CN103655874A - Externally-applied medicament for treating tinea manus and tinea pedis and onychomycosis - Google Patents
Externally-applied medicament for treating tinea manus and tinea pedis and onychomycosis Download PDFInfo
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- CN103655874A CN103655874A CN201310728704.6A CN201310728704A CN103655874A CN 103655874 A CN103655874 A CN 103655874A CN 201310728704 A CN201310728704 A CN 201310728704A CN 103655874 A CN103655874 A CN 103655874A
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Abstract
The invention relates to an externally-applied medicament for treating tinea manus and tinea pedis and onychomycosis. The externally-applied medicament is prepared from the following active pharmaceutical ingredients in weight parts: 100 parts of extracting solution from radix sophorae flavescentis, fennel and pericarpium zanthoxyli, 6-12 parts of glacial acetic acid, 3-10 parts of willow bark extract, 0.5-3 parts of benzonic acid, 3-6 parts of boric acid, and 1-3 parts of lactic acid. The externally-applied medicament has the advantages that the method of combining traditional Chinese medicine and western medicine is adopted, therefore, the characteristics of high permeability and high bactericidal activity of the western medicine are fully exerted, in addition, the high irritation of the western medicine is improved by the traditional Chinese medicine, heat-clearing and damp-drying drug are improved, aged keratin is removed, skin vitality is strengthened, antibacterial and anti-inflammatory effects are achieved, skin immunity is enhanced, the efficacy of activating and harmonizing qi-blood, balancing yin and yang and dredging liver are achieved, and therefore, the externally-applied medicament has the advantages of short medication time, no pain and no side effects, enables the skin to be bright and glossy, and has obvious curative effects.
Description
Technical field
The present invention relates to a kind of topical agent for the treatment of tinea manus and pedis, tinea unguium.
Background technology
Tinea manus and pedis, tinea unguium are to have multiple different fungal infection to form.Tinea manus and pedis, tinea unguium are the diseases that a kind of very refractory is healed, and at present, the medicine for external use of Western medicine, treatment by Chinese herbs tinea manus and pedis, tinea unguium has a lot, and still, it is strong that some Western medicine exist zest, easily causes skin allergy, volatile, the deficiency that side effect is large; Some Chinese medicine exists poor permeability, the long defect of administration time.Some medicine for external use are cured the symptoms, not the disease and are easily recurred, there are some external use liquids to become dry soon after being applied in affected part, drug effect can not be balanced, persist to affected part causes curative effect obviously to decline, have in some medicament short time and use and have certain effect, the long-time curative effect of using is not obvious, in addition, medicine for external use price is high, has increased patient's treatment cost.
Summary of the invention
For overcoming the deficiencies in the prior art, the object of this invention is to provide a kind of topical agent for the treatment of tinea manus and pedis, tinea unguium, non-stimulated, permeability is strong, remove cutin, strengthen skin vitality, anti-inflammation, raising skin immunity, resist that extraneous antibacterial corrodes, treatment time is short, cost is low.
For achieving the above object, the present invention is achieved through the following technical solutions:
Treat a topical agent for tinea manus and pedis, tinea unguium, by the crude drug of following weight portion, made: 100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 6～12 parts, glacial acetic acid, 3～10 parts of extract of willow bark, 0.5～3 part, benzoic acid, 3～6 parts of boric acid, 1～3 part of lactic acid.
Described Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is comprised of 3～6 parts of 100 parts of distilled water, 1～3 part of Radix Sophorae Flavescentis, 1～3 part, Fructus Foeniculi, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are mixed and boil 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.
Compared with prior art, the invention has the beneficial effects as follows:
Adopt the method for Chinese medicine and western medicine combination, given full play to the strong permeability of Western medicine, bactericidal feature, with Chinese medicine, improved the strong and stimulating of Western medicine simultaneously, improve heat clearing and damp drying, remove aging cutin, strengthen skin vitality, anti-inflammation, improves skin immunity, reaches and adjusts smooth QI and blood, Yin Yang balancing, the effect of dredging liver, therefore, administration time is short, without pain, has no side effect, make skin Lightening lubricated, therapeutic effect is remarkable.
