CN106215123A - A kind of Chinese medicine composition treating taste stagflation and capsule thereof and preparation method - Google Patents

A kind of Chinese medicine composition treating taste stagflation and capsule thereof and preparation method Download PDF

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CN106215123A
CN106215123A CN201610781413.7A CN201610781413A CN106215123A CN 106215123 A CN106215123 A CN 106215123A CN 201610781413 A CN201610781413 A CN 201610781413A CN 106215123 A CN106215123 A CN 106215123A
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parts
chinese medicine
medicine composition
stagflation
herba
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邢文月
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention provides a kind of Chinese medicine composition treating taste stagflation, the primary raw material weight portion preparing described Chinese medicine composition consists of: HEIQIANNIU, Herba Ludwigiae Prostratae, Semen Raphani, Rhizoma Cimicifugae, charred Radix Et Rhizoma Rhei, Herba Patriniae, Rhizoma Pinelliae, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Cortex Actinodaphnes Obovatae, Semen Euryales, Gynura bodinieri Levl., Resina Liquidambaris, Herba Epimedii, label grass, Agrimony, Fructus Momordicae, Rhizoma Curcumae Longae, Ilex purpurea Hassk.[I.chinensis Sims, Moschus, Radix Platycodonis, Radix Morindae Officinalis, Herba Menthae, Pseudobulbus Cremastrae Seu Pleiones, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi)；Another aspect of the present invention additionally provides the preparation method of a kind of Chinese medicine composition treating taste stagflation.This Traditional Chinese medicine composition formula is scientific and reasonable, each component works in coordination with compatibility, can fast onset drug effect, have invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, dyspepsia and intestinal stasis relieving effect, prove through lot of experiments, the present invention is evident in efficacy to taste stagflation, and curative effect is excellent, giving consideration to both the incidental and fundamental, curative effect is certainly, safe ready and having no side effect, does not has any Western medicine or hormone drug composition.

Description

A kind of Chinese medicine composition treating taste stagflation and capsule thereof and preparation method
Technical field
The present invention relates to technical field of Chinese medicines, particularly to a kind of Chinese medicine composition treating taste stagflation and capsule thereof And preparation method.
Background technology
Taste stagflation, disease name, middle Jiao refers to taste.I.e. damp retardance taste, affect its transportation capabilities.Disease is seen nose heave, idle Tired, gastral cavity is vexed, abdominal distention, indigestion and loss of appetite, mouth viscous thirsty, desire for hot drinks, oliguria with reddish urine, thick fur is white or greasy, moderate pulse etc..Control suitable invigorating spleen to remove dampness.Often With western medicine, side effect is big, existing Chinese medicine DeGrain.
Therefore, those skilled in the art are badly in need of developing one and can conveniently be taken, and the treatment taste stagflation of quick result Chinese medicine composition.
Summary of the invention
For above-mentioned problems of the prior art and defect, the invention provides a kind of Chinese medicine treating taste stagflation Compositions and capsule thereof and preparation method, said composition is evident in efficacy, safe ready and having no side effect, and its preparation method is high Effect, effective component extracting is effective, is suitable for commercial production.
The concrete technical scheme of the present invention is as follows:
The Chinese medicine composition of the treatment taste stagflation of the present invention, prepares the primary raw material weight portion group of described Chinese medicine composition Become: HEIQIANNIU 10-50 part, Herba Ludwigiae Prostratae 5-30 part, Semen Raphani 10-50 part, Rhizoma Cimicifugae 15-55 part, charred Radix Et Rhizoma Rhei 10-50 part, Herba Patriniae Grass 10-50 part, Rhizoma Pinelliae 10-50 part, Oletum Trogopterori 5-35 part, Pericarpium Citri Reticulatae Viride 10-50 part, Cortex Actinodaphnes Obovatae 20-60 part, Semen Euryales 10-50 Part, Gynura bodinieri Levl.'s 10-50 part, Resina Liquidambaris 30-60 part, Herba Epimedii 10-50 part, label grass 10-50 part, Agrimony 15-55 part, arhat Really 10-50 part, Rhizoma Curcumae Longae 5-30 part, Ilex purpurea Hassk.[I.chinensis Sims 10-50 part, Moschus 1-20 part, Radix Platycodonis 10-50 part, Radix Morindae Officinalis 10-50 part, Herba Menthae 1-20 part, Pseudobulbus Cremastrae Seu Pleiones 5-30 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5-30 part.
Further, the primary raw material weight portion preparing described Chinese medicine composition consists of: HEIQIANNIU 20-40 part, water fourth Fragrant 10-20 part, Semen Raphani 20-40 part, Rhizoma Cimicifugae 25-45 part, charred Radix Et Rhizoma Rhei 20-40 part, Herba Patriniae 20-40 part, Rhizoma Pinelliae 20-40 Part, Oletum Trogopterori 10-30 part, Pericarpium Citri Reticulatae Viride 20-40 part, Cortex Actinodaphnes Obovatae 30-50 part, Semen Euryales 20-40 part, Gynura bodinieri Levl.'s 20-40 part, sweetgum Fat 40-50 part, Herba Epimedii 20-40 part, label grass 20-40 part, Agrimony 25-45 part, Fructus Momordicae 20-40 part, Rhizoma Curcumae Longae 10-25 Part, Ilex purpurea Hassk.[I.chinensis Sims 20-40 part, Moschus 5-15 part, Radix Platycodonis 20-40 part, Radix Morindae Officinalis 20-40 part, Herba Menthae 5-15 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 Part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 part.
