RU2383338C1 - Preparation for treatment of serous and catarrhal inflammation of mammary gland in cows - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: preparation for treatment of serous and catarrhal inflammation of mammary gland in cows in the form of ointment consists of filler containing lanolin, vaseline and vegetable oil, and active substance - resorcin and boric acid, at the following ratio of components, wt %: Lanolin 35-40; Resorcin 2-4; Boric acid 1.5-2.5; Vaseline 35-45; Vegetable oil - the rest.

EFFECT: broader range of preparation therapeutic action.

5 ex, 1 tbl

Description

The invention relates to veterinary medicine, in particular to the treatment of serous and catarrhal inflammation of the mammary gland in cows.

Known boron ointment is 5-10% (Mashkovsky M.D. Medicines, Part 2, - M .: Medicine, 1988, p. 393-394; Nabiev F.G., Akhmadeev R.B. "Medicines for veterinary medicine ", - Kazan, 2000, Part 2, - p. 158). Boric acid has a bacteriostatic and antiseptic effect. At a concentration of 2.5% or more, it delays the growth and development of all types of microbes, penetrates well through the skin and mucous membranes, and is slowly excreted from the body. Used topically in the treatment of dermatitis, nipple skin cracks, erythema and eczema.

The disadvantage of the drug is its short duration, and also in a 5-10% concentration, boric acid strongly irritates the tissues, which leads to keratinization and the formation of cracks that make milking cows difficult.

From patent RU 2290951 C1, January 10, 2007, a preparation is known for the treatment of inflammatory processes in domestic and farm animals, including components in the following ratio, wt.%: Refined oil 20-25, lanolin 20-25, resorcinol 3-5, petrolatum 30- 35, paraffin - the rest, to give consistency as a filler. Locally, the drug is used in the form of an ointment as an anti-inflammatory, antimicrobial and distracting substance for mastitis.

The disadvantage of the drug is contraindications: frequent use leads to keratinization of the skin of the mammary gland and can cause rejection of the surface layers of the epidermis. Paraffin, which is part of the drug, is not absorbed by the skin and delays the absorption of drugs.

The technical solution to the problem is to expand the range of the therapeutic effect of the drug due to the synergistic effect (enhancing the antimicrobial effect of boric acid without increasing its concentration), and also to create an anti-inflammatory, antimicrobial, keratoplastic, astringent, antipruritic and local anesthetic effect, which is of great importance in the pathogenesis of mastitis.

This object is achieved in that in the preparation for treating serous and catarrhal inflammation of the mammary gland in cows in the form of an ointment consisting of an excipient containing lanolin and petrolatum and an active substance - resorcinol, according to the invention, the active substance additionally contains boric acid and the excipient contains vegetable oil in the following ratio of components, wt.%:

Lanolin 35-40

Resorcinol 2-4

Boric acid 1.5-2.5

Vaseline 35-45

Vegetable oil rest

The novelty of the claimed drug is due to the fact that a combination of known components with a certain percentage allows you to get a certain synergistic effect, which significantly increases the effectiveness shown by each component individually, which causes a prolonged effect (2-3 days) of this drug. It does not contain antibiotics, sulfonamides and nitrofurans. In addition, the drug has a comprehensive therapeutic effect without negative side effects.

According to the patent and scientific and technical literature, no similar set of features was found, which allows us to judge the inventive step of the proposal.

As for the criterion of "industrial applicability", it should be noted that the components of which the proposed drug consists are approved by the State Pharmacopoeia (GFK) for use in medical and veterinary practice. The components used are non-toxic and are manufactured industrially.

The preparation is a homogeneous brown ointment with a subtle, slightly perceptible specific smell. Shelf life 3 years in a cool dark place, at t = 5-20 ° C. The drug is well combined with other means and methods of therapy. The drug acts on the mucous membranes and skin softening, absorbable, analgesic, anti-inflammatory, keratoplastic, stimulates the antipruritic effect and has a longer duration.

The effect of the drug is due to the components that make up its composition. Resorcinol has anti-inflammatory, antimicrobial, keratoplastic, astringent, antipruritic and local anesthetic effects. Boric acid penetrates well through the skin and mucous membranes and is slowly excreted from the body. At a concentration of 1.0-2.5%, it delays the growth and development of all types of microbes. When applied externally, lanolin easily penetrates the skin, and with it, medicinal substances are well resorbed. It has a softening effect on the skin. Vaseline softens the epidermis of the skin and has an anti-inflammatory effect.

To confirm the effectiveness of the drug, 5 examples of the content of components in various ratios are given, in g: resorcinol 1.0, 2.0, 3.0, 4.0, 5.0, boric acid 0.5-1.0-1.5 -2.0-2.5, lanolin 25, 30, 35, 40, 45, petrolatum 25, 30, 35, 40, 45, the rest is vegetable oil.

