CN107519269B

CN107519269B - Mildew-removing and detoxifying traditional Chinese medicine powder for livestock and preparation method thereof

Info

Publication number: CN107519269B
Application number: CN201710872564.8A
Authority: CN
Inventors: 郭建钊; 付晨青; 江红格
Original assignee: Henan Darkhorse Animal Pharmaceutical Co ltd
Current assignee: Yuzhou Lianyun Technology Co.,Ltd.
Priority date: 2017-09-25
Filing date: 2017-09-25
Publication date: 2020-11-20
Anticipated expiration: 2037-09-25
Also published as: CN107519269A

Abstract

The invention specifically discloses a mildew-removing and detoxifying traditional Chinese medicine powder for animals and a preparation method thereof, wherein the mildew-removing and detoxifying traditional Chinese medicine powder for animals comprises the following components in parts by weight: 9-11% of longhairy antenoron herb, 9-11% of red halloysite, 5-7% of root of Chinese barberry, 9-11% of rhubarb, 5-7% of cape jasmine, 9-11% of talc, 5-7% of baical skullcap root, 19-20% of montmorillonite, 9-11% of gypsum, 5-7% of plantain herb and 5-7% of akebia stem; aiming at the hyperthermic diseases of livestock and poultry caused by viruses and bacteria, such as sthenic fever in triple energizer, sore, yellow swelling, toxin and the like, the invention researches and develops the mildew-removing and toxin-removing traditional Chinese veterinary medicine, determines the optimal formula through the research on the compatibility of traditional Chinese medicines and the screening of different formulas, and has the obvious effects of removing mildew, removing toxin, soothing the liver, benefiting gallbladder, clearing heat and cooling blood and the like; the superfine pulverizing technology is adopted in the preparation process of the Chinese medicinal powder, so that the dissolution rate of effective components can be improved, the bioavailability of Chinese medicinal materials is increased, and the utilization rate of the Chinese medicinal materials is improved.

Description

Mildew-removing and detoxifying traditional Chinese medicine powder for livestock and preparation method thereof

Technical Field

The invention belongs to the technical field of veterinary traditional Chinese medicines, and particularly relates to a mildew-removing and detoxifying traditional Chinese medicine powder for veterinary use and a preparation method thereof.

Background

In recent years, because the safety problem of domestic animal products is prominent, the pollution and harmful substance residue of the animal products are serious, which not only causes harm to the health of consumers, but also seriously affects and restricts the export of domestic animal products. Veterinary drugs are receiving great attention because of their unique mode of action, good efficacy, low residue, low drug resistance and low pollution. Many research results show that polysaccharides, organic acids, alkaloids, volatile oils and the like in many Chinese herbal medicines have the effect of enhancing immunity, can obviously improve the growth speed and enhance the growth performance of animals. Therefore, the active development of safe veterinary drug substitutes without toxic and side effects is an urgent key task and has wide development prospect.

The traditional Chinese medicine superfine grinding technology is a technology for fusing the superfine grinding technology with a traditional Chinese medicine theory, is a further development of the traditional grinding technology, and makes up for the defects of the traditional grinding technology, and the technology is used for micronizing traditional Chinese medicines, so that the texture and the mixing uniformity of traditional Chinese medicine powder are improved; the specific surface area is increased, and the dissolution of effective components is accelerated; the biological activity is retained, the bioavailability is improved, and the drug effect is enhanced; the utilization rate of the same amount of the traditional Chinese medicine is improved to a certain extent, the dosage of the traditional Chinese medicine is reduced, the traditional Chinese medicine resources are fully utilized, and the traditional Chinese medicine has traditional Chinese medicine significance for valuable medicinal materials which are cherished or endangered; in addition, the ultramicro-pulverization is generally carried out in a totally-enclosed dust-free system, so that the external pollution can be effectively avoided, the working environment is improved, and the contents of microorganisms and impurities in the product are effectively controlled.

The invention provides a veterinary Chinese medicinal powder for removing mold and detoxifying and a preparation method thereof by combining Chinese herbal medicines and superfine grinding.

