CN103055065A - Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the enteritis of fish. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 15 to 35 parts of common andrographis herb, 15 to 35 parts of humifuse euphorbia herb, 15 to 35 parts of acorus calamus, 15 to 35 parts of rhubarb, 25 to 45 parts of quisqualis indica, 15 to 35 parts of red-knees herb, 20 to 40 parts of portulaca oleracea, 20 to 40 parts of salt, 10 to 40 parts of amur corktree bark and 15 to 45 parts of baikal skullcap root. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the enteritis of the fish.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of fish enteritis and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to the treatment fish enteritis and preparation method thereof.
Background technology
The fish enteritis disease mostly occurs after just having begun to take food spring or spring and summer, the changeable season of friendship temperature in autumn in summer, namely between annual April～July and JIUYUE～October.This disease it is generally acknowledged by intestinal point-like aerogenesis pseudomonas bacillus and causes, also and water temperature over-high, oxygen in water is low goes bad relevant with feedstuff.Generally show as the cultured fishes inappetence, the symptoms such as solely trip, anus redness that peel off, gently press abdominal part to have yellow or yellow reddish liquid to flow out from anus, dissect visible intestinal section red and swollen, and the inflammation of erosion arranged, the while is the pathological changes such as liver enlargement, variable color as seen.
The disease of primary disease is rapid, and General Symptoms worsens fast, and malpractice easily causes death, already causes larger economic loss for fish culture, and mortality rate is generally between 5%-16%.This disease does not generally cause large quantities of death, but large quantities of death can occur when causing other complication.
The primary disease western medical treatment mainly is to clear up gastrointestinal, anti-inflammation etc., though receive certain effect, the course of disease is long, and medical expense is high, and therapeutic effect can not be satisfactory.And the traditional Chinese medical science thinks that primary disease mainly is to accumulate the infringement intestinal in the damp and hot heresy, and QI and blood hinders and causes that more serious inflammatory disorders occurs the intestinal mucosa deep layer, and Chinese veterinarian is referred to as " intestinal is yellow ".The rule for the treatment of is with heat-clearing and toxic substances removing, logical intestinal intestinal stasis relieving, strengthening the spleen and nourishing the stomach, and effacing the pernicious influence is the rule for the treatment of.
This disease almost spreads all over all fish culture countries of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine by force, easily produces the problems such as drug resistance and drug residue owing to its toxic and side effects, and clinical practice is very limited or bans use of.
Therefore research and develop a kind of Chinese and western drugs combination for the treatment of fish enteritis, Study on Supermicro-pulverization of Traditional Chinese Drugs, bioavailability are high, and the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, the Chinese and western drugs combination, Study on Supermicro-pulverization of Traditional Chinese Drugs, bioavailability are high, treating both the principal and secondary aspects of a disease, pure Chinese medicine composition of effective treatment fish enteritis of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of fish enteritis, by following component by weight mixed preparing form: Herba Andrographis 15-35 part, Herba Euphorbiae Humifusae 15-35 part, Rhizoma Acori Graminei 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Quisqualis 25-45 part, Herba polygoni hydropiperis 15-35 part, Herba Portulacae 20-40 part, Sal 20-40 part, Cortex Phellodendri 10-40 part, Radix Scutellariae 15-45 part.
Described various component optimum ratio amount is: 25 parts of Herba Andrographis, 25 parts of Herba Euphorbiae Humifusaes, 25 parts of Rhizoma Acori Gramineis, 25 parts of Radix Et Rhizoma Rhei, 35 parts of Fructus Quisqualis, 25 parts of Herba polygoni hydropiperis, 30 parts of Herba Portulacaes, 30 parts of Sal, 25 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes.
A kind of preparation method for the treatment of the pure Chinese medicine composition of fish enteritis, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Herba Andrographis 15-35 part, Herba Euphorbiae Humifusae 15-35 part, Rhizoma Acori Graminei 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Quisqualis 25-45 part, mix 5-10 minute to even;
(3) take by weighing by weight Herba polygoni hydropiperis 15-35 part, Herba Portulacae 20-40 part, Sal 20-40 part, Cortex Phellodendri 10-40 part, Radix Scutellariae 15-45 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Herba Andrographis: bitter, cold, GUIXIN, lung, bladder, large intestine channel have the function of heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Cure mainly cold, fever, damp-heat diarrhea, carbuncle sore furunculosis etc.
