CN107466235B - Formula essential oil for mild skin frostbite and preparation method thereof - Google Patents
Formula essential oil for mild skin frostbite and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The formula essential oil for treating mild skin frostbite comprises the following raw materials in parts by weight: 5-7 parts of lavender essential oil, 3-5 parts of tea tree essential oil, 3-5 parts of eucalyptus essential oil, 3-5 parts of mint essential oil, 3-5 parts of black pepper essential oil and 30-40 parts of wheat germ essential oil. The preparation method comprises the following steps: determining oil yield, determining raw material weight, obtaining crude essential oil by steam distillation, and obtaining refined formula essential oil by supercritical carbon dioxide extraction. The essential oil can promote cell repair and wound healing.
Description
Technical Field
The invention relates to the field of plant essential oil medicines, in particular to formula essential oil for mild skin frostbite and a preparation method thereof.
Background
Frostbite is a common trauma in winter, and is generally divided into four degrees: degree I frostbite: damage to the epidermis, localized redness, swelling, itching, pain, heat. And (3) frostbite at II degrees: red, swollen, painful and itchy skin layer, local blister. And (3) freezing injury at III degree: deep under the skin, early red and swollen with large blisters, the skin turns from pale to bluish-black, the sensation disappears, and the tissue becomes dry necrotic. Frostbite at IV degree: muscle and bone injuries, dry and wet gangrene, skin grafting and amputation. For severe III degree and IV degree frostbite, the patient should be in time to visit the hospital to avoid delaying the illness state. The invention aims at the research and development of medicines for mild frostbite of I-degree frostbite and II-degree frostbite.
Disclosure of Invention
In view of the above, the invention aims to provide a formula essential oil for treating mild skin frostbite and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the formula essential oil for treating mild skin frostbite comprises, by weight, 5-7 parts of lavender essential oil, 3-5 parts of tea tree essential oil, 3-5 parts of eucalyptus essential oil, 3-5 parts of mint essential oil, 3-5 parts of black pepper essential oil and 30-40 parts of wheat germ essential oil.
Preferably, the formula essential oil consists of 5 parts of lavender essential oil, 3 parts of tea tree essential oil, 3 parts of eucalyptus essential oil, 3 parts of mint essential oil, 3 parts of black pepper essential oil and 30 parts of wheat germ essential oil.
Preferably, the formula essential oil consists of 6 parts of lavender essential oil, 4 parts of tea tree essential oil, 4 parts of eucalyptus essential oil, 4 parts of mint essential oil, 4 parts of black pepper essential oil and 35 parts of wheat germ essential oil.
Preferably, the formula essential oil consists of 7 parts of lavender essential oil, 5 parts of tea tree essential oil, 5 parts of eucalyptus essential oil, 5 parts of mint essential oil, 5 parts of black pepper essential oil and 40 parts of wheat germ essential oil.
The preparation method of the formula essential oil for mild skin frostbite according to any scheme comprises the following steps:
(10) determining the required parts by weight of lavender, tea trees, eucalyptus, mint leaves, black pepper and wheat germ according to the oil yield of the lavender, the tea trees, the eucalyptus, the mint leaves, the black pepper and the wheat germ, and weighing for later use;
(20) placing the lavender, the tea trees, the eucalyptus, the mint leaves, the black pepper and the wheat germ which are obtained in the step (10) in required weight parts in a distillation container, and introducing water vapor with the temperature of 200-250 ℃, wherein essential oil components contained in the lavender, the tea trees and the eucalyptus, the mint leaves and the black pepper are diffused into the water vapor to form an azeotrope of oil and water; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
(30) loading the crude essential oil into an extractor, extracting at 45 deg.C under 35MPa with CO2And (3) continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain the essential oil in the formula.
