CN107441267B - Pharmaceutical composition for preventing and treating livestock diarrhea - Google Patents
Pharmaceutical composition for preventing and treating livestock diarrhea Download PDFInfo
- Publication number
- CN107441267B CN107441267B CN201710851708.1A CN201710851708A CN107441267B CN 107441267 B CN107441267 B CN 107441267B CN 201710851708 A CN201710851708 A CN 201710851708A CN 107441267 B CN107441267 B CN 107441267B
- Authority
- CN
- China
- Prior art keywords
- parts
- diarrhea
- pharmaceutical composition
- livestock
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
Abstract
The invention discloses a pharmaceutical composition for preventing and treating livestock diarrhea, which is a preparation prepared from the following raw material medicines in parts by weight: 4-8 parts of lacquer nut, 1-5 parts of pomegranate rind, 2-6 parts of cinnamon, 1-3 parts of pterocephalus hookeri, 3-7 parts of holarrhena, 2-7 parts of aconitum bovittae, 3-7 parts of plantain, 3-7 parts of folium allii tuberosi, 2-6 parts of cypress branch, 1-6 parts of fennel fruit and 2-4 parts of medicated leaven. Veterinary clinical use results show that the medicine has obvious effect on treating diarrhea diseases of livestock such as cattle, sheep and the like, symptoms are obviously relieved after the medicine is generally continuously taken for 3 days, the livestock can be cured after 5-6 days, and the total effective rate is up to more than 92%. Moreover, the medicine has obvious treatment effect on livestock diarrhea caused by bacteria, viruses, dyspepsia and other factors, and has wide application range and wide application prospect.
Description
Technical Field
The invention relates to a pharmaceutical composition for preventing and treating livestock diarrhea, and belongs to the field of medicines.
Background
The diarrhea of livestock is a common symptom caused by intestinal dysfunction and the like, and is characterized by increasing the frequency of defecation, and the feces are thin and soft like water, with purulent blood, mucous membranes and the like. The disease can occur all the year round, the prevention and treatment difficulty is great, the production performance of livestock is seriously influenced, great economic loss is brought to farmers, and the disease is a production problem which exists for a long time and needs to be solved urgently in the breeding industry.
At present, the main means for treating the diarrhea of livestock is to use antibiotics, such as quinolones, furans and cephalosporins, and the treatment mode can cause serious drug residue in the dairy products and seriously affect the quality and sale of the dairy products. Moreover, the livestock diarrhea diseases involve viruses, bacteria, dyspepsia and other various causes of diseases, the pathogenesis is complex, and the purpose of curing the diseases is often difficult to achieve by using a single medicine.
Therefore, the Tibetan medicine preparation which has better treatment effect on the livestock diarrhea and is suitable for diarrhea caused by various reasons is developed, and the Tibetan medicine preparation has important significance for ensuring the quality of livestock products and promoting the development of the breeding industry.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for preventing and treating livestock diarrhea.
The invention provides a pharmaceutical composition for preventing and treating livestock diarrhea, which is a preparation prepared from the following raw material medicines in parts by weight: 4-8 parts of lacquer nut, 1-5 parts of pomegranate rind, 2-6 parts of cinnamon, 1-3 parts of pterocephalus hookeri, 3-7 parts of holarrhena, 2-7 parts of aconitum bovittae, 3-7 parts of plantain, 3-7 parts of folium allii tuberosi, 2-6 parts of cypress branch, 1-6 parts of fennel fruit and 2-4 parts of medicated leaven.
Further, the pharmaceutical composition is a preparation prepared from the following raw material medicines in parts by weight: 5 parts of lacquer nut, 3 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 5 parts of holarrhena, 4 parts of aconitum bovinii, 5 parts of plantain, 5 parts of allium tuberosum, 4 parts of cypress branch, 4 parts of fennel fruit and 2 parts of medicated leaven.
