CN100398141C

CN100398141C - Medicine for treating hyperplasia of mammary glands and preparation method thereof

Info

Publication number: CN100398141C
Application number: CNB2005100170234A
Authority: CN
Inventors: 暴永贤; 暴伟明; 暴竞闲
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-08-02
Filing date: 2005-08-02
Publication date: 2008-07-02
Anticipated expiration: 2025-08-02
Also published as: CN1907459A

Abstract

The invention relates to a traditional Chinese medicinal composition for treating mammary gland hyperplasia, which is prepared from pericarpium trichosanthis, Chinese angelica root, licorice root, burred tuber, zedoary, radix paeoniae rubrathe, Bupleurum root, poria cocos, white atractylodes rhizome, root of red rooted saliva, curcuma aromatica, cyperus tuber, thunberg fritillary bulb, Chinese honeylocust spine, frankincense, myrrh, notoginseng, spatholobus stem through steps of refining, disintegrating, boiling and grilling to obtain fluid extract of Chinese herbs, mixing, drying, disintegrating and packaging into capsules.

Description

Medicine of treatment cyclomastopathy and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of mastopathy, specifically is a kind of Chinese medicine preparation for the treatment of cyclomastopathy of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.

Background technology

Cyclomastopathy is that shape scleroma lump not of uniform size appears in breast, is the common neoplastic disease of breast, how because of feelings will internal injury, liver energy depression and phlegm stagnation, due to the phlegm and blood stasis breast, good top outside breast, the irregular round or flat breast that is scattered in of form sent out, or be confined to a place, lump and surrounding tissue boundary are unclear, with the skin adhesion, push away moving, pain increases the weight of before the menstruation, and lump increases; Through after pain relief or disappearance.The possibility that cancerates is arranged, and Western medicine does not still have good Therapeutic Method to this disease, and also there is the problem of one-sidedness aspect in Chinese medicine.

Summary of the invention

The objective of the invention is in order to overcome the deficiency of existing medicine, providing a kind of is raw material with Chinese medicine, and nothing is paid effect, and onset is rapid, and the medicine of the treatment cyclomastopathy of the difficult recurrence in back of healing and preparation method thereof.

In order to achieve the above object, technical scheme of the present invention is:

Medicine of the present invention is to be made by the medicine of following weight proportion:

Fructus Trichosanthis 25-30 part, XIGUI 10-15 part, Radix Glycyrrhizae 10-15 part,

Rhizoma sparganic 5-10 part, Rhizoma Curcumae 5-10 part, Radix Paeoniae Rubra 10-15 part,

Radix Bupleuri 20-25 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Salviae Miltiorrhizae 20-25 part,

Radix Curcumae 10-15 part, Rhizoma Cyperi 10-15 part, Spina Gleditsiae 20-25 part,

Olibanum 5-10 part, Myrrha 5-10 part, Caulis Spatholobi 15-20 part,

Poria 10-15 part, Bulbus Fritillariae Thunbergii 10-15 part, Radix Notoginseng 5-10 part.

The best proportioning of medicine of the present invention is:

30 parts of Fructus Trichosanthis, 15 parts of XIGUI, 15 parts in Radix Glycyrrhizae, 10 parts of rhizoma sparganic,

10 parts of Rhizoma Curcumae, 15 parts of Radix Paeoniae Rubra, 20 parts of Radix Bupleuri, 10 parts in Poria,

15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Curcumaes, 15 parts of Rhizoma Cyperis,

15 parts of Bulbus Fritillariae Thunbergiis, 20 parts of Spina Gleditsiae, 8 parts of Olibanums, 8 parts of Myrrhas,

8 parts of Radix Notoginseng, 15 parts of Caulis Spatholobis.

The method of above-mentioned each component being made medicine of the present invention is:

1, above-mentioned Poria, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, Radix Notoginseng are selectedly cleaned, oven dry, powder become coarse powder stand-by.