Further, the primary raw material weight portion preparing described Chinese medicine composition consists of: HEIQIANNIU 30 parts, Herba Ludwigiae Prostratae 15 Part, Semen Raphani 30 parts, Rhizoma Cimicifugae 35 parts, charred Radix Et Rhizoma Rhei 30 parts, Herba Patriniae 30 parts, Rhizoma Pinelliae 30 parts, Oletum Trogopterori 20 parts, 30 parts of Pericarpium Citri Reticulatae Viride, Cortex Actinodaphnes Obovatae 40 parts, Semen Euryales 30 parts, Gynura bodinieri Levl. 30 parts, Resina Liquidambaris 45 parts, Herba Epimedii 30 parts, label grass 30 parts, Agrimony 35 Part, Fructus Momordicae 30 parts, 15 parts of Rhizoma Curcumae Longae, Ilex purpurea Hassk.[I.chinensis Sims 30 parts, 10 parts of Moschus, Radix Platycodonis 30 parts, Radix Morindae Officinalis 30 parts, Herba Menthae 10 parts, mountain are kind 15 parts of mushroom, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 parts.
The weight of composition described above crude drug calculates with crude drug, using weight portion as proportioning, when producing can according to than Example increases or reduces, as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also with gram or Milligram is unit, and weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.More than and The ratio of weight proportion obtains through science screening, can adjust the proportioning of the amount of composition accordingly, be increased or decreased and do not surpass Crossing 100%, drug effect is constant.
As a further improvement on the present invention, the invention provides a kind of preparation treating taste stagflation, described preparation by Chinese medicine composition is separately made or is formed by with Chinese medicine composition and pharmaceutically acceptable carrier.
Further, described preparation is oral formulations or external preparation, described oral formulations be water extract, tablet, pill, Water-honeyed pill, concentrated pill, powder, capsule, oral liquid, granule or health tea oral formulations；Described external preparation is stifling Agent, lotion or unguentum.
Further, described external preparation is capsule, and described capsule includes that ratio of weight and number is 1:1-2.5 Chinese drug-treated group Compound and adjuvant.
Further, described adjuvant includes the composition of following parts by weight: pregelatinized starch 5-15 part, stearic palmitamide 5-15 part, ethyl methylphenylglycidate 3-7 part, carboxymethyl starch sodium 3-7 part, microcrystalline silicon 10-20 part, sodium palmitate 3- 7 parts, ethyl cyclodextrin 5-15 part.
Further, described capsule filling includes the composition of following parts by weight: Chinese medicine composition 30 parts, pregel form sediment 10 parts of powder, stearic palmitamide 10 parts, ethyl methylphenylglycidate 5 parts, carboxymethyl starch sodium 5 parts, microcrystalline silicon 15 parts, Sodium palmitate 5 parts, ethyl cyclodextrin 10 parts.
As a further improvement on the present invention, present invention also offers the system of a kind of Chinese medicine composition treating taste stagflation Preparation Method, the method comprises the steps:
S1, weigh the HEIQIANNIU of recipe quantity, Herba Ludwigiae Prostratae, Semen Raphani, Rhizoma Cimicifugae, charred Radix Et Rhizoma Rhei, Herba Patriniae, Rhizoma Pinelliae, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Cortex Actinodaphnes Obovatae, Semen Euryales, Gynura bodinieri Levl. 12 taste crude drug, pulverize, mill, sieve and make fine powder, and the number of described screen cloth is 150-180 mesh, boiling 3 times, 12 times of water yields decoct 3h for the first time, and 10 times of water yields decoct 2h, for the second time 8 times of water yields for the second time Decoct 1h, merge to obtain decocting liquid, under the conditions of temperature 50 C, be condensed into the clear paste 1 that relative density is 1.30, cooling, the ethanol adding 75% Carry out precipitate with ethanol 2h, filter, at 50 DEG C, be condensed into the dry extract 1 that relative density is 1.45；
S2, weigh the Resina Liquidambaris of recipe quantity, Herba Epimedii, label grass, Agrimony, Fructus Momordicae, Rhizoma Curcumae Longae, Ilex purpurea Hassk.[I.chinensis Sims, Moschus, Fructus Citri tangerinae Stalk, Radix Morindae Officinalis, Herba Menthae, Pseudobulbus Cremastrae Seu Pleiones, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 13 taste crude drug, pulverize, mill, sieve and make fine powder, the number of described screen cloth For 60-100 mesh, after stirring, the reflux, extract, of 10 times of 75% ethanol of addition 3 times, each 1.5h, filter, merge backflow Liquid, is concentrated into the clear paste 2 that relative density at 55 DEG C is 1.20, is dissolved by clear paste by 5 times of water yields, upper macroporous resin column, successively With water and the ethanol elution of 45%, reclaim ethanol elution, at 55 DEG C, be concentrated into the dry extract 2 that relative density is 1.35；
S3, merging dry extract 1 and dry extract 2, be ground into powder, is subsequently placed in mixing 1h in trough type mixing machine, to obtain final product The Chinese medicine composition for the treatment of taste stagflation.
Additionally, the invention allows for the Chinese medicine composition of taste stagflation as answering in treatment taste stagflation medicine With.
As can be seen here, the Chinese medicine composition of the treatment taste stagflation that the present invention provides, this Traditional Chinese medicine composition formula science is closed Reason, each component is worked in coordination with compatibility, energy fast onset drug effect, is had effect of invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, dyspepsia and intestinal stasis relieving, through a large amount of Test proves, the present invention can be evident in efficacy to taste stagflation, and curative effect is excellent, giving consideration to both the incidental and fundamental, curative effect affirmative, safe ready and nothing Toxic and side effects, does not has any Western medicine or hormone drug composition.
Detailed description of the invention
Below in conjunction with specific embodiment further describe the present invention, advantages of the present invention and feature will be with describe and Apparent.It should be understood that described embodiment is only exemplary, the scope of the present invention is not constituted any restriction.This area Skilled artisans appreciated that, lower without departing from the spirit and scope of the present invention can to the details of technical solution of the present invention and Form is modified or replaces, but these amendments or replacement each fall within protection scope of the present invention.