Wherein the fructus Toxicodendron Verniciflum (Stokes) F.A.Barkl.seeds of Rhus vernicifluum (Toxicodendron) belonging to Anacardiaceae; the antidiarrheal is Holarrhena antipysterinia wall.ex A.DC.); the ship-shaped Aconitum carmichaeli is Aconitum naviculare (Bruhl.) Stapf; the sea leek is Triglochin maritimum; the Thuja orientalis branches are Myricaria brachacta; hypecoum leptocarpum hook.f. et Thoms.; the rest pomegranate rind, cinnamon, pterocephalus and plantain are collected and carried by using the 2015 edition of Chinese pharmacopoeia, and the medicated leaven is collected and carried by the nineteenth volume of the pharmaceutical standard Chinese medicinal prescription preparation of the ministry of health.
The raw material medicine can be used in both dry products and fresh products, preferably dry products, and the obtaining method of the dry products comprises the following steps: removing impurities, cleaning, and air drying. Wherein, the weight portions are calculated on a dry product.
Furthermore, the pharmaceutical composition is a preparation prepared by adding pharmaceutically acceptable auxiliary materials or auxiliary components into crude drug powder or extract of the raw drug materials according to the weight ratio; the extract is water or organic solvent extract.
Further, the preparation is an oral preparation.
Further, the oral preparation is powder, granules, capsules, tablets, pills or oral liquid.
The invention provides a preparation method of the pharmaceutical composition, which comprises the following steps: directly pulverizing the raw materials in weight ratio, and adding pharmaceutically acceptable adjuvants or auxiliary components; or extracting the raw materials in weight ratio with water or organic solvent, and adding pharmaceutically acceptable adjuvants or auxiliary components.
Further, the preparation method comprises the following steps: decocting the raw materials in the weight ratio twice, adding 8 times of water for decocting for 2 hours each time, mixing the decoctions, concentrating to relative density of 1.15-1.18, adding 95% ethanol until the ethanol content of the concentrated solution is 75%, standing, filtering, and concentrating the filtrate to obtain the final product.
The invention provides application of the pharmaceutical composition in preparing a medicament for treating and/or preventing livestock diarrhea.
Furthermore, the medicine is a medicine for preventing and/or treating diarrhea of cattle and/or sheep.
Further, the medicament is a medicament for preventing and/or treating diarrhea caused by bacteria, viruses and/or dyspepsia.
The invention provides a Tibetan medicine composition for preventing and treating livestock diarrhea, which mainly has the following advantages:
1. veterinary clinical use results show that the medicine has obvious effect on treating diarrhea diseases of livestock such as cattle, sheep and the like, symptoms are obviously relieved after the medicine is generally continuously taken for 3 days, the livestock can be cured after 5-6 days, and the total effective rate is up to more than 92%.
2. The medicine has obvious treatment effect on livestock diarrhea caused by bacteria, viruses, dyspepsia and other factors, and has wide application range.
3. Compared with the current western medicines (such as quinolones, furans and cephalosporins) for treating livestock diarrhea, the medicine provided by the invention does not influence milking and milk selling of livestock owners in the milking period of cattle and sheep, does not influence the quality of cattle and mutton due to antibiotic residue, and has obvious advantages.
4. The medicinal composition takes the genuine Tibetan medicinal materials as raw materials, can be prepared from local materials for livestock raised in Tibetan regions, and is convenient to use and low in price.
Detailed Description
The raw materials and equipment used in the embodiment of the present invention are known products and obtained by purchasing commercially available products.
Diarrhea includes diarrhea and dysentery, and is mainly caused by invasion of damp, heat, cold and summer-heat pathogens or internal injury of food with unclear yin-cold, and downward flow of damp and heat or cold and dampness, which causes abnormal ascending and descending of the spleen, stomach and intestine, resulting in dysfunction of spleen and stomach in receiving and transforming, and the intestine can not separate into clear and turbid, and mixed with water and feces. Or pathogenic factors of epidemic toxin entering the stomach and intestine due to deficiency, damp-heat blocking the intestine, qi and blood stagnation transforming into purulent blood and feces. Therefore, the treatment principle is warming spleen and stomach for dispelling cold, clearing heat and drying dampness, tonifying middle-jiao and Qi, warming spleen and kidney, warming kidney yang, clearing heat and eliminating dampness, regulating qi and promoting blood circulation, and cooling blood and removing toxicity.
