CN109091646B - Compound traditional Chinese medicine preparation for miscarriage prevention of livestock and preparation method thereof - Google Patents
Compound traditional Chinese medicine preparation for miscarriage prevention of livestock and preparation method thereof Download PDFInfo
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- CN109091646B CN109091646B CN201811331303.6A CN201811331303A CN109091646B CN 109091646 B CN109091646 B CN 109091646B CN 201811331303 A CN201811331303 A CN 201811331303A CN 109091646 B CN109091646 B CN 109091646B
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Abstract
The invention provides a compound traditional Chinese medicine preparation for miscarriage prevention of livestock, which is prepared from the following raw materials in parts by weight: 15-25 parts of fructus amomi, 5-10 parts of glutinous rice, 15-25 parts of scutellaria baicalensis, 5-10 parts of ramie root, 5-10 parts of purple perilla, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared rehmannia root, 5-10 parts of pumpkin pedicel and 1-5 parts of folic acid. The invention also provides a preparation method of the compound traditional Chinese medicine preparation for miscarriage prevention of livestock. The compound traditional Chinese medicine preparation for miscarriage prevention of livestock provided by the invention can treat threatened abortion caused by blood heat and qi stagnation and stomach qi disharmony, and effectively improve the litter size of livestock.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine preparation for miscarriage prevention of livestock and a preparation method thereof.
Background
In livestock farming, maternal health is related to production size and litter yield. The threatened abortion of the mother body is caused by deficiency of qi and blood due to maladjustment in feeding and insufficient nutrition. The early stage of the disease is characterized in that the sick livestock is uneasy to stand, look back to the head and abdomen, have abdominal pain to rise and lie, frequently look at urination, and if the fetus is bigger, the fetus impacts the abdominal wall at times, and feel that the fetus is unsteady when pressed by hands; then the lower back is blamed by the hunch and the anger, and a small amount of turbid liquid with blood flows out of the vagina; in the later period, the abdominal pain is aggravated, the blood turbidity flowing out of the vagina is increased, finally, the fetal membranes are ruptured, the fetal water flows out, and the fetus with insufficient months is born. The traditional Chinese medicine considers that threatened abortion damages thoroughfare and conception vessels due to qi and blood deficiency, kidney deficiency, blood heat, trauma and other reasons, so that thoroughfare and conception vessels are not solid, and blood can not be absorbed for nourishing fetus; or the toxic drug impairs the fetus, resulting in a birth in short term.
Disclosure of Invention
The compound traditional Chinese medicine preparation for miscarriage prevention of livestock provided by the invention is simple to prepare and exact in curative effect, can be used for treating threatened abortion caused by blood heat and qi stagnation and stomach qi disharmony, effectively improves the number born of livestock, and ensures the quality of cubs.
The invention aims to provide a compound traditional Chinese medicine preparation for miscarriage prevention of livestock, which is prepared from the following raw materials in parts by weight: 15-25 parts of fructus amomi, 5-10 parts of glutinous rice, 15-25 parts of scutellaria baicalensis, 5-10 parts of ramie root, 5-10 parts of purple perilla, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared rehmannia root, 5-10 parts of pumpkin pedicel and 1-5 parts of folic acid.
Preferably, the compound traditional Chinese medicine preparation for miscarriage prevention of livestock is prepared from the following raw materials in parts by weight: 20 parts of fructus amomi, 8 parts of glutinous rice, 20 parts of scutellaria baicalensis, 8 parts of ramie root, 8 parts of purple perilla, 15 parts of astragalus mongholicus, 15 parts of prepared rehmannia root, 8 parts of pumpkin pedicel and 3 parts of folic acid.
