CN104138442A - Compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis and preparing method of compound Chinese herbal medicine extracting solution - Google Patents
Compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis and preparing method of compound Chinese herbal medicine extracting solution Download PDFInfo
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Abstract
The invention relates to a compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis and a preparing method of the compound Chinese herbal medicine extracting solution. The compound Chinese herbal medicine extracting solution comprises, by weight, 29-35 parts of scutellaria baicalensis, 22-28 parts of fructus evodiae, 20-26 parts of red-knees herb, 17-23 parts of bighead atractylodes rhizome, 17-23 parts of acalypha australis, 17-23 parts of common sage herb, 17-23 parts of the root of red-rooted salvia, 13-17 parts of golden cypress, 13-17 parts of the root of kudzu vine and 8-12 parts of coptis chinensis. The preparing method of the compound Chinese herbal medicine extracting solution comprises the steps of raw medicine material picking and choosing, cleaning, medicine cutting, primary water extracting, secondary water extracting, combined decocting, concentrating, filling and packaging in sequence. By means of the compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis, the breeding survival rate of sea eel is obviously increased.
Description
Technical field
The present invention relates to prevent and treat the medicine of digestive tract or digestive system disease, refer to especially a kind of compound Chinese medicinal herb extract of preventing and treating Anguillar japonica bacterial enteritis and preparation method thereof.
Background technology
In eel culture process, often can run into bacterial enteritis disease and occur, particularly of common occurrence in Yang Man developed regions, Fujian, this disease is difficult for thoroughly curing, and relapse rate is high, seriously perplexs vast cultivation dealer.On Vehicles Collected from Market, for preventing and treating the medicine of Anguillar japonica bacterial disease, mostly be antibiotic, chemical synthetic drug etc., although can bringing into play certain curative effect, these medicines reach certain prevention effect, but also brought a series of insoluble problems such as Resistant strain increase and drug residue simultaneously, seriously restricted the sound development of eel culture.Current domestic market starts to occur that some are for preventing and treating the bacteroidal Chinese medicine preparation of Anguillar japonica, but wherein great majority are only the ground product of crude drug, exist the defect that active constituent content is low, uncertain therapeutic efficacy is cut.
Summary of the invention
Technical problem to be solved by this invention is just the defect existing for preventing and treating Anguillar japonica bacterial enteritis medicine at present, provides that a kind of curative effect of medication is definite, treated effect is high, the compound Chinese medicinal herb extract of the control Anguillar japonica bacterial enteritis of safe drug residue free and preparation method thereof.The compound Chinese medicinal herb extract of control Anguillar japonica bacterial enteritis of the present invention is prepared from by Radix Scutellariae, Fructus Evodiae, Herba polygoni hydropiperis, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Salviae Plebeiae, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Radix Puerariae and Rhizoma Coptidis, and the weight proportion scope of crude drug is: Radix Scutellariae 29-35 part, Fructus Evodiae 22-28 part, Herba polygoni hydropiperis 20-26 part, Rhizoma Atractylodis Macrocephalae 17-23 part, Herba Acalyphae 17-23 part, Herba Salviae Plebeiae 17-23 part, Radix Salviae Miltiorrhizae 17-23 part, Cortex Phellodendri 13-17 part, Radix Puerariae 13-17 part and Rhizoma Coptidis 8-12 part.Said herbal medicine is through picking, clean, cut medicine, water extraction, secondary water extraction, collecting decoction, the concentrated compound Chinese medicinal herb extract that makes control Anguillar japonica bacterial enteritis first.The conventional weight proportion of crude drug is: 10 parts of 32 parts of Radix Scutellariaes, 25 parts of Fructus Evodiaes, 23 parts of Herba polygoni hydropiperis, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Herba Acalyphaes, 20 parts of Herba Salviae Plebeiaes, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Cortex Phellodendris, 15 parts of Radix Puerariaes and Rhizoma Coptidis.
