CN102961732B - The composition and method of making the same for the treatment of rabbit enteritis - Google Patents
The composition and method of making the same for the treatment of rabbit enteritis Download PDFInfo
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Abstract
The present invention relates to a kind of compositions for the treatment of rabbit enteritis, by following component by weight mixed preparing form: dry yeast 15-25 part, tannalbin 25-45 part, basic bismuth nitrate 25-45 part, Pericarpium Citri Reticulatae 25-55 part, Cortex Magnoliae Officinalis 15-35 part, Radix Aucklandiae 15-35 part, Poria 20-40 part, Rhizoma Coptidis 30-50 part, magnesium stearate 10-40 part, norfloxacin 15-40 part, starch 590-805 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition Chinese and western drugs combines, and Study on Supermicro-pulverization of Traditional Chinese Drugs, bioavailability are high, treating both the principal and secondary aspects of a disease, curative effect highly significant, and clinical proof has specially good effect to treatment rabbit enteritis.
Description
Technical field
The present invention relates to the composition and method of making the same for the treatment of rabbit enteritis, belong to field of animal, particularly a kind of composition and method of making the same being specifically designed to treatment rabbit enteritis.
Background technology
Rabbit enteritis is the heavy hyperphlogosis of its intestinal top layer mucosa and deep tissues thereof, clinically with severe diarrhea, dehydration and self poisoning for feature.By its inflammation character, mucus, hemorrhagic, suppurative, cellulosic and gangrenosum acne gastroenteritis can be divided into.Sharply, General Symptoms worsens fast the disease of primary disease, and malpractice easily causes death, causes larger economic loss to aquaculture.The less sickness rate of rabbit age in days is higher, and mortality rate is also higher, is generally between 5%-16%.
Primary disease pathogenic factor is a lot, mainly contain bacteriovirus infection, feedstuff change improper or go mouldy, change in weather and poisoning etc.Western medical treatment is mainly cleaning gastrointestinal, anti-inflammation, heart tonifying fluid infusion, it is poisoning etc. to remove, though have received certain effect, the course of disease is long, and medical expense is high, and therapeutic effect can not be satisfactory.And the traditional Chinese medical science is thought and accumulate infringement intestinal in the heresy that primary disease is mainly damp and hot, QI and blood hinders and causes intestinal mucosa deep layer that more serious inflammatory disorders occurs, and Chinese veterinarian is referred to as " intestinal is yellow ".The rule for the treatment of, with heat-clearing and toxic substances removing, logical intestinal intestinal stasis relieving, strengthening the spleen and nourishing the stomach, effaces the pernicious influence as the rule for the treatment of.
This disease is throughout world all rabbit cultivation country almost, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And Western medicine is because its toxic and side effects is strong, easily produce the problem such as drug resistance and drug residue, clinical practice is very limited or prohibits the use.
Therefore research and develop a kind of Chinese and western drugs for the treatment of rabbit enteritis to combine, Study on Supermicro-pulverization of Traditional Chinese Drugs, bioavailability are high, and the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, Chinese and western drugs combines, and Study on Supermicro-pulverization of Traditional Chinese Drugs, bioavailability are high, treating both the principal and secondary aspects of a disease, the composition and method of making the same of effective treatment rabbit enteritis of successful.
Implementation of the present invention is as follows for achieving the above object: a kind of compositions for the treatment of rabbit enteritis, by following component by weight mixed preparing form: dry yeast 15-25 part, tannalbin 25-45 part, basic bismuth nitrate 25-45 part, Pericarpium Citri Reticulatae 25-55 part, Cortex Magnoliae Officinalis 15-35 part, Radix Aucklandiae 15-35 part, Poria 20-40 part, Rhizoma Coptidis 30-50 part, magnesium stearate 10-40 part, norfloxacin 15-40 part, starch 590-805 part.
Described various component optimum ratio amount is: dry yeast 20 parts, tannalbin 35 parts, basic bismuth nitrate 35 parts, Pericarpium Citri Reticulatae 40 parts, Cortex Magnoliae Officinalis 25 parts, the Radix Aucklandiae 25 parts, 30 parts, Poria, Rhizoma Coptidis 40 parts, magnesium stearate 25 parts, norfloxacin 25 parts, starch 700 parts.
Treat a preparation method for the compositions of rabbit enteritis, carry out as follows:
(1) 700 mesh sieves are crossed by after the Pericarpium Citri Reticulatae in prescription, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Poria, Rhizoma Coptidis respectively micronizing;
(2) take dry yeast 15-25 part, tannalbin 25-45 part, basic bismuth nitrate 25-45 part, Pericarpium Citri Reticulatae 25-55 part by weight, mix 5-10 minute to even;
(3) take Cortex Magnoliae Officinalis 15-35 part, Radix Aucklandiae 15-35 part, Poria 20-40 part, Rhizoma Coptidis 30-50 part, norfloxacin 15-40 part by weight, mix 5-10 minute to even;
(4) compositions that above-mentioned (2), (3) step are obtained is merged, continue to mix 10-15 minute to even, add starch 590-805 part (making 8% starch slurry) and make soft material, granulation, oven dry, granulate, mix after adding magnesium stearate 10-40 part, tabletting, make 1000 altogether.
