induced mice liver lipid peroxidation tool, might delay and prevent that the fatty liver due to the ethanol from forming.
Endoconcha Sepiae has another name called Os Sepiae, and main chemical compositions is tens kinds of inorganic elementss such as calcium carbonate, conchiolin, phlegmatic temperament, sodium chloride and magnesium, potassium, zinc, copper, aluminum, also contains 17 seed amino acids such as methionine, aspartic acid, glutamic acid.Salty, puckery, the tepor of property. return liver, kidney channel. there are astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness to hold back the effect of skin ulcer.The Compendium of Material Medica record: Endoconcha Sepiae has various astrictions, the treatment of clinical practice external haemorrhage, gastroduodenal ulcer, part chronic gastritis and skin ulcer etc. in various.Modern pharmacological research shows: during Endoconcha Sepiae has and multiple efficacies such as gastric acid, protection gastric mucosa, antiulcer, radioprotective.
Radix Puerariae drink liquid therefore of the present invention is primary raw material with the Radix Puerariae, is equipped with Semen Hoveniae (Fructus Hoveniae), arithoke, Endoconcha Sepiae and vitamin, and scientific formulation is reasonable, extraction process advanced person.Before the wine, drink and all can play the protection gastric mucosa, reduce the intestines and stomach in vivo the decomposition of absorption, acceleration of alcohol and the metabolite thereof of ethanol, replenish behind the heavy drinking loss of several mineral materials and vitamin in the body rapidly after drinking; thereby reduce and elimination various malaise symptoms after drinking; effectively reduce ethanol to the injury of liver and human body, play the effect of dispelling alcohol and protection of liver and stomach.
Through confirmation drunk by people, dispelling alcohol and protection of liver and stomach Radix Puerariae drink liquid of the present invention is anti-drunk remarkable with liver-protecting and stomach-protecting efficacies, tens of each consumptions, and mouthfeel is good, absorbs fast, without any side effects.Therefore has the wide development application prospect.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further explained explanation.
1 one kinds of Radix Puerariae drink liquid with sobering-up, liver-protecting and stomach-protecting efficacies of embodiment, made by the raw material of following weight (gram):
Radix Puerariae 75 Semen Hoveniae (Fructus Hoveniae)s 15
Yang Thistle 15 Endoconcha Sepiaes 10
Vitamin 0.4(is comprising 0.1 part of vitamin C; 0.1 part vitamin B1; 0.1 part vitamin B2; 0.1 part vitamin B6).
Preparation method is as follows:
1) preparation Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution: take by weighing Radix Puerariae 75 grams, Semen Hoveniae (Fructus Hoveniae) 15 grams, arithoke 15 grams by formulation weight, and be ground into powder about 60 orders respectively, each raw material after pulverizing is mixed, add mixed material weight 8-10 60%-70% ethanol doubly, prepare ethanol extract in the supersound extraction mode then, leave standstill after 24 hours and filter, filtrate decompression is distilled, concentrated and make no pure concentrated solution, be Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution;
2) preparation Endoconcha Sepiae decocting extracting solution: take by weighing Endoconcha Sepiae 10 grams by formulation weight, pulverize the deionized water that the back adds 8 times, heating decocted after 1 hour, got decoction liquor; Add 8 times of deionized waters again in the residue filtering residue, continue heating and decocted 1 hour, get decoction liquor; Twice decoction liquor merged back standing sedimentation 24 hours, filter then and namely make Endoconcha Sepiae decocting extracting solution;
3) with step 1) and step 2) extracting solution merge, press formula proportion and add vitamin 0.4 gram, after mixing, distilling under reduced pressure concentrates, filter and namely make Radix Puerariae of the present invention and drink liquid.
Embodiment 2:
Prepare Radix Puerariae drink liquid according to embodiment 1 described method, each raw material weight (gram) component is:
Radix Puerariae 65 Semen Hoveniae (Fructus Hoveniae)s 25
Yang Thistle 10 Endoconcha Sepiaes 15
Vitamin 0.5(is 0.2 part of vitamin C wherein; 0.1 part vitamin B1; 0.1 part vitamin B2; 0.1 part vitamin B12).
Embodiment 3:
Prepare Radix Puerariae drink liquid according to embodiment 1 described method, each raw material weight (gram) component is:
Radix Puerariae 55 Semen Hoveniae (Fructus Hoveniae)s 35
Yang Thistle 20 Endoconcha Sepiaes 10
Vitamin 0.8(is comprising 0.2 part of vitamin C; 0.1 part vitamin B1; 0.2 part vitamin B2; 0.1 part vitamin B3; 0.1 part vitamin B6; 0.1 part vitamin B12).