The second purpose of the invention is to provide a preparation method of a compound traditional Chinese medicine preparation for miscarriage prevention of livestock, which is implemented according to the following steps:
step 1, weighing 15-25 parts of fructus amomi, 5-10 parts of glutinous rice, 15-25 parts of scutellaria baicalensis, 5-10 parts of ramie root, 5-10 parts of perilla, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared rehmannia root, 5-10 parts of pumpkin pedicel and 1-5 parts of folic acid for later use;
step 2, uniformly mixing the sticky rice, the scutellaria baicalensis, the ramie root, the perilla frutescens, the astragalus membranaceus, the prepared rehmannia root and the pumpkin base weighed in the step 1, adding water which is 8-12 times of the total weight of the sticky rice, soaking overnight, then decocting with slow fire for 1.5-2.5 h, adding the fructus amomi weighed in the step 1, continuing to decoct for 5-10 min, and filtering to obtain a first filtrate and filter residues; adding water which is 8-12 times of the weight of the filter residue into the filter residue, continuously decocting with slow fire for 1.0-2.0 h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, uniformly mixing, concentrating to a concentration which is 1g/mL of the original medicinal material to obtain a traditional Chinese medicine composition, and refrigerating the traditional Chinese medicine composition at 4 ℃ for later use;
and 3, uniformly mixing the folic acid weighed in the step 1 with the traditional Chinese medicine composition prepared in the step 2 to obtain the traditional Chinese medicine preparation for miscarriage prevention of livestock.
Preferably, the Chinese medicinal preparation can be prepared into a pharmaceutically acceptable Chinese medicinal preparation according to a conventional method.
Preferably, the medicinal dosage form of the traditional Chinese medicine preparation is decoction, tablets, capsules, granules, pills, injection, spray or patches.
The efficacy and pharmacological action of the components of the invention are as follows:
1. amomum fruit: pungent taste and warm nature; it enters spleen, stomach and kidney meridians. Move qi and regulate middle energizer, harmonize stomach and activate spleen. It can be used for treating abdominal pain, abdominal distention, anorexia, dysphagia, emesis, cold diarrhea, dysentery, and fetal movement during pregnancy. Modern pharmacological research proves that the fructus amomi can obviously inhibit platelet aggregation and the activity of digestive protein of gastric enzyme; can strengthen the contraction of small intestine and intestine of guinea pigs and rats, has inhibiting effect on intestine when increasing dosage, reduces expression tension and reduces amplitude; also has obvious effect of resisting acute death of mice induced by collagen and adrenalin; in addition, fructus amomi has obvious protective effect on the acute death of mice induced by arachidonic acid; sha ren also has a certain action of preventing abortion.
2. Sticky rice: sweet in flavor and warm in nature, entering spleen, stomach and lung meridians; has effects in invigorating spleen, replenishing qi, invigorating spleen, nourishing stomach, and relieving sweating due to asthenia. Is suitable for patients with symptoms of regurgitation, anorexia, diarrhea, and abdominal distention due to qi deficiency, and is suitable for people with pulmonary tuberculosis, neurasthenia, and puerperal diseases.
3. Scutellaria baicalensis: bitter in taste and cold in nature, entering lung, heart, gallbladder and large intestine meridians. Has effects of clearing heat, eliminating dampness, clearing pathogenic fire, removing toxic substance, and preventing miscarriage, and has good effects on summer-heat, chest distress, emesis, cough due to lung heat, blood heat, hyperpyrexia, polydipsia, damp-heat dysentery, etc. Modern pharmacological research proves that the scutellaria has a wide antibacterial spectrum, has an inhibiting effect on various bacteria, dermatophytes, leptospira and the like, and can inhibit staphylococcus aureus which generates drug resistance to antibiotics such as penicillin and the like; scutellariae radix has effects in lowering blood pressure, tranquilizing mind, promoting urination, protecting liver, promoting function of gallbladder, resisting allergy, and relieving smooth muscle spasm.
4. Ramie root: sweet and cold in nature. Cool blood and stop bleeding, prevent abortion, clear heat and remove toxicity. Can be used for treating fever, thirst, mania, stranguria with blood, hematemesis, hematochezia, leucorrhea with red and white discharge, erysipelas, traumatic injury, and snake and insect bite. Modern pharmacological research shows that ramie root has obvious hemostatic effect, and organic acid salt and alkaloid contained in ramie root have inhibitory effect on gram-positive bacteria and gram-negative bacteria in vitro, wherein hemolytic streptococcus, pneumococcus, escherichia coli and bacillus anthracis are highly sensitive to organic acid salt, and salmonella is highly sensitive to alkaloid.
