CN101703679A - Medicament for treating onychomycosis - Google Patents

Abstract

The invention provides a medicament for treating onychomycosis, and belongs to the field of medicinal preparations. The medicament is prepared from impatiens balsamina, salicylic acid, vaseline, Chinese gall, rose-of-Sharon root bark, amur cork-tree bark, common anemarrhena rhizome, anise, pricklyash peel, garlic and acetic acid in proportion. The medicament can effectively inhibit and kill bacteria and fungus, and promote metabolism so as to improve the cure rate.

Description

A kind of medicine for the treatment of tinea unguium

Technical field

The present invention relates to pharmaceutical preparation, specifically a kind of medicine for the treatment of tinea unguium.

Background technology

Tinea unguium is being commonly called as of infectious disease on a kind of people's of occurring in first.The traditional Chinese medical science claims " tinea unguium ".Claimed tinea unguium medically, then be tinea unguium now, it is to be caused by the infected by microbes that a big class is called pathogenic fungi.The tinea unguium pathological changes starts from first far-end, lateral margin or first pleat portion.Show as first color and paramophia.Be canescence more, and tarnish; The deck thickens significantly, and the surface is uneven.Its matter ravels, and keratin and detrital deposit are often arranged under the first.Sometimes, the deck can be separated with nail matrix.

Tinea unguium is a kind of infectious disease, not only can infect to household, friend, also can cause beriberi.In addition, tinea unguium also can be given the antihygienic sensation of people, causes the embarrassment in patient's social activity, such as hands has tinea unguium and dare not shake hands with other people, or can't be engaged in the work that some can expose hands to the open air, especially as receptionist, service man ... or the like.

The effect of Perorally administrable antimicrobial medicine treatment tinea unguium is not absolutely, finds according to clinical research, and its cure rate has from 40～70%, and medicine time is long, and is very big to the toxic and side effects of Liver and kidney, should not take for a long time.

Summary of the invention

The purpose of this invention is to provide easy to use, a kind of medicine for the treatment of tinea unguium of outstanding effect, but removing damp and stopping pain, detoxifcation are treated skin ulcer, inhibited to some pathogenic dermatophytes, and can enhance metabolism, the affected part is improved rapidly.

Medicine of the present invention is formed by following composition proportion:

Flos Impatientis 1-10 part salicylic acid 5-20 part vaseline 10-30 part

Galla Chinensis 1-10 part Cortex Hibisci 1-10 part Cortex Phellodendri 10-20 part

Rhizoma Anemarrhenae 10-30 part Fructus Anisi Stellati 2-10 part Pericarpium Zanthoxyli 2-10 part

Bulbus Allii 5-20 part acetic acid 10-50 part,

Its preparation method is:

(1), the Cortex Hibisci levigation, Bulbus Allii peeling is smashed to pieces, put into acetic acid together with Fructus Anisi Stellati, Pericarpium Zanthoxyli and soak a week, filtering residue is got its juice.

(2), with salicylic acid, Cortex Phellodendri, Galla Chinensis mix and grind into powder, Flos Impatientis is smashed to pieces and mixed with vaseline with powder, stirring is the ointment shape.

(3), the ointment in (2) is mixed with juice in (1), stir, it is stand-by to bottle.

This medicine is formed by following composition proportion:

Flos Impatientis 2-8 part salicylic acid 8-16 part vaseline 15-25 part

Galla Chinensis 2-7 part Cortex Hibisci 2-8 part Cortex Phellodendri 12-18 part

Rhizoma Anemarrhenae 15-25 part Fructus Anisi Stellati 3-7 part Pericarpium Zanthoxyli 3-8 part

Bulbus Allii 6-15 part acetic acid 20-50 part.

This medicine is formed by following composition proportion:

20 parts in 12 parts of vaseline of 5 parts of salicylic acid of Flos Impatientis

15 parts of 6 portions of Cortex Phellodendris of 5 parts of Cortex Hibiscis of Galla Chinensis

6 parts in 5 portions of Pericarpium Zanthoxylies of 20 portions of Fructus Anisi Stellatis of the Rhizoma Anemarrhenae

30 parts of 10 parts of acetic acid of Bulbus Allii.

