CN102973703B - Compound pure Chinese medicine composition for treating enteritis in livestock, and preparation method thereof - Google Patents

Abstract

The invention relates to a compound pure Chinese medicine composition for treating enteritis in livestock. The compound pure Chinese medicine composition is prepared by mixing the following ingredients in parts by weight: 15-35 parts of suis fellis pulvis, 25-45 parts of mung bean, 15-25 parts of coptidis rhizome, 15-40 parts of cortex phellodendri, 10-30 parts of borneol, 15-35 parts of radix isatidis, and 20-40 parts of flos fophorae. The compound pure Chinese medicine composition has the beneficial effects of being reasonable in formula, and simple to prepare, having no toxic and side effects, as well as no pollution, no drug residue and drug resistance, being ultrafinely crushed, being high in bioavailability and obvious in curative effect, and having special effect in treating the enteritis in livestock, proved clinically.

Description

The compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis

Technical field

The compound pure Chinese medicine composition and method of making the same that the present invention relates to treat domestic animal enteritis, belongs to animal field of medicaments, particularly a kind of compound pure Chinese medicine composition and method of making the same that is specifically designed to treatment domestic animal enteritis.

Background technology

Domestic animal enteritis is the heavy hyperphlogosis of its intestinal top layer mucosa and deep tissues thereof, clinically taking severe diarrhea, dehydration and self poisoning as feature.By its inflammation character, can be divided into mucus, hemorrhagic, suppurative, fiber disposition and gangrenosum acne gastroenteritis.Sharply, General Symptoms worsens fast the disease of primary disease, and malpractice easily causes death, causes larger economic loss to aquaculture.The less sickness rate of domestic animal age in days is higher, and mortality rate is also higher, is generally between 5%-16%.

Primary disease pathogenic factor is a lot, mainly contain bacteriovirus infection, feedstuff change improper or go mouldy, change in weather and poisoning etc.Western medical treatment is mainly to clear up gastrointestinal, anti-inflammation, heart tonifying fluid infusion, it is poisoning etc. to remove, though received certain effect, the course of disease is dragged longly, and medical expense is too high, and therapeutic effect still can not be satisfactory.And the traditional Chinese medical science thinks that primary disease is mainly to accumulate infringement intestinal in damp and hot heresy, QI and blood hinders and causes that more serious inflammatory disorders occurs intestinal mucosa deep layer, and Chinese veterinarian is referred to as " intestinal Huang ".The rule for the treatment of, with heat-clearing and toxic substances removing, logical intestinal intestinal stasis relieving, strengthening the spleen and nourishing the stomach, effaces the pernicious influence as the rule for the treatment of.

This disease almost spreads all over all livestock culturings country of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine is because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.

Therefore research and develop and a kind ofly treat the having no side effect of domestic animal enteritis, drug residue free, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound pure Chinese medicine composition and method of making the same of effective treatment domestic animal enteritis of drug residue.

Implementation of the present invention is as follows for achieving the above object: a kind of compound pure Chinese medicine compositions for the treatment of domestic animal enteritis, by following component by weight mixed preparing form: Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part.

Described various component optimum ratio amount is: 25 parts of Pulvis Fellis Suiss, 35 parts, Semen phaseoli radiati, 20 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 20 parts of Borneolum Syntheticums, 25 parts of Radix Isatidis, 30 parts, Flos Sophorae.

Treat a preparation method for the compound pure Chinese medicine compositions of domestic animal enteritis, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, mix 5-10 minute to even;

(3) take by weight Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Pulvis Fellis Suis: bitter, cold, return lung, gallbladder, liver, large intestine channel, there is heat clearing away, moisturize, the function of removing toxic substances, relieving cough and asthma; Cure mainly calentura dry thirsty, conjunctival congestion, sore throat, jaundice, asthma, have loose bowels, dysentery, constipation, carbuncle pyogenic infections from tumour or sore etc.

Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, have heat-clearing and toxic substances removing, a function of the stomach invigorating of relieving summer heat; Cure mainly that diarrhea due to damp-heat, removing toxic substances protect the liver, antiallergic etc.

Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Borneolum Syntheticum: pungent, bitter, cold, GUIXIN, spleen, lung meridian, have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin etc.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

Flos Sophorae: bitter, be slightly cold, return lung, liver, the heart, large intestine channel, there is the function of cooling blood for hemostasis, liver heat removing and eyesight improving; Cure mainly discharging fresh blood stool, dysentery, hematuria, epistaxis etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of domestic animal enteritis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven tastes Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment domestic animal enteritis is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensured that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of Pulvis Fellis Suiss, 250 parts, Semen phaseoli radiati, 150 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weight 150 parts of Cortex Phellodendris, 100 parts of Borneolum Syntheticums, 150 parts of Radix Isatidis, 200 parts, Flos Sophorae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of Pulvis Fellis Suiss, 350 parts, Semen phaseoli radiati, 200 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weight 250 parts of Cortex Phellodendris, 200 parts of Borneolum Syntheticums, 250 parts of Radix Isatidis, 300 parts, Flos Sophorae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound pure Chinese medicine composition and method of making the same for the treatment of domestic animal enteritis: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of Pulvis Fellis Suiss, 450 parts, Semen phaseoli radiati, 250 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weight 400 parts of Cortex Phellodendris, 300 parts of Borneolum Syntheticums, 350 parts of Radix Isatidis, 400 parts, Flos Sophorae, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 75-85 age in days, body weight at 30kg-40kg, the ill pig that Laboratory Diagnosed is swine enteritis.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment with " dysentery health is loose " by specification; Chinese medicine composition group of the present invention can brew product of the present invention (the prepared compositions of the embodiment of the present invention 1) boiled water, and warm water gavages, and each 100 grams-150 grams, every day 1-2 time, is used in conjunction 3-5 days; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.

Table is the field applicable cases contrast of the present invention and other medicines treatment domestic animal enteritis (pig):

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	6.7	60.0	33.3
II	The dysentery health group of faling apart	3.3	80.0	16.7
					III	Present composition group	0	90.0	10.0

This clinical effectiveness statistical analysis, the loose group of present composition treatment group and dysentery health extremely significantly (P < 0.01) of difference compared with aspect cure rate.

Safety testing:

Choose 10 of 70 age in days health pig, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 gavage 10 days, during medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

Above-mentioned detailed description of the compound pure Chinese medicine composition and method of making the same of this treatment domestic animal enteritis being carried out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a compound pure Chinese medicine compositions for domestic animal enteritis, it is characterized in that by following component by weight mixed preparing form: Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part.

2. the compound pure Chinese medicine compositions for the treatment of according to claim 1 domestic animal enteritis, it is characterized in that by following component by weight mixed preparing form: 25 parts of Pulvis Fellis Suiss, 35 parts, Semen phaseoli radiati, 20 parts of Rhizoma Coptidis, 25 parts of Cortex Phellodendris, 20 parts of Borneolum Syntheticums, 25 parts of Radix Isatidis, 30 parts, Flos Sophorae.

3. a preparation method for the compound pure Chinese medicine compositions for the treatment of domestic animal enteritis according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Pulvis Fellis Suis 15-35 part, Semen phaseoli radiati 25-45 part, Rhizoma Coptidis 15-25 part, mix 5-10 minute to even;

(3) take by weight Cortex Phellodendri 15-40 part, Borneolum Syntheticum 10-30 part, Radix Isatidis 15-35 part, Flos Sophorae 20-40 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.