CN108815281A - A kind of aquatic products Sanhuang San and preparation method thereof - Google Patents
A kind of aquatic products Sanhuang San and preparation method thereof Download PDFInfo
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- CN108815281A CN108815281A CN201810916992.0A CN201810916992A CN108815281A CN 108815281 A CN108815281 A CN 108815281A CN 201810916992 A CN201810916992 A CN 201810916992A CN 108815281 A CN108815281 A CN 108815281A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The present invention relates to aquatic products pharmaceutical techniques fields, disclose a kind of aquatic products Sanhuang San, and Sanhuang San is made of the raw material of following parts by weight：40-50 parts of radix scutellariae, 40-50 parts of Cortex Phellodendri, 40-50 parts of rheum officinale and folium isatidis 10-20 parts with and preparation method thereof.The advantages that small, without drug resistance present invention can be implemented in the secondary residual for the treatment of aquatic biological enteritis poison, and effective ingredient can give full play to, be crushed to 100 mesh pharmacopeia sieve or more by using Sanhuang San as therapeutic agent and by Sanhuang San, solve the problems, such as that existing drug side-effect is big and effective component play it is insufficient.
Description
Technical field
The present invention relates to aquatic products pharmaceutical techniques fields, in particular to a kind of aquatic products Sanhuang San and preparation method thereof.
Background technique
In recent years, with the continuous improvement of aquaculture intensive degree, cultivation density increasingly increases, aquatic animal disease
Generation also get worse, occur using enteritis illness as the disease of main feature, symptom is that alimentary canal reddens color, and stomach is most
Obviously, middle intestines rear portion also reddens or swelling, rectum (hindgut) become muddy.Sick fish/shrimp torpescence, anorexia, slow growth, this disease is often
Concurrent with bacterial gill, red skin disease, the death rate is up to 90% or more when serious.
Getting to the bottom of sb.'s illness has the following：1. cultivation density is big, water environment degradation is easily caused；2. strengthening the feed fed to match
Fang Danyi is easy to cause body nutrient imbalance, metabolism disorder；3. many raiser's feed storage methods are improper, feed is caused to be sent out
Mildew matter is very big to the Gut Injury of aquatic animal after feeding；4. abusing drug, immunity of organisms is caused to decline.The disease is in recent years
Come it is generally popular high in all parts of the country, especially fish, shrimp disease incidence, the object of harm be mainly carp, crucian carp, grass carp, Tilapia mossambica,
Litopenaeus vannamei, sea cucumber, are also common in soft-shelled turtle.Enteritis disease is one of the principal disease for leading to aquaculture economic loss.In fishing medicine
In the market, many for preventing and treating the medicament categories of enteritis disease, it is being forbidden to use furans, in sulfamido after some drugs, perhaps
More producers' steering productions are some using antibiotic such as sulfamido, quinolones, terramycin classes as the drug of raw material, largely, chronically
It using these drugs, is easy to generate antibody-resistant bacterium, some areas enteritis disease is caused to break out again and again, dosage occur and increase and long
Phenomena such as controlling not more.Dose increases and medicine is residual is detrimental to health with also resulting in aquatic livestock potentiality.Therefore, in enteritis
Correctly select no matter drug considers all to be very important to disease prevention and cure or from consumer health in prevention and treatment.
Summary of the invention
Based on problem above, the present invention provides a kind of aquatic products Sanhuang Sans and preparation method thereof.The present invention by using
Four kinds of radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis Chinese medicines are crushed into powder and Sanhuang San are made, and since raw material is all made of traditional Chinese medicine ingredients, and pass through
Cross radix scutellariae, Cortex Phellodendri, rheum officinale and the compatibility of folium isatidis, have the secondary residual for the treatment of aquatic biological enteritis poison it is small, without drug resistance etc.
Advantage, and Sanhuang San is crushed to 100 mesh pharmacopeia sieve or more, it give full play to effective ingredient can, solve existing drug
Side effect is big and effective component plays insufficient problem.
In order to solve the above technical problems, the technical solution adopted by the present invention is as follows：
A kind of aquatic products Sanhuang San, Sanhuang San are made of the raw material of following parts by weight：40-50 parts of radix scutellariae, Cortex Phellodendri 40-50
Part, 40-50 parts and folium isatidis 10-20 parts of rheum officinale.