The inventor carries out long-term veterinary clinical research on the use of the Tibetan medicine for preventing and treating the livestock diarrhea, and deeply understands the efficacy and the compatibility rule of the Tibetan medicine commonly used for treating the diseases. Under the guidance of Tibetan medicine theory, the recipe is finally formulated through prescription screening and years of clinical statistics and observation. Wherein, the lacquer tree seeds can activate blood circulation to stop pain, and can tonify spleen and stomach; zhixiu (antidiarrheal) for clearing heat and promoting bile flow; the sea leek has the functions of clearing away heat, promoting the production of body fluid, detoxifying, promoting diuresis, invigorating spleen and stopping diarrhea; cortex Cinnamomi has effects in dispelling cold, relieving pain, invigorating spleen, and promoting digestion; the boat-shaped aconite and the plantain herb clear heat and promote diuresis; the cypress branches clear away heat and toxic materials and help digestion; the winged eupatorium herb has the functions of clearing away heat and toxic materials, dispelling wind and removing dampness and relieving pain; pomegranate rind astringes to stop bleeding, kills parasites to stop dysentery; the star anise has the effects of warming middle energizer, easing pain, clearing heat and eliminating phlegm; massa Medicata Fermentata has effects of activating qi-flowing, resolving food stagnation, invigorating spleen, promoting appetite, resolving food stagnation, regulating stomach function, and treating milk regurgitation, flatulence, food stagnation, abdominal distention, anorexia, etc.
EXAMPLE 1 preparation of oral liquid of pharmaceutical composition of the present invention
Prescription: 5 parts of lacquer nut, 3 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 5 parts of holarrhena, 4 parts of aconitum bovinii, 5 parts of plantain, 5 parts of allium tuberosum, 4 parts of cypress branch, 4 parts of fennel fruit and 2 parts of medicated leaven.
The preparation method comprises the following steps:
1. weighing dry medicinal materials according to the proportion of the prescription, cleaning, cutting into small sections, adding water with the weight 8 times that of the medicinal materials for the first time, decocting for 2 hours, and discharging liquid medicine; adding water 8 times the weight of the medicinal materials for the second time, decocting for 2 hr, and discharging the medicinal liquid.
2. Mixing decoctions, filtering, and concentrating the filtrate under reduced pressure to relative density of 1.15-1.18(60 deg.C).
3. Adding 95% ethanol, adjusting the concentration to alcohol content of 75%, standing at room temperature for 24 hr, filtering with non-woven fabric coarse filter, filtering again (phi 0.8 μm), recovering ethanol, volatilizing the concentrated solution to no alcohol smell, concentrating the medicinal liquid under reduced pressure, and fine filtering (phi 0.65 μm); a water feeding needle batching chamber.
4. And (5) preparing materials and fixing the volume.
5. Filtration (. PHI.0.45 μm).
6. Filling and sealing: loading: 20 ml/bottle
7. And (3) high-pressure sterilization: 105 ℃ for 30 min.
8. Labeling and packaging. 1ml of the obtained oral liquid is equivalent to 1g of the dried raw material medicine.
The following test examples demonstrate the advantageous effects of the present invention.