Herba Euphorbiae Humifusae: hot, flat, return liver, large intestine channel, have the function of heat-clearing and toxic substances removing, cooling blood for hemostasis; Cure mainly dysentery, have loose bowels, have blood in stool, furuncle carbuncle etc.
Rhizoma Acori Graminei: hot, bitter, warm, return liver, large intestine channel, have and ward off the dirty function of having one's ideas straightened out, declare gas to pursue expectorant, detoxifcation, parasite killing; Cure mainly that anemofrigid-damp arthralgia, fulminant dysentery, breast abdominal distention are vexed, chronic bronchitis etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Fructus Quisqualis: sweet, warm, return stomach, spleen channel, have the function of killing insect and eliminating accumulation; Cure mainly ascariasis, abdominal pain due to worm stagnation, enterobiasis etc.
Herba polygoni hydropiperis: hot, warm, return lung, liver, large intestine channel, have the function of detoxifcation, damp eliminating, dissipating blood stasis, hemostasis; Cure mainly dysentery, rheumatic arthralgia, carbuncle furuncle, eczema, traumatic hemorrhage etc.
Herba Portulacae: acid, one-tenth, return liver, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly pyretic toxicity dysentery, skin ulcer general edema with yellowish skin poison, pyretic stranguria hematuria, have blood in stool etc.
Sal: cold, salty, return stomach, kidney, lung, liver, large intestine, small intestine meridian, have heat-clearing and toxic substances removing, removing heat from blood, softening the hard mass, parasite killing, antipruritic function; Cure mainly trusted subordinate's distension syndrome, constipation and anuresis, hemorrhage, skin infection etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Above all herbal medicines for paathogenic factor and the clinical symptoms of fish enteritis, are brought into play the effect for the treatment of both the principal and secondary aspects of a disease according to the theoretical compatible combination of Chinese veterinarian.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, draws materials wide, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that the treatment fish enteritis is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of fish enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of Herba Andrographis, 150 parts of Herba Euphorbiae Humifusaes, 150 parts of Rhizoma Acori Gramineis, 150 parts of Radix Et Rhizoma Rhei, 250 parts of Fructus Quisqualis, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Herba polygoni hydropiperis, 200 parts of Herba Portulacaes, 200 parts of Sal, 100 parts of Cortex Phellodendris, 150 parts of Radix Scutellariaes, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of fish enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Herba Andrographis, 250 parts of Herba Euphorbiae Humifusaes, 250 parts of Rhizoma Acori Gramineis, 250 parts of Radix Et Rhizoma Rhei, 350 parts of Fructus Quisqualis, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Herba polygoni hydropiperis, 300 parts of Herba Portulacaes, 300 parts of Sal, 250 parts of Cortex Phellodendris, 300 parts of Radix Scutellariaes, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine Chinese medicine composition for the treatment of fish enteritis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Herba Andrographis, 350 parts of Herba Euphorbiae Humifusaes, 350 parts of Rhizoma Acori Gramineis, 350 parts of Radix Et Rhizoma Rhei, 450 parts of Fructus Quisqualis, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Herba polygoni hydropiperis, 400 parts of Herba Portulacaes, 400 parts of Sal, 400 parts of Cortex Phellodendris, 450 parts of Radix Scutellariaes, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
The clinical experiment animal selects 200 ages in days, body weight at 1.5kg-2.0kg, and Laboratory Diagnosed is the ill fish of grass carp Ctenopharyngodon idellus.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 30 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " it is loose that fish takes health " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 2% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment grass carp Ctenopharyngodon idellus:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 16.7 | 30.0 | 53.3 |
| II | Fish takes the loose group of health | 6.7 | 76.6 | 16.7 |
| III | Present composition group | 3.3 | 86.7 | 10.0 |
This clinical effectiveness statistical analysis, present composition treatment group takes the loose group of health with fish and is comparing difference extremely significantly (P＜0.01) aspect the cure rate.