In the present invention, the root of radix scutellariae is used as medicine, bitter, cold in nature, has heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis and other effects, to dysentery
Shigella, typhoid bacillus, hemolytic relative gene, Pseudomonas aeruginosa and staphylococcus, streptococcus have the antitoxin work of stronger antibacterial
With the clinical antibiotic property of radix scutellariae is better than the coptis, and does not develop drug resistance；The sedimentation of Cortex Phellodendri bitter cold, heat-clearing and damp-drying drug, purging fire for removing toxin power
By force, there is stronger inhibiting effect to various bacteria, fungi；Rheum officinale, which has, attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances
And other effects, folium isatidis is for treating pyreticosis hyperpyrexia polydipsia, by the way that radix scutellariae, Cortex Phellodendri, rheum officinale and the powder of folium isatidis to be mixed
Sanhuang San, the collective effect of plurality of Chinese can enhance the body's immunity of aquatic biological, comprehensive coordinate physiological metabolism.
The advantages that small, without drug resistance present invention can be implemented in the secondary residual for the treatment of aquatic biological enteritis poison, and drug has
Effect ingredient can give full play to, and be crushed to 100 mesh pharmacopeia sieve or more, solution by using Sanhuang San as therapeutic agent and by Sanhuang San
Existing drug side-effect of having determined is big and effective component plays insufficient problem.
As a preferred mode, Sanhuang San is made of the raw material of following parts by weight：Radix scutellariae is 45 parts, Cortex Phellodendri 45
Part, rheum officinale is 45 parts, and folium isatidis is 15 parts.
A kind of preparation method of aquatic products Sanhuang San, by radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis after cleaning according to the above ratio in
At 40-80 DEG C constant temperature drying to water content 8% hereinafter, drying after crushed by pulverizer, finally obtain radix scutellariae powder, Cortex Phellodendri
Powder, Rhubarb Powder and folium isatidis powder, and the radix scutellariae powder, Cortex Phellodendri powder, Rhubarb Powder and folium isatidis powder smashing fineness in 100 mesh medicines
More than allusion quotation sieve, then smashed raw material sequentially added in mixing machine, incorporation time is 15-30 minute, mixed powder requirement color
Damp uniform, epigranular and foreign.
As a preferred mode, incorporation time is 20 minutes.
As a preferred mode, pulverizer crushing process includes：
(1) coarse crushing：By radix scutellariae, Cortex Phellodendri, rheum officinale and the folium isatidis difference dissection after drying to 4-6cm, Chinese medicine is then used
Pulverizer carries out coarse crushing, smashes it through 50-80 mesh and obtains coarse powder；
(2) Ultramicro-powder (impact grinding Ultramicro-powder)：Above-mentioned gained coarse powder is crushed by impact grinding micronizer, is obtained thin
Degree is the material of 300 mesh or more (particle≤50 μm), as Ultramicro-powder.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention is crushed into powder and Sanhuang San is made by using four kinds of radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis Chinese medicines, due to original
Material is all made of traditional Chinese medicine ingredients, and passes through the compatibility of radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis, has treatment aquatic biological enteritis
Malicious pair remains the advantages that small, without drug resistance, and Sanhuang San is crushed to 100 mesh pharmacopeia sieve or more, fill effective ingredient can
Distribution is waved, solve the problems, such as that existing drug side-effect is big and effective component play it is insufficient.
Specific embodiment
The present invention is further illustrated below.Embodiments of the present invention include but is not limited to the following example.
Embodiment 1：
A kind of aquatic products Sanhuang San, the Sanhuang San are made of the raw material of following parts by weight：Radix scutellariae is 40 parts, Cortex Phellodendri 50
Part, rheum officinale is 40 parts, and folium isatidis is 10 parts.
A kind of preparation method of aquatic products Sanhuang San, by radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis after cleaning according to the above ratio in
At 40-80 DEG C constant temperature drying to water content 8% hereinafter, drying after crushed by pulverizer, finally obtain radix scutellariae powder, Cortex Phellodendri
Powder, Rhubarb Powder and folium isatidis powder, and the radix scutellariae powder, Cortex Phellodendri powder, Rhubarb Powder and folium isatidis powder smashing fineness in 100 mesh medicines
More than allusion quotation sieve, then smashed raw material sequentially added in mixing machine, incorporation time is 15-30 minute, mixed powder requirement color
Damp uniform, epigranular and foreign.
As a preferred mode, incorporation time is 20 minutes.
As a preferred mode, pulverizer crushing process includes：
(1) coarse crushing：By radix scutellariae, Cortex Phellodendri, rheum officinale and the folium isatidis difference dissection after drying to 4-6cm, Chinese medicine is then used
Pulverizer carries out coarse crushing, smashes it through 50-80 mesh and obtains coarse powder；
(2) Ultramicro-powder (impact grinding Ultramicro-powder)：Above-mentioned gained coarse powder is crushed by impact grinding micronizer, is obtained thin
Degree is the material of 300 mesh or more (particle≤50 μm), as Ultramicro-powder.