Test example 1 efficacy test of the pharmaceutical composition of the present invention for treating diarrhea in livestock
The oral liquid prepared according to the embodiment 1 of the invention is used for treating diarrhea of cattle and sheep. The method treats 5000 heads/cattle and sheep feces of diarrhea in nearly 3 years, wherein some feces are brown water samples, some feces are bloody and are adhered with mucous membranes, and part of the feces of calves and lambs are milky white and part of the feces of calves and lambs have mild dehydration symptoms. The using method comprises the following steps: orally taking; the dosage used is as follows: 40ml for adult cattle and 20ml for calf and sheep, twice a day, and continuously taking for 5-6 days. The experimental statistics are detailed in table 1:
disappearance of symptoms: indicating a cure for diarrhea;
reduction of symptoms: the diarrhea symptom basically disappears, and other medicines are adopted for assisting the recovery of the experimental animal;
the total effective rate is counted by the total number of disappearance of symptoms and reduction of symptoms.
The experimental results are as follows: clinical application proves that the medicine has obvious curative effect on cattle and sheep diarrhea, symptoms are obviously relieved after the medicine is generally taken for 3 days, the medicine is healed after 5-6 days, and the total effective rate is up to more than 92%. Moreover, compared with the current western medicines (such as quinolones, furans and cephalosporins) for treating livestock diarrhea, the medicine provided by the invention does not influence milking and selling of livestock owners in the milking period of cattle and sheep, does not influence the quality of cattle and mutton due to antibiotic residue, and has more obvious advantages.
Test example 2 typical cases of livestock diarrhea treated with the pharmaceutical composition of the present invention
In 2016, 7 months, 34 calves and 11 adult cows of the country of the Hongyuan county, the county of the Hongyuan county, the country of the mouth, more Zhou Jiajia diarrhea, according to the clinical symptom analysis, the sick cattle are the primary paratyphoid, viral diarrhea mucosa disease, the individual calves are because of the whole milk raising to the dyspepsia. The oral liquid prepared according to the embodiment 1 of the invention is taken 7 months and 11 days, 40ml of the oral liquid is taken by adult cattle and 20ml of the oral liquid is taken by calf, the oral liquid is taken 2 times a day, the diarrhea symptom is obviously improved after 2 days, 44 calves are completely cured after 5 days of taking, and 1 calf is dead.
The experimental results show that the medicine has obvious treatment effect on livestock diarrhea caused by bacteria, viruses, dyspepsia and other factors, has wide application range and has wide application prospect.
Test example 3 comparison of the drug effects of the pharmaceutical composition of the present invention
1. Design of test protocol
The first prescription is as follows: 4 parts of lacquer seed, 1 part of pomegranate rind, 2 parts of cinnamon, 1 part of pterocephalus hookeri, 3 parts of holarrhena, 2 parts of aconitum bovinii, 3 parts of plantain, 3 parts of allium tuberosum, 2 parts of cypress branch and 1 part of fennel fruit.
And a second prescription: 4 parts of lacquer seed, 2 parts of cinnamon, 1 part of pterocephalus hookeri, 2 parts of boat-shaped aconite, 3 parts of plantain, 3 parts of sea leek, 2 parts of cypress branch, 1 part of fennel fruit and 2 parts of medicated leaven.
And a third prescription: 4 parts of lacquer nut, 1 part of pomegranate rind, 2 parts of cinnamon, 1 part of pterocephalus hookeri, 3 parts of holarrhena, 2 parts of aconitum bovinii, 3 parts of plantain, 3 parts of allium tuberosum, 2 parts of cypress branch, 1 part of fennel fruit and 2 parts of medicated leaven.
2. Number of cattle and sheep put into test
The test is carried out in two places of red original soil, Kouxiang and Ruergai Hongxing, 20 cattle are put into each prescription, and 30 sheep participate in the test. Some of the feces of the diarrhea cattle and the diarrhea sheep are brown water samples, some feces are bloody and are adhered with mucous membranes, part of the feces of the calves and the lambs are milk white, and part of the feces of the calves and the lambs have mild dehydration symptoms.
3. Dosage form for input test
The 3 prescriptions are all prepared into oral liquid according to the processing technology of the embodiment 1, and the specification is 1ml which is equivalent to 1g of dry bulk drug. The using method comprises the following steps: orally taking; the dosage used is as follows: 40ml for adult cattle and 20ml for calf and sheep, twice a day, and continuously taking for 5-6 days.
