CN105663256A - Ultramicro traditional Chinese medicine for preventing and treating lactation reduction and redness and swelling of breasts of dairy cows - Google Patents

Abstract

The invention discloses an ultramicro traditional Chinese medicine for preventing and treating lactation reduction and redness and swelling of breasts of dairy cows. The ultramicro traditional Chinese medicine comprises raw materials in parts by weight as follows: 25-32 parts of dandelions, 18-22 parts of weeping forsythia, 15-25 parts of baical skullcap root, 25-34 parts of cowherb seeds, 18-22 parts of beautiful sweetgum fruits, 8-13 parts of uniflower swisscentaury root, 18-22 parts of Chinese angelica, 8-13 parts of rhizoma chuanxiong, 6-11 parts of bighead atractylodes rhizome, 9-14 parts of frankincense, 6-12 parts of myrrh and 8-11 parts of Chinese honeylocust spines. The ultramicro traditional Chinese medicine has the functions of treating both symptoms and root causes, and can be used for directly inhibiting or killing pathogenic bacteria of mastitis or inhibiting or killing pathogenic bacteria through improvement of body immunity; the medicine formula adopts the principles of heat and toxic material clearing, antisepsis, anti-inflammation, menstrual flow promotion, blood circulation promotion, swelling and pain elimination, collateral activation and lactation promotion, has functions of tonifying qi, raising yang and strengthening body resistance to dispel pathogenic factors, is effective and has a high cure rate, the milk quality of the dairy cows is improved, and the milk amount is remarkably increased. The ultramicro traditional Chinese medicine has controllable quality and the drug dependence is eliminated.

Description

Preventing and treating Lactation of Dairy Cow reduces the ultra micro Chinese medicine that breast is red and swollen

Technical field

The present invention relates to a kind of veterinary Chinese medicine, specifically reduce the Chinese medicine ultra-fine powder of breast redness for preventing and treating Lactation of Dairy Cow.

Background technology

Treatment Lactation of Dairy Cow reduces breast redness and carries out short term therapy frequently with quick-effective preparation now, emphasizes to eliminate clinical infection symptom, to recovering milk yield. The antibacterials mastitis cure rate that staphylococcus aureus is caused being currently used for preventing and treating mastitis is relatively low, the negative effect brought additionally, due to antibiotic a large amount of uses is outstanding day by day, and the drug resistance problems of the pathogenic bacterium such as staphylococcus aureus, streptococcus, escherichia coli is increasingly severe. Have been reported that proof penicillin, Macrolide, quinolones are sensitive to streptococcus, aminoglycoside and quinolones are extremely sensitive to staphylococcus aureus, penicillin, Macrolide, Tetracyclines and other antibiotic medicine then relative insensitivity. The medicines such as quinolones are extremely sensitive to escherichia coli, and penicillins, Macrolide, aminoglycoside, Tetracyclines relative insensitivity.

Antibiotic therapy has become current a kind of normality for mammitis of cow treatment, the problem brought therewith is that the unreasonable use of antibiotic is even abused, cause the generation of ill domestic animal drug resistance after medication, Immune Function In Animals reduction and on public health security produce impact. Particularly some antibiotic is the nutrient source of fungus, causes the generation of more serious fungoid mastitis. Prevent and treat in process at existing mammitis of cow, due to long-term, widely apply one or more antibiotic, and often have the phenomenon of non-rational use of drug and abuse of antibiotics to occur, antibiotic residual in milk and milk product increasingly causes the attention of people. Owing to antibiotic remains in milk, making some drinking person produce anaphylaxis, as occurred, erythra, asthma, anaphylactic shock are even dead, have a strong impact on the physical and mental health of consumer and can also cause that bacterial resistance bacterial strain increases. Resistant strain is not only transmitted between susceptible animal, also can pass to people by food chain, as having drug-fast staphylococcus aureus and escherichia coli etc.Additionally some antibiotic application, also can suppress Immune Function, milch cow phagocyte chemotactic and Phagocytosis function can be affected such as tetracycline, gentamycin, penicillin etc., suppress the cellulotoxic effect of lymphocyte cell mediation, affect humoral immune function as reduced lymphocyte quantity and antibody tormation amount, cause organism infection complicated symptoms so that the treatment of some infectious disease becomes more and more difficult.

