CN103463287A - Novel method for preparing anti-hyperosteogeny tablet - Google Patents
Novel method for preparing anti-hyperosteogeny tablet Download PDFInfo
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- CN103463287A CN103463287A CN2013103898040A CN201310389804A CN103463287A CN 103463287 A CN103463287 A CN 103463287A CN 2013103898040 A CN2013103898040 A CN 2013103898040A CN 201310389804 A CN201310389804 A CN 201310389804A CN 103463287 A CN103463287 A CN 103463287A
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- caulis spatholobi
- hyperosteogeny
- herba
- tablet
- radix rehmanniae
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Abstract
The invention mainly provides a novel method for preparing an anti-hyperosteogeny tablet. The method comprises a step of extracting the medicinal materials in the original prescription by using 60% ethanol. The method has the following beneficial effects that the precipitation of effective ingredients is increased, the quality of a product is improved, and the curative effect of the tablet is enhanced. The production cost of the anti-hyperosteogeny tablet is reduced generally and the production efficiency is improved.
Description
Technical field
The invention belongs to the field of Chinese medicines, is a kind of new technology for preparing Chinese medicine.
Background technology
Anti-hyperosteogeny tablets is the tcm product that ten thousand logical Pharmaceuticaies are produced, and has the effect of " the kidney invigorating, invigorate blood circulation, pain relieving ", for hypertrophic spondylitis, and cervical spondylosis, calcanean spur proliferative arthritis, Kaschin-Beck disease etc.Its preparation method adopts " ministry standard Traditional Chinese medicine historical preparation " the 7th standard of recording, standard No.: WS3-B-1338-93.Original prescription and method for making are as follows:
[prescription]
Radix Rehmanniae Preparata 204g Herba Pyrolae 136g Rhizoma Drynariae (scalding) 136g
Caulis Spatholobi 136g Herba Cistanches 136g Herba Epimedii 136g
Semen Raphani (stir-fry) 86g
[method for making]
Above seven flavors, get Caulis Spatholobi 68g and be ground into fine powder, and the Six-elements such as remaining Caulis Spatholobi and all the other Radix Rehmanniae Preparata decoct with water secondary, 3 hours for the first time, 2 hours for the second time, filter merging filtrate, be condensed into thick paste, add above-mentioned powder, mix, dry, pulverize, add right amount of auxiliary materials, mix, granulate, drying, be pressed into 1000, sugar coating, obtain.
Wherein, Radix Rehmanniae is concocted and forms through processing for the tuber for scrophulariaceae rehmannia glutinosa plant.Modern study, the contained Dihuang polysaccharide of Radix Rehmanniae Preparata has obvious immune antitumor activity, also has significant heart tonifying, diuresis, protects the liver, the effect such as blood sugar lowering, anti-hypertrophy, exudation, antiinflammatory, antifungal, anti-radiation.Radix Rehmanniae Preparata, containing the iridoid constituents of small amount, comprises Herba Leonuri glycoside, aucubin, catalpol, Rehmannioside A, B, C, D etc.
The herb that Herba Pyrolae is Pyrolaceae plant Herba pyrolae japonicae or Pylora rotundolia etc., have another name called Herba pyrolae japonicae.Effect comprises: tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation; For weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage etc.Herba Pyrolae is containing Homoarbutin, chimaphilin, N-phenyl-2-naphthylamine, Pyrolin (methylnaphthohydroquinone), Quercetin, protocatechuic acid and gallic acid etc.
Rhizoma Drynariae: the dry rhizome for Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi, there is the kidney invigorating, to invigorate blood circulation, the effect of hemostasis, cure mainly suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.Main containing naringin, 21-hopenen, cupreol, stigmasterol, the compositions such as oil recovery sterol and tetracyclic triterpenoid.
The dry rattan that Caulis Spatholobi is the leguminous plant spatholobus suberectus.Have and enrich blood, invigorate blood circulation, the effect of dredging collateral, for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing epicatechin, protocatechuic acid, formoononetin, ononin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol etc.
The fleshy stem of the dry zone scale leaf that Herba Cistanches is orobanchaceae plant cistanche, but kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation, for sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, the dryness of the intestine constipation.Herba Cistanches contains the Herba Cistanches element, chloro Herba Cistanches, 8-table deoxidation lognic acid, alkene ether terpene, lignanoid, Cistanoside A, B, C, D, E, F, mannitol, sitosterol, succinic acid, sitosterol-β-D-Glucose glycoside etc.
The dried leaves that Herba Epimedii is Berberidaceae plant Herba Epimedii, arrow leaf Herba Epimedii, pubescence Herba Epimedii or Herba Epimedii.Kidney-replenishing is arranged, bone and muscle strengthening, the effect of wind-damp dispelling, can be used for impotence and seminal emission, and the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension, mainly containing flavone compound, lignanoid, alkaloid, volatilization wet goods.
Semen Raphani has another name called Semen Raphani, trailing plants white chessman, Semen Raphani etc., is the mature seed of crucifer Radix Raphani.The de-swelling that can help digestion, lowering the adverse-rising QI to resolve phlegm, can be used for being used for the treatment of retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant and stop up and breath with cough etc.Fatty oil, volatilization wet goods.