The specific embodiment
Below the present invention is described in detail, but should be noted that enforcement of the present invention is not limited to following embodiment.
Treatment tinea manus and pedis, the topical agent of tinea unguium, crude drug by following weight portion is made: 100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 6～12 parts, glacial acetic acid, 3～10 parts of extract of willow bark (more than 90%), 0.5～3 part, benzoic acid, 3～6 parts of boric acid, 1～3 part of lactic acid, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is by 100 parts of distilled water, 1～3 part of Radix Sophorae Flavescentis, 1～3 part, Fructus Foeniculi, 3～6 parts of compositions of Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: by distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli mixes and boils 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.
Carry out by the following examples further to set forth the preparation method of medicine of the present invention:
Embodiment 1:
100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 9 parts, glacial acetic acid, 6 parts of extract of willow bark, 2 parts, benzoic acid, 5 parts of boric acid, 2 parts of lactic acid, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is comprised of 5 parts of 100 parts of distilled water, 2 parts of Radix Sophorae Flavescentiss, 3 parts, Fructus Foeniculi, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are mixed and boil 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate are mixed and make topical agent of the present invention according to said ratio.
Embodiment 2:
100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 7 parts, glacial acetic acid, 4 parts of extract of willow bark, 1 part, benzoic acid, 4 parts of boric acid, 1 part of lactic acid, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is comprised of 3 parts of 100 parts of distilled water, 1 part of Radix Sophorae Flavescentis, 2 parts, Fructus Foeniculi, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are mixed and boil 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate are mixed and make topical agent of the present invention according to said ratio.
Embodiment 3:
100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 11 parts, glacial acetic acid, 9 parts of extract of willow bark, 2.5 parts, benzoic acid, 6 parts of boric acid, 3 parts of lactic acid, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is comprised of 5 parts of 100 parts of distilled water, 3 parts of Radix Sophorae Flavescentiss, 2 parts, Fructus Foeniculi, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are mixed and boil 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate are mixed and make topical agent of the present invention according to said ratio.
Embodiment 4:
100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 12 parts, glacial acetic acid, 10 parts of extract of willow bark, 3 parts, benzoic acid, 5 parts of boric acid, 2 parts of lactic acid, Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is comprised of 5 parts of 100 parts of distilled water, 3 parts of Radix Sophorae Flavescentiss, 3 parts, Fructus Foeniculi, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are mixed and boil 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, ammonium lacate are mixed and make topical agent of the present invention according to said ratio.
Medicament selection Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution of the present invention, glacial acetic acid, extract of willow bark, benzoic acid, boric acid, lactic acid combine, make the effect of each medicine produce synergism these drug regimens, thereby can effectively treat tinea manus and pedis, tinea unguium, wherein the property of medicine of medication, action and efficacy are:
Radix Sophorae Flavescentis: heat clearing and damp drying, diuresis; For hematodiarrhoea, have blood in stool, jaundice urine retention, eczema, eczema, skin pruritus, scabies leprosy.
Pericarpium Zanthoxyli: nature and flavor are pungent, warm, its effect warming spleen and stomach for dispelling cold, dehumidifying, warming middle-JIAO to relieve pain, killing parasites for relieving itching; Be adapted to eczema pruritus, stubborn dermatitis brothers' rhagades of the skin.
Fructus Foeniculi: pungent, temperature; Effect warming YANG to expel cold, regulating QI to relieve pain; Control invasion by pathogenic cold vomiting, colic of cold type stomachache, lumbago due to renal deficiency, dry, beriberi caused by pathogenic damp.
Bark of willow: cold in nature, bitter in the mouth; Eliminate the phlegm improving eyesight, heat-clearing and toxic substances removing, diuresis Radix Saposhnikoviae, eliminating inflammation and expelling toxin, treatment scabies persistent ailment; Its extract has the cutin of removal, enhancing Skin Cell vigor, anti-inflammation, raising skin immunity, resists extraneous antibacterial erosion, repairs impaired skin effect.The extract of willow bark adopting in this medicament can buy on market, as: the extract of willow bark that Xi'an Hong Yue biological engineering company limited produces, containing more than 90% white powder of salicoside.