2 discard the dross and select the essential above-mentioned Fructus Trichosanthis, XIGUI, Radix Glycyrrhizae, Radix Paeoniae Rubra, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Spina Gleditsiae, Rhizoma Cyperi, Caulis Spatholobi, Olibanum, Myrrha, decoct with water, decocted 1.5 hours for the first time, decocted 1.5 hours for the second time, decocted for the third time 1 hour, gradation is filtered, merging filtrate, static 24 hours, getting supernatant concentration was 1.35-1.38 to relative density, and it is standby to make fluid extract.

3, with the coarse powder mixing and stirring in fluid extract and 1,60-80 ℃ of oven dry down, the fine powder that is ground into 80-100 is encapsulated, every 0.4 gram 10 ± %.

Instructions of taking: each 4-6 grain, day clothes 3 times, whenever half an hour after the meal, eliminating cold for resuscitation water send down, and 15 is a course of treatment.

The present invention is based on pathogenetic understanding and the rule of treatment of motherland's medical science, with reference to modern pharmacological research to cyclomastopathy; From motherland medicine treasure-house, filter out have dispersing the stagnated live-QI to relieve the stagnation of QI, warming YANG reduces phlegm, hard masses softening and resolving, the natural drug that conditioning is dashed, appointed, by the theory of Chinese medical science prescription, skimming the cream off milk makes it to reach evident in efficacy, and can prevent to cancerate, more the back is difficult for the purpose of recurrence.

Clinical therapeutic efficacy:

Cyclomastopathy is a kind of non-inflammation disease of breast portion, belongs to the nodules of the breast scope of motherland's medical science, and the cause of disease mostly is to tie in depressed rage impairing the liver, stagnation of QI due to depression of the liver, worry impairing spleen, dysfunction of the spleen in transportation, stagnation of Qi and phelgm or deficiency of the liver and kindey Chong and Ren channel disorder, the phlegm-damp and forms.

The inventor is with the over one hundred example of Chinese medicine fast active capsule treatment cyclomastopathy patient, and through clinical observation in 7 years, warp and matched group, contrast and statistical procedures proved that it is evident in efficacy, now clinical observation result were reported as follows:

1. clinical data: out-patient treatment cyclomastopathy patient now puts 100 examples in order, is the women, between age 26-50 year, is divided into two groups at random, and 50 examples are organized in the fast active capsule treatment, and matched group 50 examples adopt other drug: (RUPIXIAO, BAIXIAO DAN etc.) treatment.

2. Therapeutic Method: the Main Ingredients and Appearance of medicine of the present invention is: 18 flavor Chinese herbal medicine such as Fructus Trichosanthis, XIGUI, Radix Glycyrrhizae, rhizoma sparganic, Rhizoma Curcumae, Radix Paeoniae Rubra, Radix Bupleuri, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Radix Curcumae, Rhizoma Cyperi, Bulbus Fritillariae Thunbergii, Spina Gleditsiae, Olibanum, Myrrha, Radix Notoginseng, Caulis Spatholobi are measured selected in accordance with regulations, earlier Poria, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, Radix Notoginseng are selectedly cleaned, oven dry, powder become coarse powder; With all the other 13 flavor decoctings three times, 1.5 hours for the first time, fried in shallow oil 1.5 hours for the second time again, fried in shallow oil for the third time 1 hour, gradation is filtered, merging filtrate, static 24 hours, getting supernatant concentration to relative density is 1.35-1.38, make fluid extract, again with fluid extract and coarse powder mixing and stirring, oven dry, powder becomes 80-100 purpose fine powder encapsulated, every 0.4 gram 10 ± %.Each 4-6 grain, day clothes 3 times, whenever half an hour after the meal, eliminating cold for resuscitation water send down, and 15 is a course of treatment, observe the curative effect after 1 course of treatment, the observation period is limited to 2 hours.