Embodiment 4:
Prepare Radix Puerariae drink liquid according to embodiment 1 described method, each raw material weight (gram) component is:
Radix Puerariae 85 Semen Hoveniae (Fructus Hoveniae)s 20
Yang Thistle 10 Endoconcha Sepiaes 5.
Embodiment 5:
Prepare Radix Puerariae drink liquid according to embodiment 1 described method, each raw material weight (gram) component is:
Radix Puerariae 70 Semen Hoveniae (Fructus Hoveniae)s 30
Yang Thistle 15 Endoconcha Sepiaes 15
Vitamin 1.0(is comprising 0.2 part of vitamin C; 0.1 part vitamin B1; 0.2 part vitamin B2; 0.1 part vitamin B3; 0.1 part vitamin B6; 0.1 part vitamin B7; 0.1 part VB11; 0.1 part vitamin B12).
The eating method of above-described embodiment 1-5 drink liquid: get Radix Puerariae drink liquid 10-15 of the present invention and drip, be added in one glass of about pure water of 150 milliliters, namely drinkable after stirring evenly, twice of every day.
The anti-liquor-saturated test of Radix Puerariae drink liquid of the present invention: according to the anti-liquor-saturated effect method of inspection of conventional drunk model, the male ICR mouse (SPF level) that is provided by Department Of Medicine, Peking University's Experimental Animal Center is provided, the Radix Puerariae drink liquid of the embodiment of the invention 1 is made into basic, normal, high three concentration, i.e. 0.01ml/ml, 0.033 ml/ml, 0.10 ml/ml.Irritate stomach and give mice 0.10 ml/10g, be equivalent to (2 ml/ day) 3,10,30 times of people's consumption every day respectively.After 30 minutes, all mices give 50% ethanol 0.15 ml/10g in administration, observe mice, and righting reflex loss records drunk number of animals and drunk back sleep time as drunk standard.Adopt SPSS software to carry out one factor analysis of variance and x to experimental data
2The result of check is as follows:
Table 1: Radix Puerariae drink liquid is to the influence of mice drunk situation (`x ± s)
| Dosage (ml/kgbw) | Number of animals | Drunk number of animals | The drunk length of one's sleep (minute) |
| 0 | 10 | 9 | 131±55 |
| 0.10 | 10 | 3* | 40±66** |
| 0.33 | 10 | 6 | 69±67* |
| 1.00 | 10 | 4* | 37±53** |
* with matched group than P＜0.05; * P＜0.01
Drunk number of animals and the drunk length of one's sleep by the visible basic, normal, high dosage Radix Puerariae drink liquid processed group mice of table 1 result all obviously reduce than matched group.Show that Radix Puerariae drink liquid of the present invention has anti-drunk effect.
Radix Puerariae of the present invention is drunk the test that protects the liver of liquid: the Radix Puerariae drink liquid of the embodiment of the invention 2 is made into basic, normal, high three concentration; according to the method for inspection that in " health food function assessment assessment process and the method for inspection " chemical liver injury is had auxiliary protection function; the male ICR mouse (SPF level) that is provided by Department Of Medicine, Peking University's Experimental Animal Center is provided, is divided into blank group, model control group, low dose group, middle dosage group and high dose group at random.Each experimental mice is irritated stomach once every day, and 0.10 ml/10g is equivalent to (2 ml/ day) 3,10,30 times of people's consumption every day respectively, and blank group and model control group give distilled water, and the continuous irrigation stomach is 30 days altogether.Put to death mice after fasting 6-12 hour, carry out serum triglycerides (TG) then and measure and the hepatic pathology histological examination, the result who experimental data employing SPSS software is carried out one factor analysis of variance is as follows:
Table 2: Radix Puerariae drink liquid is to the influence of ethanol model mice serum TG (`x ± s)
| Dosage (ml/kgbw) | Number of animals | Serum TG (mmol/mg) |
| 0 | 10 | 2.07±0.52 |
| 50% ethanol | 10 | 3.68±1.16 |
| 0.10 | 10 | 2.10±0.91** |
| 0.33 | 10 | 1.94±1.16** |
| 1.00 | 10 | 2.53±1.54* |
* with model control group than P＜0.05; * P＜0.01
Table 3: Radix Puerariae drink liquid is to ethanol model mice hepatic tissue
The influence of pathology (fat stains) (`x ± s)
| Dosage (ml/kgbw) | Number of animals | The histopathology scoring |
| 0 | 10 | 0±0 |
| 50% ethanol | 10 | 1.1±0.3 |
| 0.10 | 10 | 0.1±0.3** |
| 0.33 | 10 | 0.3±0.5** |
| 1.00 | 10 | 0±0** |
* with model control group than P＜0.05; * P＜0.01
All reduced than obvious than model control group by table 2, the visible basic, normal, high dosage Radix Puerariae drink liquid processed group mice serum TG of table 3 result; The scoring of mice histopathology all reduces than obvious than model control group.Show that Radix Puerariae drink liquid of the present invention has protective effect to alcoholic liver injury.