The medicinal property of each component is as follows:
Dry yeast: the dry thalline of cereuisiae fermentum, containing abundant vitamin B1, vitamin B2, nicotinic acid and nicotiamide, in addition still containing a small amount of vitamin B6 and B12, folic acid, inositol etc.Be applicable to the control of malnutrition, dyspepsia, inappetence and vitamin B group deficiency disease.
Tannalbin: light brown or pale yellow powder, odorless, tasteless.Do not decompose at gastric after taking, solve tannic acid in small intestinal punishment, intestinal mucosa S-layer proteins is solidified, form layer protecting film, minimizing is oozed out, abirritate and enterokinesia, has convergence, anti-diarrhea effect.Be applicable to acute gastroenteritis and various Non-bacterial diarrhea, dyspepsia etc.
Rhizoma Coptidis: bitter, cold, returns spleen, stomach, large intestine, gallbladder, heart channel, has the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
Basic bismuth nitrate: six reef knot wafer-like bodies or microcrystalline powder, odorless, tasteless.In and gastric acid and astringency.For gastroenteritis, ulcer and diarrhoea etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, returns lung, spleen channel, has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe be swollen, have loose bowels, productive cough due to phlegm-damp etc.
Cortex Magnoliae Officinalis: bitter, pungent, warm, returns spleen, stomach, lung, large intestine channel, has the function of therapeutic method to keep the adverse QI flowing downwards relieving distension, dampness expectorant; Cure mainly that dyspepsia does not disappear, stagnation of QI due to dyspepsia, tripe are swollen constipation, phlegm retention cough with asthma etc.
The Radix Aucklandiae: acrid, bitter, warm, returns spleen, stomach, large intestine, three burnt, gallbladder meridians, has the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Cure mainly the gastrointestinal stagnation of QI, food stagnation tripe be swollen, weight, stomachache etc. after dysentery.
Poria: sweet, light, flat, returns lung, the heart, spleen, kidney channel, has the function of promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming; Cure mainly edema oliguria, have loose bowels in insufficiency of the spleen lack of appetite, loose stool, malaise etc.
Norfloxacin: third generation quinolones broad spectrum antibiotic, is mainly used in the gram positive bacterial infection treatment of various sensitivity.Oral rear rapid absorption, tissue distribution is good, is applicable to the bacteriological infection etc. of urinary system infection and intestinal.
Starch: the high polymer being glucose, starch has the feature of easily dispersion in water insoluble, water.Be often used as the diluent of tablet, binding agent, disintegrating agent, and can be used to prepare dextrin and starch slurry.
Magnesium stearate: white is without the fine powder of grittiness, and the main lubricant, antiplastering aid, fluidizer etc. being used as tablet, the granule made has good mobility and compressibility.Fluidizer is used as in direct compression.
All herbal medicines are according to the theoretical compatible combination of veterinary's pharmacology above, for paathogenic factor and the clinical symptoms of rabbit enteritis, play the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine Western medicine combines, treating both the principal and secondary aspects of a disease, and cost is low, and draw materials wide, Study on Supermicro-pulverization of Traditional Chinese Drugs, bioavailability are high, curative effect highly significant.The present invention is theoretical according to veterinary's pharmacology, and optimize this nine herbal medicine, and make them form according to optimum ratio, clinical practice proves, has specially good effect to treatment rabbit enteritis.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of composition and method of making the same for the treatment of rabbit enteritis: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the Pericarpium Citri Reticulatae in prescription, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Poria, Rhizoma Coptidis respectively micronizing;
(2) take dry yeast 150 parts, tannalbin 250 parts, basic bismuth nitrate 250 parts, Pericarpium Citri Reticulatae 250 parts by weight, mix 5-10 minute to even;
(3) take Cortex Magnoliae Officinalis 150 parts, the Radix Aucklandiae 150 parts, 200 parts, Poria, Rhizoma Coptidis 300 parts, norfloxacin 150 parts by weight, mix 5-10 minute to even;
(4) compositions that above-mentioned (2), (3) step are obtained is merged, continue to mix 10-15 minute to even, add starch 5900 parts (making 8% starch slurry) and make soft material, granulation, oven dry, granulate, add that magnesium stearate 100 parts mixes afterwards, tabletting, make 10000 altogether.