Embodiment 1:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 30g, Herba Ludwigiae Prostratae 15g, Semen Raphani 30g, Rhizoma Cimicifugae 35g, charred Radix Et Rhizoma Rhei 30g, Herba Patriniae 30g, Rhizoma Pinelliae 30g, Oletum Trogopterori 20g, Pericarpium Citri Reticulatae Viride 30g, Cortex Actinodaphnes Obovatae 40g, Semen Euryales 30g, Gynura bodinieri Levl. 30g, Resina Liquidambaris 45g, Herba Epimedii 30g, label grass 30g, Agrimony 35g, Fructus Momordicae 30g, Rhizoma Curcumae Longae 15g, Ilex purpurea Hassk.[I.chinensis Sims 30g, Moschus 10g, Radix Platycodonis 30g, Radix Morindae Officinalis 30g, Herba Menthae 10g, Pseudobulbus Cremastrae Seu Pleiones 15g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15g.
Wherein, the preparation method of a kind of Chinese medicine composition treating taste stagflation is present embodiments provided, including walking as follows Rapid:
S1, weigh the HEIQIANNIU of recipe quantity, Herba Ludwigiae Prostratae, Semen Raphani, Rhizoma Cimicifugae, charred Radix Et Rhizoma Rhei, Herba Patriniae, Rhizoma Pinelliae, Oletum Trogopterori, Pericarpium Citri Reticulatae Viride, Cortex Actinodaphnes Obovatae, Semen Euryales, Gynura bodinieri Levl. 12 taste crude drug, pulverize, mill, sieve and make fine powder, and the number of described screen cloth is 150-180 mesh, boiling 3 times, 12 times of water yields decoct 3h for the first time, and 10 times of water yields decoct 2h, for the second time 8 times of water yields for the second time Decoct 1h, merge to obtain decocting liquid, under the conditions of temperature 50 C, be condensed into the clear paste 1 that relative density is 1.30, cooling, the ethanol adding 75% Carry out precipitate with ethanol 2h, filter, at 50 DEG C, be condensed into the dry extract 1 that relative density is 1.45；
S2, weigh the Resina Liquidambaris of recipe quantity, Herba Epimedii, label grass, Agrimony, Fructus Momordicae, Rhizoma Curcumae Longae, Ilex purpurea Hassk.[I.chinensis Sims, Moschus, Fructus Citri tangerinae Stalk, Radix Morindae Officinalis, Herba Menthae, Pseudobulbus Cremastrae Seu Pleiones, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 13 taste crude drug, pulverize, mill, sieve and make fine powder, the number of described screen cloth For 60-100 mesh, after stirring, the reflux, extract, of 10 times of 75% ethanol of addition 3 times, each 1.5h, filter, merge backflow Liquid, is concentrated into the clear paste 2 that relative density at 55 DEG C is 1.20, is dissolved by clear paste by 5 times of water yields, upper macroporous resin column, successively With water and the ethanol elution of 45%, reclaim ethanol elution, at 55 DEG C, be concentrated into the dry extract 2 that relative density is 1.35；
S3, merging dry extract 1 and dry extract 2, be ground into powder, is subsequently placed in mixing 1h in trough type mixing machine, to obtain final product The Chinese medicine composition for the treatment of taste stagflation.
Embodiment 2:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 10g, Herba Ludwigiae Prostratae 5g, Semen Raphani 10g, Rhizoma Cimicifugae 15g, charred Radix Et Rhizoma Rhei 10g, Herba Patriniae 10g, Rhizoma Pinelliae 10g, five The careless 10g of Oletum Trogopterori 5g, Pericarpium Citri Reticulatae Viride 10g, Cortex Actinodaphnes Obovatae 20g, Semen Euryales 10g, Gynura bodinieri Levl. 10g, Resina Liquidambaris 30g, Herba Epimedii 10g, label, Agrimony 15g, Fructus Momordicae 10g, Rhizoma Curcumae Longae 5g, Ilex purpurea Hassk.[I.chinensis Sims 10g, Moschus 1g, Radix Platycodonis 10g, Radix Morindae Officinalis 10g, Herba Menthae 1g, Pseudobulbus Cremastrae Seu Pleiones 5g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5g.
Wherein, the preparation method of the Chinese medicine composition of the treatment taste stagflation of the present embodiment is identical with embodiment 1.
Embodiment 3:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 15g, Herba Ludwigiae Prostratae 8g, Semen Raphani 15g, Rhizoma Cimicifugae 25g, charred Radix Et Rhizoma Rhei 15g, Herba Patriniae 15g, Rhizoma Pinelliae 5g, five The careless 15g of Oletum Trogopterori 8g, Pericarpium Citri Reticulatae Viride 15g, Cortex Actinodaphnes Obovatae 25g, Semen Euryales 15g, Gynura bodinieri Levl. 15g, Resina Liquidambaris 35g, Herba Epimedii 15g, label, Agrimony 20g, Fructus Momordicae 15g, Rhizoma Curcumae Longae 7g, Ilex purpurea Hassk.[I.chinensis Sims 15g, Moschus 3g, Radix Platycodonis 15g, Radix Morindae Officinalis 15g, Herba Menthae 2g, Pseudobulbus Cremastrae Seu Pleiones 8g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 7g.
Wherein, the preparation method of the Chinese medicine composition of the treatment taste stagflation of the present embodiment is identical with embodiment 1.
Embodiment 4:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 20g, Herba Ludwigiae Prostratae 10g, Semen Raphani 20g, Rhizoma Cimicifugae 25g, charred Radix Et Rhizoma Rhei 20g, Herba Patriniae 20g, Rhizoma Pinelliae 20g, Oletum Trogopterori 10g, Pericarpium Citri Reticulatae Viride 20g, Cortex Actinodaphnes Obovatae 30g, Semen Euryales 20g, Gynura bodinieri Levl. 20g, Resina Liquidambaris 40g, Herba Epimedii 20g, label grass 20g, Agrimony 25g, Fructus Momordicae 20g, Rhizoma Curcumae Longae 10g, Ilex purpurea Hassk.[I.chinensis Sims 20g, Moschus 5g, Radix Platycodonis 20g, Radix Morindae Officinalis 20g, Herba Menthae 5g, mountain Rhizoma sagittariae sagittifoliae 10g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10g.