Claims (5)
1. the Radix Puerariae drink liquid with sobering-up, liver-protecting and stomach-protecting efficacies is characterized in that, in parts by weight, is mainly made by following raw material:
Radix Puerariae 50-85
Semen Hoveniae (Fructus Hoveniae) 15-35
Yang Thistle 10-20
Endoconcha Sepiae 5-15.
2. the Radix Puerariae drink liquid with sobering-up, liver-protecting and stomach-protecting efficacies according to claim 1 is characterized in that, also contains the vitamin of 0.2-1.0 part.
3. the Radix Puerariae with sobering-up, liver-protecting and stomach-protecting efficacies according to claim 2 is drunk liquid, it is characterized in that described vitamin is one or more in vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, VB11 or the vitamin B12.
4. as claim 2 or 3 described method for makings with Radix Puerariae drink liquid of sobering-up, liver-protecting and stomach-protecting efficacies, it is characterized in that step is as follows:
1) preparation Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution: take by weighing Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke and be ground into powder respectively by prescription, mix the ethanol that the back adds the 60-70% concentration of 8-10 times of weight, make ethanol extract in the supersound extraction mode, leave standstill after 24 hours and filter, filtrate decompression is distilled, concentrated and make no pure concentrated solution;
2) preparation Endoconcha Sepiae decocting extracting solution: take by weighing Endoconcha Sepiae by prescription, pulverize the deionized water that the back adds 8 times, heating decocted after 1 hour, got decoction liquor; Add 8 times of deionized waters again in the residue filtering residue, continue heating and decocted 1 hour, get decoction liquor; Twice decoction liquor merged back standing sedimentation 24 hours, filter then;
3) with step 1) and step 2) the gained extracting solution mixes, and adds after vitamin stirs, and distilling under reduced pressure concentrates, filters and make again.
5. the method for making with Radix Puerariae drink liquid of sobering-up, liver-protecting and stomach-protecting efficacies according to claim 4 is characterized in that, Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke are ground into 60-100 purpose powder respectively.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104757679A (en) * | 2015-04-14 | 2015-07-08 | 宁波可口生物工程有限公司 | Kudzuvine root beverage containing nicotinic acid |
| CN108041596A (en) * | 2017-12-08 | 2018-05-18 | 爱可道生物科技有限公司 | A kind of arithoke relieving alcoholism and protecting liver piece and preparation method thereof |
| CN111357891A (en) * | 2020-03-20 | 2020-07-03 | 广东盐业健康产业发展有限公司 | Plant beverage containing artichoke and ginseng and preparation method thereof |
| CN112089048A (en) * | 2019-11-21 | 2020-12-18 | 上海易天生物科技有限公司 | Formula of health food for dispelling effects of alcohol and protecting liver |
| CN114145405A (en) * | 2021-12-15 | 2022-03-08 | 龙岩学院 | Health beverage for relieving alcoholism and protecting liver and preparation method thereof |
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| CN102524479A (en) * | 2012-02-10 | 2012-07-04 | 夏金莲 | Artichoke health-care products and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104757679A (en) * | 2015-04-14 | 2015-07-08 | 宁波可口生物工程有限公司 | Kudzuvine root beverage containing nicotinic acid |
| CN108041596A (en) * | 2017-12-08 | 2018-05-18 | 爱可道生物科技有限公司 | A kind of arithoke relieving alcoholism and protecting liver piece and preparation method thereof |
| CN112089048A (en) * | 2019-11-21 | 2020-12-18 | 上海易天生物科技有限公司 | Formula of health food for dispelling effects of alcohol and protecting liver |
| CN111357891A (en) * | 2020-03-20 | 2020-07-03 | 广东盐业健康产业发展有限公司 | Plant beverage containing artichoke and ginseng and preparation method thereof |
| CN114145405A (en) * | 2021-12-15 | 2022-03-08 | 龙岩学院 | Health beverage for relieving alcoholism and protecting liver and preparation method thereof |
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Address after: 116600 -2, Shuang D4 street, Dalian economic and Technological Development Zone, Dalian, Liaoning, 19-5 Patentee after: Dalian life Polytron Technologies Inc Address before: 302, room 3, 116023, Gaoxin street, hi tech park, Liaoning, Dalian Patentee before: Dalian Huoer Biological Technology Co., Ltd. |