The breast of milch cow is rubescent, swelling, and milk and the abnormal minimizing of milk amount are one of diseases most commonly seen in milch cow. According to international milch cow community recent statistics, the breast of milch cow is rubescent, swelling, and the prevalence of milk and milk amount exception is 53.2%, and the prevalence of recessive disorder is 86.8%. Recessive Incidence relatively healthy cow is high 5～8 times. The Inner Mongol in 2014, Hulun Buir, Ke Shike such as rise at the ground investigation, and recessive disease accounts for 80%, and the newborn district of 50%～70% infects recessiveness. Breast latent disease is huge to the economic loss that farming and animal husbandry and raiser cause, including the expense etc. of the loss of milk amount, the input of expenses for medicine, veterinary's expense and labour force.

Cow breast disease not only makes milk yield reduce, and makes the quality of breast be greatly reduced; Aminoacid, total amino acid content must declining 30.2%, sugar, albumen, phosphorus beneficiating ingredient substantially reduce, and the harmful components such as immunoglobulin, esterase, chlorine substantially increase. At present, new Mongolian medicinal preparation is day by day paid close attention to by domestic expert and veterinary personnel, prove and is used. Chinese medicine preparation becomes increasingly conspicuous in the effect in preventing and treating milk cow recessive disease field simultaneously.

Summary of the invention

It is an object of the invention to provide a kind of Lactation of Dairy Cow of preventing and treating and reduce the ultra micro Chinese medicine that breast is red and swollen, its treating both the principal and secondary aspects of a disease, regulate milch cow body so as to get well, reduce Drug resistance, improve lactation amount, it is ensured that dairy food quality.

Technical scheme is as follows:

A kind of Lactation of Dairy Cow of preventing and treating reduces the ultra micro Chinese medicine that breast is red and swollen, and it is made up of the crude drug of following parts by weight:

Herba Taraxaci 25-32 part, Fructus Forsythiae 18-22 part, Radix Scutellariae 15-25 part, Semen Vaccariae 25-34 part, Fructus Liquidambaris 18-22 part, Radix Rhapontici 8-13 part, Radix Angelicae Sinensis 18-22 part, Rhizoma Chuanxiong 8-13 part, Rhizoma Atractylodis Macrocephalae 6-11 part, Olibanum 9-14 part, Myrrha 6-12 part, Spina Gleditsiae 8-11 part.

Above-mentioned preventing and treating Lactation of Dairy Cow reduces the ultra micro Chinese medicine that breast is red and swollen, and its preferred version is made up of the crude drug of following parts by weight:

Herba Taraxaci 30 parts, Fructus Forsythiae 20 parts, Radix Scutellariae 20 parts, Semen Vaccariae 30 parts, Fructus Liquidambaris 20 parts, Radix Rhapontici 10 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 10 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Olibanum 10 parts, Myrrha 10 parts, Spina Gleditsiae 10 parts.

Preparation:

The preparation method of said medicine group as follows carries out:

1, decoction pieces, micronizing 15um are weighed respectively;

2, freezing is difficult to Olibanum and the Myrrha pulverized, micronizing after freezing, and dextrin is coated;

3, the mixing of each medicaments uniformity, obtains micropowder powder.

Take: every ill cattle gavages 200g every time, and warm water gavages, it is possible to mix 200-300g/ in feedstuff each, every day 1 time, take 3-4 day.

Effect of each prepared slices of Chinese crude drugs and effect:

Herba Taraxaci

[nature and flavor] are bitter, sweet, cold. [return through] returns liver, stomach warp.

[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome. For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Fructus Forsythiae

[nature and flavor] are bitter, are slightly cold.[return through] returns lung, the heart, small intestine meridian.

[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds. For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.

Radix Scutellariae

[nature and flavor] are bitter, cold. [return through] returns lung, gallbladder, spleen, large intestine, small intestine meridian.

[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive. For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Semen Vaccariae

[nature and flavor] are bitter, flat. [return through] returns liver, stomach warp.

[function cures mainly] promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling. For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.

Fructus Liquidambaris

[nature and flavor] are bitter, flat. [return through] returns liver, kidney channel.

[function cures mainly] dispelling, collateral-activating, diuretic stimulates the menstrual flow. For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.