Safety testing:
Choose 80 age in days healthy grass carp, 30 tails, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment fish enteritis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of fish enteritis, it is characterized in that by following component by weight mixed preparing form: Herba Andrographis 15-35 part, Herba Euphorbiae Humifusae 15-35 part, Rhizoma Acori Graminei 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Quisqualis 25-45 part, Herba polygoni hydropiperis 15-35 part, Herba Portulacae 20-40 part, Sal 20-40 part, Cortex Phellodendri 10-40 part, Radix Scutellariae 15-45 part.
2. the pure Chinese medicine composition for the treatment of fish enteritis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Herba Andrographis, 25 parts of Herba Euphorbiae Humifusaes, 25 parts of Rhizoma Acori Gramineis, 25 parts of Radix Et Rhizoma Rhei, 35 parts of Fructus Quisqualis, 25 parts of Herba polygoni hydropiperis, 30 parts of Herba Portulacaes, 30 parts of Sal, 25 parts of Cortex Phellodendris, 30 parts of Radix Scutellariaes.
3. the preparation method of the pure Chinese medicine composition of a treatment fish enteritis according to claim 1 and 2 is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Herba Andrographis 15-35 part, Herba Euphorbiae Humifusae 15-35 part, Rhizoma Acori Graminei 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Quisqualis 25-45 part, mix 5-10 minute to even;
(3) take by weighing by weight Herba polygoni hydropiperis 15-35 part, Herba Portulacae 20-40 part, Sal 20-40 part, Cortex Phellodendri 10-40 part, Radix Scutellariae 15-45 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210549114.2A CN103055065B (en) | 2012-12-04 | 2012-12-04 | Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138442A (en) * | 2014-07-19 | 2014-11-12 | 扬中牧乐药业有限公司 | Compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis and preparing method of compound Chinese herbal medicine extracting solution |
| CN104224971A (en) * | 2014-09-29 | 2014-12-24 | 浙江海洋学院 | Fish medicine for treating enteritis |
| CN105749150A (en) * | 2016-03-07 | 2016-07-13 | 五河县金满塘生态种养殖家庭农场 | Control method of cod enteritis |
| CN108815281A (en) * | 2018-08-13 | 2018-11-16 | 成都通威三新药业有限公司 | A kind of aquatic products Sanhuang San and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055666A (en) * | 1986-10-27 | 1991-10-30 | 张仁威 | A kind of method of producing the fish medicine |
| CN101658594A (en) * | 2008-08-31 | 2010-03-03 | 高金波 | Medicine for treating fish enteritis |
| CN102640861A (en) * | 2011-02-17 | 2012-08-22 | 黄铭洪 | Fish feed containing traditional Chinese medicine component for preventing fish enteritis |
-
2012
- 2012-12-04 CN CN201210549114.2A patent/CN103055065B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055666A (en) * | 1986-10-27 | 1991-10-30 | 张仁威 | A kind of method of producing the fish medicine |
| CN101658594A (en) * | 2008-08-31 | 2010-03-03 | 高金波 | Medicine for treating fish enteritis |
| CN102640861A (en) * | 2011-02-17 | 2012-08-22 | 黄铭洪 | Fish feed containing traditional Chinese medicine component for preventing fish enteritis |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138442A (en) * | 2014-07-19 | 2014-11-12 | 扬中牧乐药业有限公司 | Compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis and preparing method of compound Chinese herbal medicine extracting solution |
| CN104224971A (en) * | 2014-09-29 | 2014-12-24 | 浙江海洋学院 | Fish medicine for treating enteritis |
| CN105749150A (en) * | 2016-03-07 | 2016-07-13 | 五河县金满塘生态种养殖家庭农场 | Control method of cod enteritis |
| CN108815281A (en) * | 2018-08-13 | 2018-11-16 | 成都通威三新药业有限公司 | A kind of aquatic products Sanhuang San and preparation method thereof |
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