Above composition all is dissolved in ethanol.
Summary of the invention
The present invention mainly has been to provide a kind of new method for preparing anti-hyperosteogeny tablets, and its positive beneficial effect is, and the one, shortened the time of extracting, reduced the consumption of solvent, the 2nd, increased yield, reduced on the whole the production cost of anti-hyperosteogeny tablets, improved production efficiency.
Prescription: Radix Rehmanniae Preparata 204g Herba Pyrolae 136g Rhizoma Drynariae (scalding) 136g
Caulis Spatholobi 136g Herba Cistanches 136g Herba Epimedii 136g
Semen Raphani (stir-fry) 86g
Method for making: above seven flavors, to get Caulis Spatholobi 68g and be ground into fine powder, the Six-elements such as remaining Caulis Spatholobi and all the other Radix Rehmanniae Preparata add 60% ethanol, the heating and refluxing extraction secondary, each 2 hours, filter merging filtrate, reclaim ethanol and be concentrated in right amount, adding the Caulis Spatholobi fine powder, mixing, dry, pulverize, add right amount of auxiliary materials, mix, granulate, drying, be pressed into 1000, sugar coating, obtain.
Technique comparative illustration before and after improving:
The traditional water extraction of 1 former process using, after improving, adopt alcohol extraction to follow the example of, the effective ingredient of above-mentioned medical material all dissolves in ethanol, therefore simple water extraction is unfavorable for the proposition of Alcohol soluble composition, change effective ingredient can be proposed after alcohol extraction more thorough into, can increase curative effect of medication.
Experiment contrast index is as follows:
The traditional water extraction of 2 former process using, directly adopt alcohol extraction after improving, shortened extraction time, increased paste-forming rate, reduced the consumption of the energy.
Claims (1)
1. a method for preparing anti-hyperosteogeny tablets, its raw material medicament preparation method is as follows:
[prescription]
Radix Rehmanniae Preparata 204g Herba Pyrolae 136g Rhizoma Drynariae (scalding) 136g
Caulis Spatholobi 136g Herba Cistanches 136g Herba Epimedii 136g
Semen Raphani (stir-fry) 86g
[preparation method]
Above seven flavors, get Caulis Spatholobi 68g and be ground into fine powder, and the Six-elements such as remaining Caulis Spatholobi and all the other Radix Rehmanniae Preparata add 60% ethanol, the heating and refluxing extraction secondary, each 2 hours, filter merging filtrate, reclaim ethanol and be concentrated in right amount, adding the Caulis Spatholobi fine powder, mixing, dry, pulverize, add right amount of auxiliary materials, mix, granulate, drying, be pressed into 1000, sugar coating, obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103898040A CN103463287A (en) | 2013-08-28 | 2013-08-28 | Novel method for preparing anti-hyperosteogeny tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103898040A CN103463287A (en) | 2013-08-28 | 2013-08-28 | Novel method for preparing anti-hyperosteogeny tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103463287A true CN103463287A (en) | 2013-12-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2013103898040A Pending CN103463287A (en) | 2013-08-28 | 2013-08-28 | Novel method for preparing anti-hyperosteogeny tablet |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919905A (en) * | 2014-04-01 | 2014-07-16 | 湖南方盛制药股份有限公司 | Medicine composition as well as preparation method and application of medicine composition in preparation of medicines for treating osteoporosis |
| CN108186791A (en) * | 2018-03-27 | 2018-06-22 | 国药集团冯了性（佛山）药业有限公司 | A kind of Chinese medicine composition and its preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456241A (en) * | 2003-02-18 | 2003-11-19 | 毛友昌 | Method for preparing capsules against osteoproliferation |
| CN1742871A (en) * | 2005-09-23 | 2006-03-08 | 北京阜康仁生物制药科技有限公司 | Gamboge bone-tonifying preparation and new preparation method thereof |
| CN102961494A (en) * | 2012-11-22 | 2013-03-13 | 新乡医学院第三附属医院 | Plaster for treating lumbar hyperosteogeny |
-
2013
- 2013-08-28 CN CN2013103898040A patent/CN103463287A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456241A (en) * | 2003-02-18 | 2003-11-19 | 毛友昌 | Method for preparing capsules against osteoproliferation |
| CN1742871A (en) * | 2005-09-23 | 2006-03-08 | 北京阜康仁生物制药科技有限公司 | Gamboge bone-tonifying preparation and new preparation method thereof |
| CN102961494A (en) * | 2012-11-22 | 2013-03-13 | 新乡医学院第三附属医院 | Plaster for treating lumbar hyperosteogeny |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919905A (en) * | 2014-04-01 | 2014-07-16 | 湖南方盛制药股份有限公司 | Medicine composition as well as preparation method and application of medicine composition in preparation of medicines for treating osteoporosis |
| CN103919905B (en) * | 2014-04-01 | 2015-11-18 | 湖南方盛制药股份有限公司 | Pharmaceutical composition, preparation method and the application in the medicine for the preparation for the treatment of osteoporosis thereof |
| CN108186791A (en) * | 2018-03-27 | 2018-06-22 | 国药集团冯了性（佛山）药业有限公司 | A kind of Chinese medicine composition and its preparation method and application |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C05 | Deemed withdrawal (patent law before 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131225 |