Radix Rhapontici

[nature and flavor] are bitter, cold. [return through] returns stomach warp.

[function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation. Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.

Radix Angelicae Sinensis

[nature and flavor] sweet, acrid, warm. [return through] enters the heart, liver, spleen channel.

[function cures mainly] benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation. Controlling menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia, weight after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.

Rhizoma Chuanxiong

[nature and flavor] are pungent, temperature. [return through] returns liver, gallbladder, pericardium channel.

[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping. For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.

The Rhizoma Atractylodis Macrocephalae

[nature and flavor] are bitter, sweet, temperature. [return through] returns spleen, stomach warp.

[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive. For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement. Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive. For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Olibanum

[nature and flavor] are pungent, bitter, temperature. [return through] enters the heart, liver, spleen channel.

[function cures mainly] promoting blood circulation and stopping pain. For all pains of trusted subordinate, muscle arteries and veins contracture, traumatic injury, sore, carbuncle and painful swelling; Externally used detumescence is raw

Myrrha

[nature and flavor] are bitter, flat. [return through] enters Liver Channel.

[function cures mainly] dissipates blood blood stasis removing, subduing swelling and relieving pain. Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye,

Spina Gleditsiae

[nature and flavor] are pungent, temperature. [return through] returns liver, stomach warp.

[function cures mainly] detumescence detoxification, evacuation of pus, parasite killing. For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.

It is an advantage of the current invention that: 1, Chinese medicine selected by the present invention has the effect for the treatment of both the principal and secondary aspects of a disease, it can directly suppress or kill the pathogen of mastitis, or suppress by improving the immunity of body or kill pathogen. The effective percentage of this medicine, cure rate are high, see clinical trial. Contained by Chinese medicine, effective ingredient is mostly biological organism, it is easy to metabolism, little compared with antibiotic and chemical synthetic drug toxic and side effects, and is not likely to produce bacterial drug resistance. Medicament composing prescription of the present invention contains multiple biological effective components, with heat-clearing and toxic substances removing, anti-inflammation, restore menstrual flow and invigorate blood circulation, reducing swelling and alleviating pain, active lactogenesis for principle, tonifying Qi and lifting yang, strengthening vital QI to eliminate pathogenic factors, thus keeping the dynamic equilibrium of organismic internal environment, reach to prevent and treat purpose. 2, promoting the dynamic industry of protecting of veterinary drug to more healthy, Green Development, make Lactation of Dairy Cow reduce the red and swollen symptom of breast and reach recovery from illness, the milk matter of milch cow makes moderate progress, and milk amount significantly improves.Milk is made to become the green product that availability height, drug residue are minimum. Meet people's requirement to food health. 3, this medicine large-scale production, with low cost, modern processing method makes material effective component to make full use of, and easy to use, quality controllable. 4, this medicine no dependence and substantially without teratogenecity, has positive role to calf survival rate.

Detailed description of the invention

Embodiment 1: Herba Taraxaci 25 parts, Fructus Forsythiae 18 parts, Radix Scutellariae 15 parts, Semen Vaccariae 25 parts, Fructus Liquidambaris 18 parts, Radix Rhapontici 8 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 8 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Olibanum 9 parts, Myrrha 6 parts, Spina Gleditsiae 8 parts.

Embodiment 2: Herba Taraxaci 30 parts, Fructus Forsythiae 20 parts, Radix Scutellariae 20 parts, Semen Vaccariae 30 parts, Fructus Liquidambaris 20 parts, Radix Rhapontici 10 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 10 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Olibanum 10 parts, Myrrha 10 parts, Spina Gleditsiae 10 parts.

Embodiment 3: Herba Taraxaci 32 parts, Fructus Forsythiae 22 parts, Radix Scutellariae 25 parts, Semen Vaccariae 34 parts, Fructus Liquidambaris 22 parts, Radix Rhapontici 13 parts, Radix Angelicae Sinensis 22 parts, Rhizoma Chuanxiong 13 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Olibanum 14 parts, Myrrha 12 parts, Spina Gleditsiae 11 parts.