The property of medicine of this medicine is as follows:

Flos Impatientis: sweet, temperature is returned kidney channel; Slightly poisonous.Promoting blood circulation to restore menstrual flow, wind-expelling pain-stopping, external detoxifcation.Dispelling the wind and dampness pathogens is attached undue importance to one thing to the neglect of the other, traumatic injury, carbuncle, furuncle, fungal infection of hand and foot, tinea unguium.

Salicylic acid: can remove aging cutin and pile up, improve skin texture; Porous hair follicle, the suppuration position of dry pimples effectively.

Vaseline: can keep skin wet, make the skin histology of wound location keep optimum state, quicken the repair ability of skin self.

Galla Chinensis: cure mainly traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten all has significantly antibacterial or bactericidal action to staphylococcus aureus, streptococcus, streptococcus pneumoniae and typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, bacillus pyocyaneus etc.

Cortex Hibisci: sweet, tepor is used for clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.Be used for dysentery, leucorrhea; Eczema scrotum tinea corporis, tinea pedis are controlled in external.

Cortex Phellodendri: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.

The Rhizoma Anemarrhenae: the effect that the Rhizoma Anemarrhenae has clearing away heat-fire, promotes the production of body fluid and moisturize, Bacillus typhi, dysentery bacterium, diphtheria corynebacterium, staphylococcus aureus, Diplococcus pneumoniae etc. there are certain inhibitory action, some pathogenic dermatophytes and Candida albicans are also had in various degree inhibitory action.

Fructus Anisi Stellati: suffering, temperature has stronger bacteriostasis.

Pericarpium Zanthoxyli: warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing detoxifcation, antipruritic effect of separating raw meat, to 10 kinds of gram positive bacterias such as anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and Staphylococcus albus, bacillus subtilis, and enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have the obvious suppression effect.

Bulbus Allii: pungent, warm in nature, can separate stagnant gas, warming the spleen and stomach, eliminating mass amass, detoxify parasite killing, control stagnant, tool fungicidal effectiveness; Also have and enhance metabolism promotion epithelial proliferation, effects such as accelerated wound healing.

This curative effect of medication is remarkable, and is easy to use, has no side effect, but suppresses and kill bacteria and fungus within a short period of time, and can improve the affected part rapidly and effectively, makes it to return to normal condition.

The specific embodiment

Embodiment 1:

This medicine adopts following composition proportion to form:

23 parts in 10 parts of vaseline of 4 parts of salicylic acid of Flos Impatientis

13 parts of 5 portions of Cortex Phellodendris of 3 parts of Cortex Hibiscis of Galla Chinensis

5 parts in 4 portions of Pericarpium Zanthoxylies of 16 portions of Fructus Anisi Stellatis of the Rhizoma Anemarrhenae

30 parts of 9 parts of acetic acid of Bulbus Allii,

Its preparation method is:

(1), the Cortex Hibisci levigation, Bulbus Allii peeling is smashed to pieces, put into acetic acid together with Fructus Anisi Stellati, Pericarpium Zanthoxyli and soak a week, filtering residue is got its juice.

(2), with salicylic acid, Cortex Phellodendri, Galla Chinensis mix and grind into powder, Flos Impatientis is smashed to pieces and mixed with vaseline with powder, stirring is the ointment shape.

(3), the ointment in (2) is mixed with juice in (1), stir, it is stand-by to bottle.

Embodiment 2:

This medicine adopts following composition proportion to form:

24 parts in 13 parts of vaseline of 6 parts of salicylic acid of Flos Impatientis

16 parts of 7 portions of Cortex Phellodendris of 6 parts of Cortex Hibiscis of Galla Chinensis

7 parts in 6 portions of Pericarpium Zanthoxylies of 22 portions of Fructus Anisi Stellatis of the Rhizoma Anemarrhenae

40 parts of 12 parts of acetic acid of Bulbus Allii.

Its preparation method is identical with embodiment 1.

During use, refer to (toe) portion with warm water soaking earlier, with mill fingernail instrument sick fingernail layer removed then that the cotton rod of reuse is coated in the foot affected part with this medicine, one day three times, can take effect after seven days.

Clinical efficacy:

The present invention uses through 82 routine patients, and is wherein male, 47 examples; The woman, 35 examples.30-50 year, 60 examples; More than 50 years old, 22 examples.

