CN103655874B - A kind of topical agent for the treatment of tinea manus and pedis, tinea unguium - Google Patents
A kind of topical agent for the treatment of tinea manus and pedis, tinea unguium Download PDFInfo
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- CN103655874B CN103655874B CN201310728704.6A CN201310728704A CN103655874B CN 103655874 B CN103655874 B CN 103655874B CN 201310728704 A CN201310728704 A CN 201310728704A CN 103655874 B CN103655874 B CN 103655874B
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Abstract
The present invention relates to a kind of topical agent for the treatment of tinea manus and pedis, tinea unguium, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis Fructus Anisi Stellati Pericarpium Zanthoxyli extracting solution 100 parts, 6 ~ 12 parts, glacial acetic acid, extract of willow bark 3 ~ 10 parts, 0.5 ~ 3 part, benzoic acid, boric acid 3 ~ 6 parts, lactic acid 1 ~ 3 part.Advantage of the present invention is: the method that have employed Integrated TCM, the strong permeability of Western medicine, bactericidal feature are given full play to, improve the strong and stimulating of Western medicine with Chinese medicine simultaneously, improve heat clearing and damp drying, remove aging cutin, strengthen skin vitality, anti-inflammation, improve skin immunity, skin Lightening is lubricated, and therapeutic effect is remarkable.
Description
Technical field
The present invention relates to a kind of topical agent for the treatment of tinea manus and pedis, tinea unguium.
Background technology
Tinea manus and pedis, tinea unguium have multiple different fungal infection to form.Tinea manus and pedis, tinea unguium are the diseases that a kind of very refractory is healed, and at present, the medicine for external use of Western medicine, treatment by Chinese herbs tinea manus and pedis, tinea unguium has a lot, but it is strong that some Western medicine also exist zest, easily causes skin allergy, volatile, the deficiency that side effect is large; Some Chinese medicine also exists the defect of poor permeability, administration time length.Some medicine for external use are cured the symptoms, not the disease and are easily recurred, some external use liquids are had to become dry soon after being applied in affected part, drug effect can not balanced, persist to affected part and cause curative effect obviously to decline, have in some medicament short time to use and have certain effect, long-time use curative effect is not obvious, in addition, medicine for external use price is high, adds the treatment cost of patient.
Summary of the invention
For overcoming the deficiencies in the prior art, the object of this invention is to provide a kind of topical agent for the treatment of tinea manus and pedis, tinea unguium, non-stimulated, permeability is strong, remove cutin, strengthen skin vitality, anti-inflammation, raising skin immunity, resist that extraneous antibacterial corrodes, treatment time is short, cost is low.
For achieving the above object, the present invention is achieved through the following technical solutions:
Treat a topical agent for tinea manus and pedis, tinea unguium, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 100 parts, 6 ~ 12 parts, glacial acetic acid, extract of willow bark 3 ~ 10 parts, 0.5 ~ 3 part, benzoic acid, boric acid 3 ~ 6 parts, lactic acid 1 ~ 3 part.
Described Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, Radix Sophorae Flavescentis 1 ~ 3 part, 1 ~ 3 part, Fructus Foeniculi, 3 ~ 6 parts, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are boiled 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.
Compared with prior art, the invention has the beneficial effects as follows:
Have employed the method for Integrated TCM, given full play to the strong permeability of Western medicine, bactericidal feature, improve the strong and stimulating of Western medicine simultaneously with Chinese medicine, improve heat clearing and damp drying, remove aging cutin, strengthen skin vitality, anti-inflammation, improves skin immunity, reaches and adjusts smooth QI and blood, Yin Yang balancing, the effect of dredging liver, therefore, administration time is short, without pain, has no side effect, skin Lightening is lubricated, and therapeutic effect is remarkable.
Detailed description of the invention
Below the present invention is described in detail, but it should be noted that enforcement of the present invention is not limited to following embodiment.
Treatment tinea manus and pedis, the topical agent of tinea unguium, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 100 parts, 6 ~ 12 parts, glacial acetic acid, extract of willow bark (more than 90%) 3 ~ 10 parts, 0.5 ~ 3 part, benzoic acid, boric acid 3 ~ 6 parts, lactic acid 1 ~ 3 part, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is by distilled water 100 parts, Radix Sophorae Flavescentis 1 ~ 3 part, 1 ~ 3 part, Fructus Foeniculi, 3 ~ 6 parts, Pericarpium Zanthoxyli composition, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: by distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli boils 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.
Carry out the preparation method setting forth medicine of the present invention further by the following examples:
Embodiment 1:
Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 100 parts, 9 parts, glacial acetic acid, extract of willow bark 6 parts, 2 parts, benzoic acid, boric acid 5 parts, lactic acid 2 parts, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, Radix Sophorae Flavescentis 2 parts, 3 parts, Fructus Foeniculi, 5 parts, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are boiled 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.By Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate according to the obtained topical agent of the present invention of said ratio mixing.
