CN103251698B - Puerarin beverage with effects of dispelling alcoholism, protecting liver and protecting stomach and preparation method thereof - Google Patents
Puerarin beverage with effects of dispelling alcoholism, protecting liver and protecting stomach and preparation method thereof Download PDFInfo
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Abstract
The invention discloses healthcare functional beverage, and in particular relates to puerarin beverage with effects of dispelling the alcoholism, protecting the liver and protecting the stomach. The puerarin beverage is prepared by extracting the following raw materials in part by weight: 50-85 parts of puerarin, 15-35 parts of turnjujube, 10-20 parts of artichoke and 5-15 parts of cuttlebone. The formula of the puerarin beverage is scientific and rational, an extracting technology is advanced, and all effective components are from purely natural plants and marine extracts; the effects of dispelling the alcoholism, protecting the liver and protecting the stomach are outstanding; and side effects are avoided. The invention also provides a preparation method of the puerarin beverage.
Description
Technical field
The invention belongs to function drink, specifically a kind of Radix Puerariae drink and method for making thereof with sobering-up, liver-protecting and stomach-protecting efficacies.
Background technology
Wine is the necessary of the activities such as people associate, celebration, dinner party.No matter be that relatives and friends get together, or the contact on business field, all be unable to do without and drink.Spirits culture is of long standing and well established in China.Responsible drinking can play the effect of relaxing muscles and tendons to promote blood circulation, appetite stimulator, allaying tiredness, and can play medicinal effect to some disease.If but excessive consumption of alcohol or be addicted to drink for a long time, not only can serious harm healthy, also can bring out various diseases, gently then cause the drunk symptoms such as headache, dizziness, Nausea and vomiting, heavy then cause the serious liver such as alcoholism, fatty liver, liver cirrhosis and gastric ulcer, gastric injury.
China's excessive drinking in recent years and alcoholism number increasing, badly influenced the healthy of people and family, the stablizing of society.According to data, global alcohol consumption is also in rising trend, increasing containing spirituous beverage, and the relation of drinking & health has become the important topic of medical circle further investigation.Research proves: the ethanol that per os is taken in mainly is rapidly absorbed at upper part of small intestine, and after absorption, the ethanol of about 95% is catabolic by liver, and therefore liver is the maximum victim of ethanol.When not protecting, an excessive consumption of alcohol is equivalent to once light-duty hepatitis.The ability of liver decomposing alcohol varies with each individual, and the capacity for liquor that normal person decomposes a whole night is: Chinese liquor 2 ~ 3 liang, medicated beer 2 bottles, and whiskey 2 glasss exceedes this limit and just can damage liver.Well imagine, concerning those frequent heavy drinkings or the people that is addicted to drink, how serious ethanol will have to the injury that liver and health cause.
Therefore development has the product of sobering-up, liver-protecting and stomach-protecting efficacies, particularly develops instant, does not have again the dispelling alcohol and protection of liver and stomach function drink of any side effect significant.At present solution alcohol product is on the market mainly with relieving alcoholic intoxication or to alleviate drunk degree be main, really accomplishes that the product relieving the effect of alcohol, protect the liver and protect stomach does not almost have.
Summary of the invention
The object of this invention is to provide a kind of Radix Puerariae drink with sobering-up, liver-protecting and stomach-protecting efficacies, also comprise method for making in addition, this scientific formula is reasonable, active constituent content is high and absorb fast, Antialcoholic liver-protecting Be very effective.
Technical scheme of the present invention is achieved in that a kind of Radix Puerariae drink with sobering-up, liver-protecting and stomach-protecting efficacies, with weight parts, makes primarily of following raw material:
Radix Puerariae 50-85
Semen Hoveniae (Fructus Hoveniae) 15-35
Yang Thistle 10-20
Endoconcha Sepiae 5-15.
Further, the vitamin of described Radix Puerariae drink also containing 0.2-1.0 part.Wherein, vitamin is one or more in vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, VB11 or vitamin B12.
