CN102755428A - Calculus bovis yijin tablet for treating chronic pharyngitis and preparation method thereof - Google Patents
Calculus bovis yijin tablet for treating chronic pharyngitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a calculus bovis yijin tablet for treating chronic pharyngitis. The calculus bovis yijin tablet for treating chronic pharyngitis comprises the following raw materials by part of weight: 150-250 parts of golden cypress, 80-120 parts of honeysuckle, 70-120 parts of platycodon grandiflorum, 50-80 parts of blackberry lily, 1-4 parts of menthol crystal and 1-4 parts of calculus bovis. The invention further discloses a preparation method of the calculus bovis yijin tablet. The preparation method is simple in preparation, the obtained medicine can clear heat to decrease internal heat, clear away intense heat and toxic substances, dissolve phlegm, scatter wind heat, diffuse lung qi, relieve sore throat, eliminate phlegm and pus and cure pharyngitis and pharyngalgia, radically solves the problem of aetiological agent of chronic pharyngitis, directly removes nidus, achieves the aim of treating both principal and secondary aspects of diseases, and is good in curing effect and chronic pharyngitis is not apt to reappear.
Description
Technical field
The present invention relates to a kind of medicine of treating chronic pharyngitis, be specifically related to a kind of compositions of forming by Chinese medicinal ingredients, belong to medical technical field.
Background technology
Chronic pharyngitis is common clinical, frequently-occurring disease, and according to statistics, China has millions of patients suffering the puzzlement of chronic pharyngitis every year, and the sickness rate in annual spring has a strong impact on people's orthobiosis up to 70%.Chronic pharyngitis mainly is the diffuse inflammation of pharyngeal mucosa, lymphoid tissue and mucous gland.Clinical chronic simple pharyngitis, chronic hypertrophic pharyngitis and the atrophic pharyngitis of being divided into.Along with the aggravation of environmental pollution, the increasingly high river of chronic pharyngitis sickness rate.Mainly adopt western medicines such as antibiotic, hormone at present clinically, but curative effect is not good enough.The chronic pharyngitis majority show effect repeatedly by acute pharyngitis or treat thoroughly due to, environment dust, tobacco and wine are excessive etc. simultaneously also is the major reason that causes chronic pharyngitis.
Pharyngitis belongs to categories such as the traditional Chinese medical science " sore throat ", " pharyngalgia ", " chronic throat obstruction, chronic pharyngitis ", " globus hystericus ", mainly shows as red swelling of the pharynx pain, the puckery discomfort of itching, foreign body sensation etc.; The traditional Chinese medical science thinks that the pharyngitis cause of disease is a hyperactivity of fire caused by deficiency of YIN, disturb on the asthenic fire to cause due to bottleneck throat body fluid lose to support, YIN-deficiency of the lung and kidney then body fluid can not on hold, throat loses in moistening foster; Hyperactivity of deficient fire causes in throat, or because of acute pharyngitis due to wind-heat shows effect repeatedly, surplus evil delay the, or dust; Foul smell stimulates, and the hobby tobacco and wine are pungent, and impairment caused by overstrain excessively waits and causes; Deficiency of lung-YIN is deficiency of body fluid then, and throat loses in moistening foster, and furthermore asthenic fire is followed through last inflammation; Deficiency of the kidney yin, network is in lung on the passages through which vital energy circulates of kidney, and deficiency of the kidney yin whenever causes the also deficiency of YIN of lung, and hyperactivity of deficient fire is satisfied to sore throat.In addition, steam on the asthenic fire, bright Tianjin becomes expectorant, venation numbness resistance in addition, and disorder of QI movement causes stagnation of QI expectorant and coagulates phlegm-fire pent-up.Throat is the door of lung stomach, like the lung stomach intrinsic heat is arranged, and burning hot scorchingly, and QI and blood is tied in throat, visible local chronic congestion, and mucosa is dry and fall ill.Deficiency of kidney-YIN in addition, hyperactivity of deficient fire, dry laryngopharynx can be sent out for a long time and also and is pharyngitis.
Primary disease is mainly in middle age, and the course of disease is long, symptom is obstinate, and pharyngitis pathological changes master is dirty at lung; Relevant with liver, spleen, then reach kidney for a long time, doctor trained in Western medicine is difficult for curing; The traditional Chinese medical science has curative effect preferably to the treatment of primary disease, and adopt regulated equilibrium between yin and yang, nourishing YIN to lower pathogenic fire, the medication of the heat-clearing and toxic substances removing side of sending more.