The present invention is the basis in a large amount of investigation and practice for preventing and treating the compound Chinese medicinal herb extract of Anguillar japonica bacterial enteritis, according to the design function of product, require more than 150 kinds of Chinese herbal medicine to screen, monarch, seven emotions compatibility, eighteen incompatible medicaments nineteen medicaments of mutual restraint scheduling theory according to Chinese medicine, screen one by one and the Chinese herbal medicine effective ingredients filtering out, bacteriostasis are extracted, verified, final definite formula.In prescription, the pharmacology situation of each component is: (1) Radix Scutellariae: be a kind of plant of Labiatae Scutellaria, and bitter in the mouth, cold in nature, energy heat clearing and damp drying, eliminating fire and detoxication, hemostasis.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis.(2) Fructus Evodiae: another name Fructus Evodiae, tea is peppery, paint spicy, smelly spicy tree, the deep and remote son of Zuo Lichun, rice spicy etc.Immature fruit for rutaceae Fructus Evodiae.Property: pungent, bitter, heat; Slightly poisonous; Return liver, spleen, stomach, kidney channel dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha.(3) Herba polygoni hydropiperis: acrid in the mouth, warm in nature, main component is polygodial, confertifolin, polygonone, persicarin etc.There is expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching effect.Be usually used in clinically dysentery, gastroenteritis, diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage; Venom is controlled in external, skin eczema.(4) Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature; Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration.(5) Herba Acalyphae: bitter in the mouth, puckery, cool in nature, GUIXIN, lung meridian.Be rich in alkaloid, flavonoid glycoside, phenols.There is heat-clearing and toxic substances removing, dampness removing, astringing to arrest bleeding effect.Clinically be mainly used to enteritis, dysentery, haematemesis, epistaxis, have blood in stool, hematuria, metrorrhagia, carbuncle furuncle infections, skin eczema.(6) Herba Salviae Plebeiae: be the aerial parts of labiate Herba Salviae Plebeiae SvlviaplebeiaR.Br..Herb contains flavone compound: homoplantaginin, dinatin, eupacunin and 7-glycoside thereof.Another containing phenolic substance, volatile oil, Saponin, cardiotonic glycoside, unsaturated sterol and Polyterpenes.The fatty oil of seed.Property is put down, and acrid in the mouth is nontoxic.Function: removing heat from blood, diuretic, removing toxic substances, parasite killing.(7) Radix Salviae Miltiorrhizae: for being the dry root and rhizome of dicotyledon Labiatae Labiatae Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Meridian distribution of property and flavor: hardship, is slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.(8) Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri, heat clearing away, dampness, pathogenic fire purging, removing toxic substances.Cure mainly hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, stranguria with turbid discharge, has blood in stool, aphtha of the mouth and tongue, sore swollen toxin.(9) Radix Puerariae: be the tuber of liana Herba Gelsemii Elegantis, property: sweet, pungent, cool; Return spleen, stomach warp; Function: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, angina pectoris, deafness.(10) Rhizoma Coptidis: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis.Bitter in the mouth, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, hyperactivity of heart-fire, heat in blood is told nosebleed, and conjunctival congestion is quenched one's thirst, carbuncle furuncle; External treatment eczema, eczema.
The present invention for preventing and treating the preparation flow of compound Chinese medicinal herb extract of Anguillar japonica bacterial enteritis is: the water extraction → secondary water extraction → collecting decoction → concentrated → fill → packing of the picking → clean of crude drug → cut medicine → first.
Major control condition:
Operating ambient temperature: 20-30 ℃, relative humidity 45-75%, the clean rank of production area is general production area;
Water extraction is controlled: water extraction water supply standard is drinking water, 10 times (W/W) that water extraction amount of water is inventory first, and material adds rear immersion 2 hours, and extraction time is 2 hours, and extracting and controlling temperature is 100 ℃, and mixing speed is 20 revs/min; The amount of water of secondary water extraction is 5 times (W/W) of inventory, and extraction time is 1 hour, and extracting and controlling temperature is 100 ℃, and mixing speed is 20 revs/min;
Concentrated control: adopt Steam Heating mode to concentrate under stirring, 50 revs/min of speeds of agitator, mixing time 20 minutes, the heating-up temperature that is heated medicinal liquid in control concentration heater is 90～100 ℃, vacuum is-0.05～0.08MPa, and medicinal liquid is concentrated into and crude drug identical weight.