Disclosure of Invention

In order to solve the problems, the invention provides the livestock traditional Chinese medicine powder with the functions of removing mildew, detoxifying and expelling toxin, soothing liver and benefiting gallbladder, clearing heat and cooling blood and the like and the traditional Chinese medicine powder for removing mildew and expelling toxin for livestock and poultry and the preparation method thereof.

The technical scheme adopted by the invention is as follows:

a veterinary Chinese medicinal powder for removing mold and detoxifying is prepared from the following raw materials: herba Lysimachiae Christinae, Halloysitum rubrum, radix Berberidis, radix et rhizoma Rhei, fructus Gardeniae, pulvis Talci, Scutellariae radix, montmorillonite, Gypsum Fibrosum, herba plantaginis and caulis Akebiae.

A veterinary mildew-removing and toxin-removing traditional Chinese medicine powder is prepared from the following raw materials in percentage by weight: 9-11% of longhairy antenoron herb, 9-11% of red halloysite, 5-7% of root of Chinese barberry, 9-11% of rhubarb, 5-7% of cape jasmine, 9-11% of talc, 5-7% of baical skullcap root, 19-20% of montmorillonite, 9-11% of gypsum, 5-7% of plantain herb and 5-7% of akebia stem.

A veterinary Chinese medicinal powder for removing mold and detoxifying is prepared from the following raw materials: 10% of longhairy antenoron herb, 10% of red halloysite, 6% of root of Chinese barberry, 10% of rhubarb, 6% of cape jasmine fruit, 10% of talc, 6% of baical skullcap root, 20% of montmorillonite, 10% of gypsum, 6% of plantain herb and 6% of akebia stem.

A preparation method of the livestock mildew-removing and toxin-removing traditional Chinese medicine powder comprises the steps of weighing the traditional Chinese medicines according to the weight percentage, uniformly mixing, carrying out superfine grinding on the traditional Chinese medicine mixture by using a superfine grinder, and then sieving by using a 100-mesh sieve to obtain the superfine powder.

Herba Lysimachiae Christinae: sweet, salty and slightly cold. It enters liver, gallbladder, kidney and bladder meridians. Induce diuresis to alleviate jaundice, induce diuresis to treat stranguria, remove toxicity and relieve swelling. Can be used for treating damp-heat jaundice, gallbladder distention, hypochondriac pain, stranguria with stone, stranguria with heat, difficulty and pain in urination, carbuncle, furuncle, and snake and insect bite.

Halloysitum rubrum: sweet, sour, astringent and warm. It enters large intestine and stomach meridians. Astringe intestines, stop bleeding, promote granulation and heal wound. Can be used for treating chronic diarrhea, dysentery, hematochezia, metrorrhagia, leukorrhagia, etc.; it is indicated for chronic ulcer without healing, abscess and abscess due to damp sores.

Root of Chinese barberry: bitter and cold. Is toxic. It enters liver, stomach and large intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity. Can be used for treating damp-heat dysentery, jaundice, eczema, pharyngalgia, conjunctival congestion, purulent otitis media, carbuncle, swelling, and sore.

Rhubarb: bitter and cold. It enters spleen, stomach, large intestine, liver and pericardium meridians. Purgation and eliminating accumulation, clearing heat and purging fire, cooling blood and removing toxicity, removing blood stasis and dredging channels, promoting diuresis and eliminating jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, intestinal carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal blood stasis, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it can be used for external treatment of burn and scald. The wine rhubarb is good at clearing heat and toxicity in the upper jiao and blood system. It can be used for treating conjunctival congestion, pharyngeal swelling, and gingival swelling and pain. The cooked rhubarb has the functions of relieving the purgation, purging fire and removing toxicity. It can be used for treating pyocutaneous disease due to fire toxin. Rhubarb charcoal cools blood, removes stasis and stops bleeding. Can be used for treating blood heat with blood stasis and hemorrhage.

Gardenia: bitter and cold. It enters heart, lung and triple energizer meridians. Purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain. Can be used for treating pyretic vexation, jaundice due to damp-heat pathogen, stranguria, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to pathogenic fire; it can be used for treating sprain, contusion and pain.