Preferably, the oil yield of lavender, tea tree, eucalyptus, peppermint leaf, black pepper and wheat germ is determined by the following steps:
(11) selecting lavender, tea tree, eucalyptus, mint leaf, black pepper or wheat germ;
(12) placing the lavender, tea trees, eucalyptus, mint leaves, black pepper or wheat germ selected in the step (11) into a distillation container, introducing water vapor with the temperature of 200-; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
(13) putting the crude essential oil obtained in the step (12) into an extractor, wherein the extraction temperature is 45 ℃, the extraction pressure is 35MPa, and CO is used2Continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain refined essential oil;
(14) dividing the weight of the obtained refined essential oil into the weight of the raw materials to obtain the oil yield of lavender, tea trees, eucalyptus, mint leaves, black pepper or wheat germ;
(15) repeating the steps (11) to (14) for 5 times until the oil yield of lavender, tea trees, eucalyptus, mint leaves, black pepper and wheat germ is calculated.
Preferably, the oil yield of lavender, tea tree, eucalyptus, peppermint leaf, black pepper and wheat germ determined in step (15) respectively correspond to: 0.9%, 1.8%, 0.8%, 1.0%, 2.5%, 7.5%.
The extraction rate of the aromatic vegetable oil by supercritical carbon dioxide comprises the extraction temperature, extraction pressure and CO2Flow rate, thereforeThe Ming people pay creative labor, and the optimal mixing operation conditions of the lavender, the tea tree, the Eucalyptus, the mint leaves, the black pepper and the wheat germ are obtained as follows: the extraction temperature is 45 ℃, the extraction pressure is 35MPa, and CO is added2The flow rate was 35L/h. And according to the optimal mixing operation condition, under the same operation submission, respectively determining the oil yield of lavender, tea tree, eucalyptus, peppermint leaf, black pepper and wheat germ.
The invention has the beneficial effects that:
in the preparation method, the required dosage of the raw materials is determined according to the oil yield, so that the essential oil does not need to be fractionated and then mixed, and the preparation steps are greatly simplified.
The essential oil for treating mild frostbite of skin, prepared by the invention, is prepared from components extracted from pure natural plants, and can effectively promote cell repair of frostbite skin parts to heal wounds.
The essential oil prepared by the formula is used for treating mild frostbite, and each part of the essential oil has different curative effects on frostbite skin. The lavender essential oil has antibacterial and anti-inflammatory effects, and can promote cell tissue regrowth. The tea tree essential oil has good sterilization and disinfection effects, can be used for well diminishing inflammation of wounds, has an obvious effect on skin frostbite, and has good reaction after being used. Eucalyptus oil has obvious effect on skin frostbite, prevents cell breeding and pus accumulation, and promotes the establishment of new tissues. The herba Menthae essential oil has effects of contracting skin capillary, promoting blood circulation, and promoting toxin discharge. The black pepper essential oil has the effects of purifying and improving wound infection suppuration. The wheat germ essential oil is used as the base oil in the essential oil, has antioxidant effect, and has effects of promoting skin moisture, moistening skin, promoting skin metabolism and skin regeneration.
The invention selects 5 different essential oils and 1 base oil to form the essential oil, the coordination of all the components in the essential oil has stronger sterilization effect, the sterilization rate reaches 100 percent, the wound infection is prevented, and simultaneously the product can also control the exudation of the frostbite wound tissue fluid; the essential oil has high penetration speed, can improve the blood circulation of the wound surface, quickly diminish inflammation and relieve pain, and accelerate the healing of the wound surface without leaving scars, so the essential oil with the formula provided by the invention can be used for treating mild skin frostbite.
Detailed Description
The present invention is described in detail below with reference to specific examples, but the use and purpose of these exemplary embodiments are merely to exemplify the present invention, and do not set forth any limitation on the actual scope of the present invention in any form, and the scope of the present invention is not limited thereto.
The inventor obtains the invention after multiple times of component adjustment and dosage test and creative labor. While the following examples are intended to illustrate only some of the preferred embodiments and include particular components and amounts thereof that have been adjusted, the present invention is not limited to the particular examples and examples, and those skilled in the art can adjust other components and ratios accordingly and their effectiveness is to be construed as being within the scope of the present invention.
In addition, the parts used for the following components are all parts by weight unless otherwise specified.