4. Statistics of experimental results
TABLE 2 statistics of efficacy on diarrhea cattle (Experimental group 20/group)
| Group of | Cure of disease | Is effective | Invalidation | Cure rate (%) | Effective rate (%) |
| Prescription one | 11 | 4 | 5 | 55.00 | 75.00 |
| Prescription two | 12 | 4 | 4 | 60.00 | 80.00 |
| Prescription three | 18 | 1 | 1 | 90.00 | 95.00 |
TABLE 3 statistics of the efficacy of the diarrhea sheep (30 experimental groups/group)
| Group of | Cure of disease | Is effective | Invalidation | Cure rate (%) | Effective rate (%) |
| Prescription one | 16 | 6 | 8 | 53.33 | 73.33 |
| Prescription two | 17 | 7 | 6 | 56.67 | 80.00 |
| Prescription three | 25 | 3 | 2 | 83.33 | 93.33 |
5. Analysis of Experimental results
The third prescription has the best effect of treating the livestock diarrhea under the same administration dosage; if the medicated leaven (prescription one) is subtracted from the formula, the effective rate is reduced from 95% to 75%, and the cure rate is reduced from 90% to 55%; if two medicines of pomegranate rind and antidiarrheal wood (formula II) are subtracted, the treatment effect is also greatly reduced, the effective rate is reduced to 80%, and the cure rate is reduced to 60%.
The experimental results show that the medicated leaven, the pomegranate bark and the antidiarrheal are essential for the exertion of the drug effect of the pharmaceutical composition, and the drugs supplement each other, can exert the synergistic effect, and obviously improve the treatment effect on the diarrhea of livestock.
Test example 4 influence of the dose ratio of each ingredient on the efficacy of the Tibetan medicine composition of the present invention
1. Design of test protocol
For the Tibetan medicine composition, whether the dosage proportion of the medicines is reasonable or not is closely related to the curative effect of the medicine. Therefore, after the treatment method is determined and the appropriate drugs are selected, the reasonable dosage proportion relationship needs to be determined repeatedly, so that the satisfactory curative effect can be obtained in clinic. The test is carried out on the dosage and the proportion of each medicine in the composition. The inventor designs 6 prescriptions with different proportions for testing on the basis of Tibetan medicine theory and on the premise of ensuring the curative effect of the prescription by comprehensively considering the medicine cost so as to obtain the dose floating range capable of realizing the treatment effect and the optimal proportion relation.
The first prescription is as follows: 4 parts of lacquer nut, 1 part of pomegranate rind, 2 parts of cinnamon, 1 part of pterocephalus hookeri, 3 parts of holarrhena, 2 parts of aconitum bovinii, 3 parts of plantain, 3 parts of allium tuberosum, 2 parts of cypress branch, 1 part of fennel fruit and 2 parts of medicated leaven.
And a second prescription: 8 parts of lacquer nut, 1 part of pomegranate rind, 6 parts of cinnamon, 3 parts of pterocephalus hookeri, 7 parts of holarrhena, 5 parts of aconitum bovinii, 7 parts of plantain, 7 parts of allium tuberosum, 6 parts of cypress branch, 6 parts of fennel fruit and 4 parts of medicated leaven.
And a third prescription: 5 parts of lacquer nut, 3 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 5 parts of holarrhena, 4 parts of aconitum bovinii, 5 parts of plantain, 5 parts of allium tuberosum, 4 parts of cypress branch, 4 parts of fennel fruit and 2 parts of medicated leaven.
And a fourth prescription: 5 parts of lacquer nut, 5 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 4 parts of holarrhena, 5 parts of aconitum bovinii, 4 parts of plantain, 6 parts of allium tuberosum, 4 parts of cypress branch, 3 parts of fennel fruit and 3 parts of medicated leaven.