Embodiment 2
A kind of composition and method of making the same for the treatment of rabbit enteritis: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the Pericarpium Citri Reticulatae in prescription, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Poria, Rhizoma Coptidis respectively micronizing;
(2) take dry yeast 200 parts, tannalbin 350 parts, basic bismuth nitrate 350 parts, Pericarpium Citri Reticulatae 400 parts by weight, mix 5-10 minute to even;
(3) take Cortex Magnoliae Officinalis 250 parts, the Radix Aucklandiae 250 parts, 300 parts, Poria, Rhizoma Coptidis 400 parts, norfloxacin 250 parts by weight, mix 5-10 minute to even;
(4) compositions that above-mentioned (2), (3) step are obtained is merged, continue to mix 10-15 minute to even, add starch 7250 parts (making 8% starch slurry) and make soft material, granulation, oven dry, granulate, add that magnesium stearate 250 parts mixes afterwards, tabletting, make 10000 altogether.
Embodiment 3
A kind ofly treat Chinese medicine composition of rabbit enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the Pericarpium Citri Reticulatae in prescription, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Poria, Rhizoma Coptidis respectively micronizing;
(2) take dry yeast 250 parts, tannalbin 450 parts, basic bismuth nitrate 450 parts, Pericarpium Citri Reticulatae 550 parts by weight, mix 5-10 minute to even;
(3) take Cortex Magnoliae Officinalis 350 parts, the Radix Aucklandiae 350 parts, 400 parts, Poria, Rhizoma Coptidis 500 parts, norfloxacin 400 parts by weight, mix 5-10 minute to even;
(4) compositions that above-mentioned (2), (3) step are obtained is merged, continue to mix 10-15 minute to even, add starch 8050 parts (making 8% starch slurry) and make soft material, granulation, oven dry, granulate, add that magnesium stearate 400 parts mixes afterwards, tabletting, make 10000 altogether.
Clinical trial:
Clinical experiment animal selects 205 ages in days, body weight at 5kg-10kg, and Laboratory Diagnosed is the ill rabbit of rabbit enteritis.Ill rabbit isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, and experiment carries out 5 days altogether; Blank group is left intact, and drug control group " dysentery health is fallen apart " by specification uses treatment; Product of the present invention (compositions obtained by the embodiment of the present invention 1) can take orally by present composition group, and each 2-4 sheet, every day 2-3 time, is used in conjunction 3-5 days; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the Field information situation that the present invention and other medicines treat rabbit enteritis contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 16.7 | 30.0 | 53.3 |
| II | Dysentery health sheet group | 6.7 | 76.6 | 16.7 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group and dysentery health sheet group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 70 age in days healthy rabbits 10,5 times according to the made compositions recommended dose of the embodiment of the present invention 1 take orally 10 days, during medication, healthy rabbits is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of carrying out with reference to the composition and method of making the same of embodiment to this treatment rabbit enteritis; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a compositions for rabbit enteritis, it is characterized in that by following component by weight mixed preparing form: dry yeast 15-25 part, tannalbin 25-45 part, basic bismuth nitrate 25-45 part, Pericarpium Citri Reticulatae 25-55 part, Cortex Magnoliae Officinalis 15-35 part, Radix Aucklandiae 15-35 part, Poria 20-40 part, Rhizoma Coptidis 30-50 part, magnesium stearate 10-40 part, norfloxacin 15-40 part, starch 590-805 part.
2. the compositions for the treatment of rabbit enteritis according to claim 1, it is characterized in that by following component by weight mixed preparing form: dry yeast 20 parts, tannalbin 35 parts, basic bismuth nitrate 35 parts, Pericarpium Citri Reticulatae 40 parts, Cortex Magnoliae Officinalis 25 parts, the Radix Aucklandiae 25 parts, 30 parts, Poria, Rhizoma Coptidis 40 parts, magnesium stearate 25 parts, norfloxacin 25 parts, starch 700 parts.
3. a preparation method for the compositions for the treatment of rabbit enteritis according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the Pericarpium Citri Reticulatae in prescription, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Poria, Rhizoma Coptidis respectively micronizing;
(2) take dry yeast 15-25 part, tannalbin 25-45 part, basic bismuth nitrate 25-45 part, Pericarpium Citri Reticulatae 25-55 part by weight, mix 5-10 minute to even;
(3) take Cortex Magnoliae Officinalis 15-35 part, Radix Aucklandiae 15-35 part, 2040 parts, Poria, Rhizoma Coptidis 30-50 part, norfloxacin 15-40 part by weight, mix 5-10 minute to even;
(4) compositions that above-mentioned (2), (3) step are obtained is merged, continue to mix 10-15 minute to even, add starch 590-805 part and make soft material, described starch makes 8% starch slurry, granulation, oven dry, granulate, mix after adding magnesium stearate 10-40 part, tabletting, make 1000 altogether.
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| CN108338279A (en) * | 2018-01-19 | 2018-07-31 | 普安县红星种养殖有限责任公司 | A kind of prevention is become mildewed the feed addictive and preparation method thereof of rabbit hemorrhagic disease |
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| CN1872327A (en) * | 2005-06-01 | 2006-12-06 | 天津天士力制药股份有限公司 | Composition of medicine for treating diarrhea |
| CN102552871A (en) * | 2011-12-13 | 2012-07-11 | 海南康芝药业股份有限公司 | Albumin tannate and yeast chewable tablet and production method thereof |
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