5. Purple perilla: pungent and warm in flavor. Relieving exterior syndrome, dispelling cold, promoting qi circulation, and regulating stomach function. Mainly treats wind-cold type common cold, spleen and stomach qi stagnation, chest distress and vomiting, and can regulate qi and prevent miscarriage; and fish and crab poison cause abdominal pain, vomiting and diarrhea. Modern pharmacological research proves that the purple perilla has the effects of relieving fever, inhibiting bacteria, tranquilizing and increasing blood sugar; perilla frutescens can also promote intestinal peristalsis.
6. Astragalus root: sweet and slightly warm in taste. Has effects of invigorating qi, consolidating exterior, promoting urination, expelling toxin, expelling pus, healing sore, and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, carbuncle, cellulitis, ulcer, blood deficiency, sallow complexion, internal heat, and diabetes. Modern pharmacological research proves that astragalus can enhance the immune function of organisms and the hematopoietic function; improving metabolism, improving gonadal function, resisting stress, and delaying aging; radix astragali also has effects in tonifying heart, regulating blood pressure, resisting viral myocarditis, protecting liver, and resisting ulcer.
7. Prepared rehmannia root: sweet and warm. It enters liver and kidney meridians. To nourish yin, enrich blood, replenish essence and benefit marrow. Can be used for treating asthenia of waist and knees, fatigue, cough, steaming bone, spermatorrhea, metrorrhagia, menoxenia, diabetes, deafness, blurred vision, palpitation, insomnia, amnesia, night sweat, etc. due to deficiency of yin and blood, and brain marrow deficiency. Modern pharmacological research proves that the prepared rehmannia root decoction can promote the recovery of red blood cells and hemoglobin of anemic animals and accelerate the proliferation and differentiation of multipotent hematopoietic stem cells and myeloid erythroid progenitor cells; the prepared rehmannia root can obviously inhibit hemorrhagic necrosis of the liver and simple necrosis; the prepared rehmannia root alcohol extract is infused into a mouse, and has obvious protective effect on macrophage functions inhibited by carrageenan; has inhibitory effect on antibody-forming cells; the wine prepared rehmannia root and the steamed rehmannia root have obvious blood pressure reducing effect, and the systolic pressure and the diastolic pressure are both obviously reduced; radix rehmanniae Preparata also has antioxidant effect.
8. Pedicel of pumpkin: bitter, slightly sweet and neutral in nature. Enter lung and liver meridians. Detoxification; diuresis; preventing miscarriage. Abscess, deep-rooted carbuncle, pyogenic infections, furuncle, scald, unhealed sores, edema, ascites, threatened abortion.
The prescription takes fructus amomi and scutellaria baicalensis as monarch drugs, promotes qi circulation, regulates middle energizer, clears heat and prevents miscarriage; the astragalus, the prepared rehmannia root, the ramie root and the purple perilla are ministerial drugs and assist the effect of promoting the circulation of qi of monarch drugs, and the astragalus and the prepared rehmannia root can tonify qi and enrich blood and mutually generate qi and blood and can treat the symptoms of qi deficiency and blood deficiency caused by qi stagnation; glutinous rice and pumpkin pedicel are used as adjuvant drugs to help the whole formula to prevent miscarriage; and folic acid can be added to prevent fetal malformation. The medicines are combined to promote the circulation of qi, invigorate qi and enrich blood, clear heat and harmonize stomach and prevent abortion, and can be used for treating threatened abortion caused by blood heat and qi stagnation and stomach qi disharmony.
Compared with the prior art, the invention has the beneficial effects that:
1. the compound traditional Chinese medicine preparation for miscarriage prevention of livestock provided by the invention utilizes the modern traditional Chinese medicine preparation technology, and has the characteristics of simplicity, easiness in preparation, low cost and easiness in large-scale production.