For preventing and treating the concrete steps of the compound Chinese medicinal herb extract preparation process of Anguillar japonica bacterial enteritis:
1, picking crude drug lay in picking on platform of crude drug, sorts out the impurity in crude drug one by one.
2, clean and will put in service sink through the crude drug of picking, with drinking water washing, and the medical material after washing is put into second service sink and embathe, clean in rearmounted container and drain away the water.
3, cut medicine and according to routine, tubers crude drug is put and in medicine cutter, is cut into lamellar, and the crude drug that needs coarse crushing is put to coarse crushing in boulder crusher, put into container, send into next procedure stand-by.
4, water extraction
4.1 weigh each component according to the weight proportion of crude drug, batching operating ambient temperature: 20-30 ℃, relative humidity 45-75%;
4.2 first water extraction in extraction pot, be incorporated as the drinking water of inventory 10 times (W/W), start stirring motor, mixing speed is 20 revs/min;
4.3 join required various Chinese herbal medicine in water extraction tank, and material soaks 2 hours;
4.4 adopt extractions that heat up of Steam Heating modes, open steam valve and heat up, and control extraction temperature is 100 ℃, keep after 2 hours water extraction first to finish, and the medicinal liquid having extracted is delivered to storage tank after filtering;
During 4.5 2 water extractions, in extraction pot, add the drinking water of inventory 5 times (W/W), repeat 4.3,4.4 steps, mixing speed is 20 revs/min, wait being warming up to 100 ℃ of materials, boil extraction time while reaching 1 hour, steam off inlet valve, the medicinal liquid that secondary water extraction is extracted is transported to storage tank after filtering;
4.6 merge the extracted twice liquid of water extraction and secondary water extraction first.
5, concentrate the merging medicinal liquid after water extraction is transported to concentration heater through head tank, under stirring, adopt Steam Heating mode to concentrate, 50 revs/min of speeds of agitator, mixing time 20 minutes, opening steam valve heats up concentrated, the heating-up temperature that is heated medicinal liquid in control concentration heater is 90～100 ℃, and vacuum is-0.05～0.08MPa, until be concentrated into and crude drug identical weight.
6, fill is placed in Packaging Bottle on the feed hopper for bottle machine of fill train line, and loading amount is according to the rules carried out the fill of product, and opens automatic labeling machine Packaging Bottle is carried out to labeling.
7, packaging product packs in packing crates, and on packing crates Paste Product label.
8, warehouse-in deposits packaged product in warehouse for finished product.
What through above method, make is as follows for preventing and treating the technical specification of the bacteroidal compound Chinese medicinal herb extract finished product of Anguillar japonica:
The compound Chinese medicinal herb extract that the invention has the advantages that control Anguillar japonica bacterial enteritis has removing dampness dysentery relieving, cure mainly Anguillar japonica bacterial enteritis effect, because product of the present invention is through crude drug extraction, concentrated making, thereby this extracting solution to possess active constituent content high, using dosage is little, be easy to administration and have natural sex, noresidue, the advantage such as have no drug resistance.The compound Chinese medicinal herb extract preparation of control of the present invention Anguillar japonica bacterial enteritis to the encountered pathogenic bacteria that causes Anguillar japonica bacterial enteritis as Aeromonas hydrophila, Aeromonas sobrias etc. all have good inhibition and killing action, by repairing Anguillar japonica intestinal mucosa, helping intestinal microecology flora to rebuild.The compound Chinese medicinal herb extract preparation of control Anguillar japonica bacterial enteritis of the present invention trying out through the 85 domestic eel fields in a plurality of provinces such as Guangdong, Fujian over 2 years, by spice administration, according to every 1kg feedstuff, add medicine 2ml of the present invention, be used in conjunction 5 days, result shows the cure rate of Anguillar japonica bacterial enteritis to reach more than 91.24%, this product is regularly made an addition in feedstuff simultaneously, Anguillar japonica enteritis is had to good preventive effect.Therefore the compound Chinese medicinal herb extract of control Anguillar japonica bacterial enteritis of the present invention has wide marketing prospect.