Example 1:
a preparation method of formula essential oil for treating mild skin frostbite comprises the following steps:
1) weighing 556 parts of lavender, 167 parts of tea trees, 375 parts of eucalyptus, 300 parts of mint leaves, 120 parts of black pepper and 400 parts of wheat germs, placing the materials into a distillation container, introducing water vapor with the temperature of 200-; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
2) loading the crude essential oil into an extractor, extracting at 45 deg.C under 35MPa with CO2And (3) continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain the essential oil in the formula.
Example 2
A preparation method of formula essential oil for treating mild skin frostbite comprises the following steps:
1) weighing 667 parts of lavender, 222 parts of tea tree, 500 parts of eucalyptus, 400 parts of mint leaf, 160 parts of black pepper and 467 parts of wheat germ, placing the mixture into a distillation container, and introducing water vapor at 250 ℃ of 200-; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
2) loading the crude essential oil into an extractor, extracting at 45 deg.C under 35MPa with CO2And (3) continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain the essential oil in the formula.
Example 3
A preparation method of formula essential oil for treating mild skin frostbite comprises the following steps:
1) weighing 778 parts of lavender, 278 parts of tea tree, 625 parts of eucalyptus, 500 parts of mint leaf, 200 parts of black pepper and 533 parts of wheat germ, placing the materials into a distillation container, introducing water vapor at 250 ℃ of 200-; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
2) loading the crude essential oil into an extractor, extracting at 45 deg.C under 35MPa with CO2And (3) continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain the essential oil in the formula.
The essential oils of the formulas prepared in examples 1-3 were tested for bactericidal effect, and the tested species were Escherichia coli, Staphylococcus aureus and Candida albicans. The test method is carried out according to the sterilization performance test method of appendix C3 of GB15979-2002 sanitation Standard for Disposable sanitary articles, and the test results are shown in Table 1.
TABLE 1
As can be seen from the table 1, the essential oil prepared in the example has a very good sterilization effect, the sterilization rate reaches 100% after the essential oil is applied for 2 minutes, and the essential oil can inhibit bacteria for a long time.
The essential oil of the formula for treating mild skin frostbite prepared in the examples 1 to 3 is used for a frostbite patient for testing, and the using method comprises the following steps: the cold injury is immediately dripped into the affected part 3-5 drops after being washed by warm water, and the medicine is used 3-5 times per day. The results of a survey of 30 patients using the product are shown in table 2 below.
TABLE 2
As can be seen from Table 2, the essential oils of the formulas for treating mild frostbite of skin according to the embodiments 1 to 3 are effective for patients with mild frostbite, do not cause wound infection, and create good conditions for skin recovery and cell regeneration. Under the synergistic effect of various components, the cure rate is 100%.
The formula essential oil of the invention comprises, by weight, 5-7 parts of lavender essential oil, 3-5 parts of tea tree essential oil, 3-5 parts of eucalyptus essential oil, 3-5 parts of mint essential oil, 3-5 parts of black pepper essential oil and 30-40 parts of wheat germ essential oil. The content parts include the parts which can be obtained by rounding off within the error range and fall within the content range of the present application. Within the error range of 2%, the content values are considered to be equivalent, such as 5 parts of lavender essential oil, which can be equivalent to 4.9 parts of lavender essential oil or 4.99 parts of lavender essential oil, and 7 parts of lavender essential oil, which can be equivalent to 7.1 parts of lavender essential oil or 7.01 parts of lavender essential oil. All of the above-mentioned parts are included in the content range of the present application.
It will be appreciated that various alterations, modifications and/or variations may be made by those skilled in the art after reading the technical disclosure of the present invention, and all such equivalents may fall within the scope of the present invention.
Claims (7)
1. The formula essential oil for treating mild skin frostbite is characterized by comprising, by weight, 5-7 parts of lavender essential oil, 3-5 parts of tea tree essential oil, 3-5 parts of eucalyptus essential oil, 3-5 parts of mint essential oil, 3-5 parts of black pepper essential oil and 30-40 parts of wheat germ essential oil.
2. The essential oil composition for treating mild skin frostbite according to claim 1, wherein the essential oil composition comprises 5 parts of lavender essential oil, 3 parts of tea tree essential oil, 3 parts of eucalyptus essential oil, 3 parts of mint essential oil, 3 parts of black pepper essential oil and 30 parts of wheat germ essential oil.