Getting the drug

By heating the lanolin to a temperature of 45-55 ° C, sterile white or yellow petroleum jelly is added, mixed, and then resorcinol powder, boric acid and vegetable oil are added successively, while the resulting mixture is thoroughly mixed into a homogeneous mass. A brown ointment is obtained. It is packaged in a container of dark glass, sealed and stored in a cool dark place. Shelf life 3 years.

Example 1. In a lanolin weighing 25.0 g, heated to a temperature of 45-55 ° C, add 25.0 g of sterile white or yellow petroleum jelly and introduce 1.0 g of resorcinol powder, then 0.5 g of boric acid, mix thoroughly and the rest up to 100 g of the mixture is vegetable oil, in this case 48.5 g. The resulting mixture is additionally thoroughly mixed into a homogeneous mass.

This ratio of components has a weaker antimicrobial, keratoplastic, anti-inflammatory, antipruritic and local anesthetic effect. The course of treatment is increasing.

Example 2. In 30.0 g of lanolin, heated to a temperature of 45-55 ° C, add 30.0 g of sterile petroleum jelly (white or yellow) and, thoroughly mixing, introduce 2.0 g of resorcinol and 1.0 g of boric acid. Then combined with 37.0 g of vegetable oil to obtain 100 g of the mixture. The resulting mixture is additionally thoroughly mixed into a homogeneous mass.

This ratio of components also has a weak antimicrobial, keratoplastic, anti-inflammatory, antipruritic and local anesthetic effects. The course of treatment is also increasing.

Example 3. In 35.0 g of lanolin, softened at a temperature of 45-55 ° C, mixed with 35.0 g of sterile white or yellow petroleum jelly, and then 3.0 g of resorcinol powder and 1.5 g of boric acid powder are successively added, further thoroughly mixed into a homogeneous mass. After this, vegetable oil is introduced up to 100 g, in this case 25.5 g. A brown ointment is obtained. This ratio of components is optimal, pronounced antimicrobial, keratoplastic, anti-inflammatory, anti-itching and local anesthetic effects are manifested.

Example 4. In a sample of lanolin weighing 40.0 g, heated to a temperature of 45-55 ° C, sterile white or yellow petroleum jelly weighing 40.0 g is introduced, 4.0 g of resorcinol is added, 2.0 g of boric acid powder is thoroughly mixed and then introduced the rest up to 100 g of the mixture is vegetable oil, in this case 14.0 g. The resulting mixture is additionally thoroughly mixed into a homogeneous mass. A brown ointment is obtained. This ratio of components is optimal, a pronounced antimicrobial, anti-inflammatory, antipruritic and local anesthetic effects are manifested.

Example 5. In a softened lanolin weighing 45.0 g, add sterile white or yellow petrolatum 45.0 g, then, thoroughly mixing, successively introduce resorcinol powder 5.0 g and boric acid 2.5 g. The resulting mixture was brought to 100 g vegetable oil, in this case 2.5 g and mix thoroughly again. A pronounced antimicrobial, anti-inflammatory, antipruritic and local anesthetic action is also manifested. Noticeable differences in the action of the drug in examples 3, 4 and 5 were not detected.

An example of the effectiveness of a specific use of the drug in comparison with an ointment made according to the recipe specified in patent RU 2290951 C1, 10.01.2007.

No. p / p Groups Number of goals Duration of treatment (days) The number of treatments per day Relapse within 30 days The cost of treatment RUB / goal one. Control (serous mastitis) 25 5-7 2-3 one 80 2. Control (catarrhal mastitis) 25 6-8 2-3 2 91.5 3. Experience (serous mastitis) 25 2-4 1-2 0 68 four. Experience (catarrhal mastitis) 25 2-4.5 1-2 0 73.5

Analysis of the results of the experimental studies and presented in the table indicates that the proposed drug provides a high therapeutic effect in serous and catarrhal inflammation of the mammary gland - 100% than the drug specified in patent RU 2290951 C1, 01/10/2007. The proposed drug reduces the course of treatment by 3 days, reduces the number of treatments per day to 1-2 times, it can be combined with other methods of therapy. The cost of treatment, compared with a close analogue, is reduced by 12 rubles.

Claims (1)

The drug for the treatment of serous and catarrhal inflammation of the mammary gland in cows in the form of an ointment, consisting of a filler containing lanolin and petrolatum, and an active substance - resorcinol, characterized in that the active substance additionally contains boric acid, and the filler contains vegetable oil in the following ratio of components , wt.%:
Lanolin 35-40 Resorcinol 2-4 Boric acid 1.5-2.5 Petroleum jelly 35-45 Vegetable oil rest