And a fifth prescription: 6 parts of lacquer nut, 3 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 5 parts of holarrhena, 7 parts of aconitum bovinii, 4 parts of plantain, 6 parts of folium allii tuberose, 5 parts of cypress branch, 4 parts of fennel fruit and 3 parts of medicated leaven.
And a sixth prescription: 6 parts of lacquer nut, 4 parts of pomegranate rind, 5 parts of cinnamon, 2 parts of pterocephalus hookeri, 4 parts of holarrhena, 4 parts of aconitum bovinii, 4 parts of plantain, 5 parts of allium tuberosum, 5 parts of cypress branch, 3 parts of fennel fruit and 4 parts of medicated leaven.
2. Number of cattle and sheep put into test
The test is carried out in two places of Anqu town in Hongyuan and Yankouxiang town, 20 cattle are put into each proportioning prescription, and 30 sheep participate in the test. Some of the feces of the diarrhea cattle and the diarrhea sheep are brown water samples, some feces are bloody and are adhered with mucous membranes, part of the feces of the calves and the lambs are milk white, and part of the feces of the calves and the lambs have mild dehydration symptoms.
3. Dosage form for input test
The 6 prescriptions are all prepared into oral liquid according to the processing technology of the embodiment 1, and the specification is 1ml which is equivalent to 1g of dry bulk drug. The using method comprises the following steps: orally taking; the dosage used is as follows: 40ml for adult cattle and 20ml for calf and sheep, twice a day, and continuously taking for 5-6 days.
4. Statistics of experimental results
TABLE 4 statistics of the efficacy of diarrhea cattle (Experimental group 20/group)
| Group of | Cure of disease | Is effective | Invalidation | Cure rate | Effective rate (%) |
| Prescription one | 11 | 6 | 3 | 55.00 | 85.00 |
| Prescription two | 17 | 1 | 2 | 85.00 | 90.00 |
| Prescription three | 18 | 1 | 1 | 90.00 | 95.00 |
| Prescription four | 16 | 2 | 2 | 80.00 | 90.00 |
| Prescription five | 15 | 2 | 3 | 75.00 | 85.00 |
| Prescription six | 15 | 3 | 2 | 75.00 | 90.00 |
TABLE 5 statistics of the efficacy of the diarrhea sheep (30 experimental groups/group)
| Group of | Cure of disease | Is effective | Invalidation | Cure rate | Effective rate (%) |
| Prescription one | 16 | 6 | 8 | 53.33 | 73.33 |
| Prescription two | 19 | 6 | 5 | 63.33 | 83.33 |
| Prescription three | 27 | 1 | 2 | 90.00 | 93.33 |
| Prescription four | 23 | 4 | 3 | 76.67 | 90.00 |
| Prescription five | 23 | 2 | 5 | 76.67 | 83.33 |
| Prescription six | 20 | 3 | 7 | 66.67 | 76.67 |
And (3) curing: indicating disappearance and recovery of diarrhea symptoms;
the method has the following advantages: the diarrhea symptom basically disappears, and other medicines are adopted for the rehabilitation of the experimental animal; and (4) invalidation: the diarrhea symptom is not improved, and the effect of other auxiliary medicines is not good.
5. Analysis of Experimental results
Under the same administration dosage, the effective rate of the livestock diarrhea of one to six groups of the prescription can reach more than 70 percent, wherein, the three prescriptions have the best drug effect.
The above experimental results show that the proportion of the medicine of the invention can float in the following range, and can achieve better curative effect: 4-8 parts of lacquer nut, 1-5 parts of pomegranate rind, 2-6 parts of cinnamon, 1-3 parts of pterocephalus hookeri, 3-7 parts of holarrhena, 2-7 parts of aconitum bovittae, 3-7 parts of plantain, 3-7 parts of leek, 2-6 parts of cypress branch, 1-6 parts of fennel fruit and 2-4 parts of medicated leaven;
the optimal proportion of the curative effect is as follows: 5 parts of lacquer nut, 3 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 5 parts of holarrhena, 4 parts of aconitum bovinii, 5 parts of plantain, 5 parts of allium tuberosum, 4 parts of cypress branch, 4 parts of fennel fruit and 2 parts of medicated leaven.