3. The essential oil composition for treating mild skin frostbite according to claim 1, wherein the essential oil composition comprises 6 parts of lavender essential oil, 4 parts of tea tree essential oil, 4 parts of eucalyptus essential oil, 4 parts of mint essential oil, 4 parts of black pepper essential oil and 35 parts of wheat germ essential oil.
4. The essential oil composition for treating mild skin frostbite according to claim 1, wherein the essential oil composition comprises 7 parts of lavender essential oil, 5 parts of tea tree essential oil, 5 parts of eucalyptus essential oil, 5 parts of mint essential oil, 5 parts of black pepper essential oil and 40 parts of wheat germ essential oil.
5. The process for preparing essential oil formulations for mild frostbite of skin according to any of claims 1 to 4, characterized in that it comprises the following steps:
(1) determining the required parts by weight of lavender, tea trees, eucalyptus, mint leaves, black pepper and wheat germ according to the oil yield of the lavender, the tea trees, the eucalyptus, the mint leaves, the black pepper and the wheat germ, and weighing for later use;
(2) placing the lavender, the tea trees, the eucalyptus, the mint leaves, the black pepper and the wheat germ which are obtained in the step (1) in required weight parts in a distillation container, introducing water vapor with the temperature of 200-250 ℃, and diffusing essential oil components contained in the lavender, the tea trees and the eucalyptus, the mint leaves and the black pepper into the water vapor to form an azeotrope of oil and water; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
(3) loading the crude essential oil into an extractor, extracting at 45 deg.C under 35MPa with CO2And (3) continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain the essential oil in the formula.
6. The method of claim 5, wherein the oil yield of lavender, tea tree, eucalyptus, peppermint leaf, black pepper and wheat germ is determined by the steps of:
1) selecting lavender, tea tree, eucalyptus, mint leaf, black pepper or wheat germ;
2) placing the lavender, tea trees, eucalyptus, mint leaves, black pepper or wheat germ selected in the step 1) into a distillation container, introducing water vapor with the temperature of 200-; then cooling the azeotrope to 25-30 ℃ to obtain crude essential oil;
3) loading the crude essential oil obtained in the step 2) into an extractor, wherein the extraction temperature is 45 ℃, the extraction pressure is 35MPa, and CO is used2Continuously extracting for 3-5 h at the flow rate of 35L/h, inputting a mixture of carbon dioxide and extracted essential oil into a separator, reducing the pressure to 11MPa and reducing the temperature to 35 ℃, and separating carbon dioxide gas from the essential oil to obtain refined essential oil;
4) dividing the weight of the refined essential oil by the weight of the raw materials to obtain the oil yield of lavender, tea tree, eucalyptus, peppermint leaf, black pepper or wheat germ;
5) repeating the steps 1) to 4) for 5 times until the oil yield of the lavender, the tea tree, the eucalyptus, the mint leaf, the black pepper and the wheat germ is calculated.
7. The method for preparing essential oil in accordance with claim 6, wherein the oil yield of lavender, tea tree, eucalyptus, peppermint leaf, black pepper and wheat germ determined in step 5) respectively correspond to: 0.9%, 1.8%, 0.8%, 1.0%, 2.5%, 7.5%.
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| PCT/CN2016/080301 WO2017185246A1 (en) | 2016-04-27 | 2016-04-27 | Compound essential oil for treating mild skin frostbite, and preparation method therefor |
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| CN112450229B (en) * | 2020-12-09 | 2021-06-15 | 华南农业大学 | Plant essential oil type ultraviolet sterilization synergist and ultraviolet combined sterilization method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843652A (en) * | 2009-03-24 | 2010-09-29 | 常昊 | Moleplant seed composite essential oil |
| CN102836351A (en) * | 2012-09-03 | 2012-12-26 | 皖南医学院 | Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843652A (en) * | 2009-03-24 | 2010-09-29 | 常昊 | Moleplant seed composite essential oil |
| CN102836351A (en) * | 2012-09-03 | 2012-12-26 | 皖南医学院 | Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof |
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