Wherein, the preparation method of the Chinese medicine composition of the treatment taste stagflation of the present embodiment is identical with embodiment 1.
Embodiment 5:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 40g, Herba Ludwigiae Prostratae 20g, Semen Raphani 40g, Rhizoma Cimicifugae 45g, charred Radix Et Rhizoma Rhei 40g, Herba Patriniae 40g, Rhizoma Pinelliae 40g, Oletum Trogopterori 30g, Pericarpium Citri Reticulatae Viride 40g, north worm winter, 50g summer, Semen Euryales 40g, Gynura bodinieri Levl. 40g, Resina Liquidambaris 50g, Herba Epimedii 40g, label grass 40g, Agrimony 45g, Fructus Momordicae 40g, Rhizoma Curcumae Longae 25g, Ilex purpurea Hassk.[I.chinensis Sims 40g, Moschus 15g, Radix Platycodonis 40g, Radix Morindae Officinalis 40g, Herba Menthae 15g, Pseudobulbus Cremastrae Seu Pleiones 20g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 20g.
Wherein, the preparation method of the Chinese medicine composition of the treatment taste stagflation of the present embodiment is identical with embodiment 1.
Embodiment 6:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 45g, Herba Ludwigiae Prostratae 25g, Semen Raphani 45g, Rhizoma Cimicifugae 50g, charred Radix Et Rhizoma Rhei 45g, Herba Patriniae 45g, Rhizoma Pinelliae 45g, Oletum Trogopterori 32g, Pericarpium Citri Reticulatae Viride 45g, north worm winter, 55g summer, Semen Euryales 45g, Gynura bodinieri Levl. 45g, Resina Liquidambaris 55g, Herba Epimedii 45g, label grass 45g, Agrimony 50g, Fructus Momordicae 45g, Rhizoma Curcumae Longae 27g, Ilex purpurea Hassk.[I.chinensis Sims 45g, Moschus 17g, Radix Platycodonis 45g, Radix Morindae Officinalis 45g, Herba Menthae 18g, Pseudobulbus Cremastrae Seu Pleiones 25g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 25g.
Wherein, the preparation method of the Chinese medicine composition of the treatment taste stagflation of the present embodiment is identical with embodiment 1.
Embodiment 7:
Present embodiments providing a kind of Chinese medicine composition treating taste stagflation, this Chinese medicine composition includes following weight in grams The raw material of number:
HEIQIANNIU 50g, Herba Ludwigiae Prostratae 30g, Semen Raphani 50g, Rhizoma Cimicifugae 55g, charred Radix Et Rhizoma Rhei 50g, Herba Patriniae 50g, Rhizoma Pinelliae 50g, Oletum Trogopterori 35g, Pericarpium Citri Reticulatae Viride 50g, Cortex Actinodaphnes Obovatae 60g, Semen Euryales 50g, Gynura bodinieri Levl. 50g, Resina Liquidambaris 60g, Herba Epimedii 50g, label grass 50g, Agrimony 55g, Fructus Momordicae 50g, Rhizoma Curcumae Longae 30g, Ilex purpurea Hassk.[I.chinensis Sims 50g, Moschus 20g, Radix Platycodonis 50g, Radix Morindae Officinalis 50g, Herba Menthae 20g, Pseudobulbus Cremastrae Seu Pleiones 30g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 30g.
Wherein, the preparation method of the Chinese medicine composition of the treatment taste stagflation of the present embodiment is identical with embodiment 1.
Embodiment 8:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 30g of embodiment 1, pregelatinized starch 10g, stearic palmitamide 10g, aminomethyl phenyl glycidic acid Ethyl ester 5g, carboxymethyl starch sodium 5g, microcrystalline silicon 15g, sodium palmitate 5g, ethyl cyclodextrin 10g.
Embodiment 9:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:1 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 34g of embodiment 1, pregelatinized starch 5g, stearic palmitamide 5g, aminomethyl phenyl glycidic acid second Ester 3g, carboxymethyl starch sodium 3g, microcrystalline silicon 10g, sodium palmitate 3g, ethyl cyclodextrin 5g.
Embodiment 10:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2.5 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 34g of embodiment 1, pregelatinized starch 15g, stearic palmitamide 15g, aminomethyl phenyl glycidic acid Ethyl ester 7g, carboxymethyl starch sodium 7g, microcrystalline silicon 20g, sodium palmitate 7g, ethyl cyclodextrin 15g.
Embodiment 11:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 30g of embodiment 1, stearic palmitamide 30g, ethyl methylphenylglycidate 14g, Palmic acid Sodium 16g.
Embodiment 12:
The present embodiment proposes the Chinese medicine composition application as treatment taste stagflation medicine for the treatment of taste stagflation.
Reference examples 1:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 22g of embodiment 1, stearic palmitamide 30g, ethyl methylphenylglycidate 14g.
Reference examples 2:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 23g of embodiment 1, stearic palmitamide 30g, sodium palmitate 16g.
Reference examples 3:
External preparation prepared by the Chinese medicine composition of the present embodiment offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 15g of embodiment 1, ethyl methylphenylglycidate 14g, sodium palmitate 16g.
Comparative example 4:
External preparation prepared by the Chinese medicine composition of this reference examples offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 30g of embodiment 1, pregelatinized starch 10g, stearic palmitamide 10g, aminomethyl phenyl glycidic acid Ethyl ester 8g, carboxymethyl starch sodium 2g, microcrystalline silicon 15g, sodium palmitate 5g, ethyl cyclodextrin 10g.
Comparative example 5:
External preparation prepared by the Chinese medicine composition of this reference examples offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:2 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 30g of embodiment 1, pregelatinized starch 10g, stearic palmitamide 10g, carboxymethyl starch sodium 10g, Microcrystalline silicon 15g, sodium palmitate 5g, ethyl cyclodextrin 10g.