3. observational technique: index and curative effect judging standard.Observe index, curative effects such as patient's symptom and sign weekly and be divided into recovery from illness, produce effects, enabledisable.Recovery from illness with effectively add up to effectively.Tie full judgement treatment standard with the ultrasound diagnosis result mutually with subjective symptoms.Subjective symptoms disappears, and ultrasound diagnosis and palpation lump disappear and be recovery from illness.Subjective symptoms is clearly better, and ultrasound diagnosis and first visit contrast lump obviously reduces, is reduced to produce effects, and subjective symptoms alleviates not obvious, and the ultrasound diagnosis lump is reduced to effectively, subjective symptoms and ultrasound diagnosis all do not have transfer to invalid.

4. result

Observation of curative effect the results are shown in Table:

Group	Case load	Recovery from illness	Produce effects	Effectively	Invalid	Cure rate	Effective percentage
Group	Case load	Recovery from illness	Produce effects	Effectively	Invalid	Cure rate	Effective percentage	The treatment group	50	40	6	4	Do not have	80％	100％
Synopsis	50	18	5	7	20	36％	60％	The treatment group	50	40	6	4	Do not have	80％	100％

As can be seen from the table, treatment group and matched group exist significant difference, and the curative effect of medicine of the present invention (fast active capsule) obviously is better than other medicines.

5. model case

Liu Shufen: 38 years old, body township, big room, Lishu County, December was gone to a doctor on the 21st in 1999, readme both sides mastalgia more than a year, the time heavy when light, the outer quadrants of going up of two breasts can contact egg yolk size lump, quality is soft, and mobility is fair, with the surrounding tissue adhesion, no aversion to cold, heating, local nothing is red and swollen, and the distention and pain of breast before menstruation mastalgia increases the weight of, ultrasound diagnosis prompting cyclomastopathy, give fast active capsule and treat each 6, day obvious dissipation of clothes twice, 20 pain disappearance .B super demonstration cyclomastopathy is obeyed 20 again as a means of consolidation.

Wei Shuzhen: 49 years old, Siping City Tiexi District Xi Qiao committee, June 8 in 2004 examined, conscious two suppurative mastitis expand, the time pain arranged.Can touch the large and small enclosed mass that do not wait on two breasts are outer, ache through foremilk and increase the weight of, lump has increase, enclosed mass is big as egg yolk in the breast that touches, little of prunus mume (sieb.) sieb.et zucc., Lee, with lassitude, soreness of the waist and knees, ultrasound diagnosis, the prompting cyclomastopathy, behind the clothes fast active capsule treatment first quarter moon, symptom is obviously alleviated, symptom fades away after 30 days, and the ultrasound diagnosis lump dissipates to follow up a case by regular visits to and do not see recurrence in 3 months.

6. discuss

The pathogenesis of primary disease is a depressed rage impairing the liver, stagnation of QI due to depression of the liver, excessive thinking damage heart spleen, dysfunction of the spleen in transportation, accumulate in the mental disorder, so that liver spleen two is hindered stagnation of Qi and phelgm or deficiency of the liver and kindey, knot forms in the Chong and Ren channel disorder yang deficiency phlegm-damp, and controlling should be at pathogenesis, dispersing the stagnated live-QI to relieve the stagnation of QI, dissipating phlegm and resolving masses, activating blood circulation to dissipate blood stasis, Chong and Ren Meridians regulating.Fructus Trichosanthis, Radix Bupleuri, Radix Curcumae dispersing the stagnated live-QI to relieve the stagnation of QI in the side; Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae invigorating the spleen for dissipating phlegm, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, Olibanum, Myrrha hard masses softening and resolving, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, pseudo-ginseng blood-circulation-invigovating blood stasis dispelling; XIGUI, Rhizoma Cyperi, Caulis Spatholobi invigorating the liver and kidney; Chong and Ren Meridians regulating, Spina Gleditsiae, detoxifcation and tying-in.All medicines share, just middle pathogenesis.