Cured person 67 examples wherein, produce effects person's 12 examples, improvement person's 2 examples, nonresponder's 1 example, total effective rate reaches 98.7%, and toxicity had not been found in clinical use under therapeutic dose, was exemplified below:

The week *, the man, outside nail fold and near-end nail fold, epidermis cuticula are rotten or turn brown, and first week pleat swelling and do not have subungual hyperkeratosis has a small amount of sepage.After the use, nail fold disappears, and epidermis cuticula color restoration is normal.

Old * *, the man, described according to it, irregular small pieces white macula appears in far-end (lateral margin) deck plane that just shows as first, becomes lacklustre greyness subsequently, and gradually becomes yellowish-brown until black.Soon the deck is rotten, and cutin talus accumulation, nail matrix thicken under the first.Last deck becomes atrophy, and idol has hemorrhage.After using this medicine, no longer hemorrhage under the deck, keratin debris disappears under the deck, and the deck color restoration is normal.

Open * *, the man shows as the patch that deck surface has white point or white 1 mm dia size, and sick first is fragility and scrapes.After adhering to using this medicine, the deck gloss that grows again is even, and first matter is good.

Zheng *, the man, show as full first go bad, swell, crisp, surperficial excipuliform, uneven.After the use, the deck pinkiness, deck surface is smooth smooth.

Wu * *, suffer from tinea unguium for many years, its full first tarnishes, goes bad, thickens, and the deck that has is cracked, stay the nail matrix that thickens unusually after coming off.Use this medicine after one week, the nail matrix attenuation grows the deck again on the nail matrix that comes off, and all the other deck first matter recover normal, and the deck color becomes pink.

Xiao *, the woman, to be the initial stage deck split place (being the proximal part on deck) near nail fold to its symptom turns white, and is expanded into speckle thereafter gradually, and final local deck disappearance expands to first entirely.After using this medicine, white macula disappears, and new first grows gradually.

Thank * *, the woman, talus accumulation under the first makes the deck become empty and perk, separates with nail matrix gradually, and deck surface is uneven.After using this medicine, chip disappears under the deck, and deck and nail matrix combine, and it is level and smooth that deck surface becomes.

Lee *, nail fold, rough and uneven in surface, full first tarnishes, thickens, and the deck color becomes taupe brown; After using this medicine, above transference cure, not recurrence so far.

Claims (3)

1. medicine for the treatment of tinea unguium is characterized in that comprising that this medicine is formed by following composition proportion:

Flos Impatientis 1-10 part salicylic acid 5-20 part vaseline 10-30 part

Galla Chinensis 1-10 part Cortex Hibisci 1-10 part Cortex Phellodendri 10-20 part

Rhizoma Anemarrhenae 10-30 part Fructus Anisi Stellati 2-10 part Pericarpium Zanthoxyli 2-10 part

Bulbus Allii 5-20 part acetic acid 10-50 part,

Its preparation method is as follows:

(1), the Cortex Hibisci levigation, Bulbus Allii peeling is smashed to pieces, put into acetic acid together with Fructus Anisi Stellati, Pericarpium Zanthoxyli and soak a week, filtering residue is got its juice.

(2), with salicylic acid, Cortex Phellodendri, Galla Chinensis mix and grind into powder, Flos Impatientis is smashed to pieces and mixed with vaseline with powder, stirring is the ointment shape.

(3), the ointment in (2) is mixed with juice in (1), stir, it is stand-by to bottle.

2. a kind of medicine for the treatment of tinea unguium according to claim 1 is characterized in that this medicine is formed by following composition proportion:

Flos Impatientis 2-8 part salicylic acid 8-16 part vaseline 15-25 part

Galla Chinensis 2-7 part Cortex Hibisci 2-8 part Cortex Phellodendri 12-18 part

Rhizoma Anemarrhenae 15-25 part Fructus Anisi Stellati 3-7 part Pericarpium Zanthoxyli 3-8 part

Bulbus Allii 6-15 part acetic acid 20-50 part.

3. a kind of medicine for the treatment of tinea unguium according to claim 1 is characterized in that this medicine is formed by following composition proportion:

20 parts in 12 parts of vaseline of 5 parts of salicylic acid of Flos Impatientis

15 parts of 6 portions of Cortex Phellodendris of 5 parts of Cortex Hibiscis of Galla Chinensis

6 parts in 5 portions of Pericarpium Zanthoxylies of 20 portions of Fructus Anisi Stellatis of the Rhizoma Anemarrhenae

30 parts of 10 parts of acetic acid of Bulbus Allii.