CN1742871A - Gamboge bone-tonifying preparation and new preparation method thereof - Google Patents
Gamboge bone-tonifying preparation and new preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a prescription of Chinese medicine preparation for effectively curing the diseases of hypertrophic spondylopathy, cervical spondylopathy, calcaneal spur, hyperplastic arthritis and Kaschin-Beck disease with obvious therapeutic effect and its preparation process. It is made up by using 7 Chinese medicinal materials of cooked rehmannia root, pyrola, drynaria root, cistanche stem, epimedium, millettia root and stem and radish seed. Said preparation can be made into various dosage forms of dripping pills and soft capsule, et.
Description
Technical field:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, particularly a kind of treatment hypertrophic spondylitis, cervical spondylosis, calcanean spur, proliferative arthritis, the preparation recipe of Kaschin-Beck disease and preparation technology thereof.
Background technology:
Hypertrophic spondylitis, cervical spondylosis, calcanean spur, proliferative arthritis, Kaschin-Beck disease all belong to osteopathia.Wherein cervical spondylosis is because the syndrome of degeneration of cervical intervertebral disc, the caused a series of clinical symptoms of hyperosteogeny of cervical vertebra; Proliferative arthritis also claims osteoarthritis, hypertrophy or degenerative osteoarthritis, clinical with rest pain, arthroncus, joint motion is limited and lopsided be cardinal symptom, be middle-aged and elderly people and heavy worker's commonly encountered diseases.
More than be common clinical.
The Radix Rehmanniae Preparata yin nourishing of enriching blood among the we, life essence-filling, marrow-benefitting; The Herba Pyrolae wind-damp dispelling, bone and muscle strengthening, hemostasis, cough-relieving; Rhizoma Drynariae is invigorated blood circulation to continue and is hindered the kidney invigorating bone strengthening; The Herba Cistanches reinforcing the kidney and supporting YANG, loosening bowel to relieve constipation; The Herba Epimedii kidney invigorating and YANG supporting, expelling wind and removing dampness.Many medicines share, and play the kidney invigorating altogether, invigorate blood circulation the analgesic effect.Preparation behind the change preparation technology is easy to dissolving and absorption than elite and thick putting that previous technology more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, capsule, tablet, pill, its various dosage forms that make can be used for curing mainly hypertrophic spondylitis, cervical spondylosis, calcanean spur, proliferative arthritis, Kaschin-Beck disease.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is made up of following proportion raw material and adjuvant:
72～1000 parts of Radix Rehmanniae Preparata 72～1000 parts of Rhizoma Drynariae of 107～1500 portions of Herba Pyrolaes (scalding)
72～1000 parts of 72～1000 portions of Caulis Spatholobis of 72～1000 parts of Herba Epimedii of Herba Cistanches
36～500 parts of Semen Raphanis (stir-fry)
Preferably:
500 parts of Radix Rehmanniae Preparata 500 parts of Rhizoma Drynariae of 750 portions of Herba Pyrolaes (scalding)
500 parts of 500 portions of Caulis Spatholobis of 500 parts of Herba Epimedii of Herba Cistanches
250 parts of Semen Raphanis (stir-fry)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, granule 1000g etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50-1000 taking dose,, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, tablet, capsule or pill.
The above new technology of the present invention may further comprise the steps:
Method a:
(1) get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 50～75% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste;
(2) get the residue medical material, decoct three times with 10 times of water gagings, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste;
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:
(1) get medical material except that Herba Epimedii, Herba Pyrolae, place container, it is an amount of to add aqueous solution, and supersound extraction certain hour (about 30～45 minutes) is put to room temperature, adds aqueous solution to scale, shakes up, and filters, and gets filtrate, reclaims promptly;
(2) all the other medicinal material extract are the same.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, perhaps their mixture or other suitable other auxiliary elements such as glycerol, gelatin or stearic acid sodium etc. of making drop pill.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2.Wherein the weight proportion between active component and the pharmaceutically useful organic solvent is: the content of active component is 50mg-500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with above-mentioned extract obtained, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with above-mentioned extract obtained, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation such as granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
(1) to the influence of rats with osteoporosis
1, animal model
Get 40 of rats by document, be divided into 4 groups at random, the anesthesia of ip35mg/kg amobarbital sodium, dorsal position is fixed, vertical red incision rat neck center skin, subcutaneous tissue.Cut off platysma with eye scissors, passivity is separated the throat fascia, with pulling force with muscle group laterally, appears thyroid cartilage.Rat thyroid and parathyroid gland are provoked trachea between trachea and esophagus, be sandwiched in thyroid with mosquito forceps, and parathyroid gland is the syringe needle size, and rice white is positioned at the outside before the thyroid, about each 1.Clamp the both sides parathyroid gland respectively with pincet, with excising after No. 1 silk thread ligation.With No. 1 silk suture platysma, with ampicillin injection flushing otch surrounding tissue, reuse No. 3 silk suture throats flesh and fascia, subcutaneous tissue and skin.Postoperative 6d takes out stitches under anesthesia, raises after 3 months as experiment.The matched group surgical procedure of playing tricks is only cut the throat fascia, exposes thyroid and parathyroid gland, but does not excise.
2, result
2.1 influence to rat body bone density and bone mineral content
Rat is divided into 3 groups at random after getting modeling, irritate stomach respectively with 1. 2. extractum group (0.11g/kg) of extractum group (0.18g/kg) technology of volume normal saline (NS), technology, get simultaneously with 10 of the rats (sham operated rats) of end of term modeling, irritate stomach and made blank with the normal saline of volume.Every day 1 time, after continuous 90 days, use the amobarbital sodium anesthetized rat, bone density (BMD) and bone mineral content (BMC) with dual intensity X line bone densitometry rat body the results are shown in Table 1.
The bone density of table 1 pair rat body and the influence of bone mineral content (
x± s)
| Group | Dosage (g/kg) | Animal (only) | BMD(g/cm 2) | BMC(g) |
| Blank model technology is 1. extractum group of extractum group technology 1. | - - 0.18 0.11 | 10 10 10 10 | 0.432±0.037 0.332±0.024 0.395±0.028 ** 0.387±0.015 ** | 0.35±0.062 0.22±0.042 0.31±0.057 ** 0.30±0.01 ** |
Compare with model group
*P＜0.01,
*P＜0.05 (down together)
Gamboge bone-tonifying extractum whole body BMD, BMC are significantly increased as shown in Table 1.
2.2 to the bone density of rat femur and the influence of bone mineral content
Above-mentioned rat is measured rat femur density, bone mineral content simultaneously with the close analyzer of dual intensity X line bone, the results are shown in Table 2.
Table 2
| Group | Dosage (g/kg) | Animal (only) | BMD(g/cm 2) | BMC(g) |
| Blank model technology is 1. extractum group of extractum group technology 1. | - - 0.18 0.11 | 10 10 10 10 | 0.371±0.0.025 0.286±0.018 0.330±0.018 ** 0.313±0.011 ** | 8.56±1.321 6.63±0.797 7.76±0.917 ** 7.45±0.360 ** |
As shown in Table 2, Gamboge bone-tonifying extractum and model group compare, and femoral bmd, bone mineral content all have highly significant difference.
(2) toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment hypertrophic spondylitises, cervical spondylosis, calcanean spur, proliferative arthritis, the medicine of Kaschin-Beck disease, and change preparation technology, can obviously strengthen its kidney invigorating, invigorate blood circulation, clinical efficacy such as pain relieving, do not have tangible toxicity, prolonged application safety in addition, therefore, being worth clinical further applies.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Radix Rehmanniae Preparata 107g Herba Pyrolae 72g Rhizoma Drynariae (scalding) 72g
Herba Cistanches 72g Herba Epimedii 72g Caulis Spatholobi 72g
Semen Raphani (stir-fry) 36g
PEG600 100g
Make 1000 balls
Preparation method:
Get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 75% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste; Get the residue medical material, decoct three times with 10 times of water gagings, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste; With above-mentioned extract obtained, the PEG600 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Radix Rehmanniae Preparata 461g Herba Pyrolae 307g Rhizoma Drynariae (scalding) 307g
Herba Cistanches 307g Herba Epimedii 307g Caulis Spatholobi 307g
Semen Raphani (stir-fry) 154g
PEG600 470g
Make 1000
Preparation method:
Get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 75% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste; Get the residue medical material, decoct three times with 10 times of water gagings, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste; With above-mentioned extract obtained, add an amount of PEG600 mixing and pulverizing, add the PEG600 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable splashes in the coolant (liquid paraffin), promptly.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Rehmanniae Preparata 1500g Herba Pyrolae 1000g Rhizoma Drynariae (scalding) 1000g
Herba Cistanches 1000g Herba Epimedii 1000g Caulis Spatholobi 1000g
Semen Raphani (stir-fry) 500g
Make 1000g
Preparation method:
Get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 60% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste; Get the residue medical material, place container, the adding aqueous solution is an amount of, supersound extraction certain hour (about 30～45 minutes) is put to room temperature, adds aqueous solution to scale, shake up, filter, get filtrate, reclaim promptly. with above extract drying, be ground into fine powder, sieve, mixing adds aspartame 5.0g, dextrin 100.0g, granulates, drying promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Radix Rehmanniae Preparata 500g Herba Pyrolae 333g Rhizoma Drynariae (scalding) 333g
Herba Cistanches 333g Herba Epimedii 333g Caulis Spatholobi 333g
Semen Raphani (stir-fry) 167g
Make 1000
Preparation method:
Get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 60% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste; Get the residue medical material, place container, the adding aqueous solution is an amount of, and supersound extraction certain hour (about 30～45 minutes) is put to room temperature, adds aqueous solution to scale, shakes up, and filters, and gets filtrate, reclaims promptly.The extract of gained is pulverized, sieved, mixing adds aspartame 3.0g, mannitol 200.0g, granulation, and drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine composition is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
72～1000 parts of Radix Rehmanniae Preparata 72～1000 parts of Rhizoma Drynariae of 107～1500 portions of Herba Pyrolaes (scalding)
72～1000 parts of 72～1000 portions of Caulis Spatholobis of 72～1000 parts of Herba Epimedii of Herba Cistanches
36～500 parts of Semen Raphanis (stir-fry)
2, the compound preparation of claim 1～2 is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
500 parts of Radix Rehmanniae Preparata 500 parts of Rhizoma Drynariae of 750 portions of Herba Pyrolaes (scalding)
500 parts of 500 portions of Caulis Spatholobis of 500 parts of Herba Epimedii of Herba Cistanches
250 parts of Semen Raphanis (stir-fry)
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, granule, chewable tablet, tablet, capsule or pill.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 50～75% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste;
(2) get the residue medical material, decoct three times with 10 times of water gagings, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:(technology 2.)
(1) get medical material except that Herba Epimedii, Herba Pyrolae, place container, it is an amount of to add aqueous solution, and supersound extraction certain hour (about 30～45 minutes) is put to room temperature, adds aqueous solution to scale, shakes up, and filters, and gets filtrate, reclaims promptly;
(2) all the other medicinal material extract are the same.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
6, the Chinese medicine preparation of claim 5, it is characterized in that: described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60-115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, coolant temperature is-and 10-5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that: described soft capsule, and its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg-500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of granule is as follows: with above-mentioned extract obtained, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of correctives, filler, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that: described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1-9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:
(1) get Herba Epimedii, Herba Pyrolae two flavor medical materials, measure 50～75% alcohol reflux 3 times with 8 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste;
(2) get the residue medical material, decoct three times with 10 times of water gagings, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing drop pill of the present invention and soft capsule preparation.
Method b:
(1) get medical material except that Herba Epimedii, Herba Pyrolae, place container, it is an amount of to add aqueous solution, and supersound extraction certain hour (about 30～45 minutes) is put to room temperature, adds aqueous solution to scale, shakes up, and filters, and gets filtrate, reclaims promptly.
(2) all the other medicinal material extract are the same.
Above extract lumps together the active constituents of medicine into preparation of the present invention; This active component is suitable for preparing other dosage forms except that drop pill and soft capsule preparation of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60-115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, coolant temperature is-and 10-5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg-500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101053312A CN1742871A (en) | 2005-09-23 | 2005-09-23 | Gamboge bone-tonifying preparation and new preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101053312A CN1742871A (en) | 2005-09-23 | 2005-09-23 | Gamboge bone-tonifying preparation and new preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1742871A true CN1742871A (en) | 2006-03-08 |
Family
ID=36138496
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005101053312A Pending CN1742871A (en) | 2005-09-23 | 2005-09-23 | Gamboge bone-tonifying preparation and new preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102608249A (en) * | 2012-03-06 | 2012-07-25 | 长春人民药业集团有限公司 | Detection method of Tenghuang Jiangu pill |
| CN103463287A (en) * | 2013-08-28 | 2013-12-25 | 李颖 | Novel method for preparing anti-hyperosteogeny tablet |
| CN103919905A (en) * | 2014-04-01 | 2014-07-16 | 湖南方盛制药股份有限公司 | Medicine composition as well as preparation method and application of medicine composition in preparation of medicines for treating osteoporosis |
| CN116808111A (en) * | 2023-08-21 | 2023-09-29 | 长春中医药大学 | Hydrogel film loaded with traditional Chinese medicine, preparation method thereof and application of hydrogel film in resisting osteosarcoma |
-
2005
- 2005-09-23 CN CNA2005101053312A patent/CN1742871A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102608249A (en) * | 2012-03-06 | 2012-07-25 | 长春人民药业集团有限公司 | Detection method of Tenghuang Jiangu pill |
| CN102608249B (en) * | 2012-03-06 | 2013-11-20 | 长春人民药业集团有限公司 | Detection method of Tenghuang Jiangu pill |
| CN103463287A (en) * | 2013-08-28 | 2013-12-25 | 李颖 | Novel method for preparing anti-hyperosteogeny tablet |
| CN103919905A (en) * | 2014-04-01 | 2014-07-16 | 湖南方盛制药股份有限公司 | Medicine composition as well as preparation method and application of medicine composition in preparation of medicines for treating osteoporosis |
| CN103919905B (en) * | 2014-04-01 | 2015-11-18 | 湖南方盛制药股份有限公司 | Pharmaceutical composition, preparation method and the application in the medicine for the preparation for the treatment of osteoporosis thereof |
| CN116808111A (en) * | 2023-08-21 | 2023-09-29 | 长春中医药大学 | Hydrogel film loaded with traditional Chinese medicine, preparation method thereof and application of hydrogel film in resisting osteosarcoma |
| CN116808111B (en) * | 2023-08-21 | 2023-12-26 | 长春中医药大学 | Hydrogel film loaded with traditional Chinese medicine, preparation method thereof and application of hydrogel film in resisting osteosarcoma |
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