2. The compound traditional Chinese medicine preparation for miscarriage prevention of livestock provided by the invention has a definite curative effect, can be used for treating threatened abortion caused by blood heat and qi stagnation and stomach qi disharmony, effectively improves the number born of livestock, and ensures the quality of cubs.
Detailed Description
In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
The fructus amomi, the sticky rice, the scutellaria baicalensis, the ramie root, the perilla frutescens, the astragalus mongholicus, the prepared rehmannia root and the pumpkin pedicel used in the embodiments of the invention are all sold in the market, and the test methods are all conventional methods unless otherwise specified.
Example 1
A compound traditional Chinese medicine preparation for miscarriage prevention of livestock is prepared from the following raw materials in parts by weight: 15 parts of fructus amomi, 5 parts of glutinous rice, 15 parts of scutellaria baicalensis, 5 parts of ramie root, 5 parts of purple perilla, 10 parts of astragalus mongholicus, 10 parts of prepared rehmannia root, 5 parts of pumpkin pedicel and 1 part of folic acid.
The method is implemented according to the following steps:
step 1, weighing 15 parts of fructus amomi, 5 parts of sticky rice, 15 parts of scutellaria baicalensis, 5 parts of ramie root, 5 parts of purple perilla, 10 parts of astragalus membranaceus, 10 parts of prepared rehmannia root, 5 parts of pumpkin pedicel and 1 part of folic acid for later use;
step 2, uniformly mixing the sticky rice, the scutellaria baicalensis, the ramie root, the perilla frutescens, the astragalus membranaceus, the prepared rehmannia root and the pumpkin base weighed in the step 1, adding water which is 8 times of the total weight of the sticky rice, soaking the sticky rice overnight, then decocting the sticky rice for 1.5 hours by using slow fire, adding the fructus amomi weighed in the step 1, continuing to decoct the mixture for 5 minutes, and filtering the mixture to obtain first filtrate and filter residues; adding water which is 8 times of the weight of the filter residue into the filter residue, continuously decocting with slow fire for 1.0h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, uniformly mixing, concentrating to a concentration which is 1g/mL of the original medicinal material to obtain a traditional Chinese medicine composition, and refrigerating the traditional Chinese medicine composition at 4 ℃ for later use;
and 3, when in use, uniformly mixing the folic acid weighed in the step 1 with the traditional Chinese medicine composition prepared in the step 2 to obtain the decoction-type traditional Chinese medicine preparation for miscarriage prevention of livestock.
Example 2
A compound traditional Chinese medicine preparation for miscarriage prevention of livestock is prepared from the following raw materials in parts by weight: 25 parts of fructus amomi, 10 parts of glutinous rice, 25 parts of scutellaria baicalensis, 10 parts of ramie root, 10 parts of purple perilla, 20 parts of astragalus mongholicus, 20 parts of prepared rehmannia root, 10 parts of pumpkin pedicel and 5 parts of folic acid.
The method is implemented according to the following steps:
step 1, weighing 25 parts of fructus amomi, 10 parts of sticky rice, 25 parts of scutellaria baicalensis, 10 parts of ramie root, 10 parts of purple perilla, 20 parts of astragalus membranaceus, 20 parts of prepared rehmannia root, 10 parts of pumpkin base and 5 parts of folic acid for later use;
step 2, uniformly mixing the sticky rice, the scutellaria baicalensis, the ramie root, the perilla frutescens, the astragalus membranaceus, the prepared rehmannia root and the pumpkin base weighed in the step 1, adding water which is 12 times of the total weight of the sticky rice, soaking the sticky rice overnight, then decocting the sticky rice for 2.5 hours by using slow fire, adding the fructus amomi weighed in the step 1, continuing to decoct the sticky rice for 10 minutes, and filtering the mixture to obtain a first filtrate and filter residues; adding water which is 12 times of the weight of the filter residue into the filter residue, continuously decocting with slow fire for 2.0h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, uniformly mixing, concentrating to a concentration which is 1g/mL of the original medicinal material to obtain a traditional Chinese medicine composition, and refrigerating the traditional Chinese medicine composition at 4 ℃ for later use;
and (3) continuously concentrating the traditional Chinese medicine composition prepared in the step (2) into a thick extract, adding the weighed folic acid and a proper amount of auxiliary materials, uniformly mixing, granulating, sieving and drying to obtain the granular traditional Chinese medicine preparation for preventing miscarriage of livestock.