The method for making with the Radix Puerariae drink of sobering-up, liver-protecting and stomach-protecting efficacies is that step is as follows:
1) Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution is prepared: take Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke be ground into powder respectively by formula, the ethanol of the 60-70% concentration of 8-10 times of weight is added after mixing, ethanol extract is made in supersound extraction mode, leave standstill after 24 hours and filter, filtrate decompression is distilled, concentrate and make without alcohol concentrated solution;
2) prepare Endoconcha Sepiae Decoction: take Endoconcha Sepiae by formula, add the deionized water of 8 times after pulverizing, heating decoction 1 hour, after decoction liquor being merged, standing sedimentation 24 hours, then filters;
3) by step 1) and step 2) mixing of gained extracting solution, add after vitamin stirs, then distilling under reduced pressure concentrated, filter obtained.
Preferred value is further: Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke are ground into respectively 60-100 object powder.
Radix Puerariae drink eating method of the present invention: get this drink 10-15 and drip, is added in the pure water of a glass about 150 milliliters, namely drinkable after stirring evenly.If insobriety, can eat at doubling dosage after drinking.
The effective ingredient of Radix Puerariae drink of the present invention is all from pure natural plant and ocean elite, and wherein Radix Puerariae is the root of pulse family perennial defoliation liana Herba Gelsemii Elegantis or Radix Puerariae rattan, and cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, toxin expelling, all effects of relieving the effect of alcohol.Main component has osajin (mainly comprising puerarin, daidzein, daiazi etc.), Radix Puerariae glycoside, triterpene saponin, alkaloid and other compounds, and trace element enriches.In the effective ingredient of Radix Puerariae, of greatest concern is osajin, is also its main active.Numerous research proves that Radix Puerariae extract has the large mice alcohol absorption amount of suppression, acceleration of alcohol metabolism, raising is to dosis tolerata, the reduction mortality rate of ethanol and reduce effects such as liver injury. Radix Puerariae isoflavone significantly can reduce the rising of rat blood serum AST, ALT and HA content caused by carbon tetrachloride; alleviate hepatocellular pathologic lesion, have certain protective effect to chronic hepatic injury.Its mechanism may be relevant to scavenging activated oxygen, anti peroxidation of lipid and fibrosis.
Arithoke is a kind of natural plants with special health care, the edible history of centuries is had America and Europe, be rich in vegetable protein, vitamin, cinarine, cynarin, coffee alkyd, flavonoid isoreactivity composition, particularly its cynarin contained can improve the vigor of liver, promote to get rid of toxin in liver (as digesting protein the ammonia that produces), promote the regeneration of liver cell, promote the secretion of bile and the digestion (cholesterol in control agent) of fat, other compositions contained by arithoke have flavonoid (Fiavonoid:Luteotin, Cynaosid, Scdymosin etc.), bitter principle (Sesquiterpenlacton, wherein 50% is Cynaropikrin), these materials have auxiliary cynarin the liver protecting and promote the function of liver toxin expelling.Normal food arithoke has treatment chronic hepatitis, reduces cholesterol and treatment dyspepsia, improves gastrointestinal function, increases bile secretion, effect of alleviate constipation, diarrhoea, Nausea and vomiting etc.
Semen Hoveniae (Fructus Hoveniae) is the drying with meat fruit stem of Rhamnaceae plant Semen Hoveniae (Fructus Hoveniae), mellow fruit or seed.Main component is hovenoside, alkaloid, flavone compound, glucose and potassium malate etc., have relieve the effect of alcohol, protect the liver, diuresis, blood pressure lowering, the multiple efficacies such as antitumor.Pharmacological evaluation shows, Semen Hoveniae (Fructus Hoveniae) decocting liquid can accelerating alcohol metabolism, strengthen alcohol dehydrogenase activity, shorten the significantly antialcoholism action such as mice relieving alcoholic intoxication time; Investigate the test of Semen Hoveniae (Fructus Hoveniae) hepatoprotective effect with acute alcoholism mice model to show; Semen Hoveniae (Fructus Hoveniae) Decoction in advance gastric infusion can stop the mouse liver MDA caused by ethanol to raise and GSH decline; and the cholesterol of energy caused by Anti-ethanol, glyceric acid three ester increase; point out it to the protective effect of ethanol induced mice hepatic lipid peroxidation tool, likely delay and prevent the fatty liver caused by ethanol from being formed.