In this example, drug powder is made by above-mentioned formula and preparation method, randomly selects 100 with enteritis disease
The fish of disease, mix bait for made drug powder and feed, and dosage is every 1 kilogram of fish, 0.5 gram of medicine, are used in conjunction 6, and illness fish cure item
Number 82, cure rate 82%.
Embodiment 2：
Sanhuang San is made of the raw material of following parts by weight：Radix scutellariae is 45 parts, and Cortex Phellodendri is 45 parts, and rheum officinale is 45 parts, folium isatidis
It is 15 parts.
A kind of preparation method of aquatic products Sanhuang San, by radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis after cleaning according to the above ratio in
At 40-80 DEG C constant temperature drying to water content 8% hereinafter, drying after crushed by pulverizer, finally obtain radix scutellariae powder, Cortex Phellodendri
Powder, Rhubarb Powder and folium isatidis powder, and the radix scutellariae powder, Cortex Phellodendri powder, Rhubarb Powder and folium isatidis powder smashing fineness in 100 mesh medicines
More than allusion quotation sieve, then smashed raw material sequentially added in mixing machine, incorporation time is 15-30 minute, mixed powder requirement color
Damp uniform, epigranular and foreign.
As a preferred mode, incorporation time is 20 minutes.
As a preferred mode, pulverizer crushing process includes：
(1) coarse crushing：By radix scutellariae, Cortex Phellodendri, rheum officinale and the folium isatidis difference dissection after drying to 4-6cm, Chinese medicine is then used
Pulverizer carries out coarse crushing, smashes it through 50-80 mesh and obtains coarse powder；
(2) Ultramicro-powder (impact grinding Ultramicro-powder)：Above-mentioned gained coarse powder is crushed by impact grinding micronizer, is obtained thin
Degree is the material of 300 mesh or more (particle≤50 μm), as Ultramicro-powder.
In this example, drug powder is made by above-mentioned formula and preparation method, randomly selects 100 with enteritis disease
The fish of disease, mix bait for made drug powder and feed, and dosage is every 1 kilogram of fish, 0.5 gram of medicine, are used in conjunction 6, and illness fish cure item
Number 91, cure rate 91%.
Embodiment 3：
Sanhuang San is made of the raw material of following parts by weight：Radix scutellariae is 50 parts, and Cortex Phellodendri is 45 parts, and rheum officinale is 50 parts, folium isatidis
It is 20 parts.
A kind of preparation method of aquatic products Sanhuang San, by radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis after cleaning according to the above ratio in
At 40-80 DEG C constant temperature drying to water content 8% hereinafter, drying after crushed by pulverizer, finally obtain radix scutellariae powder, Cortex Phellodendri
Powder, Rhubarb Powder and folium isatidis powder, and the radix scutellariae powder, Cortex Phellodendri powder, Rhubarb Powder and folium isatidis powder smashing fineness in 100 mesh medicines
More than allusion quotation sieve, then smashed raw material sequentially added in mixing machine, incorporation time is 15-30 minute, mixed powder requirement color
Damp uniform, epigranular and foreign.
As a preferred mode, incorporation time is 20 minutes.
As a preferred mode, pulverizer crushing process includes：
(1) coarse crushing：By radix scutellariae, Cortex Phellodendri, rheum officinale and the folium isatidis difference dissection after drying to 4-6cm, Chinese medicine is then used
Pulverizer carries out coarse crushing, smashes it through 50-80 mesh and obtains coarse powder；
(2) Ultramicro-powder (impact grinding Ultramicro-powder)：Above-mentioned gained coarse powder is crushed by impact grinding micronizer, is obtained thin
Degree is the material of 300 mesh or more (particle≤50 μm), as Ultramicro-powder.
In this example, drug powder is made by above-mentioned formula and preparation method, randomly selects 100 with enteritis disease
The fish of disease, mix bait for made drug powder and feed, and dosage is every 1 kilogram of fish, 0.5 gram of medicine, are used in conjunction 6, and illness fish cure item
Number 93, cure rate 93%.
Described based on the above embodiments, the present invention is ground by using four kinds of radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis Chinese medicines
Sanhuang San is made in powder, since raw material is all made of traditional Chinese medicine ingredients, and passes through the compatibility of radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis, has and control
The advantages that secondary residual of aquatic biological enteritis poison is small, without drug resistance is treated, and Sanhuang San is crushed to 100 mesh pharmacopeia sieve or more,
Give full play to effective ingredient can, solve the problems, such as that existing drug side-effect is big and effective component play it is insufficient.