Reference examples 6:
External preparation prepared by the Chinese medicine composition of this reference examples offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:3 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 20g of embodiment 1, pregelatinized starch 10g, stearic palmitamide 10g, aminomethyl phenyl glycidic acid Ethyl ester 5g, carboxymethyl starch sodium 5g, microcrystalline silicon 15g, sodium palmitate 5g, ethyl cyclodextrin 10g.
Reference examples 7:
External preparation prepared by the Chinese medicine composition of this reference examples offer treatment taste stagflation and adjuvant, described external preparation For capsule, described capsule includes ratio of weight and number 1:4 Chinese medicine composition and adjuvant, and concrete content is as follows:
The Chinese medicine composition 15g of embodiment 1, pregelatinized starch 10g, stearic palmitamide 10g, aminomethyl phenyl glycidic acid Ethyl ester 5g, carboxymethyl starch sodium 5g, microcrystalline silicon 15g, sodium palmitate 5g, ethyl cyclodextrin 10g.
Capsule in above example and comparative example is all prepared with routine fashion.
Reference examples 8:
Present embodiments providing the Chinese medicine composition of a kind of cure scapulohumeral periarthritis, this Chinese medicine composition includes following weight grams Raw material:
HEIQIANNIU 60g, Herba Ludwigiae Prostratae 25g, Semen Raphani 13g, Rhizoma Cimicifugae 40g, charred Radix Et Rhizoma Rhei 80g, Herba Patriniae 10g, Rhizoma Pinelliae 35g, Oletum Trogopterori 15g, Pericarpium Citri Reticulatae Viride 50g, Cortex Actinodaphnes Obovatae 35g, Semen Euryales 50g, Gynura bodinieri Levl. 70g, Resina Liquidambaris 40g, Herba Epimedii 50g, label grass 60g, Agrimony 30g, Fructus Momordicae 50g, Rhizoma Curcumae Longae 30g, Ilex purpurea Hassk.[I.chinensis Sims 50g, Moschus 20g, Radix Platycodonis 30g, Radix Morindae Officinalis 20g, Herba Menthae 40g, Pseudobulbus Cremastrae Seu Pleiones 15g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10g.
Wherein, the preparation method of the Chinese medicine composition of the cure scapulohumeral periarthritis of the present embodiment is identical with embodiment 1.
Reference examples 9:
Present embodiments providing the Chinese medicine composition of a kind of cure scapulohumeral periarthritis, this Chinese medicine composition includes following weight grams Raw material:
HEIQIANNIU 30g, Semen Raphani 30g, Rhizoma Cimicifugae 35g, charred Radix Et Rhizoma Rhei 30g, Herba Patriniae 30g, Rhizoma Pinelliae 30g, Oletum Trogopterori 20g, Pericarpium Citri Reticulatae Viride 30g, Cortex Actinodaphnes Obovatae 40g, Semen Euryales 30g, Gynura bodinieri Levl. 30g, Resina Liquidambaris 45g, Agrimony 35g, Fructus Momordicae 30g, Rhizoma Curcumae Longae 15g, Ilex purpurea Hassk.[I.chinensis Sims 30g, Moschus 10g, Radix Platycodonis 30g, Herba Menthae 10g, Pseudobulbus Cremastrae Seu Pleiones 15g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15g.
Wherein, the preparation method of the Chinese medicine composition of the cure scapulohumeral periarthritis of the present embodiment is identical with embodiment 1.
Reference examples 10:
Present embodiments providing the Chinese medicine composition of a kind of cure scapulohumeral periarthritis, this Chinese medicine composition includes following weight grams Raw material:
HEIQIANNIU 5g, Herba Ludwigiae Prostratae 10g, Semen Raphani 15g, Rhizoma Cimicifugae 8g, charred Radix Et Rhizoma Rhei 7g, Herba Patriniae 4g, Rhizoma Pinelliae 5g, Oletum Trogopterori 15g, Pericarpium Citri Reticulatae Viride 20g, Cortex Actinodaphnes Obovatae 10g, Semen Euryales 5g, Gynura bodinieri Levl. 8g, Resina Liquidambaris 15g, Herba Epimedii 5g, label grass 15g, Agrimony 10g, Fructus Momordicae 8g, Rhizoma Curcumae Longae 5g, Ilex purpurea Hassk.[I.chinensis Sims 7g, Moschus 5g, Radix Platycodonis 5g, Radix Morindae Officinalis 15g, Herba Menthae 5g, Pseudobulbus Cremastrae Seu Pleiones 10g, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 8g。
The vitro release determination test of the capsule including Chinese medicine composition that test example 1, the present invention provide
The release detection of pharmaceutical composition: with reference to 2010 editions " Chinese Pharmacopoeia " annex XIXD vitro drug release degree inspections Look into.
Take the capsule that above example 11, reference examples 1, reference examples 2 and reference examples 3 provide, and the glue that will take out respectively Wafer is respectively implanted in digestion instrument, separately sampled in 1h, 2h, 4h, 6h, 12h, 16h, 24h, and by the sample high-efficient liquid of taking-up Phase chromatography detection dissolution percentage rate, and calculate the cumulative release percentage rate of medicine.
Dissolution (%) result of the test of table 1. inventive samples
The pharmaceutical composition of embodiment 11 all discharges in 10h as can be seen from the table, the pharmaceutical composition of reference examples 1 All discharging in 6h, the capsule of the pharmaceutical composition of reference examples 2 and reference examples 3 released within 24 hours the most respectively 90% and 85%, therefore, the pharmaceutical composition that the present invention provides is adding stearic palmitamide, ethyl methylphenylglycidate After sodium palmitate, it is possible to significantly improve the stability of drug regimen raw material, play slow release effect, promote Chinese medicine major ingredient is lived Property composition absorption, meanwhile, with reference to upper table, it appeared that stearic palmitamide, ethyl methylphenylglycidate and Palmic acid Sodium three has synergism, lacks any one of which and rents a house, and its releasing effect is the most undesirable.