Endoconcha Sepiae has another name called Os Sepiae, and main chemical compositions is tens kinds of inorganic elementss such as calcium carbonate, conchiolin, phlegmatic temperament, sodium chloride and magnesium, potassium, zinc, copper, aluminum, also containing 17 seed amino acids such as methionine, aspartic acid, glutamic acid.Salty, puckery, the tepor of property. return liver, kidney channel. there is effect of astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Compendium of Material Medica is recorded: Endoconcha Sepiae has various astriction, and clinical practice is in the treatment of various interior external haemorrhage, gastroduodenal ulcer, part chronic gastritis and skin ulcer etc.Modern pharmacological research shows: during Endoconcha Sepiae has and gastric acid, multiple efficacies such as protection gastric mucosa, antiulcer, radioprotective etc.
Therefore Radix Puerariae drink of the present invention is primary raw material with Radix Puerariae, is equipped with Semen Hoveniae (Fructus Hoveniae), arithoke, Endoconcha Sepiae and vitamin, and scientific formulation is reasonable, and extraction process is advanced.Before wine, after drinking drink all can play protection gastric mucosa, reduce the intestines and stomach to the absorption of ethanol, acceleration of alcohol and metabolite decomposition in vivo thereof, supplement rapidly the loss of several mineral materials and vitamin in body after heavy drinking; thus reduce and eliminate various malaise symptoms after drinking; effective reduction ethanol, to the injury of liver and human body, plays effect of dispelling alcohol and protection of liver and stomach.
Through confirmation drunk by people, dispelling alcohol and protection of liver and stomach Radix Puerariae drink of the present invention resists drunk and liver-protecting and stomach-protecting efficacies remarkable, each consumption tens, and mouthfeel is good, absorbs fast, without any side effects.Therefore there is wide development prospect.
Detailed description of the invention
Below in conjunction with specific embodiment, explanation is further explained to the present invention.
Embodiment 1 one kinds has the Radix Puerariae drink of sobering-up, liver-protecting and stomach-protecting efficacies, is made up of the raw material of following weight (gram):
Radix Puerariae 75 Semen Hoveniae (Fructus Hoveniae) 15
Yang Thistle 15 Endoconcha Sepiae 10
Vitamin 0.4(is comprising 0.1 part of vitamin C; 0.1 part of vitamin B1; 0.1 part of vitamin B2; 0.1 part of vitamin B6).
Preparation method is as follows:
1) Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution is prepared: take Radix Puerariae 75 grams, Semen Hoveniae (Fructus Hoveniae) 15 grams, arithoke 15 grams by formulation weight, and the powder be ground into respectively about 60 orders, each raw material after pulverizing is mixed, add mixed material weight 8-10 60%-70% ethanol doubly, then ethanol extract is prepared in supersound extraction mode, leave standstill after 24 hours and filter, filtrate decompression is distilled, concentrate and make without alcohol concentrated solution, be Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution;
2) prepare Endoconcha Sepiae Decoction: take Endoconcha Sepiae 10 grams by formulation weight, add the deionized water of 8 times after pulverizing, heating decoction, after 1 hour, gets decoction liquor; Add 8 times of deionized waters again in residue filtering residue, continue heating decoction 1 hour, get decoction liquor; Standing sedimentation 24 hours after twice decoction liquor being merged, then filters i.e. obtained Endoconcha Sepiae Decoction;
3) by step 1) and step 2) extracting solution merge, add vitamin 0.4 gram by formula proportion, after being uniformly mixed, distilling under reduced pressure be concentrated, filter i.e. obtained Radix Puerariae drink of the present invention.
Embodiment 2:
Prepare Radix Puerariae drink according to the method described in embodiment 1, each raw material weight (gram) component is:
Radix Puerariae 65 Semen Hoveniae (Fructus Hoveniae) 25
Yang Thistle 10 Endoconcha Sepiae 15
Vitamin 0.5(is 0.2 part of vitamin C wherein; 0.1 part of vitamin B1; 0.1 part of vitamin B2; 0.1 part of vitamin B12).
Embodiment 3:
Prepare Radix Puerariae drink according to the method described in embodiment 1, each raw material weight (gram) component is:
Radix Puerariae 55 Semen Hoveniae (Fructus Hoveniae) 35
Yang Thistle 20 Endoconcha Sepiae 10
Vitamin 0.8(is comprising 0.2 part of vitamin C; 0.1 part of vitamin B1; 0.2 part of vitamin B2; 0.1 part of vitamin B3; 0.1 part of vitamin B6; 0.1 part of vitamin B12).