The specific embodiment
Be below embodiments of the invention, actual use of the present invention is not limited to embodiment.
embodiment 1:
The compound Chinese medicinal herb extract preparation method that adopts the present invention to prevent and treat Anguillar japonica bacterial enteritis is prepared extracts of Chinese herbal medicine, crude drug is comprised of Radix Scutellariae, Fructus Evodiae, Herba polygoni hydropiperis, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Salviae Plebeiae, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Radix Puerariae and Rhizoma Coptidis, and the weight proportion of crude drug is Radix Scutellariae 32kg, Fructus Evodiae 25kg, Herba polygoni hydropiperis 23kg, Rhizoma Atractylodis Macrocephalae 20kg, Herba Acalyphae 20kg, Herba Salviae Plebeiae 20kg, Radix Salviae Miltiorrhizae 20kg, Cortex Phellodendri 15kg, Radix Puerariae 15kg and Rhizoma Coptidis 10kg.
Main production equipments
Major control condition:
Operating ambient temperature: 20-30 ℃, relative humidity 45-75%, the clean rank of production area is general production area;
Water extraction is controlled: water extraction water supply standard is drinking water, 10 times (W/W) that water extraction amount of water is inventory first, and material adds rear immersion 2 hours, and extraction time is 2 hours, and extracting and controlling temperature is 100 ℃, and mixing speed is 20 revs/min; The amount of water of secondary water extraction is 5 times (W/W) of inventory, and extraction time is 1 hour, and extracting and controlling temperature is 100 ℃, and mixing speed is 20 revs/min;
Concentrated control: adopt Steam Heating mode to concentrate under stirring, 50 revs/min of speeds of agitator, mixing time 20 minutes, the heating-up temperature that is heated medicinal liquid in control concentration heater is 90～100 ℃, vacuum is-0.05～0.08MPa, and medicinal liquid is concentrated into and crude drug identical weight.
To according to following operation, operate by the crude drug of proportioning preparation:
1, picking crude drug lay in picking on platform of crude drug, sorts out the impurity in crude drug one by one.
2, clean and will put in service sink through the crude drug of picking, with drinking water washing, and the medical material after washing is put into second service sink and embathe, clean in rearmounted container and drain away the water.
3, cut medicine and according to routine, tubers crude drug is put and in reciprocating medicine cutter, is cut into lamellar, and the crude drug that needs coarse crushing is put to coarse crushing in boulder crusher, put into container, send into next procedure stand-by.
4, water extraction
4.1 weigh each component according to the weight proportion of crude drug, batching operating ambient temperature: 20-30 ℃, relative humidity 45-75%;
4.2 first water extraction in dynamic extraction pot, be incorporated as the drinking water that inventory 10 times (W/W) is 2000kg, start stirring motor, mixing speed is 20 revs/min;
4.3 join required various Chinese herbal medicine in dynamic extraction pot, and material soaks 2 hours;
4.4 adopt extractions that heat up of Steam Heating modes, open steam valve and heat up, and control extraction temperature is 100 ℃, keep after 2 hours water extraction first to finish, and the medicinal liquid having extracted is delivered to basin after filtering;
The drinking water that adds 5 times of (W/W) 1000kg of inventory during 4.5 2 water extractions in dynamic extraction pot, repeat 4.3,4.4 steps, mixing speed is 20 revs/min, wait being warming up to 100 ℃ of materials, boil extraction time while reaching 1 hour, steam off inlet valve, the medicinal liquid that secondary water extraction is extracted is transported to storage tank after filtering;
4.6 merge the extracted twice liquid of water extraction and secondary water extraction first.
5, concentrate the merging medicinal liquid after water extraction is transported to scraper-type vacuum concentrator through head tank, under stirring, adopt Steam Heating mode to concentrate, 50 revs/min of speeds of agitator, mixing time 20 minutes, opening steam valve heats up concentrated, the heating-up temperature that is heated medicinal liquid in control scraper-type vacuum concentrator is 90～100 ℃, and vacuum is-0.05～0.08MPa, and being concentrated into crude drug identical weight is 200kg.