The specific embodiment

By proportioning raw materials, take by weighing Fructus Trichosanthis 300g, XIGUI 150g, Radix Glycyrrhizae 100g, rhizoma sparganic 80g, Rhizoma Curcumae 80g, Radix Paeoniae Rubra 150g, Radix Bupleuri 200g, Poria 100g, Rhizoma Atractylodis Macrocephalae 150g, Radix Salviae Miltiorrhizae 200g, Radix Curcumae 150g, Rhizoma Cyperi 150g, Bulbus Fritillariae Thunbergii 100g, Spina Gleditsiae 200g, Olibanum 80g, Myrrha 80g, Radix Notoginseng 80g, Caulis Spatholobi 200g.

1, above-mentioned 18 Poria 100g, rhizoma sparganic 80g, Rhizoma Curcumae 80g, Bulbus Fritillariae Thunbergii 100g, the Radix Notoginseng 80gs of flavor among the Chinese herbal medicine selectedly cleaned, dry, to be ground into coarse powder stand-by;

2, again with all the other 13 flavor Fructus Trichosanthis 300g, XIGUI 150g, Radix Glycyrrhizae 100g, Radix Paeoniae Rubra 150g, Radix Bupleuri 200g, Rhizoma Atractylodis Macrocephalae 150g, Radix Salviae Miltiorrhizae 200g, Radix Curcumae 150g, Rhizoma Cyperi 150g, Spina Gleditsiae 200g, Olibanum 80g, Myrrha 80g, Caulis Spatholobi 200g, decocting boils three times, decocted 1.5 hours for the first time, decocted 1.5 hours for the second time, decoct 1 hour (all using slow fire) for the third time, gradation is filtered, merging filtrate, static 24 hours, getting supernatant concentration to relative density was 1.35-1.38, makes fluid extract.

3, again with the fluid extract mixing and stirring in the coarse powder and 2 in above-mentioned 1, oven dry is ground into the fine powder of 80-100, and encapsulated, every 0.4 gram 10 ± % promptly.

Claims

1. medicine for the treatment of cyclomastopathy, it is characterized in that: it is the medicament of being made by following materials of weight proportions medicine:

Olibanum 5-10 part, Myrrha 5-10 part, Caulis Spatholobi 15-20 part,

Poria 10-15, Bulbus Fritillariae Thunbergii 10-15 part, Radix Notoginseng 5-10 part.

2. the medicine of treatment cyclomastopathy according to claim 1 is characterized in that: wherein the proportioning of each crude drug is:

8 parts of Radix Notoginseng, 15 parts of Caulis Spatholobis.

3. the medicine of treatment cyclomastopathy according to claim 1 and 2 is characterized in that: described medicament is a capsule.

4. the preparation method of the medicine of treatment cyclomastopathy according to claim 3 is characterized in that the preparation method of described capsule is as follows:

(1), above-mentioned Poria, rhizoma sparganic, Rhizoma Curcumae, Bulbus Fritillariae Thunbergii, Radix Notoginseng are selectedly cleaned, oven dry, powder become coarse powder stand-by;

(2), above-mentioned Fructus Trichosanthis, XIGUI, Radix Glycyrrhizae, Radix Paeoniae Rubra, Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Spina Gleditsiae, Rhizoma Cyperi, Caulis Spatholobi, Olibanum, Myrrha are discarded the dross and selected the essential, decoct with water, decocted 1.5 hours for the first time, decocted 1.5 hours for the second time, decocted for the third time 1 hour, gradation is filtered, merging filtrate, static 24 hours, getting supernatant concentration was 1.35-1.38 to relative density, and it is standby to make fluid extract;

(3), with the coarse powder mixing and stirring in fluid extract and 1,60-80 ℃ of down oven dry, the fine powder that is ground into 80-100 is encapsulated, every 0.4 gram ± 10%.