Example 3
A compound traditional Chinese medicine preparation for miscarriage prevention of livestock comprises the following raw materials in parts by weight: 20 parts of fructus amomi, 8 parts of glutinous rice, 20 parts of scutellaria baicalensis, 8 parts of ramie root, 8 parts of purple perilla, 15 parts of astragalus mongholicus, 15 parts of prepared rehmannia root, 8 parts of pumpkin pedicel and 3 parts of folic acid.
The method is implemented according to the following steps:
step 1, weighing 20 parts of fructus amomi, 8 parts of sticky rice, 20 parts of scutellaria baicalensis, 8 parts of ramie root, 8 parts of purple perilla, 15 parts of astragalus membranaceus, 15 parts of prepared rehmannia root, 8 parts of pumpkin base and 3 parts of folic acid for later use;
step 2, uniformly mixing the sticky rice, the scutellaria baicalensis, the ramie root, the perilla frutescens, the astragalus membranaceus, the prepared rehmannia root and the pumpkin base weighed in the step 1, adding water which is 10 times of the total weight of the sticky rice, soaking the sticky rice overnight, then decocting the sticky rice with slow fire for 2.0h, adding the fructus amomi weighed in the step 1, continuing to decoct the sticky rice for 8min, and filtering the mixture to obtain first filtrate and filter residues; adding water which is 10 times of the weight of the filter residue into the filter residue, continuously decocting with slow fire for 1.5h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, uniformly mixing, concentrating to a concentration which is 1g/mL of the original medicinal material to obtain a traditional Chinese medicine composition, and refrigerating the traditional Chinese medicine composition at 4 ℃ for later use;
and (3) continuously concentrating the traditional Chinese medicine composition prepared in the step (2) into a thick extract, adding the weighed folic acid and a proper amount of auxiliary materials, uniformly mixing, granulating, sieving, drying, further tabletting the prepared granules, and drying to obtain the tablet-type traditional Chinese medicine preparation for preventing miscarriage of livestock.
The traditional Chinese medicine preparations for miscarriage prevention for livestock prepared in the examples 1 to 3 have good effects, and the effects of the invention are described only by using the traditional Chinese medicine preparation prepared in the example 1 because the effects of the traditional Chinese medicine preparations for miscarriage prevention for livestock prepared in the examples 1 to 3 are basically parallel.
1. Experimental methods
In the experiment, 150 pregnant sows and 150 pregnant queens are selected and divided into two groups for experiment, wherein the pregnant sows are the first group, and the pregnant queens are the second group. Each group was randomly divided into three groups of 50/group, and the experimental groups were fed with the herbal preparation of example 1; the positive control group is injected with 50-75 mg of progesterone per head/single muscle according to the size of the pregnant animals; the remaining subset served as a blank control without any treatment.
2. Statistical method
Analyzing by SPSS17.0 statistical software, performing paired t-test for the front and back comparison of the measurement data, performing independent sample t-test for the inter-group comparison of the measurement data, and performing x-test for the inter-group comparison of the count data2And (6) checking.
3. Results of the experiment
The first group of delivery results are shown in table 1. The second group of delivery results are shown in table 2.