6, fill is placed in Packaging Bottle on the feed hopper for bottle machine of fill train line, and loading amount is according to the rules carried out the fill of product.
7, packing is opened automatic labeling machine Packaging Bottle is carried out to labeling, and loading amount packs product in packing crates in accordance with regulations, and on packing crates Paste Product label.
8, warehouse-in deposits packaged product in warehouse for finished product.
The compound Chinese medicinal herb extract finished product of the control Anguillar japonica bacterial enteritis making according to above method reaches following technical specification:
The compound Chinese medicinal herb extract finished product technical specification of control Anguillar japonica bacterial enteritis
| Sequence number | Project | Index |
| 1 | Character | Brown liquid |
| 2 | PH value | 4.8 |
| 3 | Relative density | 1.09 |
| 4 | Effective ingredient total flavones (in rutin) | 7.9mg/ml |
Through 3 Anguillar japonica fields, amounting to tail more than 4000 suffers from the Anguillar japonica of bacterial enteritis and applies this finished product, the consumption that adds compound Chinese medicinal herb extract 2 mL of the present invention according to per kilogram feedstuff is used, and is used in conjunction 5 days, result: show that the total effective rate that this invention is used for the treatment of Anguillar japonica bacterial enteritis has reached 93.3%.
embodiment 2:
Adopt the present invention to prevent and treat the bacteroidal compound Chinese medicinal herb extract preparation method of Anguillar japonica and prepare extracts of Chinese herbal medicine, crude drug is comprised of Radix Scutellariae, Fructus Evodiae, Herba polygoni hydropiperis, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Salviae Plebeiae, Radix Salviae Miltiorrhizae, Cortex Phellodendri and Rhizoma Coptidis, and the weight proportion of crude drug is Radix Scutellariae 29 kg, Fructus Evodiae 22 kg, Herba polygoni hydropiperis 20 kg, Rhizoma Atractylodis Macrocephalae 17kg part, Herba Acalyphae 17 kg, Herba Salviae Plebeiae 17kg, Radix Salviae Miltiorrhizae 17kg, Cortex Phellodendri 13kg, Radix Puerariae 13kg and Rhizoma Coptidis 8 kg.
Main production equipments, major control condition and production process are with embodiment 1.
The bacteroidal compound Chinese medicinal herb extract finished product of control Anguillar japonica making reaches following technical specification:
| Sequence number | Project | Index |
| 1 | Character | Brown liquid |
| 2 | PH value | 5.0 |
| 3 | Relative density | 1.06 |
| 4 | Effective ingredient total flavones (in rutin) | 7.3 mg/ml |
Through 4 Anguillar japonica fields, amounting to tail more than 7500 suffers from the Anguillar japonica of bacterial enteritis and applies this finished product, the consumption that adds compound Chinese medicinal herb extract 2mL of the present invention according to per kilogram feedstuff is used, and is used in conjunction 5 days, result: show that the total effective rate that this invention is used for the treatment of Anguillar japonica bacterial enteritis has reached 91.4%.
embodiment 3:
The compound Chinese medicinal herb extract preparation method that adopts the present invention to prevent and treat Anguillar japonica bacterial enteritis is prepared extracts of Chinese herbal medicine, crude drug is comprised of Radix Scutellariae, Fructus Evodiae, Herba polygoni hydropiperis, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Salviae Plebeiae, Radix Salviae Miltiorrhizae, Cortex Phellodendri and Rhizoma Coptidis, and the weight proportion of crude drug is Radix Scutellariae 35kg, Fructus Evodiae 28kg, Herba polygoni hydropiperis 26kg, Rhizoma Atractylodis Macrocephalae 23kg, Herba Acalyphae 23kg, Herba Salviae Plebeiae 23kg, Radix Salviae Miltiorrhizae 23kg, Cortex Phellodendri 17kg, Radix Puerariae 17kg and Rhizoma Coptidis 12kg.
Main production equipments, major control condition and production process are with embodiment 1.