The bacteriostasis of component of the present invention:

These latent mammitis pathogenic bacterium testing main Cow product base, first Inner Mongolia Autonomous Region Chifeng City are easily separated, identify, its Antibiotic Resistance is determined then by drug sensitive test, traditional classical prescription according to clinical treatment mammitis of cow, screening multi-medicament, adopts different extraction, method for concentration and forms compound recipe selected compound Chinese medicine extract finally carries out the research of antibacterial activity in vitro mensuration, antiinflammatory action and immunological enhancement.

Herba Taraxaci: staphylococcus aureus, Hemolytic streptococcus and micrococcus catarrhalis are had stronger inhibitory action, to Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, shigella flexneri, bacillus pyocyaneus and leptospira etc. also have certain inhibitory action.

Fructus Forsythiae: to staphylococcus aureus, dysentery bacterium has very strong inhibitory action, and other pathogenic bacterium, influenza virus and leptospira also all have certain inhibitory action.

Radix Scutellariae: to dysentery bacterium, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, Bacillus proteus, staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, meningococcus, vibrio cholera etc. has inhibitory action in various degree.

Semen Vaccariae: have antitumor action.

Fructus Liquidambaris: anti-hepatocyte cytotoxic activity.

Radix Rhapontici: improve cellular immunity.

Radix Angelicae Sinensis: nothing

Rhizoma Chuanxiong: multiple bacillus can be suppressed.

The Rhizoma Atractylodis Macrocephalae: promote cellular immunization, have antibacterial action.

Olibanum: easing pain and diminishing inflammation, strengthens inflammatory seep excretion.

Myrrha: multiple fungus is had inhibitory action, volatile oil can slightly suppress mycete.

Spina Gleditsiae: to trichophyton, star slave Salmonella has inhibitory action.

Clinical test of pesticide effectiveness research

1. materials and methods

1.1 trial drugs

The medicine of the embodiment of the present invention 2.

1.2 clinic mastitis diagnostic criterias

1.2.1 slight mastitis diagnostic criteria

Without General Symptoms, body temperature is without exception, and breast has slight redness, and palpation heat, pain react inconspicuous; Milk is thinning, or containing a small amount of floccule or ziega; SCC (Ruzhong somatic number) > 200,000/ml; Milk yield reduces.

1.2.2 moderate mastitis diagnostic criteria

Body temperature, General Symptoms are inconspicuous, and appetite is slightly worse; Breast mild redness, and have lump; Palpation has heat, pain reaction; Milk is water sample, or containing floccule or ziega; SCC (Ruzhong somatic number) > 200,000/ml;Milk yield significantly reduces.

1.2.3 severe mastitis diagnostic criteria

General Symptoms is obvious, and body temperature significantly raises, loss of appetite, ruminates minimizing, and asthenia universalis, spirit are depressed; District is rubescent for breast, swelling, hardening; Palpation heat, pain significant reaction; Milk is significantly abnormal; SCC (Ruzhong somatic number) significantly increases; Milk yield degradation, even stops.

1.3 experimental animals

3000 cow head cases chosen by the Dairy Cattle feed lots such as 2014-2015 Chifeng, Hulun Buir, Huhehaote, packet header. Wherein suffer from slight mastitis for 1000, suffer from moderate mastitis for 1000, suffer from severe mastitis for 1000.

2. test method

2.1 medications: mixed with appropriate feedstuff by 200～300g medicine, once/every day, are fed for morbidity milch cow, are used in conjunction 4 days.

2.2 index of assessment of curative effects

2.2.1 cure

General Symptoms disappears, and appetite recovers normal; The symptoms such as red, swollen, hot, the pain in ill breast district are wholly absent, and milk outward appearance recovers normal, milk yield rebound significantly; SCC (Ruzhong somatic number) < 200,000/ml; Milk sample does not detect pathogenic bacterium.

2.2.2 effective

General Symptoms disappears substantially, and appetite recovers normal; The symptoms such as red, swollen, hot, the pain in ill breast district are obviously improved or alleviate; Milk outward appearance is normal, and milk yield has a degree of recovery; SSC (Ruzhong somatic number) substantially reduces; Pathogenic bacterium < 1000cfu/ml in milk sample.