Effect measuring disintegration of the capsule including Chinese medicine composition that test example 2, the present invention provide
According to the regulation in Chinese Pharmacopoeia, the disintegration surveying capsule surveys its emulsifying effectiveness to pharmaceutical composition.
Take the capsule that above example 8, reference examples 4 and reference examples 5 provide respectively, test disintegration respectively, test Data result is as follows:
The impact on capsule disintegration of table 2. different auxiliary material
As can be seen from the table, the capsule phase that the capsule that the embodiment of the present invention 8 provides provides with reference examples 4, reference examples 5 Ratio, the present invention contains ethyl methylphenylglycidate and carboxymethyl starch sodium, can be effectively improved Chinese medicine composition at capsule Disintegration in agent, lacking any one, disintegrate effect is the most bad, additionally, sucrose monolaurate fat and starch glycolate When the ratio of acid sodium is close to 1:1, its disintegrate efficiency is the fastest, thus may certify that, sucrose monolaurate fat and sodium starch glycol There is the collaborative effect promoting disintegrate, therefore the capsule that provides of the present invention can fater disintegration, it is possible to make active ingredient the fastest Speed arrives pathogenic site, thus alleviates the pain of sufferer.
Test example 3, stability test
1. accelerated test
Example 1, embodiment 6, embodiment 7, reference examples 6 and the mixture of reference examples 7, be divided into 3 batches, respectively numbered sample Product 1, sample 2, sample 3, sample 4 and sample 5, at temperature 40 DEG C ± 2 DEG C, relative humidity is to put under conditions of 75% ± 5% Putting 6 months, testing, 1 month period, 2 months, 3 months, 6 the end of month are separately sampled once, by the regulation in Chinese Pharmacopoeia, inspection Survey the character of mixture, color and luster, abnormal smells from the patient and the content (labelled amount %) of main component, dissolution and have related substance, it was found that Sample 1, sample 2 and sample 3 indices have no significant change, and sample 4 and sample 5 darken, and precipitation occur, and 6 Slight abnormal flavour all occurred the when of individual month.
2. long term test
Example 1, embodiment 6, embodiment 7, reference examples 6 and the mixture of reference examples 7, be divided into 3 batches, respectively numbered sample Product 1, sample 2, sample 3, sample 4 and sample 5, at temperature 25 DEG C ± 2 DEG C, relative humidity is to put under conditions of 60% ± 10% Put 24 months, testing 0 month period, 3 months, 6 months, 9 months, 12 months, 18 months, 24 the end of month separately sampled one Secondary, by the regulation in Chinese Pharmacopoeia, the detection character of mixture, color and luster, abnormal smells from the patient and the content (labelled amount %) of main component, dissolution Spend and have related substance, it was found that sample 1, sample 2 and sample 3 indices have no significant change, and sample 4 and sample 5 Darken, precipitation occurs, and slight abnormal flavour all occurred 6 months when, when 12 months, less malodor occurs.
The mixture that conclusion Chinese medicine composition of the present invention is made is due to the reasonable selection of adjuvant, and stability of drug products is good, when storing Between long, and the addition of stearic palmitamide and ethyl cyclodextrin more significantly improves the stability of mixture.
Test example 4, toxicity test
(1) acute toxicity test
1. subjects: healthy SD rat
Test group 50 example, male Mus, age 5 week old；
Matched group 50 example, male Mus, age 5 week old.
2. test method:
Test group: the Chinese medicine composition normal saline that the present invention treats taste stagflation becomes the molten of 65% concentration Liquid, to rat by a 40mL/kg gavage, double in one day, then drug withdrawal, continues after drug withdrawal to observe 7 days.
Matched group: with normal saline to rat by a 40mL/kg gavage, double in one day, then drug withdrawal, drug withdrawal Rear continuation is observed 7 days.
3. statistical method: respectively test 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, record the mortality rate of two groups of rats And rat behavior has Non Apparent Abnormality；After the observation period terminates, put to death rat in the 8th day, carry out cuing open inspection, record two groups of rats Internal organs abnormal change situation.
4. result of the test:
Result of the test is shown in Table 3.
Table 3. the acute toxicity tests
The comparative result of table 3 is as follows:
From test group and the comparison of matched group, the Chinese medicine composition that the present invention treats taste stagflation is the most anxious to rat Property toxicity.
5. conclusion: the present invention treats the Chinese medicine composition of taste stagflation, degree of safety is high, without acute toxicity.
(2) long term toxicity test
1. subjects: healthy SD rat
Test group 50 example, male Mus, age 5 week old；
Matched group 50 example, male Mus, age 5 week old.
2. test method:
Test group: the Chinese medicine composition that the present invention treats taste stagflation is dissolved in water gavage, and dosage is with white mouse Weighing machine, every day, 0.05g/kg, continuous 180 days, continued after drug withdrawal to observe 30 days.
Matched group: feeding as test group and without the food of Chinese medicine composition of the present invention, quantity of food also with test group Equally, and gavage normal saline, continuous 180 days；During 30 day observation period subsequently, rat is treated as test group.
3. statistical method: respectively at test 0 day, 30 days, 60 days, 90 days, 120 days, 150 days, 180 days and observation period knot Shu Shi, the mortality rate and the rat behavior that record two groups of rats have Non Apparent Abnormality；After the observation period terminates, put to death rat, carry out Cut open inspection, record the diet of two groups of rats, drinking-water, body weight growth and internal organs abnormal change situation.
4. result of the test: result of the test is shown in Table 4.
Table 4. long term toxicity test result
The comparative result of table 4 is as follows:
From test group and the comparison of matched group, the present invention treats the Chinese medicine composition of taste stagflation to rat without for a long time Toxicity；
5. conclusion: the Chinese medicine composition of the treatment taste stagflation of the present invention, degree of safety is high, without long term toxicity.