TABLE 1 first set of delivery outcomes
| Grouping | Normal delivery (head) | Abnormal childbirth (head) | Average litter size (head) | Normal parturition rate (%) |
| Blank control group | 41 | 9 | 8.2 | 82 |
| Positive control group | 45 | 5 | 11.5* | 90 |
| Experimental group | 48 | 2 | 12.8* | 96 |
Indicates significant difference (P < 0.05); indicates that the difference is extremely significant (P <0.01)
TABLE 2 second group of delivery outcomes
| Grouping | Normal delivery (head) | Abnormal childbirth (head) | Average litter size (head) | Normal parturition rate (%) |
| Blank control group | 43 | 7 | 4.3 | 86 |
| Positive control group | 46 | 4 | 6.2 | 92 |
| Experimental group | 49 | 1 | 7.1* | 98 |
Indicates significant difference (P < 0.05); indicates that the difference is extremely significant (P <0.01)
The results show that the normal labor rate of the experimental group and the positive control group of the first group and the second group is higher than that of the blank control group, the average litter size of the experimental group and the positive control group of the first group is significantly higher than that of the blank control group (P <0.05), and the average litter size of the experimental group and the positive control group of the second group is significantly higher than that of the blank control group (P < 0.05). The traditional Chinese medicine preparation prepared in the embodiment 1 of the invention can prevent abortion and premature birth of pregnant sows and pregnant cats, and has a good fetus protection effect on the pregnant sows and the pregnant cats.
It should be noted that when the following claims refer to numerical ranges, it should be understood that both endpoints of each numerical range and any numerical value between the two endpoints can be selected, and since the steps and methods adopted are the same as those in embodiments 1 to 3, the present invention describes preferred embodiments in order to prevent redundant description, but once a person skilled in the art knows the basic inventive concept, other changes and modifications can be made to these embodiments. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (4)
1. The compound traditional Chinese medicine preparation for miscarriage prevention of livestock is characterized by comprising the following raw materials in parts by weight: 15-25 parts of fructus amomi, 5-10 parts of glutinous rice, 15-25 parts of scutellaria baicalensis, 5-10 parts of ramie root, 5-10 parts of purple perilla, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared rehmannia root, 5-10 parts of pumpkin pedicel and 1-5 parts of folic acid.
2. The compound traditional Chinese medicine preparation for livestock miscarriage prevention according to claim 1, which is characterized in that the preparation raw materials comprise the following components in parts by weight: 20 parts of fructus amomi, 8 parts of glutinous rice, 20 parts of scutellaria baicalensis, 8 parts of ramie root, 8 parts of purple perilla, 15 parts of astragalus mongholicus, 15 parts of prepared rehmannia root, 8 parts of pumpkin pedicel and 3 parts of folic acid.
3. The preparation method of the compound traditional Chinese medicine preparation for miscarriage prevention of livestock according to claim 1, which is characterized by comprising the following steps:
step 1, weighing 15-25 parts of fructus amomi, 5-10 parts of glutinous rice, 15-25 parts of scutellaria baicalensis, 5-10 parts of ramie root, 5-10 parts of perilla, 10-20 parts of astragalus membranaceus, 10-20 parts of prepared rehmannia root, 5-10 parts of pumpkin pedicel and 1-5 parts of folic acid for later use;
step 2, uniformly mixing the sticky rice, the scutellaria baicalensis, the ramie root, the perilla frutescens, the astragalus membranaceus, the prepared rehmannia root and the pumpkin base weighed in the step 1, adding water which is 8-12 times of the total weight of the sticky rice, soaking overnight, then decocting with slow fire for 1.5-2.5 h, then adding the fructus amomi weighed in the step 1, continuing to decoct for 5-10 min, and filtering to obtain a first filtrate and filter residues; adding water which is 8-12 times of the weight of the filter residue into the filter residue, continuously decocting with slow fire for 1.0-2.0 h, filtering to obtain a second filtrate, combining the first filtrate and the second filtrate, uniformly mixing, concentrating to a concentration which is 1g/mL of the original medicinal material to obtain a traditional Chinese medicine composition, and refrigerating the traditional Chinese medicine composition at 4 ℃ for later use;
and 3, uniformly mixing the folic acid weighed in the step 1 with the traditional Chinese medicine composition prepared in the step 2 to obtain the traditional Chinese medicine preparation for miscarriage prevention of livestock.
4. The method for preparing the compound traditional Chinese medicine preparation for livestock miscarriage prevention according to claim 3, wherein the medicinal dosage form of the traditional Chinese medicine preparation is decoction, tablets, capsules, granules, pills and injection.
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