The bacteroidal compound Chinese medicinal herb extract finished product of control Anguillar japonica making reaches following technical specification:
| Sequence number | Project | Index |
| 1 | Character | Brown liquid |
| 2 | PH value | 4.7 |
| 3 | Relative density | 1.11 |
| 4 | Effective ingredient total flavones (in rutin) | 8.1mg/ml |
Through 2 Anguillar japonica fields, amounting to tail more than 3000 suffers from the Anguillar japonica of bacterial enteritis and applies this finished product, the consumption that adds compound Chinese medicinal herb extract 2mL of the present invention according to per kilogram feedstuff is used, and is used in conjunction 5 days, result: show that the total effective rate that this invention is used for the treatment of Anguillar japonica bacterial enteritis has reached 94.8%.
Claims (9)
1. a compound Chinese medicinal herb extract of preventing and treating Anguillar japonica bacterial enteritis, it is characterized in that being prepared from by Radix Scutellariae, Fructus Evodiae, Herba polygoni hydropiperis, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Salviae Plebeiae, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Radix Puerariae and Rhizoma Coptidis, the weight proportion scope of crude drug is: Radix Scutellariae 29-35 part, Fructus Evodiae 22-28 part, Herba polygoni hydropiperis 20-26 part, Rhizoma Atractylodis Macrocephalae 17-23 part, Herba Acalyphae 17-23 part, Herba Salviae Plebeiae 17-23 part, Radix Salviae Miltiorrhizae 17-23 part, Cortex Phellodendri 13-17 part, Radix Puerariae 13-17 part and Rhizoma Coptidis 8-12 part.
2. the compound Chinese medicinal herb extract of control Anguillar japonica bacterial enteritis according to claim 1, is characterized in that the weight proportion of crude drug is: Radix Scutellariae 32 kg, Fructus Evodiae 25 kg, Herba polygoni hydropiperis 23 kg, the Rhizoma Atractylodis Macrocephalae 20 kg, Herba Acalyphae 20 kg, Herba Salviae Plebeiae 20 kg, Radix Salviae Miltiorrhizae 20 kg, Cortex Phellodendri 15 kg, Radix Puerariae 15 kg and Rhizoma Coptidis 10 kg.
3. the compound Chinese medicinal herb extract of control Anguillar japonica bacterial enteritis according to claim 1, is characterized in that the weight proportion of crude drug is: Radix Scutellariae 29 kg, Fructus Evodiae 22 kg, Herba polygoni hydropiperis 20 kg, Rhizoma Atractylodis Macrocephalae 17kg part, Herba Acalyphae 17 kg, Herba Salviae Plebeiae 17kg, Radix Salviae Miltiorrhizae 17kg, Cortex Phellodendri 13kg part, 13 parts of Radix Puerariaes and Rhizoma Coptidis 8 kg.
4. the compound Chinese medicinal herb extract of control according to claim 1 Anguillar japonica bacterial enteritis, is characterized in that the weight proportion of crude drug is: Radix Scutellariae 35kg, Fructus Evodiae 28kg, Herba polygoni hydropiperis 26kg, Rhizoma Atractylodis Macrocephalae 23kg, Herba Acalyphae 23kg, Herba Salviae Plebeiae 23 kg, Radix Salviae Miltiorrhizae 23 kg, Cortex Phellodendri 17kg,, 17 parts of Radix Puerariaes and Rhizoma Coptidis 12kg.
5. the compound Chinese medicinal herb extract of control according to claim 1 Anguillar japonica bacterial enteritis, it is characterized in that compound Chinese medicinal herb extract finished product is brown liquid, pH value is 4.5～6.5, and relative density is 1.05～1.12, effective ingredient total flavones (in rutin) >=7.2mg/ml.
6. the compound Chinese medicinal herb extract of control according to claim 2 Anguillar japonica bacterial enteritis, is characterized in that compound Chinese medicinal herb extract finished product pH value is 4.8, and relative density is 1.09, and effective ingredient total flavones (take rutin) is 7.9mg/ml.
7. the compound Chinese medicinal herb extract of control according to claim 3 Anguillar japonica bacterial enteritis, is characterized in that compound Chinese medicinal herb extract finished product pH value is 5.0, and relative density is 1.06, and effective ingredient total flavones (take rutin) is 7.3mg/ml.