The medicine that a lot of treatment chronic pharyngitiss are arranged now, existing Chinese medicine also has Western medicine, though can both play a role, can not effect a radical cure, easy relapse, drug dependence is strong.
Summary of the invention
In order to overcome the deficiency of prior art, the invention provides a kind of Chinese medicine composition of treating chronic pharyngitis, these Chinese medicine composition commodity are called tablet of cow-bezoar for throat trouble, have the effect of relieving sore-throat by clearing away heat, reducing swelling and alleviating pain, can treating both the principal and secondary aspects of a disease to chronic pharyngitis, effective.
The present invention also provides the method for preparing of this Chinese medicine composition tablet of cow-bezoar for throat trouble.
The present invention realizes through following technical scheme:
A kind of Chinese medicine composition of treating chronic pharyngitis is characterized in that comprising the raw material of following weight portion:
Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part, Calculus Bovis 1-4 part.
In the above-mentioned Chinese medicine composition, preferred composition of raw materials is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss.
Main prescription of the present invention is Cortex Phellodendri, Flos Lonicerae, Radix Platycodonis, Rhizoma Belamcandae, Mentholum and Calculus Bovis.Cortex Phellodendri is bitter, cold, goes into kidney, urinary bladder channel, ability heat clearing and damp drying, eliminating fire and detoxication; Flos Lonicerae is sweet, cold, goes into lung, stomach warp, the ability heat-clearing and toxic substances removing; Radix Platycodonis toil, flat is gone into lung, stomach warp, can open lung qi dispersing gas, and the exogenous cough is controlled in the evacuation of pus of eliminating the phlegm, laryngopharynx swelling and pain; Rhizoma Belamcandae is bitter, cold, goes into lung, Liver Channel, can detoxify by pathogenic fire reducing, and the sore throat pharyngalgia is controlled in expectorant; Lung, Liver Channel are gone in Herba Menthae serious sinusitis with purulent discharge, cold, and dispelling wind-heat is arranged, and the effect of throat can promote secretion to remove and be attached to the mucus on the mucosa, and respiratory inflammation is had therapeutical effect; Calculus Bovis is bitter, cool, goes into the heart, Liver Channel, can clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, endogenous wind stopping, detoxifcation.With these 6 kinds of drug combinations, can play the effect of relieving sore-throat by clearing away heat, reducing swelling and alleviating pain.
Except above primary raw material medicine, can also add some synergistic components in the prescription of the present invention with auxiliary primary raw material, play the effect of enhancing treatment effect.Said synergistic component is one or more in the following ingredients: Radix Scutellariae 70-130 part, Radix Glycyrrhizae 60-120 part, Borax 40-70 part; Matrii Sulfas Exsiccatus 10-30 part; Radix Pseudostellariae 60-100 part; Radix Isatidis 40-80 part, Radix Ophiopogonis 60-100 part, Rhizoma Coptidis 80-120 part, Radix Rehmanniae 60-90 part, Lasiosphaera Seu Calvatia 60-100 part, Semen Oroxyli 100-150 part, Bulbus Fritillariae Thunbergii 80-120 part, Oleum menthae 1-4 part, Fructus Canarii 70-110 part.
According to the difference that synergistic component is selected, can form a series of is master's son side with Cortex Phellodendri, Flos Lonicerae, Radix Platycodonis, Rhizoma Belamcandae, Mentholum and Calculus Bovis.Among this a little side, the most preferred with following six groups of son sides:
First group: on the basis of original raw material, add Radix Scutellariae, Radix Glycyrrhizae, Borax synergistic component; Increase heat-clearing and toxic substances removing, pathogenic fire purging expectorant effect; Son side's (weight portion) below forming: Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part; Calculus Bovis 1-4 part, Radix Scutellariae 70-130 part, Radix Glycyrrhizae 60-120 part, Borax 40-70 part, optimum ratio is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums; 2 parts of Calculus Boviss, 100 parts of Radix Scutellariaes, 80 parts in Radix Glycyrrhizae, 50 parts of Boraxs.