2.2.3 invalid

General Symptoms does not disappear and even increases the weight of; Ill breast district symptom is not improved and even increases the weight of; Milk outward appearance is substantially abnormal, and milk yield does not recover even lactogenic and stops; Or recurrence in drug withdrawal two weeks after; SCC (Ruzhong somatic number) is substantially unchanged and content is higher; Pathogenic bacterium quantity in milk sample > 1000cfu/ml.

2.4 relapse rate monitorings

To the milch cow after curing, after drug withdrawal in 1 week, monitor clinical symptoms and the milk sample pathogenic bacterium in breast district.

2.5 daily yieldings and milk composition monitoring

To the milch cow after curing, after drug withdrawal in 1 week, monitor average daily milk production and milk composition. 3. clinical efficacy result

Clinical test results shows, the effective percentage of slight, moderate and severe mastitis is all reached 100.0% by test group medicine, and the effective percentage of slight mastitis is reached 100.0%, and overall efficiency is 100.0%; Slight and moderate mastitis cure rate all being reached more than 98.6%, the cure rate of slight mastitis is reached 99.7%, overall cure rate is 95.1%.

3.1 clinical efficacy results

Table 3-1 clinical efficacy result table

4. relapse rate monitoring result

Observe in 1 week after drug withdrawal, in test of cure group, suffer from after slight mastitis is cured there are no recurrent cases for 1000, suffer from after moderate mastitis is cured for 1000 and only have 1 recurrence, suffer from only 4 recurrences after severe mastitis is cured for 1000.

5. daily yielding and milk composition monitoring

Table 5-1 cures milch cow average daily milk production measurement result

Table 5-2 cures fat of milk cow assay result

Table 5-3 cures milch cow content of milk protein measurement result

Table 5-4 cures milch cow lactose content measuring result

6. conclusion (of pressure testing)

Above-mentioned result of the test shows, the medicine of the present invention, it is possible to effectively treat mammitis of cow, and the cure rate of mammitis of cow is higher, controls recurrence rate after healing relatively low; Can effectively treat mammitis of cow, without the off-drug period, have no drug resistance, alternative antibiotic medicine, it is also possible to strengthen milch cow body immunologic function. This medicine can as the herbal medicine thing preparation for the treatment of mammitis of cow.

Model case

Example in November, 1,2014,100, cattle farm, Yuanbaoshan District, Chifeng City milking cow milk yield die-offs three one-tenth, gos up limited through this veterinary treatment milk yield. At cattle farm invitation, research and development department of Hua Tian pharmaceutical Co. Ltd co-treatment. Through looking into, this new introduction automatic milking machine, due to misoperation, there is mastitis in various degree, application we serious symptom disease cattle 4～5 doses in the milch cow of 80%, slight sick cattle 2～3 doses is almost recovered, and milk yield quickly recovers.

Example in April, 2,2015, dairy village 42 milking cows in Hongshan District, Chifeng City, because changing keeper, cause that milking method is improper, the milch cow generation mastitis of 1/3rd. Research and development department of Hua Tian pharmaceutical Co. Ltd applies the treatment of this medicine, fully recovers after five days.

Claims (2)

1. prevent and treat the ultra micro Chinese medicine that Lactation of Dairy Cow minimizing breast is red and swollen for one kind, it is characterised in that: it is made up of the crude drug of following parts by weight:

Herba Taraxaci 25-32 part, Fructus Forsythiae 18-22 part, Radix Scutellariae 15-25 part, Semen Vaccariae 25-34 part, Fructus Liquidambaris 18-22 part, Radix Rhapontici 8-13 part, Radix Angelicae Sinensis 18-22 part, Rhizoma Chuanxiong 8-13 part, Rhizoma Atractylodis Macrocephalae 6-11 part, Olibanum 9-14 part, Myrrha 6-12 part, Spina Gleditsiae 8-11 part.

2. preventing and treating Lactation of Dairy Cow according to claim 1 reduces the ultra micro Chinese medicine that breast is red and swollen, it is characterised in that: it is made up of the crude drug of following parts by weight:

Herba Taraxaci 30 parts, Fructus Forsythiae 20 parts, Radix Scutellariae 20 parts, Semen Vaccariae 30 parts, Fructus Liquidambaris 20 parts, Radix Rhapontici 10 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 10 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Olibanum 10 parts, Myrrha 10 parts, Spina Gleditsiae 10 parts.