(3) conclusion
From the acute toxicity tests and long term toxicity test result, the Chinese drug-treated group of the treatment taste stagflation of the present invention Compound, degree of safety is high, avirulence.
Test example 5, bacteriostatic test
Use following compounds, use filter paper enzyme classical in this area to carry out bacteriostatic test.
For examination strain Rhodobacter capsulatus ATCC11166 purchased from Bei Nuo bio tech ltd, Shanghai.
Culture fluid
Nutrient agar and nutrient broth, purchased from Chen Yu experimental facilities company limited of BeiJing ZhongKe.
Test method
Rhodobacter capsulatus ATCC11166 is inoculated in agar plate nutritional solution plane, uniformly gathers during inoculation.
Take aseptic circular filter paper sheet, spray solution, the enforcement of 5mL that embodiment 1 Chinese medicine composition of 5mL is dissolved into respectively The solution that example 2 Chinese medicine composition is dissolved into, to complete wetting, is attached in the agar plate nutritional solution plane of inoculated bacteria.Will Agar plate is placed in the incubator of 37 DEG C, incubation 4 hours.Measure the diameter of antibacterial ring.Measure and average for 3 times.
Conclusion
The average diameter of the antibacterial ring of the Rhodobacter capsulatus ATCC11166 of the solution that embodiment 1 Chinese medicine composition is dissolved into For 11.20mm, the antibacterial ring of the Rhodobacter capsulatus ATCC11166 of the solution that embodiment 2 Chinese medicine composition is dissolved into average straight Footpath is 13.75mm.
The effect assessment test for the treatment of taste stagflation
The Chinese medicine composition effect of the treatment taste stagflation of the present invention is as follows:
1, clinical data
Each preferred embodiment of the present invention obtains checking in the scale of 500 people is tested.
2, efficacy evaluation
Recovery from illness: clinical symptoms all disappears, in check in a year, drug withdrawal has no that any pathologic changes later six months:
Effective: clinical symptoms all disappears, drug withdrawal is checked pathological change and is tended to curing after half a year；
Invalid: though clinical symptoms has improvement, but pathological change is without being clearly better.
3, statistical standard
Using SPSS forWindows 10.0.7 statistical package, enumeration data uses x2 inspection, and ranked data use Ridit analyzes, and measurement data uses t inspection, and in group, different time points compare employing one factor analysis of variance, and P ＜ 0.05 is for there being difference The opposite sex, test result is as with following table:
Group Case load Cure Effectively Invalid Effectively (%)
Embodiment 1 50 46 3 1 98
Embodiment 3 50 45 3 2 96
Embodiment 5 50 45 3 2 96
Reference examples 1 50 10 10 30 40
Reference examples 8 50 20 5 25 50
Reference examples 9 50 15 9 26 48
Each preferred embodiment of the present invention obtains checking in the scale of 150 people is tested, and after medication, has Having effect of invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, dyspepsia and intestinal stasis relieving, taste stagflation is had good therapeutic effect, cure rate is 90% Above, obvious effective rate is more than 95%.
Model case 1:
Shen, female, 38 years old, gastral cavilty distension, poor appetite, singultus, inappetence.Gastroscopy gastric mucosa is smooth slightly congested, deep and remote Door Helicobacter negative, gets rid of occupying lesion through other auxiliary examinations.The Chinese medicine composition of the present invention, two weeks are taken After, symptom all disappears, and follows up a case by regular visits to recur the most again.
Model case 2:
Korea Spro, man, 30 years old, abdominal distention, poor appetite is weak, stool row and smooth, inappetence.Through repeatedly treating, recur time and again, DeGrain.Having taken the Chinese medicine composition of the present invention, after one month, symptom all disappears, and follows up a case by regular visits to recur the most again.
Model case 3:
Ferrum, man, 50 years old, taste stagflation, poor appetite.Obstinate, agonizing.Take the Chinese medicine composition of the present invention Thing, after two months, lump all disappears, and follows up a case by regular visits to recur the most again
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art 's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed Scope.

Claims (10)

1. the Chinese medicine composition treating taste stagflation, it is characterised in that prepare the primary raw material weight of described Chinese medicine composition Amount part consists of: HEIQIANNIU 10-50 part, Herba Ludwigiae Prostratae 5-30 part, Semen Raphani 10-50 part, Rhizoma Cimicifugae 15-55 part, charred Radix Et Rhizoma Rhei 10-50 Part, Herba Patriniae 10-50 part, Rhizoma Pinelliae 10-50 part, Oletum Trogopterori 5-35 part, Pericarpium Citri Reticulatae Viride 10-50 part, Cortex Actinodaphnes Obovatae 20-60 part, Gorgon euryale Real 10-50 part, Gynura bodinieri Levl.'s 10-50 part, Resina Liquidambaris 30-60 part, Herba Epimedii 10-50 part, label grass 10-50 part, Agrimony 15-55 Part, Fructus Momordicae 10-50 part, Rhizoma Curcumae Longae 5-30 part, Ilex purpurea Hassk.[I.chinensis Sims 10-50 part, Moschus 1-20 part, Radix Platycodonis 10-50 part, Radix Morindae Officinalis 10-50 Part, Herba Menthae 1-20 part, Pseudobulbus Cremastrae Seu Pleiones 5-30 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 5-30 part.
2. the Chinese medicine composition treating taste stagflation as claimed in claim 1, it is characterised in that prepare described Chinese medicine composition Primary raw material weight portion consist of: HEIQIANNIU 20-40 part, Herba Ludwigiae Prostratae 10-20 part, Semen Raphani 20-40 part, Rhizoma Cimicifugae 25-45 part, Charred Radix Et Rhizoma Rhei 20-40 part, Herba Patriniae 20-40 part, Rhizoma Pinelliae 20-40 part, Oletum Trogopterori 10-30 part, Pericarpium Citri Reticulatae Viride 20-40 part, one, seven leaf Umbrella 30-50 part, Semen Euryales 20-40 part, Gynura bodinieri Levl.'s 20-40 part, Resina Liquidambaris 40-50 part, Herba Epimedii 20-40 part, label grass 20-40 Part, Agrimony 25-45 part, Fructus Momordicae 20-40 part, Rhizoma Curcumae Longae 10-25 part, Ilex purpurea Hassk.[I.chinensis Sims 20-40 part, Moschus 5-15 part, Radix Platycodonis 20-40 Part, Radix Morindae Officinalis 20-40 part, Herba Menthae 5-15 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 10-20 part.