The pharmaceutical composition has obvious effect of treating diarrhea diseases of cattle, sheep and other livestock, has obvious treatment effect on livestock diarrhea caused by bacteria, viruses, dyspepsia and other factors, and has wide application range and wide application prospect.
Claims (9)
1. The pharmaceutical composition for preventing and treating the livestock diarrhea is characterized in that: is prepared from the following raw material medicaments in part by weight: 5 parts of lacquer nut, 3 parts of pomegranate rind, 4 parts of cinnamon, 2 parts of pterocephalus hookeri, 5 parts of holarrhena, 4 parts of aconitum bovinii, 5 parts of plantain, 5 parts of allium tuberosum, 4 parts of cypress branch, 4 parts of fennel fruit and 2 parts of medicated leaven.
2. The pharmaceutical composition of claim 1, wherein: is prepared by mixing crude drug powder or extract of raw drug materials in weight ratio, and adding pharmaceutically acceptable adjuvants or auxiliary components; the extract is water or organic solvent extract.
3. The pharmaceutical composition according to claim 1 or 2, characterized in that: the preparation is an oral preparation.
4. The pharmaceutical composition of claim 3, wherein: the oral preparation is powder, granules, capsules, tablets, pills or oral liquid.
5. A process for the preparation of a pharmaceutical composition according to any one of claims 1 to 4, characterized in that: the method comprises the following steps: directly pulverizing the raw materials in weight ratio, and adding pharmaceutically acceptable adjuvants or auxiliary components; or extracting the raw materials in weight ratio with water or organic solvent, and adding pharmaceutically acceptable adjuvants or auxiliary components.
6. The method of claim 5, wherein: the method comprises the following steps: decocting the raw materials in the weight ratio twice, adding 8 times of water for decocting for 2 hours each time, mixing the decoctions, concentrating to relative density of 1.15-1.18, adding 95% ethanol until the ethanol content of the concentrated solution is 75%, standing, filtering, and concentrating the filtrate to obtain the final product.
7. Use of the pharmaceutical composition of any one of claims 1 to 4 for the manufacture of a medicament for the treatment and/or prevention of diarrhea in livestock.
8. Use according to claim 7, characterized in that: the medicine is a medicine for preventing and/or treating diarrhea of cattle and/or sheep.
9. Use according to claim 7, characterized in that: the medicine is used for preventing and/or treating diarrhea caused by bacteria, viruses and/or dyspepsia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710851708.1A CN107441267B (en) | 2017-09-19 | 2017-09-19 | Pharmaceutical composition for preventing and treating livestock diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710851708.1A CN107441267B (en) | 2017-09-19 | 2017-09-19 | Pharmaceutical composition for preventing and treating livestock diarrhea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107441267A CN107441267A (en) | 2017-12-08 |
| CN107441267B true CN107441267B (en) | 2021-06-04 |
Family
ID=60497795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710851708.1A Active CN107441267B (en) | 2017-09-19 | 2017-09-19 | Pharmaceutical composition for preventing and treating livestock diarrhea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107441267B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552668A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating lamb diarrhoea and preparation method thereof |
| CN104706728A (en) * | 2015-03-23 | 2015-06-17 | 四川成康动物药业有限公司 | Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof |
| CN105708984A (en) * | 2016-04-13 | 2016-06-29 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine composition for treating diarrhea of sheep and application of Tibetan medicine composition |
-
2017
- 2017-09-19 CN CN201710851708.1A patent/CN107441267B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552668A (en) * | 2010-12-09 | 2012-07-11 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for treating lamb diarrhoea and preparation method thereof |