8. the compound Chinese medicinal herb extract of control according to claim 4 Anguillar japonica bacterial enteritis, is characterized in that compound Chinese medicinal herb extract finished product pH value is 4.7, and relative density is 1.11, and effective ingredient total flavones (take rutin) is 8.1mg/ml.
9. the compound Chinese medicinal herb extract of control according to claim 1 Anguillar japonica bacterial enteritis, is characterized in that the preparation flow of compound Chinese medicinal herb extract is: the water extraction → secondary water extraction → collecting decoction → concentrated → fill → packing of the picking → clean of crude drug → cut medicine → first; Major control condition: operating ambient temperature: 20-30 ℃, relative humidity 45-75%, the clean rank of production area is general production area; Water extraction is controlled: water extraction water supply standard is drinking water, and water extraction amount of water is 10 times of weight of feeding intake first, and material adds rear immersion 2 hours, and extraction time is 2 hours, and extracting and controlling temperature is 100 ℃, and mixing speed is 20 revs/min; The amount of water of secondary water extraction is 5 times of weight of feeding intake, and extraction time is 1 hour, and extracting and controlling temperature is 100 ℃, and mixing speed is 20 revs/min; Concentrated control: adopt Steam Heating mode to concentrate under stirring, 50 revs/min of speeds of agitator, mixing time 20 minutes, the heating-up temperature that is heated medicinal liquid in control concentration heater is 90～100 ℃, vacuum is-0.05～0.08MPa, and medicinal liquid is concentrated into and crude drug identical weight.
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| CN105749150A (en) * | 2016-03-07 | 2016-07-13 | 五河县金满塘生态种养殖家庭农场 | Control method of cod enteritis |
| CN106074737A (en) * | 2016-08-12 | 2016-11-09 | 镇江天和生物技术有限公司 | A kind of pharmaceutical preparation preventing Ctenopharyngodon idellus bacterial enteritis |
| CN107714842A (en) * | 2017-10-26 | 2018-02-23 | 贵州省松桃吉光农业发展有限责任公司 | A kind of Chinese medicine preparation for treating mandarin sturgeon enteritis disease and preparation method thereof |
| CN107927330A (en) * | 2017-11-21 | 2018-04-20 | 山东省海洋生物研究院 | A kind of Chinese herbal feed additive for treating fish enteritis |
| CN116327830A (en) * | 2023-05-04 | 2023-06-27 | 海南医学院 | Traditional Chinese medicine composition for resisting oxidization and regulating intestinal flora and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055065A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition |
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2014
- 2014-07-19 CN CN201410343801.8A patent/CN104138442A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055065A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating enteritis of fish and preparation method of pure Chinese medicinal composition |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749150A (en) * | 2016-03-07 | 2016-07-13 | 五河县金满塘生态种养殖家庭农场 | Control method of cod enteritis |
| CN106074737A (en) * | 2016-08-12 | 2016-11-09 | 镇江天和生物技术有限公司 | A kind of pharmaceutical preparation preventing Ctenopharyngodon idellus bacterial enteritis |
| CN107714842A (en) * | 2017-10-26 | 2018-02-23 | 贵州省松桃吉光农业发展有限责任公司 | A kind of Chinese medicine preparation for treating mandarin sturgeon enteritis disease and preparation method thereof |
| CN107927330A (en) * | 2017-11-21 | 2018-04-20 | 山东省海洋生物研究院 | A kind of Chinese herbal feed additive for treating fish enteritis |
| CN107927330B (en) * | 2017-11-21 | 2020-02-14 | 山东省海洋生物研究院 | Chinese herbal medicine feed additive for treating fish enteritis |
| CN116327830A (en) * | 2023-05-04 | 2023-06-27 | 海南医学院 | Traditional Chinese medicine composition for resisting oxidization and regulating intestinal flora and preparation method thereof |
| CN116327830B (en) * | 2023-05-04 | 2024-04-12 | 海南医学院 | Traditional Chinese medicine composition for resisting oxidization and regulating intestinal flora and preparation method thereof |
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Application publication date: 20141112 |