Second group: on the basis of original raw material, add the Matrii Sulfas Exsiccatus synergistic component; Increase and purge heat, moisturize effect, son side's (weight portion) below forming: Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part, Calculus Bovis 1-4 part; Matrii Sulfas Exsiccatus 10-30 part; Optimum ratio is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 15 parts of Matrii Sulfas Exsiccatus.
The 3rd group: on the basis of original raw material, add the Radix Pseudostellariae synergistic component, increase replenishing QI to invigorate the spleen, the promoting the production of body fluid for nourishing the lung effect; Son side's (weight portion) below forming: Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part; Calculus Bovis 1-4 part, Radix Pseudostellariae 60-100 part, optimum ratio is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums; 2 parts of Calculus Boviss, 70 parts of Radix Pseudostellariaes.
The 4th group: on the basis of original raw material, add Radix Isatidis, Radix Ophiopogonis synergistic component; Increase YIN nourishing and the production of body fluid promoting, the lung moistening effect that clears away heart-fire; Son side's (weight portion) below forming: Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part; Calculus Bovis 1-4 part, Radix Isatidis 40-80 part, Radix Ophiopogonis 60-100 part, optimum ratio is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums; 2 parts of Calculus Boviss, 45 parts of Radix Isatidiss, 80 parts of Radix Ophiopogonis.
The 5th group: on the basis of original raw material, add Rhizoma Coptidis, Radix Rehmanniae, Lasiosphaera Seu Calvatia synergistic component; Increase clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing and the production of body fluid promoting, removing heat from the lung and relieving sorethroat effect; Son side's (weight portion) below forming: Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part; Calculus Bovis 1-4 part, Rhizoma Coptidis 80-120 part, Radix Rehmanniae 60-90 part, Lasiosphaera Seu Calvatia 60-100 part, optimum ratio is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums; 2 parts of Calculus Boviss, 80 parts of Rhizoma Coptidis, 65 parts of Radix Rehmanniae, 70 parts of Lasiosphaera Seu Calvatia.
The 6th group: on the basis of original raw material, add Semen Oroxyli, Bulbus Fritillariae Thunbergii, Oleum menthae, Fructus Canarii synergistic component, increase clearing away heart-fire and moistening the lung, relieving sore-throat by clearing away heat, the effect of reducing phlegm of promoting the production of body fluid, son side's (weight portion) below forming: Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part; Calculus Bovis 1-4 part; Semen Oroxyli 100-150 part, Bulbus Fritillariae Thunbergii 80-120 part, Oleum menthae 1-4 part, Fructus Canarii 70-110 part, optimum ratio is (weight portion): 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss; 110 parts of Semen Oroxylis; 85 parts of Bulbus Fritillariae Thunbergiis, 2 parts of Oleum menthae, 80 parts of Fructus Canariis.
Above-mentioned sub-Fang Junneng plays the effect of treatment chronic pharyngitis, and therapeutic effect is increasing in varying degrees.In addition, the synergistic component in each son side can also mix stack each other to be used, and forms new son side.For example, on the basis of original prescription, can the synergistic component in first group and the second group of son side be used with, add Radix Scutellariae, Radix Glycyrrhizae, Borax, Matrii Sulfas Exsiccatus synergistic component simultaneously, form new son side.Also can be on the basis of original prescription the synergistic component in the 3rd group and the 4th group of son side be used with, added Radix Pseudostellariae, Radix Isatidis, Radix Ophiopogonis synergistic component simultaneously, form new son side.Synergistic component in other son sides also can be used with.
Tablet of cow-bezoar for throat trouble adjuvant of the present invention is starch, microcrystalline Cellulose, pregelatinized Starch, lactose, carboxymethylstach sodium, hypromellose, Pulvis Talci, magnesium stearate; Method for using is: oral, and a 2-4 sheet, three times on the one; 7 is a course of treatment, and take effect general 2 courses of treatment.
When crude drug was Cortex Phellodendri, Flos Lonicerae, Radix Platycodonis, Rhizoma Belamcandae, Mentholum and Calculus Bovis, method for preparing may further comprise the steps:
(1) Mentholum and Calculus Bovis are ground to form fine powder, subsequent use;
(2) with all the other raw materials mix, with ethanol extraction twice, merge extractive liquid;
(3) extracting solution is condensed into thick paste, drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds the adjuvant of Mentholum, Calculus Bovis and survival dose, make.