| CN104706728A (en) * | 2015-03-23 | 2015-06-17 | 四川成康动物药业有限公司 | Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof |
| CN105708984A (en) * | 2016-04-13 | 2016-06-29 | 中国农业科学院兰州畜牧与兽药研究所 | Tibetan medicine composition for treating diarrhea of sheep and application of Tibetan medicine composition |
Non-Patent Citations (2)
| Title |
|---|
| 仔牛泄泻的辨证论治;刘永祥;《中兽医学杂志》;19860531(第03期);第26-28页 * |
| 治疗猪病验方选;马保良;《甘肃畜牧兽医》;19760331(第01期);第42-43页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107441267A (en) | 2017-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2236149B1 (en) | Medicinal composition for treating respiratory infectious diseases | |
| CN102512531B (en) | Chinese veterinary medicinal composition for preventing and treating pullorum and preparation method of same | |
| CN101744924B (en) | Multiple-effect Chinese herbal medicine compound of bacterial diseases of turbot | |
| JPH04128237A (en) | Preventive and therapeutic agent for animal corona virus infectious disease | |
| CN108272874B (en) | Traditional Chinese medicine preparation for laying hens and preparation method thereof | |
| CN112516205A (en) | Traditional Chinese medicine composition for treating helicobacter pylori infection | |
| CN108096355B (en) | Traditional Chinese medicine compound formula for treating cold-dampness type diarrhea of pigs, preparation and application | |
| CN107441267B (en) | Pharmaceutical composition for preventing and treating livestock diarrhea | |
| CN107233454B (en) | Traditional Chinese medicine and Tibetan medicine composition for preventing and treating livestock diarrhea | |
| CN100471510C (en) | Combination of lmedication for treatig mastitis of cow and preparation method | |
| CN104825753B (en) | A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow | |
| CN110721256B (en) | Traditional Chinese medicine composition for preventing and treating teniasis of laying hens and preparation method thereof | |
| CN103169825A (en) | Drug for treating enteric disease of beasts and birds | |
| CN101804135A (en) | Compound combined drug for treating poultry coccidiosis and preparation method thereof | |
| CN113577187A (en) | Anti-influenza traditional Chinese medicine composition, traditional Chinese medicine extract and preparation method and application thereof | |
| CN112675234A (en) | Preparation for treating animal damp-heat diarrhea and dysentery, preparation method and quality detection method | |
| CN113181317B (en) | Traditional Chinese medicine composition, preparation method thereof and application thereof in preventing diarrhea or resisting diarrhea | |
| CN113876853B (en) | Medicine for preventing and treating cow mastitis disease and preparation method and application thereof | |
| CN115671192B (en) | Traditional Chinese medicine composition for preventing and treating taeniasis of ducks | |
| CN115845004B (en) | Traditional Chinese medicine microcapsule for treating pig diarrhea and preparation method thereof | |
| CN101653567A (en) | Chinese veterinary medicament oral liquid for preventing and treating piglet yellow or white dysentery and preparation method thereof | |
| CN106310122A (en) | Traditional Chinese medicine composition for treating chronic gastritis as well as capsules and preparation method of traditional Chinese medicine composition | |
| CN115192683A (en) | Traditional Chinese medicine composition for treating/preventing mycotoxin poisoning and preparation method and application thereof | |
| CN112057534A (en) | Novel pure traditional Chinese medicine composite soluble powder preparation for preventing and treating pullorum disease and preparation method thereof | |
| CN106215123A (en) | A kind of Chinese medicine composition treating taste stagflation and capsule thereof and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yu Zhonghua Inventor after: He Shiming Inventor after: Wu Jinbo Inventor after: Yu Kangjian Inventor after: Lu Yong Inventor after: Qiu Yun Inventor before: Yu Zhonghua Inventor before: He Shiming Inventor before: Tang Muke Inventor before: Li Xuting Inventor before: Wu Jinbo Inventor before: Yu Kangjian Inventor before: Lu Yong Inventor before: Qiu Yun Inventor before: Nishina |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |