CN107334885A - A kind of compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis - Google Patents

A kind of compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis Download PDF

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CN107334885A
CN107334885A CN201710588156.XA CN201710588156A CN107334885A CN 107334885 A CN107334885 A CN 107334885A CN 201710588156 A CN201710588156 A CN 201710588156A CN 107334885 A CN107334885 A CN 107334885A
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chinese medicinal
medicinal herb
herb extract
compound chinese
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于杰
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Jiangsu Happy Biotechnology Co Ltd
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Jiangsu Happy Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The present invention relates to a kind of compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis, the compound Chinese medicinal herb extract is made up of geranium wilfordii, radix scutellariae, the root of herbaceous peony, the dried immature fruit of citron orange, the root of bidentate achyranthes, the dried rhizome of rehmannia, purslane, radix glycyrrhizae, plantain seed, sweet wormwood, the coptis, cape jasmine, the Radix Astragali, Poria cocos, the taste Chinese herbal medicine of rhizoma alismatis 15, and the weight proportion of raw material is：28~32 parts of geranium wilfordii, 88~92 parts of the coptis, 38~42 parts of the root of herbaceous peony, 8~12 parts of the dried immature fruit of citron orange, 18~22 parts of the root of bidentate achyranthes, 48~52 parts of the dried rhizome of rehmannia, 38~42 parts of purslane, 28~32 parts of radix glycyrrhizae, 18~22 parts of plantain seed, 18~22 parts of sweet wormwood, 23~27 parts of radix scutellariae, 28~32 parts of cape jasmine, 43~47 parts of the Radix Astragali, 23~27 parts of Poria cocos and rhizoma alismatis 23~27.The preparation method of the compound Chinese medicinal herb extract is：Crude drug, which is picked, → cleaning → cuts medicine → water extraction first → secondary water extraction → collecting decoction → concentration → filling → sterilizing → packaging.By the present invention in that preventing and treating fowl bacterial enteritis with compound Chinese medicinal herb extract, the survival rate of livestock and poultry cultivation is significantly improved.

Description

A kind of compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis
Technical field
The present invention relates to preventing and treating alimentary canal or the medicine of disease of digestive system, particularly relates to a kind of preventing and treating fowl bacterial intestines Scorching compound Chinese medicinal herb extract and preparation method thereof.
Background technology
During livestock and poultry cultivation, bacterial enteritis disease is frequently encountered, is particularly seen repeatly not in broiler chicken and suckling piglet Fresh, the disease is not easy thoroughly to cure, and high recurrence rate, seriously perplexs vast cultivation dealer.It is thin for preventing and treating livestock and poultry on Vehicles Collected from Market The medicine of bacterium property enteritis is mostly antibiotic, chemical synthetic drug etc., although these medicines can play certain curative effect and reach certain Prevention effect, but also bring antibody-resistant bacterium increase and a series of insoluble problems such as medicament residue simultaneously, serious system The about sound development of livestock and poultry cultivation.Domestic market starts some Chinese medicine preparations for being used to prevent and treat fowl bacterial occur, But the crushed material of wherein most of only crude drugs, there is the defects of active constituent content is low, uncertain therapeutic efficacy is cut.
The content of the invention
The technical problems to be solved by the invention are that for existing currently used for preventing and treating fowl bacterial enteritis medicine The defects of, there is provided a kind of curative effect of medication is definite, treated effect is high, the preventing and treating fowl bacterial enteritis of safe drug residue free Compound Chinese medicinal herb extract.The compound Chinese medicinal herb extract of the preventing and treating fowl bacterial enteritis of the present invention is by geranium wilfordii, radix scutellariae, white Chinese herbaceous peony, the dried immature fruit of citron orange, the root of bidentate achyranthes, the dried rhizome of rehmannia, purslane, radix glycyrrhizae, plantain seed, sweet wormwood, the coptis, cape jasmine, the Radix Astragali, Poria cocos and rhizoma alismatis are prepared, The weight proportion scope of crude drug is：28~32 parts of geranium wilfordii, 88~92 parts of the coptis, 38~42 parts of the root of herbaceous peony, 8~12 parts of the dried immature fruit of citron orange, 18~22 parts of the root of bidentate achyranthes, 48~52 parts of the dried rhizome of rehmannia, 38~42 parts of purslane, 28~32 parts of radix glycyrrhizae, 18~22 parts of plantain seed, sweet wormwood 18~ 22 parts, 23~27 parts of radix scutellariae, 28~32 parts of cape jasmine, 43~47 parts of the Radix Astragali, 23~27 parts of Poria cocos and rhizoma alismatis 23~27.Above-mentioned medium-height grass Medicine is through picking, cleaning, cutting medicine, water extraction first, secondary water extraction, collecting decoction, concentration are made preventing and treating fowl bacterial enteritis and answered Square extracts of Chinese herbal medicine.The conventional weight proportion of crude drug is：30 parts of geranium wilfordii, 90 parts of the coptis, 40 parts of the root of herbaceous peony, 10 parts of the dried immature fruit of citron orange, 20 parts of the root of bidentate achyranthes, 50 parts of the dried rhizome of rehmannia, 40 parts of purslane, 30 parts of radix glycyrrhizae, 20 parts of plantain seed, 20 parts of sweet wormwood, 25 parts of radix scutellariae, 30 parts of cape jasmine, 25 parts of 45 parts of the Radix Astragali, 25 parts of Poria cocos and rhizoma alismatis.
The compound Chinese medicinal herb extract that the present invention is used to prevent and treat fowl bacterial enteritis is in folk secret and a large amount of practices On the basis of, more than 150 kinds of Chinese herbal medicines are screened according to the characteristics of livestock and poultry, the monarch of foundation traditional Chinese medicine, seven Feelings compatibility, eighteen incompatibilities nineteen counteraction scheduling theory, screen one by one and the Chinese herbal medicine effective ingredientses to filtering out, bacteriostasis carry Take, verify, final to determine to be formulated, the pharmacology situation of each component is in prescription：(1) geranium wilfordii：It is pungent, bitter, flat, return liver,kidney,spleen Through containing compositions such as volatile oil, Quercetin, tannin, gallic acid, butanedioic acid, Quercetin and its glucosides, there is wind-damp dispelling, lead to Channels and collaterals, antidiarrheal dysentery effect.Its herb decoction is to micrococcus catarrhalis, staphylococcus aureus, bacterium flexneri, beta chain coccus, lung Scorching coccus etc. has obvious inhibitory action；To the 68-1 strains of Asia influenza A virus capital section and hemagglutinating virus of Japan celestial platform strain Also there is obvious inhibitory action.(2) coptis：For the dry rhizome of the ranunculaceae plant coptis.Bitter, tremble with fear.The thoughts of returning home, spleen, stomach, Liver, courage, large intestine channel.Effect：Heat-clearing and damp-drying drug, purging intense heat and detonicating.(3) root of herbaceous peony：For the dry root of ranunculaceae plant Chinese herbaceous peony.Bitter, acid, it is micro- It is cold；Return liver, the spleen channel.Cure mainly：Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.(4) dried immature fruit of citron orange：With relieving stagnant Qi disperse accumulations, resolving sputum dissipates ruffian.With In internal stagnation, feeling of fullness distending pain, weight after rush down dysentery, constipation, the phlegm stagnant gas resistance obstruction of qi in the chest, accumulation of pathogens in chest；Gastroptosis, prolapse of the anus, the prolapse of uterus. (5) root of bidentate achyranthes：For the dry root of the amaranthaceous plant root of bidentate achyranthes.Cure mainly：Filling liver kidney；Strengthening the bones and muscles；Invigorate blood circulation；It is descending to draw enemy state's (fire)；Profit Urinate treating stranguria.(6) dried rhizome of rehmannia：The dried root of celebrating glutinous rehmannia is cherished for Scrophulariaceae herbaceos perennial.It is sweet, bitter, cold, enter the heart, liver, kidney three Through.Function：Enriching yin, cool blood.(7) purslane：For the annual meat herbaceous plant of Portulacaceae, clearing heat and detoxicating, cooling blood and hemostasis.With In toxic-heat and blood stasis, carbuncle swells are treated sore, eczema, erysipelas, snake bite and insect sting, had blood in stool, diarrhea.Research shows that purslane contains abundant fat A variety of chemical compositions with medical value such as fat acid, volatile oil, polysaccharide, amino acid, vitamin and mineral, exempt from enhancing Epidemic disease, reducing blood lipid, hypoglycemic, antibacterial, antitumor, anti-oxidant and health care are waited for a long time pharmacological action.Purslane ethanol extract is congratulated will Shigella flexneri and dysentery characterized by blood in the stool bacillus have significant inhibitory action, and to various common food pollutantbacterias such as Escherichia coli, sramana Salmonella, Shigella, staphylococcus aureus, proteus, bacillus subtilis etc. have stronger inhibitory action, even if dilute When releasing to 12.5%, still there is certain bacteriostasis.In addition, He Shengwen etc. is by studying purslane to rabbit lymphopoiesis Influence, the results showed that, purslane can significantly improve the multiplication capacity of rabbit lymphocyte.(8) radix glycyrrhizae：It is sweet for legume The dry root of grass, swollen fruit Radix or glycyrrhiza glabra.Function：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, reconcile all Medicine.(9) plantain seed：For plantago plant Chinese herbaceous peony or the dry mature seed of ordinary building.Return liver, kidney, lung, small intestinl channel.Function：Clearly Hot diuresis, excreting dampness is treating stranguria, improving eyesight, eliminating the phlegm.(10) sweet wormwood：For composite family is annual or biennial herb plant artemisia annua or sweet wormwood are opened The cauline leaf of harvesting, wild before spending.Enter liver, gallbladder channel.Function：Clearing heat and cooling blood, relieving summer-heat is except steaming.(11) radix scutellariae：It is lamiaceae labiatae scutellaria A kind of plant, it is bitter, cold in nature, can heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis.Cure mainly warm heat disease, the infection of the upper respiratory tract, lung heat cough Cough, the disease such as neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis.(12) cape jasmine：For the dry mature fruit of madder wort cape jasmine, its root It can be used as medicine.The thoughts of returning home, lung, tri-jiao channel.Major function：Purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.(13) Radix Astragali：For legume The dry root of astragalus mongolicus or Astragalus membranacus.Cure mainly：Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.(14) Poria cocos：To be more The dry sclerotia of pore fungi section fungi Poria cocos.The thoughts of returning home, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen calming heart.(15) rhizoma alismatis：For Alismataceae The dry tuber of plant rhizoma alismatis.Cure mainly：Diuresis, clearing away damp-heat.
The preparation flow of compound Chinese medicinal herb extract that the present invention is used to prevent and treat fowl bacterial enteritis is：Crude drug is chosen Pick → cleaning → and cut medicine → water extraction first → secondary water extraction → collecting decoction → concentration → filling → sterilizing → packaging.
Major control condition：
Operating ambient temperature：20-30 DEG C, relative humidity 45-75%, the clean rank of production district is general production district；
Water extraction controls：Water extraction water supply standard is drinking water, and water extraction amount of water is 8 times of weight of inventory first, and material adds Soaked 2 hours after entering, extraction time is 2 hours, and it is 100 DEG C that extraction, which controls temperature, and mixing speed is 20 revs/min；Secondary water extraction Amount of water be inventory 7 times of weight, extraction time be 1 hour, extraction control temperature be 100 DEG C, mixing speed for 20 turns/ Point；
Concentration control：Concentrated, 50 revs/min of speed of agitator, controlled using steam mode of heating under stirring The heating-up temperature that decoction is heated in concentration heater is 75~85 DEG C, and vacuum is -0.05~-0.09MPa, and decoction is dense It is reduced to and the weight of crude drug 1/2.
For the specific steps for the compound Chinese medicinal herb extract preparation process for preventing and treating fowl bacterial enteritis：
1st, picking for crude drug lays crude drug in picking on platform, one by one sorts out the impurity in crude drug.
2nd, cleaning puts the crude drug through picking in service sink, with drinking water washing, and the medicinal material after washing is put into second Embathed in individual service sink, clean and drained away the water in rearmounted container.
3rd, cut medicine and put tubers crude drug according to routine and sheet is cut into medicine cutter, and the crude drug for needing coarse crushing is put Coarse crushing in boulder crusher, is put into container, and it is stand-by to be sent into next procedure.
4th, water extraction
4.1 weigh each component, dispensing operating ambient temperature according to the weight proportion of crude drug：20-30 DEG C, relative humidity 45-75%；
4.2 water extractions first are incorporated as the drinking water of 8 times of weight of inventory in extractor, start stirring motor, stirring speed Spend for 20 revs/min；
4.3 are added to required various Chinese herbal medicines in water extraction tank, and material soaks 2 hours；
4.4 carry out heating extraction using steam mode of heating, open steam valve heating, and it is 100 DEG C to control Extracting temperature, Water extraction first terminates after being kept for 2 hours, and the decoction extracted is delivered into storage tank after filtering；
The drinking water of 7 times of weight of inventory is added during 4.5 2 water extractions in extractor, repeats 4.3,4.4 steps, stirring Speed is 20 revs/min, and when being warming up to 100 DEG C of materials and boiling extraction time and reach 1 hour, steam off inlet valve will be secondary The decoction that water extraction has been extracted is transported to storage tank after filtering；
4.6 merge the extract solution twice of water extraction first and secondary water extraction.
5th, the merging decoction after water extraction is transported to concentration heater by concentration through head tank, using steaming under stirring Vapour mode of heating is concentrated, 50 revs/min of speed of agitator, is opened steam valve heating concentration, is controlled quilt in concentration heater The heating-up temperature for heating decoction is 75~85 DEG C, and vacuum is -0.05~-0.09MPa, until being concentrated into and crude drug 1/2 Weight.
6th, it is filling that Packaging Bottle is placed on the feed hopper for bottle machine of filling train line, produced according to the loading amount of regulation Product it is filling, and open automatic labeling machine and Packaging Bottle labelled.
7th, sterilizing is sterilized using sterilization by saturated steam under pressure.
8th, product is packed to load in packing case, and the Paste Product label on packing case.
9th, packaged product is stored in warehouse for finished product by storage.
By the technical indicator for being used to prevent and treat the compound Chinese medicinal herb extract finished product of fowl bacterial made from above method It is as follows：
The advantage of the invention is that the compound Chinese medicinal herb extract of preventing and treating fowl bacterial enteritis has dampness elimination stop dysentery, cure mainly Fowl bacterial enteritis effect, because the product of the present invention extracts through crude drug, it is obtained concentrate, thus the extract solution possesses effectively Component content is high, and dosage is small, be easy to be administered and have the advantages that natural sex, noresidue, has no drug resistance.The present invention's is anti- The compound Chinese medicinal herb extract preparation of fowl bacterial enteritis is controlled to causing the encountered pathogenic bacteria such as large intestine of fowl bacterial enteritis Bacillus, Pasteurella, salmonella etc. have suppression and killing action well, moreover it is possible to repair animal and bird intestines mucous membrane, help intestines Road Tiny ecosystem flora is rebuild.The compound Chinese medicinal herb extract preparation of the preventing and treating fowl bacterial enteritis of the present invention is passed through in river over 2 years 85 livestock and poultry farms in multiple provinces such as Soviet Union, Shandong, Fujian are tried out, of the invention according to being added in every 1L water by drinking water administration Medicine 1ml, it is used in conjunction 5 days, the results showed that to the cure rate of fowl bacterial enteritis up to more than 85.28%, and meanwhile this product is regular Make an addition in drinking-water, there is good preventive effect to domestic animal and fowl's enteritis.Therefore the preventing and treating fowl bacterial enteritis of the present invention is answered Square extracts of Chinese herbal medicine has wide market promotion prospect.
Embodiment
It is embodiments of the invention below, actual use of the invention is not limited to embodiment.
Embodiment 1:
Chinese herbal medicine extraction is prepared using the compound Chinese medicinal herb extract preparation method of present invention preventing and treating fowl bacterial enteritis Liquid, crude drug by geranium wilfordii, radix scutellariae, the root of herbaceous peony, the dried immature fruit of citron orange, the root of bidentate achyranthes, the dried rhizome of rehmannia, purslane, radix glycyrrhizae, plantain seed, sweet wormwood, the coptis, cape jasmine, The Radix Astragali, Poria cocos and rhizoma alismatis composition, the weight proportion of crude drug is geranium wilfordii 28kg, coptis 88kg, root of herbaceous peony 38kg, dried immature fruit of citron orange 8kg, ox Knee 18kg, dried rhizome of rehmannia 48kg, purslane 38kg, radix glycyrrhizae 28kg, plantain seed 18kg, sweet wormwood 18kg, radix scutellariae 23kg, cape jasmine 28kg, Huang Stilbene 43kg, Poria cocos 23kg and rhizoma alismatis 23kg.
Main production equipments
Major control condition：
Operating ambient temperature：20-30 DEG C, relative humidity 45-75%, the clean rank of production district is general production district；
Water extraction controls：Water extraction water supply standard is drinking water, and water extraction amount of water is 8 times of weight of inventory first, and material adds Soaked 2 hours after entering, extraction time is 2 hours, and it is 100 DEG C that extraction, which controls temperature, and mixing speed is 20 revs/min；Secondary water extraction Amount of water be inventory 7 times of weight, extraction time be 1 hour, extraction control temperature be 100 DEG C, mixing speed for 20 turns/ Point；
Concentration control：Concentrated, 50 revs/min of speed of agitator, controlled using steam mode of heating under stirring The heating-up temperature that decoction is heated in concentration heater is 75~85 DEG C, and vacuum is -0.05~-0.09MPa, and decoction is dense It is reduced to 1/2 weight with crude drug.
The crude drug prepared by proportioning is operated according to following process：
1st, picking for crude drug lays crude drug in picking on platform, one by one sorts out the impurity in crude drug.
2nd, cleaning puts the crude drug through picking in service sink, with drinking water washing, and the medicinal material after washing is put into second Embathed in individual service sink, clean and drained away the water in rearmounted container.
3rd, cut medicine and put tubers crude drug according to routine and sheet is cut into reciprocating medicine cutter, and the original that coarse crushing will be needed Medicinal material puts coarse crushing in boulder crusher, is put into container, and it is stand-by to be sent into next procedure.
4th, water extraction
4.1 weigh each component, dispensing operating ambient temperature according to the weight proportion of crude drug：20-30 DEG C, relative humidity 45-75%；
4.2 water extractions first are incorporated as 8 times of weight of inventory i.e. 3760kg drinking water in dynamic extraction pot, start stirring Motor, mixing speed are 20 revs/min；
4.3 are added to required various Chinese herbal medicines in dynamic extraction pot, and material soaks 2 hours；
4.4 carry out heating extraction using steam mode of heating, open steam valve heating, and it is 100 DEG C to control Extracting temperature, Water extraction first terminates after being kept for 2 hours, and the decoction extracted is delivered into basin after filtering；
During 4.5 2 water extractions in dynamic extraction pot add 7 times of weight of inventory be 3290kg drinking water, repeat 4.3, 4.4 steps, mixing speed are 20 revs/min, and when being warming up to 100 DEG C of materials and boiling extraction time and reach 1 hour, steam off enters Mouth valve, storage tank is transported to by the decoction that secondary water extraction has been extracted after filtering；
4.6 merge the extract solution twice of water extraction first and secondary water extraction.
5th, the merging decoction after water extraction is transported to scraper-type vacuum concentrator by concentration through head tank, under stirring Concentrated using steam mode of heating, 50 revs/min of speed of agitator, open steam valve heating concentration, control scraper-type is true The heating-up temperature that decoction is heated in empty inspissator is 75~85 DEG C, and vacuum is -0.05~-0.09MPa, is concentrated into and original The weight of medicinal material 1/2 is 235kg.
6th, it is filling that Packaging Bottle is placed on the feed hopper for bottle machine of filling train line, produced according to the loading amount of regulation Product it is filling.
7th, sterilizing is sterilized using sterilization by saturated steam under pressure.
8th, packaging opens automatic labeling machine and Packaging Bottle is labelled, and loads product in packing case by regulation loading amount, And the Paste Product label on packing case.
9th, packaged product is stored in warehouse for finished product by storage.
Compound Chinese medicinal herb extract finished product according to fowl bacterial enteritis is prevented and treated made from above method reaches following skill Art index：
Prevent and treat the compound Chinese medicinal herb extract finished product technical indicator of fowl bacterial enteritis
Through 3 pig farms, child care pig of 4000 bulls with bacillary enteritis applies the finished product altogether, according to adding in every 1L water Add medicine 1ml of the present invention, be used in conjunction 5 days, as a result：Show that the invention reaches for treating the total effective rate of fowl bacterial enteritis 89.3%.
Embodiment 2:
Chinese herbal medicine extraction is prepared using the compound Chinese medicinal herb extract preparation method of present invention preventing and treating fowl bacterial enteritis Liquid, crude drug by geranium wilfordii, radix scutellariae, the root of herbaceous peony, the dried immature fruit of citron orange, the root of bidentate achyranthes, the dried rhizome of rehmannia, purslane, radix glycyrrhizae, plantain seed, sweet wormwood, the coptis, cape jasmine, The Radix Astragali, Poria cocos and rhizoma alismatis composition, the weight proportion of crude drug is geranium wilfordii 30kg, coptis 90kg, root of herbaceous peony 40kg, dried immature fruit of citron orange 10kg, Root of bidentate achyranthes 20kg, dried rhizome of rehmannia 50kg, purslane 40kg, radix glycyrrhizae 30kg, plantain seed 20kg, sweet wormwood 20kg, radix scutellariae 25kg, cape jasmine 30kg, Radix Astragali 45kg, Poria cocos 25kg and rhizoma alismatis 25kg.
Main production equipments, major control condition and production process are the same as embodiment 1.
The compound Chinese medicinal herb extract finished product of obtained preventing and treating fowl bacterial reaches following technical indicator：
Through 4 laying hen fields, more than 7500 laying hen with bacillary enteritis applies the finished product altogether, according to adding in every 1L water Add medicine 1ml of the present invention, be used in conjunction 5 days, as a result：Show that the invention reaches for treating the total effective rate of laying hen bacillary enteritis 91.4%.
Embodiment 3:
Chinese herbal medicine extraction is prepared using the compound Chinese medicinal herb extract preparation method of present invention preventing and treating fowl bacterial enteritis Liquid, crude drug by geranium wilfordii, radix scutellariae, the root of herbaceous peony, the dried immature fruit of citron orange, the root of bidentate achyranthes, the dried rhizome of rehmannia, purslane, radix glycyrrhizae, plantain seed, sweet wormwood, the coptis, cape jasmine, The Radix Astragali, Poria cocos and rhizoma alismatis composition, the weight proportion of crude drug is geranium wilfordii 32kg, coptis 92kg, root of herbaceous peony 42kg, dried immature fruit of citron orange 12kg, Root of bidentate achyranthes 22kg, dried rhizome of rehmannia 52kg, purslane 42kg, radix glycyrrhizae 32kg, plantain seed 22kg, sweet wormwood 22kg, radix scutellariae 27kg, cape jasmine 32kg, Radix Astragali 47kg, Poria cocos 27kg and rhizoma alismatis 27kg.
Main production equipments, major control condition and production process are the same as embodiment 1.
The compound Chinese medicinal herb extract finished product of obtained preventing and treating fowl bacterial reaches following technical indicator：
Through 2 broiler chicken fields, more than 30000 broiler chicken with bacillary enteritis applies the finished product altogether, according in every 1L water Medicine 1ml of the present invention is added, is used in conjunction 5 days, as a result：Show that the invention reaches for treating the total effective rate of fowl bacterial enteritis 87.8%.
In summary visible, the compound Chinese medicinal herb extract for preventing and treating fowl bacterial of the invention is to controlling fowl bacterial Enteritis has good therapeutic effect.

Claims (5)

1. it is a kind of prevent and treat fowl bacterial enteritis compound Chinese medicinal herb extract, it is characterised in that by geranium wilfordii, radix scutellariae, the root of herbaceous peony, The dried immature fruit of citron orange, the root of bidentate achyranthes, the dried rhizome of rehmannia, purslane, radix glycyrrhizae, plantain seed, sweet wormwood, the coptis, cape jasmine, the Radix Astragali, Poria cocos and rhizoma alismatis are prepared, active compound The weight proportion scope of material is：28~32 parts of geranium wilfordii, 88~92 parts of the coptis, 38~42 parts of the root of herbaceous peony, 8~12 parts of the dried immature fruit of citron orange, the root of bidentate achyranthes 18~22 parts, 48~52 parts of the dried rhizome of rehmannia, 38~42 parts of purslane, 28~32 parts of radix glycyrrhizae, 18~22 parts of plantain seed, sweet wormwood 18~22 23~27 parts of part, 23~27 parts of radix scutellariae, 28~32 parts of cape jasmine, 43~47 parts of the Radix Astragali, 23~27 parts of Poria cocos and rhizoma alismatis.
A kind of 2. compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis according to claim 1, it is characterised in that The conventional weight proportion of crude drug is：30 parts of geranium wilfordii, 90 parts of the coptis, 40 parts of the root of herbaceous peony, 10 parts of the dried immature fruit of citron orange, 20 parts of the root of bidentate achyranthes, the dried rhizome of rehmannia 50 Part, 40 parts of purslane, 30 parts of radix glycyrrhizae, 20 parts of plantain seed, 20 parts of sweet wormwood, 25 parts of radix scutellariae, 30 parts of cape jasmine, 45 parts of the Radix Astragali, Poria cocos 25 25 parts of part and rhizoma alismatis.
A kind of 3. compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis according to claim 1, it is characterised in that Compound Chinese medicinal herb extract finished product is brown liquid, and pH value is 4.5~6.5, and relative density is 1.08~1.12, active ingredient Jamaicin >=20.8mg/ml, Gardenoside >=2mg/ml.
A kind of 4. compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis according to claim 2, it is characterised in that Compound Chinese medicinal herb extract finished product pH value is 5.2, and relative density 1.11, active ingredient jamaicin is 22mg/ml, and Gardenoside is 2.2mg/ml。
A kind of 5. compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis according to claim 1, it is characterised in that The preparation flow of compound Chinese medicinal herb extract is：Crude drug, which is picked, → cleaning → cuts medicine → water extraction first → secondary water extraction → conjunction And decocting liquid → concentration → filling → sterilizing → packaging；Major control condition：Operating ambient temperature：20-30 DEG C, relative humidity 45- 75%, the clean rank of production district is general production district；Water extraction controls：Water extraction water supply standard is drinking water, and water extraction first adds water Measure as 8 times of charged material weight, material soaks 2 hours after adding, and extraction time is 2 hours, and it is 100 DEG C that extraction, which controls temperature, is stirred Speed is mixed as 20 revs/min；The amount of water of secondary water extraction is 7 times of charged material weight, and extraction time is 1 hour, extraction control temperature For 100 DEG C, mixing speed is 20 revs/min；Concentration control：Concentrated, stirred using steam mode of heating under stirring 50 revs/min of rotating speed, the heating-up temperature for controlling heated decoction in concentration heater are 75~85 DEG C, and vacuum is -0.05 ~-0.09MPa, decoction is concentrated into 1/2 weight of crude drug.
CN201710588156.XA 2017-07-19 2017-07-19 A kind of compound Chinese medicinal herb extract for preventing and treating fowl bacterial enteritis Pending CN107334885A (en)

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