Wherein, in the step (2), used concentration of ethanol is 50～80wt%, and the 6-12 that to extract used alcoholic acid quality be raw materials quality at every turn doubly extracts 2h at every turn.In the step (3), be condensed into 50 ℃ of following relative densities and be 1.10～1.40 thick paste.
When adding synergistic component in the crude drug, method for preparing and said method are basic identical, but when containing Borax, Oleum menthae composition in the compositions, slightly different to the processing of these synergistic components.Method is:
(1) Mentholum, Calculus Bovis and Borax pulverize separately fine powder is subsequent use; Oleum menthae is subsequent use;
(2) all the other crude drug beyond Mentholum, Calculus Bovis, Borax and the Oleum menthae are mixed, with the ethanol extraction of 6～12 quality times 2 times, each 2 hours, merge extractive liquid;
(3) extracting solution being condensed into 50 ℃ of following relative densities is 1.10～1.40 thick paste, and drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds the adjuvant of Mentholum, Oleum menthae, Calculus Bovis, Borax and survival dose, process the product of different dosage form.
The present invention is a primary raw material with Cortex Phellodendri, Flos Lonicerae, Radix Platycodonis, Rhizoma Belamcandae, Mentholum, Calculus Bovis, and preparation is simple, ability resolving heat and reducing pathogenic fire, eliminating fire and detoxication; Lung qi dispersing gas, sore-throat relieving are opened in expectorant, dispelling wind-heat; The sore throat pharyngalgia is controlled in the evacuation of pus of eliminating the phlegm, and fundamentally solves the chronic pharyngitis pathogenic factor; Straight except that focus, reach the purpose of treating both the principal and secondary aspects of a disease, the good and difficult recurrence of therapeutic effect.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described further, should be understood that, following explanation only is in order to explain the present invention, its content not to be limited.Following composition is if no specified otherwise is weight portion.
Embodiment 1
Tablet of the present invention is prepared by following method:
(1) 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss;
(2) Mentholum, Calculus Bovis are ground to form fine powder, subsequent use;
(3) all the other medical materials are measured 65% ethanol extractions 2 times with 10 times, and each 2 hours, merge extractive liquid, filtered, and filtrating is concentrated into the thick paste that relative density is 1.25～1.30 (50 ℃);
(4) thick paste is dry;
(5) be ground into fine powder, add an amount of pharmaceutic adjuvant, mixing is granulated, and drying adds the magnesium stearate of Mentholum, Calculus Bovis and 0.5%, mixing, and tabletting promptly gets.
Embodiment 2
Tablet of the present invention is prepared by following method:
(1) 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 100 parts of Radix Scutellariaes, 80 parts in Radix Glycyrrhizae, 50 parts of Boraxs;
(2) with Mentholum, Calculus Bovis grind to form fine powder, Borax is ground into fine powder, and is subsequent use;
(3) all the other medical materials are measured 80% ethanol extractions 2 times with 6 times, and each 2 hours, merge extractive liquid, filtered, and filtrating is concentrated into the thick paste that relative density is 1.10～1.25 (50 ℃);
(4) thick paste is dry;
(5) be ground into fine powder, add Borax, an amount of pharmaceutic adjuvant, mixing is granulated, and drying adds the magnesium stearate of Mentholum, Calculus Bovis and 0.5%, mixing, and tabletting promptly gets.
Embodiment 3
Tablet of the present invention is prepared by following method:
(1) 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 15 parts of Matrii Sulfas Exsiccatus;
(2) with Mentholum, Calculus Bovis grind to form fine powder, Matrii Sulfas Exsiccatus is ground into fine powder, and is subsequent use;
(3) all the other medical materials are measured 50% ethanol extractions 2 times with 12 times, and each 2 hours, merge extractive liquid, filtered, and filtrating is concentrated into the thick paste that relative density is 1.25～1.40 (50 ℃);
(4) thick paste is dry;
(5) be ground into fine powder, add Matrii Sulfas Exsiccatus, an amount of pharmaceutic adjuvant, mixing is granulated, and drying adds the magnesium stearate of Mentholum, Calculus Bovis and 0.5%, mixing, and tabletting promptly gets.
Embodiment 4
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 70 parts of Radix Pseudostellariaes.
Embodiment 5
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 45 parts of Radix Isatidiss, 80 parts of Radix Ophiopogonis.