It as above is the embodiment of the present invention.Design parameter in above-described embodiment and embodiment is merely to understand table
Verification process of the invention is stated, the scope of patent protection being not intended to limit the invention, scope of patent protection of the invention is still
It is subject to the claims, it is all to change with equivalent structure made by description of the invention, similarly should all include
Within the scope of the present invention.
Claims (7)
1. a kind of aquatic products Sanhuang San, it is characterised in that：The Sanhuang San is made of the raw material of following parts by weight：Radix scutellariae 40-50
Part, 40-50 parts of Cortex Phellodendri, 40-50 parts and folium isatidis 10-20 parts of rheum officinale.
2. aquatic products Sanhuang San according to claim 1, it is characterised in that：The Sanhuang San by following parts by weight raw material
Composition：Radix scutellariae is 40 parts, and Cortex Phellodendri is 50 parts, and rheum officinale is 40 parts, and folium isatidis is 10 parts.
3. aquatic products Sanhuang San according to claim 1, it is characterised in that：The Sanhuang San by following parts by weight raw material
Composition：Radix scutellariae is 45 parts, and Cortex Phellodendri is 45 parts, and rheum officinale is 45 parts, and folium isatidis is 15 parts.
4. aquatic products Sanhuang San according to claim 1, it is characterised in that：The Sanhuang San by following parts by weight raw material
Composition：Radix scutellariae is 50 parts, and Cortex Phellodendri is 45 parts, and rheum officinale is 50 parts, and folium isatidis is 20 parts.
5. a kind of preparation method of aquatic products Sanhuang San, it is characterised in that：Radix scutellariae, Cortex Phellodendri, rheum officinale and folium isatidis after cleaning are pressed
40-50 parts of radix scutellariae, 40-50 parts of Cortex Phellodendri, constant temperature drying is extremely at 40-80 DEG C for 40-50 parts of rheum officinale and folium isatidis 10-20 parts of ratio
Water content 8% hereinafter, drying after crushed by pulverizer, finally obtain radix scutellariae powder, Cortex Phellodendri powder, Rhubarb Powder and folium isatidis powder,
And the radix scutellariae powder, Cortex Phellodendri powder, Rhubarb Powder and folium isatidis powder smashing fineness more than 100 mesh pharmacopeia sieve, then after crushing
Raw material sequentially add in mixing machine, incorporation time is 15-30 minute, and color is uniform for mixed powder requirement, epigranular and nothing
Foreign matter.
6. the preparation method of aquatic products Sanhuang San according to claim 5, it is characterised in that：The incorporation time is 20 points
Clock.
7. the preparation method of aquatic products Sanhuang San according to claim 5, it is characterised in that：The pulverizer crushing process
Including：
(1) coarse crushing：By radix scutellariae, Cortex Phellodendri, rheum officinale and the folium isatidis difference dissection after drying to 4-6cm, then crushed with Chinese medicine
Machine carries out coarse crushing, smashes it through 50-80 mesh and obtains coarse powder；
(2) Ultramicro-powder (impact grinding Ultramicro-powder)：Above-mentioned gained coarse powder is crushed by impact grinding micronizer, obtaining fineness is
More than 300 the mesh materials of (particle≤50 μm), as Ultramicro-powder.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112617054A (en) * | 2020-12-14 | 2021-04-09 | 惠州市渔业研究推广中心(广东省(惠州)区域性水产试验中心、广东省区域性水产技术推广(惠州)中心) | Tilapia embrittlement feed and embrittlement method thereof |
Citations (3)
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| CN1887322A (en) * | 2006-01-19 | 2007-01-03 | 北京大北农动物保健科技有限责任公司 | Compound Chinese medicine composition and its prepn and use |
| CN103055065A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition |
| CN104352617A (en) * | 2014-10-11 | 2015-02-18 | 中国科学院海洋研究所 | Sanhuang supper micropowder as well as preparing method and application thereof |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1887322A (en) * | 2006-01-19 | 2007-01-03 | 北京大北农动物保健科技有限责任公司 | Compound Chinese medicine composition and its prepn and use |
| CN103055065A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition |
| CN104352617A (en) * | 2014-10-11 | 2015-02-18 | 中国科学院海洋研究所 | Sanhuang supper micropowder as well as preparing method and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112617054A (en) * | 2020-12-14 | 2021-04-09 | 惠州市渔业研究推广中心(广东省(惠州)区域性水产试验中心、广东省区域性水产技术推广(惠州)中心) | Tilapia embrittlement feed and embrittlement method thereof |
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