Embodiment 4:
Prepare Radix Puerariae drink according to the method described in embodiment 1, each raw material weight (gram) component is:
Radix Puerariae 85 Semen Hoveniae (Fructus Hoveniae) 20
Yang Thistle 10 Endoconcha Sepiae 5.
Embodiment 5:
Prepare Radix Puerariae drink according to the method described in embodiment 1, each raw material weight (gram) component is:
Radix Puerariae 70 Semen Hoveniae (Fructus Hoveniae) 30
Yang Thistle 15 Endoconcha Sepiae 15
Vitamin 1.0(is comprising 0.2 part of vitamin C; 0.1 part of vitamin B1; 0.2 part of vitamin B2; 0.1 part of vitamin B3; 0.1 part of vitamin B6; 0.1 part of vitamin B7; 0.1 part of VB11; 0.1 part of vitamin B12).
The eating method of above-described embodiment 1-5 drink: get Radix Puerariae drink 10-15 of the present invention and drip, is added in the pure water of a glass about 150 milliliters, namely drinkable after stirring evenly, every day twice.
The anti-liquor-saturated test of Radix Puerariae drink of the present invention: according to the anti-liquor-saturated effect method of inspection of conventional drunk model, the male ICR mouse (SPF level) provided by Department Of Medicine, Peking University's Experimental Animal Center is provided, the Radix Puerariae drink of the embodiment of the present invention 1 is made into basic, normal, high three concentration, i.e. 0.01ml/ml, 0.033 ml/ml, 0.10 ml/ml.Gavage gives mice 0.10 ml/10g, is equivalent to 3,10,30 times of (the 2 ml/ day) of people's consumption every day respectively.In administration after 30 minutes, all mices give 50% ethanol 0.15 ml/10g, and observe mice, righting reflex loss, as drunk standard, records drunk number of animals and drunk rear sleep time.SPSS software is adopted to carry out one factor analysis of variance and x to experimental data
2the result of inspection is as follows:
Table 1: Radix Puerariae drink is on the impact (`x ± s) of mice drunk situation
| Dosage (ml/kgbw) | Number of animals | Drunk number of animals | The drunk length of one's sleep (minute) |
| 0 | 10 | 9 | 131±55 |
| 0.10 | 10 | 3* | 40±66** |
| 0.33 | 10 | 6 | 69±67* |
| 1.00 | 10 | 4* | 37±53** |
* with matched group than P < 0.05; * P < 0.01
By the drunk number of animals of the visible basic, normal, high dosage Radix Puerariae drink processed group mice of table 1 result and the drunk length of one's sleep all comparatively matched group obviously reduce.Show that Radix Puerariae drink of the present invention has anti-drunk effect.
Radix Puerariae drink of the present invention protect the liver test: the Radix Puerariae drink of the embodiment of the present invention 2 is made into basic, normal, high three concentration; according to the method for inspection in " function of health food assessment process and the method for inspection ", chemical liver injury being had to auxiliary protection function; the male ICR mouse (SPF level) provided by Department Of Medicine, Peking University's Experimental Animal Center is provided, is divided into blank group, model control group, low dose group, middle dosage group and high dose group at random.Once, 0.10 ml/10g, be equivalent to 3,10,30 times of (the 2 ml/ day) of people's consumption every day respectively, blank group and model control group give distilled water to each experimental mice gavage every day, altogether continuous gavage 30 days.Put to death mice after fasting 6-12 hour, then carry out serum triglycerides (TG) and measure and hepatic pathology histological examination, the result of experimental data employing SPSS software being carried out to one factor analysis of variance is as follows:
Table 2: Radix Puerariae drink is on the impact (`x ± s) of ethanol model mice serum TG
| Dosage (ml/kgbw) | Number of animals | Serum TG (mmol/mg) |
| 0 | 10 | 2.07±0.52 |
| 50% ethanol | 10 | 3.68±1.16 |
| 0.10 | 10 | 2.10±0.91** |
| 0.33 | 10 | 1.94±1.16** |
| 1.00 | 10 | 2.53±1.54* |
* with model control group than P < 0.05; * P < 0.01
Table 3: Radix Puerariae drink is to ethanol model mice hepatic tissue
The impact (`x ± s) of pathology (fat stains)
| Dosage (ml/kgbw) | Number of animals | Histopathology is marked |
| 0 | 10 | 0±0 |
| 50% ethanol | 10 | 1.1±0.3 |
| 0.10 | 10 | 0.1±0.3** |
| 0.33 | 10 | 0.3±0.5** |
| 1.00 | 10 | 0±0** |
* with model control group than P < 0.05; * P < 0.01
By table 2, the visible basic, normal, high dosage Radix Puerariae drink processed group mice serum TG of table 3 result all comparatively model control group ratio obviously reduction; Mice histopathology scoring all comparatively model control group reduces than obvious.Show that Radix Puerariae drink of the present invention has protective effect to alcoholic liver injury.