Talc: sweet, bland and cold. It enters bladder, lung and stomach meridians. Induce diuresis to treat stranguria, clear away summer-heat, dispel dampness and heal wound. Can be used for treating pyretic stranguria, urolithiasis, odynuria, summer-heat dampness polydipsia, damp-heat watery diarrhea; it can be used for treating eczema, and miliaria.

Scutellaria baicalensis: bitter and cold. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Montmorillonite: montmorillonite has good application in livestock (pig, rabbit) breeding, especially yellow and white dysentery of piglets and suckling pigs, and diarrhea of little rabbits, and has prevention effect, and can be used as the first choice of the most elegant feed mold remover in view of the characteristics of montmorillonite.

Plantain herb: sweet and cold in nature. It enters liver, kidney, lung and small intestine meridians. Clear heat, induce diuresis, treat stranguria, dispel phlegm, cool blood and remove toxicity. Can be used for treating pyretic stranguria, edema, oliguria, summer-heat dampness, diarrhea, phlegm heat, cough, hematemesis, epistaxis, carbuncle, swelling, and sore.

B, wood through: bitter and cold. It enters heart, small intestine and bladder meridians. Induce diuresis to treat stranguria, clear heart fire and relieve restlessness, dredge meridians and promote lactation. Can be used for treating stranguria, edema, vexation, dark urine, aphtha, amenorrhea, hypogalactia, and arthralgia due to damp-heat.

The prescription of the invention determines the prescription of 11 traditional Chinese medicines of desmodium, red halloysite, root of Chinese barberry, rhubarb, gardenia, talc, radix scutellariae, montmorillonite, gypsum, plantain and akebiaquinata through the compatibility of the traditional Chinese medicines and the research and screening of different components, wherein the rhubarb, the gardenia and the radix scutellariae have the efficacy of clearing away heat and toxic materials; the prepared traditional Chinese medicine powder has the effects of removing mildew, detoxifying, expelling toxin, soothing liver, benefiting gallbladder, clearing heat and cooling blood and the like, and can treat the livestock and poultry triple warmer excess heat, sore yellow swelling and isothermal and hot diseases caused by viruses and bacteria.

The invention has the beneficial effects that: the livestock mildew-removing and detoxifying traditional Chinese medicine powder has the effects of purging fire and detoxifying, and is clinically used for treating diseases such as livestock and poultry triple-jiao excess heat, sore yellow pyogenic infections and the like caused by viruses and bacteria. In the production and preparation process, an ultrafine grinding technology is adopted, so that on one hand, the micronized material has strong surface adsorption force, affinity, dispersibility and dissolubility, and thus the dissolution speed and dissolution rate of the effective components are improved; on the other hand, after the traditional Chinese medicine raw materials are subjected to superfine grinding, the loss of active ingredients in the production link is reduced, the raw materials are utilized to the maximum extent, the dosage of the medicinal materials can be reduced, and a breakthrough progress is obtained for the research, development and utilization of traditional Chinese veterinary medicines of the company.

Detailed Description

Example 1

A veterinary mildew-removing and toxin-removing traditional Chinese medicine powder comprises the following components in percentage by weight: 11% of longhairy antenoron herb, 11% of red halloysite, 5% of root of Chinese barberry, 11% of rhubarb, 5% of cape jasmine, 9% of talc, 5% of baical skullcap root, 20% of montmorillonite, 11% of gypsum, 5% of plantain herb and 7% of akebia stem.

Mixing the above traditional Chinese medicines according to weight ratio, pulverizing the traditional Chinese medicine composition by using an ultrafine pulverizer, sieving with a 100-mesh sieve, and mixing to obtain ultrafine powder.

Example 2

A veterinary mildew-removing and toxin-removing traditional Chinese medicine powder comprises the following components in percentage by weight: 9% of longhairy antenoron herb, 9% of red halloysite, 7% of root of Chinese barberry, 9% of rhubarb, 7% of cape jasmine fruit, 11% of talc, 7% of baical skullcap root, 19% of montmorillonite, 9% of gypsum, 7% of plantain herb and 5% of akebia stem.