Embodiment 2:
Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 100 parts, 7 parts, glacial acetic acid, extract of willow bark 4 parts, 1 part, benzoic acid, boric acid 4 parts, lactic acid 1 part, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, Radix Sophorae Flavescentis 1 part, 2 parts, Fructus Foeniculi, 3 parts, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are boiled 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.By Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate according to the obtained topical agent of the present invention of said ratio mixing.
Embodiment 3:
Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 100 parts, 11 parts, glacial acetic acid, extract of willow bark 9 parts, 2.5 parts, benzoic acid, boric acid 6 parts, lactic acid 3 parts, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, Radix Sophorae Flavescentis 3 parts, 2 parts, Fructus Foeniculi, 5 parts, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are boiled 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.By Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate according to the obtained topical agent of the present invention of said ratio mixing.
Embodiment 4:
Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 100 parts, 12 parts, glacial acetic acid, extract of willow bark 10 parts, 3 parts, benzoic acid, boric acid 5 parts, lactic acid 2 parts, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, Radix Sophorae Flavescentis 3 parts, 3 parts, Fructus Foeniculi, 5 parts, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are boiled 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.By Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate according to the obtained topical agent of the present invention of said ratio mixing.
Medicament selection Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution of the present invention, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, lactic acid carry out combining, effect of each medicine is made by these drug regimens to produce synergism, thus can effectively treat tinea manus and pedis, tinea unguium, the property of medicine, the action and efficacy of wherein medication are:
Radix Sophorae Flavescentis: heat clearing and damp drying, diuresis; For hematodiarrhoea, have blood in stool, jaundice urine retention, eczema, eczema, skin pruritus, scabies leprosy.
Pericarpium Zanthoxyli: nature and flavor are pungent, warm, its effect warming spleen and stomach for dispelling cold, dehumidifying, warming middle-JIAO to relieve pain, killing parasites for relieving itching; Be adapted to eczema pruritus, stubborn dermatitis brothers rhagades of the skin.
Fructus Foeniculi: pungent, temperature; Effect warming YANG to expel cold, regulating QI to relieve pain; Control invasion by pathogenic cold vomiting, colic of cold type is suffered from abdominal pain, lumbago due to renal deficiency, dry, beriberi caused by pathogenic damp.
Bark of willow: cold in nature, bitter in the mouth; To eliminate the phlegm improving eyesight, heat-clearing and toxic substances removing, diuresis Radix Saposhnikoviae, eliminating inflammation and expelling toxin, treatment scabies persistent ailment; Its extract has removal cutin, enhancing Skin Cell vigor, anti-inflammation, raising skin immunity, resists the erosion of extraneous antibacterial, repairs impaired skin effect.The extract of willow bark adopted in this medicament commercially can buy, as: the extract of willow bark that Xi'an Hong Yue biological engineering company limited produces, containing the white powder of salicoside more than 90%.
Benzoic acid: disinfection preservative, can grow, outward for the mycotic infection of superficial part such as tinea corporis, tinea manus and pedis by Antifungi.
Boric acid: effect is external antibacterial, disinfectant, astringent and antiseptic; All inhibitory action is had to various bacteria, mycete; As the cleaning agent of skin lesion, also can be used for the acute eczema, impetigo etc. of accompanying a large amount of sepage.
Glacial acetic acid: antibacterial, destroys fungus living environment, and plays bactericidal action; Be used for the treatment of the treatment of the infection of various superficial skin fungus and clavus wart.
Lactic acid: be widely used as antiseptic, carrier agent, cosolvent, pharmaceutical preparation, pH adjusting agent etc.; There is permeability strong, the feature that moistening effect is good.
Using method:
1, first hands, foot, sick first are cleaned and dried;
2, medicament is all poured in trick cover; Polyethylene from high pressure process is applied mechanically in described trick, and through blowing the first day of the lunar month, heat seal forms;
When 3, treating at every turn, hands or foot are put into take out after soaking 5-10 minute in hands or footmuff and dry, trick cover is sealed, within second day, repeat to soak, continuous 5-7 days;
4, sick first morning and evening every day liquid medicine is smeared once, within continuous 7 days, is a course for the treatment of, continuous two courses for the treatment of.
Curative effect judging standard:
Effective: tinea manus and pedis medication is after 3 days, and brothers' aging cutin starts to come off, there is tender skin in surface, affected part, micro-red, smooth, removes pruritus.After two courses for the treatment of of tinea unguium medication, suffer from first painless, after a few days (30 days) suffer from first nail root turn white, smooth;
Recovery from illness: tinea manus and pedis medication is after 5-7 days, and brothers' aging cutin all comes off, surface, affected part is in intact skin, and skin surface light lubrication, thoroughly removes aging cutin and killing fungus.Two courses for the treatment of of tinea unguium medication, after a few days, (90 days) new first slowly grows, sick onychoptosis, new first smooth shinny, turn white interior red, smooth.
Adopt the present invention to treat the topical agent of tinea manus and pedis, tinea unguium, as stated above 150 tinea manus and pedis patients and 50 onychomycosis are treated and its curative effect situation of tracing observation as follows:
150 tinea manus and pedis patient clinical experiments are proved, its cure rate 99%, effective percentage 100%; To 50 onychomycosis's clinical trial certificates, its cure rate 92%, effective percentage 99%, observed and does not have recurrent cases after 1 year.