Benzoic acid: disinfection preservative, can grow by Antifungi, outward for mycotic infection of superficial part such as tinea corporis, tinea manus and pedis.
Boric acid: effect is external antibacterial, disinfectant, astringent and antiseptic; Various bacteria, mycete are all had to inhibitory action; As the cleaning agent of skin lesion, also can be used for accompanying the acute eczema, impetigo of a large amount of sepages etc.
Glacial acetic acid: antibacterial, destroys fungus living environment, and plays bactericidal action; Be used for the treatment of the treatment of various superficial skin fungus infection and clavus wart.
Lactic acid: be widely used as antiseptic, carrier agent, cosolvent, pharmaceutical preparation, pH adjusting agent etc.; There is permeability strong, the feature that moistening effect is good.
Using method:
1, first hands, foot, sick first are cleaned and dried;
2, medicament is all poured in trick cover; Polyethylene from high pressure process is applied mechanically in described trick, through blowing the first day of the lunar month, heat seal forms;
While 3, treating at every turn, hands or foot are put in hands or footmuff, to soak after 5-10 minute and take out and dry, trick cover is sealed, second day repeats to soak, continuously 5-7 days;
4, sick first is smeared once with liquid medicine every day sooner or later, within continuous 7 days, is a course for the treatment of, continuous two courses for the treatment of.
Curative effect judging standard:
Effective: tinea manus and pedis medication is after 3 days, and brothers' aging cutin starts to come off, there is tender skin in surface, affected part, micro-red, smooth, removes pruritus.After two courses for the treatment of of tinea unguium medication, suffer from first painless, after a few days (30 days) suffer from first nail root turn white, smooth;
Recovery from illness: tinea manus and pedis medication is after 5-7 days, and brothers' aging cutin all comes off, and surface, affected part is intact skin, skin surface light is lubricated, thoroughly removes aging cutin and killing fungus.Two courses for the treatment of of tinea unguium medication, after a few days, (90 days) new first slowly grows, sick onychoptosis, new first smooth shinny, turn white interior red, smooth.
Adopt the present invention to treat the topical agent of tinea manus and pedis, tinea unguium, to 150 tinea manus and pedis patients and 50 tinea unguium patients, treat with its curative effect situation of tracing observation as follows as stated above:
150 tinea manus and pedis patient clinicals be experiment showed, to its cure rate 99%, effective percentage 100%; 50 tinea unguium patient clinicals be experiment showed, to its cure rate 92%, and effective percentage 99% was observed and be there is no recurrent cases after 1 year.
Case 1: Kuan Dian town, In Kuandian, Liaoning Province Lee so-and-so, man, 58 years old, suffer from beriberi more than 20 years, very itch every spring incomparably, often smear various beriberi medicine liquids, recurrence afterwards in several days, he scratches affected part through commonly using hands, causes affected part to play Lao Pi 0.2 cm thick; With medicament of the present invention, soak after 3 days, Lao Pi starts to come off, and pruritus improves, and soaks after 7 days, and aging cutin all comes off, and skin Lightening is lubricated, and beriberi is thoroughly cured.
Case 2: Yuanbao District, Dandong City Sui so-and-so, female, 56 years old, suffer from beriberi more than 20 years, sole is transparent, the transparent the inside of sole is played little plain boiled water and is steeped and itch very much; With product of the present invention, soak after 3 days, Lao Pi starts to come off, and little plain boiled water bubbles open and begins to reduce, and pruritus improves, and soaks after 7 days, and aging cutin all comes off, and little plain boiled water bubble all disappears, and beriberi is thoroughly cured.