Embodiment 6
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 80 parts of Rhizoma Coptidis, 65 parts of Radix Rehmanniae, 70 parts of Lasiosphaera Seu Calvatia.
Embodiment 7
Tablet of the present invention is prepared by following method:
(1) 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 110 parts of Semen Oroxylis, 85 parts of Bulbus Fritillariae Thunbergiis, 2 parts of Oleum menthae, 80 parts of Fructus Canariis;
(2) Mentholum is ground to form fine powder, bovine calculus powder is broken into fine powder, and is subsequent use; Oleum menthae is subsequent use;
(3) all the other medical materials are measured 75% ethanol extractions 2 times with 10 times, and each 2 hours, merge extractive liquid, filtered, and filtrating is concentrated into the thick paste that relative density is 1.20～1.35 (50 ℃);
(4) thick paste is dry;
(5) be ground into fine powder, add an amount of pharmaceutic adjuvant, mixing is granulated, and drying adds the magnesium stearate of Mentholum, Calculus Bovis and 0.5%, sprays into Oleum menthae, mixing, and tabletting promptly gets.
Embodiment 8
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 150 parts of Cortex Phellodendris, 80 parts of Flos Loniceraes, 70 parts of Radix Platycodoniss, 50 parts of Rhizoma Belamcandae, 1 part of Mentholum, 1 part of Calculus Bovis.
Embodiment 9
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 250 parts of Cortex Phellodendris, 120 parts of Flos Loniceraes, 120 parts of Radix Platycodoniss, 80 parts of Rhizoma Belamcandae, 4 parts of Mentholums, 4 parts of Calculus Boviss.
Embodiment 10
Method according to embodiment 1 prepares tablet; Different is that crude drug is: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 80 parts of Rhizoma Coptidis, 80 parts in Radix Glycyrrhizae, 15 parts of Matrii Sulfas Exsiccatus, 80 parts of Radix Ophiopogonis, 110 parts of Semen Oroxylis, 70 parts of Radix Pseudostellariaes.
Embodiment 11
Method according to embodiment 1 prepares tablet; Different is that crude drug is: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 100 parts of Radix Scutellariaes, 45 parts of Radix Isatidiss, 65 parts of Radix Rehmanniae, 70 parts of Lasiosphaera Seu Calvatia, 80 parts of Fructus Canariis.
Embodiment 12
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 250 parts of Cortex Phellodendris, 120 parts of Flos Loniceraes, 120 parts of Radix Platycodoniss, 80 parts of Rhizoma Belamcandae, 4 parts of Mentholums, 4 parts of Calculus Boviss, 80 parts of Rhizoma Coptidis, 60 parts in Radix Glycyrrhizae, 10 parts of Matrii Sulfas Exsiccatus.
Embodiment 13
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 150 parts of Cortex Phellodendris, 80 parts of Flos Loniceraes, 70 parts of Radix Platycodoniss, 50 parts of Rhizoma Belamcandae, 1 part of Mentholum, 1 part of Calculus Bovis, 100 parts of Semen Oroxylis, 70 parts of Radix Scutellariaes, 1 part of Oleum menthae.
Embodiment 14
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 250 parts of Cortex Phellodendris, 120 parts of Flos Loniceraes, 120 parts of Radix Platycodoniss, 80 parts of Rhizoma Belamcandae, 4 parts of Mentholums, 4 parts of Calculus Boviss, 40 parts of Boraxs, 60 parts of Radix Pseudostellariaes, 70 parts of Fructus Canariis, 60 parts of Lasiosphaera Seu Calvatia.
Embodiment 15
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 150 parts of Cortex Phellodendris, 80 parts of Flos Loniceraes, 70 parts of Radix Platycodoniss, 50 parts of Rhizoma Belamcandae, 1 part of Mentholum, 1 part of Calculus Bovis, 40 parts of Radix Isatidis, 60 parts of Radix Ophiopogonis, 60 parts of Radix Rehmanniae, 80 parts of Bulbus Fritillariae Thunbergiis.
Embodiment 16
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 250 parts of Cortex Phellodendris, 120 parts of Flos Loniceraes, 120 parts of Radix Platycodoniss, 80 parts of Rhizoma Belamcandae, 4 parts of Mentholums, 4 parts of Calculus Boviss, 120 parts of Rhizoma Coptidis, 120 parts in Radix Glycyrrhizae, 150 parts of Semen Oroxylis.