Case 1: Kuan Dian town, In Kuandian, Liaoning Province Lee so-and-so, man, 58 years old, suffer from more than 20 years of beriberi, very itch every spring incomparably, often smear various beriberi medicine liquid, recur after several days, he scratches affected part through conventional hands, causes affected part to play Lao Pi 0.2 cm thick; After soaking 3 days with medicament of the present invention, Lao Pi starts to come off, and pruritus improves, and soak after 7 days, aging cutin all comes off, and skin Lightening lubricates, and beriberi is thoroughly cured.
Case 2: Sui of Yuanbao District of Dandong City so-and-so, female, 56 years old, suffer from more than 20 years of beriberi, sole is transparent, the transparent the inside of sole rise little plain boiled water bubble itch very much; After soaking 3 days with product of the present invention, Lao Pi starts to come off, and little plain boiled water bubbles open and begins to reduce, and pruritus improves, and soak after 7 days, aging cutin all comes off, and little plain boiled water bubble all disappears, and beriberi is thoroughly cured.
Case 3: Zhenxing District, Dandong City Lee, man, 46 years old, suffer from more than 10 years of beriberi, very itch throughout the year, often smear various beriberi medicine liquid and ointment, recurrence after one week, after soaking 3 days with product of the present invention, Lao Pi starts to come off, pruritus improves, soak after 7 days, aging cutin all comes off, and skin Lightening lubricates, beriberi is thoroughly cured, and observes no recurrence afterwards in a year.
Case 4: Bai, female, 50 years old, people from Zhenxing District, Dandong City, foot suffers from tinea unguium 8 years, and toenail is greyish white, suffer from the half that first only remains toenail, after soaking with product of the present invention, every day smears once sooner or later, discontinues medication after 14 days, after 30 days, suffer from nail root portion and slowly occur normal toenail, after 100 days, normal toenail all grows.
Case 5: cold so-and-so, female, 48 years old, people from Zhenan District, Dandong City, foot suffers from tinea unguium 10 years, and toenail is greyish black, and recovery from illness is failed in many places treatment; After soaking with product of the present invention, every day smears once sooner or later, discontinues medication after 14 days, and after 30 days, suffer from nail root portion and slowly occur normal toenail, after 100 days, normal toenail all grows.
The present invention treats the topical agent of tinea manus and pedis, tinea unguium, owing to have employed Integrated TCM, has given full play to the strong permeability of Western medicine, bactericidal feature, improve the strong and stimulating of Western medicine simultaneously with Chinese medicine, improve heat clearing and damp drying, remove aging cutin, reach and adjust smooth QI and blood, Yin Yang balancing, the effect of dredging liver, therefore, administration time is short, without pain, has no side effect, skin Lightening is lubricated, and therapeutic effect is remarkable.
Claims (1)
1. treat the topical agent of tinea manus and pedis, tinea unguium for one kind, it is characterized in that, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis Fructus Anisi Stellati Pericarpium Zanthoxyli extracting solution 100 parts, 6 ~ 12 parts, glacial acetic acid, extract of willow bark 3 ~ 10 parts, 0.5 ~ 3 part, benzoic acid, boric acid 3 ~ 6 parts, lactic acid 1 ~ 3 part;
Described Radix Sophorae Flavescentis Fructus Anisi Stellati Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, Radix Sophorae Flavescentis 1 ~ 3 part, Fructus Anisi Stellati 1 ~ 3 part, 3 ~ 6 parts, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Anisi Stellati Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Anisi Stellati, Pericarpium Zanthoxyli are boiled 15-20 minute by said ratio mixing, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.
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| CN201310728704.6A CN103655874B (en) | 2013-12-25 | 2013-12-25 | A kind of topical agent for the treatment of tinea manus and pedis, tinea unguium |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049362A (en) * | 2007-05-09 | 2007-10-10 | 丹东源甲科技有限公司 | External remedy for treating onychomycosis |
| CN101703679A (en) * | 2009-11-10 | 2010-05-12 | 阚恭勇 | Medicament for treating onychomycosis |
| CN102225071A (en) * | 2011-06-21 | 2011-10-26 | 哈尔滨乐泰药业有限公司 | Preparation method of external medicine for treating tinea manuum and tinea pedis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010046526A1 (en) * | 2000-04-19 | 2001-11-29 | C-Quest | Treatment of fungal infections |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049362A (en) * | 2007-05-09 | 2007-10-10 | 丹东源甲科技有限公司 | External remedy for treating onychomycosis |
| CN101703679A (en) * | 2009-11-10 | 2010-05-12 | 阚恭勇 | Medicament for treating onychomycosis |
| CN102225071A (en) * | 2011-06-21 | 2011-10-26 | 哈尔滨乐泰药业有限公司 | Preparation method of external medicine for treating tinea manuum and tinea pedis |
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