CN103550360A

CN103550360A - Compound radix pulsatillae granule and preparation method thereof

Info

Publication number: CN103550360A
Application number: CN201310569213.1A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Agricultural University
Current assignee: Qingdao Agricultural University
Priority date: 2013-11-15
Filing date: 2013-11-15
Publication date: 2014-02-05

Abstract

The invention belongs to the technical field of veterinary medicine and discloses a compound radix pulsatillae granule and a preparation method thereof. The preparation method is characterized by comprising the following steps: crushing four medicinal material components including radix pulsatillae, coptis, cortex phellodendri and the bark of ash, carrying out reflux extracting on the medicinal materials, concentrating the medicinal materials to a liquid extract, drying the liquid extract, mixing the liquid extract with additives, and finally preparing the mixture into granules. The extraction process of the medicine is improved on the basis of boiling decoction extraction of traditional decoction, thereby having the advantages of reducing the dose, improving the quality, and the like.

Description

A kind of compound recipe Radix Pulsatillae granule and preparation method thereof

Technical field

The invention belongs to dysentery stopping preparation for animals field, relate to a kind of Radix Pulsatillae granule and preparation method thereof.

Background technology

Piglet pujos blancos is that suckling pig be take a kind of infectious intestinal disease that the stench loose stool of milky is feature of having loose bowels.Primary disease mainly causes by Escherichia coli, and cause of disease is through digestive tract infection.Being commonly encountered diseases and the frequently-occurring disease of piglet, all there is piglet pujos blancos in nearly all pig farm.Primary disease all can occur throughout the year, but common with early spring, severe winter and torridity summer.One of several large diseases of puzzlement raiser.

Compound recipe Radix Pulsatillae granule prescription derives from the Radix Pulsatillae Decoction of < < Treatise on Febrile Diseases > >, by the Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri and Cortex Fraxini 4 taste medicines, formed, there is the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly under hematodiarrhoea and weigh, stomachache pain in the abdomen, under pus and blood is assorted, burning sensation of the anus, yellow fur, wiry and frequent pulse person.It is the classics side of the diseases such as clinical treatment dysentery, chronic ulcerative colitis, colitis.

But it is inconvenient that using appears in common Radix Pulsatillae Decoction decoction in clinical practice, after oral Radix Pulsatillae Decoction, medicine was easily absorbed decomposition before arriving colon, rectum (coloclysis or suppository) administration does not arrive colon yet, and increases patient's misery and medical worker's the shortcomings such as burden.By modern preparation technique, carry out dosage form improvement, develop a kind of preparation method that meets modern medicine technology novel form granule, meanwhile, there is dose few, quality advantages of higher.

Summary of the invention

The object of the present invention is to provide a kind of compound recipe Radix Pulsatillae granule, its prescription source Radix Pulsatillae Decoction (Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini) is the conventional prescription for the treatment of diarrhea of heat type hematodiarrhoea.Radix Pulsatillae clearing away heat,cooling blood and removing toxin in side, for controlling the key medicine of dysentery; Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini dispelling the damp pathogen with drugs of bitter in taste and cold in nature, rush down clearly three warmers, and four medicines share, and have heat-clearing and toxic substances removing, the merit of dampness-eliminating and dysentery-stopping.According to modern medicine study, prove, the Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri have significant inhibitory action to dysentery bacterium, escherichia coli, staphylococcus etc., control dysentery effect better, and compatibility application, brings out the best in each other, and treatment piglet pujos blancos effect is more remarkable.

The specific embodiment

In the present invention, the preparation method step of compound recipe Radix Pulsatillae granule is as follows:

1, press 4 parts of the formula proportion weight Radix Pulsatillaes, 2 parts of Cortex Phellodendris, 3 parts of Rhizoma Coptidis, 4 parts of Cortex Fraxinis.Take above 4 taste medical materials, be ground into fritter;

2, the water reflux, extract, 3 times that at every turn adds 10 times of amounts, 2h/ time;

3, extracting solution concentrate drying, add adjuvant, pulverizing, granulation.

Below in conjunction with instantiation, further illustrate the present invention.

embodiment 1

The four kinds of medical materials such as the Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini that take formula proportion weight portion, are ground into fritter, and mixed extraction 3 times adds 10 times, water (weight portion, as follows) at every turn, and reflux, extract, 2 hours filters merging filtrate stand for standby use.

Extracting solution is concentrated, is concentrated into relative density 1.10, and concentrated solution be dry, pulverize.Add appropriate amount of starch, mix granulation finished product.

embodiment 2

The four kinds of medical materials such as the Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini that take formula proportion weight portion, are ground into fritter, and mixed extraction 3 times, adds 10 times, water, and reflux, extract, 2.0 hours filters merging filtrate stand for standby use.

Extracting solution is concentrated, is concentrated into relative density 1.15, and concentrated solution be dry, pulverize.Add appropriate dextrin, mix granulation finished product.

embodiment 3

Extracting solution is concentrated, is concentrated into relative density 1.2, and concentrated solution be dry, pulverize.Add appropriate microcrystalline Cellulose, mix granulation finished product.

Claims

1. a preparation method for compound recipe Radix Pulsatillae granule, extractum and the pharmaceutically acceptable adjuvant after reflux, extract, containing the Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini chopping or after pulverizing, with conventional process for producing granula granulation agent.

2. the preparation method of compound recipe Radix Pulsatillae granule as claimed in claim 1, comprises the following steps:

1) four kinds of compositions such as the Radix Pulsatillae of formula proportion weight portion, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini are ground into fritter;

2) condition of water extraction is: water extraction 3 times, and add water is 10 times of amounts 1h/ time at every turn;

3) water extraction adopts the method for reflux, extract;

4) relative density of extracting solution after concentrated is 1.10-1.20 (room temperature), and dry dry cream is standby;

5) adjuvant that can add has: the mixture of one or more of dextrin, starch, lactose, microcrystalline cellulose, micropowder silica gel, cyclodextrin etc.;

6) by 4), 5) in spares according to the dosage of Radix Pulsatillae Decoction, feed intake, be prepared into granule.

3. the preparation method of Radix Pulsatillae granule as claimed in claim 2, is characterized in that the extracting solution relative density after concentrated is 1.20.