Embodiment 17
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 150 parts of Cortex Phellodendris, 80 parts of Flos Loniceraes, 70 parts of Radix Platycodoniss, 50 parts of Rhizoma Belamcandae, 1 part of Mentholum, 1 part of Calculus Bovis, 30 parts of Matrii Sulfas Exsiccatus, 130 parts of Radix Scutellariaes, 4 parts of Oleum menthae.
Embodiment 18
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 250 parts of Cortex Phellodendris, 120 parts of Flos Loniceraes, 120 parts of Radix Platycodoniss, 80 parts of Rhizoma Belamcandae, 4 parts of Mentholums, 4 parts of Calculus Boviss, 70 parts of Boraxs, 100 parts of Radix Pseudostellariaes, 90 parts of Radix Rehmanniae, 120 parts of Bulbus Fritillariae Thunbergiis.
Embodiment 19
Tablet of the present invention is prepared by following method:
(1) 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 65 parts of Radix Rehmanniae, 2 parts of Calculus Boviss;
(2) Mentholum is ground to form fine powder, bovine calculus powder is broken into fine powder, and is subsequent use;
(3) all the other medical materials are measured 80% ethanol extractions 2 times with 10 times, and each 2 hours, merge extractive liquid, filtered, and filtrating is concentrated into the thick paste that relative density is 1.20～1.35 (50 ℃);
(4) thick paste is dry;
(5) be ground into fine powder, add an amount of pharmaceutic adjuvant, mixing is granulated, and drying adds the magnesium stearate of Mentholum, Calculus Bovis and 0.5%, mixing, and tabletting promptly gets.
Embodiment 20
Method according to embodiment 1 prepares tablet, and different is that crude drug is: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 110 parts of Fructus Canariis, 100 parts of Lasiosphaera Seu Calvatia, 80 parts of Radix Isatidis, 100 parts of Radix Ophiopogonis.
Embodiment 21
Tablet of the present invention, filling a prescription is 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 110 parts of Semen Oroxylis, 2 parts of Calculus Boviss, 80 parts in Radix Glycyrrhizae, method for preparing is with embodiment 19.
Embodiment 22
Tablet of the present invention, filling a prescription is 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 65 parts of Radix Rehmanniae, 2 parts of Calculus Boviss, 80 parts in Radix Glycyrrhizae, method for preparing is with embodiment 19.
Embodiment 23
Tablet of the present invention, filling a prescription is 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 65 parts of Radix Rehmanniae, 110 parts of Semen Oroxylis, 2 parts of Calculus Boviss, 80 parts in Radix Glycyrrhizae, method for preparing is with embodiment 19.
Embodiment 24
Tablet of the present invention, filling a prescription is 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss, 80 parts in Radix Glycyrrhizae, method for preparing is with embodiment 19.
Embodiment 25
Tablet of the present invention, filling a prescription is 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 110 parts of Semen Oroxylis, 2 parts of Calculus Boviss, method for preparing is with embodiment 19.
Present composition commodity are called tablet of cow-bezoar for throat trouble, according to the prescription of the foregoing description, process tablet respectively.The present invention has no side effect, and can effect a radical cure chronic pharyngitis, and treatment cycle is short, rapid-action, down in the face of medicine of the present invention carries out animal and clinical experiment, proves its effect.
One, toxicity test
Test method: get 80 of SD rats, body weight 180～220g, male and female half and half are equally divided into 8 groups with rat, respectively the medicine of feeding embodiment of the invention 1-8.The medicine feeding method is: with medicine pulverize of the present invention, water is made into suspension.Every group of rat three fillings every day stomach drug suspension, every day, the rat dosage was 1.5g/Kg, and water is can't help in the rat fasting, and method continuous irrigation stomach is 15 days like this.
The result: during the rat medication, rat does not all have poisoning, the phenomena of mortality, and each organizes activities in rats, appetite is normal.Have no significant change through dissection kidney, liver, adrenal cortex, genitals.
Conclusion: can find out that from The above results the used medication amount of zoopery exceeds the dose of adult's clinical application far away, but rat does not have death or organ variation situation takes place, therefore can draw medicine of the present invention and when human body uses, have no side effect.