Claims (3)
1. there is a Radix Puerariae drink for sobering-up, liver-protecting and stomach-protecting efficacies, it is characterized in that, with weight parts, make primarily of following raw material:
Radix Puerariae 50-85
Semen Hoveniae (Fructus Hoveniae) 15-35
Arithoke 10-20
Endoconcha Sepiae 5-15; Vitamin also containing 0.2-1.0 part; Its method for making is as follows:
1) Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke extracting solution is prepared: take Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke be ground into powder respectively by formula, the ethanol of the 60-70% concentration of 8-10 times of weight is added after mixing, ethanol extract is made in supersound extraction mode, leave standstill after 24 hours and filter, filtrate decompression is distilled, concentrate and make without alcohol concentrated solution;
2) prepare Endoconcha Sepiae Decoction: take Endoconcha Sepiae by formula, add the deionized water of 8 times after pulverizing, heating decoction, after 1 hour, gets decoction liquor; Add 8 times of deionized waters again in residue filtering residue, continue heating decoction 1 hour, get decoction liquor; After twice decoction liquor being merged, standing sedimentation 24 hours, then filters;
3) by step 1) and step 2) mixing of gained extracting solution, add after vitamin stirs, then distilling under reduced pressure concentrated, filter obtained.
2. the Radix Puerariae drink with sobering-up, liver-protecting and stomach-protecting efficacies according to claim 1, it is characterized in that, described vitamin is one or more in vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, VB11 or vitamin B12.
3. the method for making with the Radix Puerariae drink of sobering-up, liver-protecting and stomach-protecting efficacies according to claim 1, is characterized in that, Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), arithoke is ground into respectively 60-100 object powder.
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| CN104757679A (en) * | 2015-04-14 | 2015-07-08 | 宁波可口生物工程有限公司 | Kudzuvine root beverage containing nicotinic acid |
| CN108041596A (en) * | 2017-12-08 | 2018-05-18 | 爱可道生物科技有限公司 | A kind of arithoke relieving alcoholism and protecting liver piece and preparation method thereof |
| CN112089048A (en) * | 2019-11-21 | 2020-12-18 | 上海易天生物科技有限公司 | Formula of health food for dispelling effects of alcohol and protecting liver |
| CN111357891A (en) * | 2020-03-20 | 2020-07-03 | 广东盐业健康产业发展有限公司 | Plant beverage containing artichoke and ginseng and preparation method thereof |
| CN114145405A (en) * | 2021-12-15 | 2022-03-08 | 龙岩学院 | Health beverage for relieving alcoholism and protecting liver and preparation method thereof |
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| CN102524479A (en) * | 2012-02-10 | 2012-07-04 | 夏金莲 | Artichoke health-care products and preparation method thereof |
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| CN102524479A (en) * | 2012-02-10 | 2012-07-04 | 夏金莲 | Artichoke health-care products and preparation method thereof |
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| Title |
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| 海螵蛸一般药理实验研究;王慧等;《中国热带医学》;20101231;第10卷(第6期);713-714 * |
| 解酒饮料的研制;张智等;《酿酒》;20080331;第35卷(第2期);93-95 * |
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Address after: 116600 -2, Shuang D4 street, Dalian economic and Technological Development Zone, Dalian, Liaoning, 19-5 Patentee after: Dalian life Polytron Technologies Inc Address before: 302, room 3, 116023, Gaoxin street, hi tech park, Liaoning, Dalian Patentee before: Dalian Huoer Biological Technology Co., Ltd. |