Case 3: Zhenxing District, Dandong City Lee, man, 46 years old, suffer from beriberi more than 10 years, very itch throughout the year, often smear various beriberi medicine liquids and ointment, recurrence after one week, soaks after 3 days with product of the present invention, and Lao Pi starts to come off, pruritus improves, soak after 7 days, aging cutin all comes off, and skin Lightening is lubricated, beriberi is thoroughly cured, and observes no recurrence afterwards in a year.
Case 4: Bai, female, 50 years old, people from Zhenxing District, Dandong City, foot is suffered from tinea unguium 8 years, and toenail is greyish white, trouble first only remains half of toenail, after soaking with product of the present invention, sooner or later smear once every day, after 14 days, discontinues medication, after 30 days, suffer from nail root portion and slowly occur normal toenail, after 100 days, normal toenail all grows.
Case 5: cold so-and-so, female, 48 years old, people from Zhenan District, Dandong City, foot is suffered from tinea unguium 10 years, toenail is greyish black, recovery from illness is failed in many places treatment; After soaking with product of the present invention, sooner or later smear once every day, after 14 days, discontinues medication, and after 30 days, suffers from nail root portion and slowly occur normal toenail, and after 100 days, normal toenail all grows.
The present invention treats the topical agent of tinea manus and pedis, tinea unguium, owing to having adopted Chinese medicine and western medicine combination, has given full play to the strong permeability of Western medicine, bactericidal feature, with Chinese medicine, improve the strong and stimulating of Western medicine simultaneously, improve heat clearing and damp drying, remove aging cutin, reach and adjust smooth QI and blood, Yin Yang balancing, the effect of dredging liver, therefore, administration time is short, without pain, has no side effect, make skin Lightening lubricated, therapeutic effect is remarkable.
Claims (2)
1. a topical agent for the treatment of tinea manus and pedis, tinea unguium, it is characterized in that, by the crude drug of following weight portion, made: 100 parts of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, 6～12 parts, glacial acetic acid, 3～10 parts of extract of willow bark, 0.5～3 part, benzoic acid, 3～6 parts of boric acid, 1～3 part of lactic acid.
2. a kind of topical agent for the treatment of tinea manus and pedis, tinea unguium according to claim 1, it is characterized in that, described Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is comprised of 3～6 parts of 100 parts of distilled water, 1～3 part of Radix Sophorae Flavescentis, 1～3 part, Fructus Foeniculi, Pericarpium Zanthoxyli, the preparation process of Radix Sophorae Flavescentis Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is: distilled water, Radix Sophorae Flavescentis, Fructus Foeniculi, Pericarpium Zanthoxyli are mixed and boil 15-20 minute by said ratio, be cooled to room temperature, soak 24 hours, with the above screen filtration of 200 order.
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| CN201310728704.6A CN103655874B (en) | 2013-12-25 | 2013-12-25 | A kind of topical agent for the treatment of tinea manus and pedis, tinea unguium |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010046526A1 (en) * | 2000-04-19 | 2001-11-29 | C-Quest | Treatment of fungal infections |
| CN101049362A (en) * | 2007-05-09 | 2007-10-10 | 丹东源甲科技有限公司 | External remedy for treating onychomycosis |
| CN101703679A (en) * | 2009-11-10 | 2010-05-12 | 阚恭勇 | Medicament for treating onychomycosis |
| CN102225071A (en) * | 2011-06-21 | 2011-10-26 | 哈尔滨乐泰药业有限公司 | Preparation method of external medicine for treating tinea manuum and tinea pedis |
-
2013
- 2013-12-25 CN CN201310728704.6A patent/CN103655874B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010046526A1 (en) * | 2000-04-19 | 2001-11-29 | C-Quest | Treatment of fungal infections |
| CN101049362A (en) * | 2007-05-09 | 2007-10-10 | 丹东源甲科技有限公司 | External remedy for treating onychomycosis |
| CN101703679A (en) * | 2009-11-10 | 2010-05-12 | 阚恭勇 | Medicament for treating onychomycosis |
| CN102225071A (en) * | 2011-06-21 | 2011-10-26 | 哈尔滨乐泰药业有限公司 | Preparation method of external medicine for treating tinea manuum and tinea pedis |
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