Two, clinical experiment
1, case source
Choose 960 routine chronic pharyngitis disease patients in each big department of stomatology of this city, the patient all has following cardinal symptom and sign: pharyngeal drying or itch, hypodynia, foreign body sensation, zest dry cough etc.; Inspection sees pharynx mucosa swelling or has dendroid congested, and lateral pharyngeal band is plump, retropharyneal folliculosis etc., and male's 443 examples wherein, women's 517 examples, the course of disease is the shortest 2 years, and is the longest 20 years, and average course of disease 9 years, patient age be in 20-60 year, 30.6 ± 6.5 years old mean age.
2, test method
The patient is equally divided into 10 groups, and each organizes no difference of science of statistics, and every group of patient uses the medicine of the embodiment of the invention respectively, containing, one time 2～4 (every 0.5 gram), 3 times on the one, each group was a course of treatment with 7 days all, serve on 4 courses of treatment, evaluating efficacy.Pungent, the fish raw meat food of fasting during the medication.The careful usefulness of anemia of pregnant woman.Should not take the temperaturing injecting-ability Chinese patent medicine simultaneously at period in a medicine.Be not suitable for the pharyngalgia person of the affection of exogenous wind-cold.
3, efficacy assessment standard
Cure: subjective symptoms disappears or basic the disappearance, and pharyngeal mucosa is congested to disappear;
Effectively: symptom obviously alleviates, and pharyngeal mucosa hyperemia is disappeared to some extent;
Invalid: symptom and sign does not have improvement.
4, therapeutic outcome
Each is organized the patient treatment situation and sees the following form.
Above-mentioned 960 routine patients when treatment the overwhelming majority show good effect, and rapid-action, through further taking this medicine, the patient all cures, in the shortest 1 week of healing time, healing 5 weeks of time in Changzhi, pays a return visit no recidivist after the patient fully recovered 1 year.And during taking medicine, the generation that has no adverse reaction explains that medicine of the present invention has no side effect to human body basically.
Model case
High certain, the woman, 36 years old, 1 year cause flu of patient, dry pharynx pain, pharyngeal congestion, hoarseness, through controlling the several months, celostomia is not removed.Card sees that chronic facies, pharyngeal little red, scorching hot pain, expectoration are unfavorable, hoarseness, red tongue, the little Huang of tongue, slippery and rapid pulse.Examine and be chronic pharyngitis.Use medicine of the present invention, the back recovery from illness of 2 weeks is followed up a case by regular visits to and was not seen recurrence in 1 year.
The Wang, the man, 30 years old, catch a cold in the recent period back heating of patient, dry pharynx and dry, pharyngalgia hoarseness, mood are irritated.Card is seen red swelling of the pharynx, scorching hot pain, hoarseness, yellow fur, rapid pulse.Examine and be chronic pharyngitis.Use medicine of the present invention, recurrence is not seen in the back recovery from illness of 2 weeks.
Claims (8)
1. Chinese medicine composition of treating chronic pharyngitis is characterized in that comprising the raw material of following weight portion:
Cortex Phellodendri 150-250 part, Flos Lonicerae 80-120 part, Radix Platycodonis 70-120 part, Rhizoma Belamcandae 50-80 part, Mentholum 1-4 part, Calculus Bovis 1-4 part.
2. Chinese medicine composition according to claim 1 is characterized in that comprising the raw material of following weight portion: 200 parts of Cortex Phellodendris, 100 parts of Flos Loniceraes, 100 parts of Radix Platycodoniss, 60 parts of Rhizoma Belamcandae, 2 parts of Mentholums, 2 parts of Calculus Boviss.
3. Chinese medicine composition according to claim 1 and 2; It is characterized in that also comprising in the raw material synergistic component; Said synergistic component is one or more in the following ingredients: Radix Scutellariae 70-130 part, Radix Glycyrrhizae 60-120 part, Borax 40-70 part; Matrii Sulfas Exsiccatus 10-30 part, Radix Pseudostellariae 60-100 part, Radix Isatidis 40-80 part, Radix Ophiopogonis 60-100 part; Rhizoma Coptidis 80-120 part, Radix Rehmanniae 60-90 part, Lasiosphaera Seu Calvatia 60-100 part, Semen Oroxyli 100-150 part, Bulbus Fritillariae Thunbergii 80-120 part, Oleum menthae 1-4 part, Fructus Canarii 70-110 part.