3. the Chinese medicine composition treating taste stagflation as claimed in claim 1, it is characterised in that it is characterized in that, prepare institute The primary raw material weight portion stating Chinese medicine composition consists of: HEIQIANNIU 30 parts, Herba Ludwigiae Prostratae 15 parts, Semen Raphani 30 parts, Rhizoma Cimicifugae 35 parts, Charred Radix Et Rhizoma Rhei 30 parts, Herba Patriniae 30 parts, Rhizoma Pinelliae 30 parts, Oletum Trogopterori 20 parts, 30 parts of Pericarpium Citri Reticulatae Viride, Cortex Actinodaphnes Obovatae 40 parts, Semen Euryales 30 parts, Gynura bodinieri Levl. 30 parts, Resina Liquidambaris 45 parts, Herba Epimedii 30 parts, sign grass 30 parts, Agrimony 35 parts, Fructus Momordicae 30 parts, 15 parts of Rhizoma Curcumae Longae, four Blue or green 30 parts of season, 10 parts of Moschus, Radix Platycodonis 30 parts, Radix Morindae Officinalis 30 parts, Herba Menthae 10 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 15 parts.
4. the preparation of the Chinese medicine composition of the treatment taste stagflation as according to any one of claim 1-3, it is characterised in that institute State preparation separately made by Chinese medicine composition or formed by with Chinese medicine composition and pharmaceutically acceptable carrier.
5. preparation as claimed in claim 4, it is characterised in that described preparation is oral formulations or external preparation, described oral Preparation is that water extract, tablet, pill, water-honeyed pill, concentrated pill, powder, capsule, oral liquid, granule or health tea are oral Preparation；Described external preparation is fumigant, lotion or unguentum.
6. preparation as claimed in claim 5, it is characterised in that described external preparation is capsule, and described capsule includes weight Amount portion rate is 1:1-2.5 Chinese medicine composition and adjuvant.
7. preparation as claimed in claim 6, it is characterised in that described adjuvant includes the composition of following parts by weight: pregel Starch 5-15 part, stearic palmitamide 5-15 part, ethyl methylphenylglycidate 3-7 part, carboxymethyl starch sodium 3-7 part, micro- Crystal silicon glue 10-20 part, sodium palmitate 3-7 part, ethyl cyclodextrin 5-15 part.
Preparation the most as claimed in claims 6 or 7, it is characterised in that described capsule filling includes the one-tenth of following parts by weight Point: Chinese medicine composition 30 parts, pregelatinized starch 10 parts, stearic palmitamide 10 parts, ethyl methylphenylglycidate 5 parts, carboxylic 5 parts of methyl starch sodium, microcrystalline silicon 15 parts, sodium palmitate 5 parts, ethyl cyclodextrin 10 parts.
9. a preparation method for the Chinese medicine composition of the treatment taste stagflation as according to any one of claim 1-3, it is special Levying and be, described method comprises the steps:
S1, weigh the HEIQIANNIU of recipe quantity, Herba Ludwigiae Prostratae, Semen Raphani, Rhizoma Cimicifugae, charred Radix Et Rhizoma Rhei, Herba Patriniae, Rhizoma Pinelliae, Oletum Trogopterori, green grass or young crops Skin, Cortex Actinodaphnes Obovatae, Semen Euryales, Gynura bodinieri Levl. 12 taste crude drug, pulverize, mill, sieve and make fine powder, and the number of described screen cloth is 150-180 mesh, boiling 3 times, 12 times of water yields decoct 3h for the first time, and 10 times of water yields decoct 2h, for the second time 8 times of water yields for the second time Decoct 1h, merge to obtain decocting liquid, under the conditions of temperature 50 C, be condensed into the clear paste 1 that relative density is 1.30, cooling, the ethanol adding 75% Carry out precipitate with ethanol 2h, filter, at 50 DEG C, be condensed into the dry extract 1 that relative density is 1.45；
S2, weigh the Resina Liquidambaris of recipe quantity, Herba Epimedii, label grass, Agrimony, Fructus Momordicae, Rhizoma Curcumae Longae, Ilex purpurea Hassk.[I.chinensis Sims, Moschus, Radix Platycodonis, Radix Morindae Officinalis, Herba Menthae, Pseudobulbus Cremastrae Seu Pleiones, Ramulus et folium glochidionis eriocarpi (Folium Glochidii Eriocarpi) 13 taste crude drug, pulverize, mill, sieve and make fine powder, and the number of described screen cloth is 60-100 mesh, after stirring, the reflux, extract, of 10 times of 75% ethanol of addition 3 times, each 1.5h, filter, merge back into flow liquid, It is concentrated into the clear paste 2 that relative density at 55 DEG C is 1.20, by 5 times of water yields, clear paste is dissolved, upper macroporous resin column, use water successively Ethanol elution with 45%, reclaims ethanol elution, is concentrated into the dry extract 2 that relative density is 1.35 at 55 DEG C；
S3, merging dry extract 1 and dry extract 2, be ground into powder, is subsequently placed in mixing 1h in trough type mixing machine, obtains treatment The Chinese medicine composition of taste stagflation.
10. the Chinese medicine composition described in an any one of claim 1-3 is as the application in treatment taste stagflation medicine.
CN201610781413.7A 2016-08-31 2016-08-31 A kind of Chinese medicine composition treating taste stagflation and capsule thereof and preparation method Withdrawn CN106215123A (en)

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