Example 3

Example three: a veterinary mildew-removing and toxin-removing traditional Chinese medicine powder comprises the following components in percentage by weight: 10% of longhairy antenoron herb, 10% of red halloysite, 6% of root of Chinese barberry, 10% of rhubarb, 6% of cape jasmine fruit, 10% of talc, 6% of baical skullcap root, 20% of montmorillonite, 10% of gypsum, 6% of plantain herb and 6% of akebia stem.

Clinical trial

1. Test materials and methods

Test drugs: the invention discloses a product.

Test animals: a naturally-occurring pig in the Yuzhou region. The sick pigs are mainly caused by the excess heat of the triple warmer, and have the symptoms of toxic heat, depression, decreased appetite, even abominability, asthma, skin congestion, redness, conjunctival congestion, redness, dry and spherical feces, and short and yellow urine.

The test method comprises the following steps: the test is divided into a control group (no administration) and a drug treatment group (administration group), wherein 30 pigs in each group are fed with feed through feed mixing, the dosage is 50g at a time, the feeding and administration are carried out according to a feeding rule, the administration time lasts for 5 days, clinical symptom observation is carried out after the administration is finished, and the observation time lasts for 5 days. No other similar drugs were used during the test.

And (3) judging the curative effect: after the application and observation for 5 days, the clinical symptoms of the sick pigs disappear during the disease attack, and the sick pigs are cured without relapse before slaughtering; after 5 days of medication observation, the disease symptoms and the general condition are not improved obviously and are ineffective.

2. Test results and analysis

Clinical observation in the test period shows that the symptoms of the sick pigs in the control group are not improved, the symptoms of 8 pigs are obviously aggravated in the test period, the pigs are tired in spirit and cannot stand up on the ground, red bleeding points appear on the surface of the skin, the excrement is dry and hard and is small in quantity, and the body types of the sick pigs are obviously leaner than those of the drug-treated pigs. After the drug treatment group is used for 3 days, the mental state of sick pigs is obviously improved, the appetite is changed to be normal, the symptoms of asthma and skin redness disappear, after the drug treatment group is used for 5 days, the symptoms disappear, the pig is cheerful in spirit, the appetite is gradually increased, the skin of the pigs is clean, the pigs are bright by hair, the eyes are bright and have spirit, excrement is changed from dry to wet, no special smell is pungent, and the discharged urine is changed from yellow and thick before the drug administration into colorless and transparent. The test result shows that the product of the invention can obviously radically cure the diseases caused by the excess heat of the triple energizer after being used, and the medicine is prepared by adopting traditional Chinese medicines, thereby having small side effect and no medicine residue problem.

Claims

1. A veterinary mildew-removing and toxin-removing traditional Chinese medicine powder is characterized in that: the material is prepared from the following raw materials in percentage by weight: 9-11% of longhairy antenoron herb, 9-11% of red halloysite, 5-7% of root of Chinese barberry, 9-11% of rhubarb, 5-7% of cape jasmine, 9-11% of talc, 5-7% of baical skullcap root, 19-20% of montmorillonite, 9-11% of gypsum, 5-7% of plantain herb and 5-7% of akebia stem.

2. The veterinary mildew-removing and detoxifying traditional Chinese medicine powder as claimed in claim 1, is characterized in that: it is prepared from the following raw materials: 10% of longhairy antenoron herb, 10% of red halloysite, 6% of root of Chinese barberry, 10% of rhubarb, 6% of cape jasmine fruit, 10% of talc, 6% of baical skullcap root, 20% of montmorillonite, 10% of gypsum, 6% of plantain herb and 6% of akebia stem.

3. A preparation method of the veterinary moldproof and detoxifying traditional Chinese medicine powder as claimed in any one of claims 1-2, which is characterized in that: weighing the traditional Chinese medicines according to the weight percentage, uniformly mixing, carrying out superfine grinding on the traditional Chinese medicine mixture by using a superfine grinder, and then sieving by using a 100-mesh sieve to obtain the superfine powder.