4. Chinese medicine composition according to claim 3 is characterized in that said synergistic component is one or more in following six kinds of combinations:
Combination one: Radix Scutellariae 70-130 part, Radix Glycyrrhizae 60-120 part, Borax 40-70 part;
Combination two: Matrii Sulfas Exsiccatus 10-30 part;
Combination three: Radix Pseudostellariae 60-100 part;
Combination four: Radix Isatidis 40-80 part, Radix Ophiopogonis 60-100 part;
Combination five: Rhizoma Coptidis 80-120 part, Radix Rehmanniae 60-90 part, Lasiosphaera Seu Calvatia 60-100 part;
Combination six: Semen Oroxyli 100-150 part, Bulbus Fritillariae Thunbergii 80-120 part, Oleum menthae 1-4 part, Fructus Canarii 70-110 part.
5. Chinese medicine composition according to claim 4 is characterized in that said synergistic component is one or more in following six kinds of combinations:
Combination one: 100 parts of Radix Scutellariaes, 80 parts in Radix Glycyrrhizae, 50 parts of Boraxs;
Combination two: 15 parts of Matrii Sulfas Exsiccatus;
Combination three: 70 parts of Radix Pseudostellariaes;
Combination four: 45 parts of Radix Isatidiss, 80 parts of Radix Ophiopogonis;
Combination five: 80 parts of Rhizoma Coptidis, 65 parts of Radix Rehmanniae, 70 parts of Lasiosphaera Seu Calvatia;
Combination six: 110 parts of Semen Oroxylis, 85 parts of Bulbus Fritillariae Thunbergiis, 2 parts of Oleum menthae, 80 parts of Fructus Canariis.
6. the method for preparing of the Chinese medicine composition of the described treatment chronic pharyngitis of claim 1 is characterized in that may further comprise the steps:
(1) Mentholum and Calculus Bovis are ground to form fine powder, subsequent use;
(2) with all the other raw materials mix, with ethanol extraction twice, merge extractive liquid;
(3) extracting solution is condensed into thick paste, drying gets dry extract;
(4) dried cream powder is broken into fine powder, adds the adjuvant of Mentholum, Calculus Bovis and survival dose, make.
7. method for preparing according to claim 6 is characterized in that: in the step (2), used concentration of ethanol is 50～80wt%, and the 6-12 that to extract used alcoholic acid quality be raw materials quality at every turn doubly extracts 2h at every turn.
8. method for preparing according to claim 6 is characterized in that: in the step (3), be condensed into 50 ℃ of following relative densities and be 1.10～1.40 thick paste.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232939A (en) * | 2015-11-23 | 2016-01-13 | 贵州省仁怀市雨花中药材种植有限公司 | Lozenge treating chronic pharyngitis |
| CN106421236A (en) * | 2016-10-31 | 2017-02-22 | 张家港市中医医院 | External traditional Chinese medicine for treating chronic pharyngitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422563A (en) * | 2007-10-31 | 2009-05-06 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating wean sphagitis and preparation method and quality control method thereof |
| CN102100789A (en) * | 2011-01-31 | 2011-06-22 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
-
2012
- 2012-08-10 CN CN201210283895.5A patent/CN102755428B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422563A (en) * | 2007-10-31 | 2009-05-06 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for treating wean sphagitis and preparation method and quality control method thereof |
| CN102100789A (en) * | 2011-01-31 | 2011-06-22 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李书良: "关于耳鼻喉中成药研发的几点意见(提纲)", 《中华中医药学会耳鼻咽喉科分会第十二次学术研讨会暨嗓音言语听力医学专题学术研讨会论文集》, 31 December 2005 (2005-12-31) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232939A (en) * | 2015-11-23 | 2016-01-13 | 贵州省仁怀市雨花中药材种植有限公司 | Lozenge treating chronic pharyngitis |
| CN106421236A (en) * | 2016-10-31 | 2017-02-22 | 张家港市中医医院 | External traditional Chinese medicine for treating chronic pharyngitis |
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Denomination of invention: Calculus bovis yijin tablet for treating chronic pharyngitis and preparation method thereof Effective date of registration: 20200623 Granted publication date: 20150401 Pledgee: Dongyinghekou sub branch of Agricultural Bank of China Ltd. Pledgor: SHANDONG XIANHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020370010021 |
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