CN108186818B - Plaster for softening and removing cutin and preparation method thereof - Google Patents

Plaster for softening and removing cutin and preparation method thereof Download PDF

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CN108186818B
CN108186818B CN201810134544.5A CN201810134544A CN108186818B CN 108186818 B CN108186818 B CN 108186818B CN 201810134544 A CN201810134544 A CN 201810134544A CN 108186818 B CN108186818 B CN 108186818B
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plaster
oil
sesame oil
parts
banana peel
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CN108186818A (en
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周建华
高宇
韩静琳
王海韵
路丽霞
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Shandong Normal University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether

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Abstract

The invention discloses a formula of a plaster for softening and removing cutin and a preparation method thereof. The plaster for softening and removing cutin comprises the following raw materials in parts by weight: 23-27 parts of sesame oil, 18-22 parts of eggplant stalk, 18-22 parts of banana peel, 8-10 parts of yellow lead, 2-4 parts of folium artemisiae argyi, 0.8-1.2 parts of safflower and 0.2-0.6 part of fig white juice.

Description

Plaster for softening and removing cutin and preparation method thereof
Technical Field
The invention relates to an exfoliating drug composition and a preparation method thereof, in particular to a softening exfoliating plaster and a preparation method thereof, belonging to the technical field of pharmaceutical preparations.
Background
The health care and maintenance of hands and feet are valued by human beings since ancient times, the elbows are easy to generate cutin, the feet are the thickest parts of the cutin of the whole body, and the skin peeling, the foot cocoon, the dryness, the chapping and the like are most easy to occur. The foot bears most weight of the body, can continuously rub with the shoe and even be extruded by the shoe, and the sole of the foot is naturally easy to generate cutin; when people reach a certain age, the moisture of the body is reduced, the skin is dry, the elbow cutin is thickened, the heel is dry and cracked, the foot cutin and the calluses are thick and hard, the appearance is influenced by a light person, the walking is influenced by a heavy person, and even the body health is influenced. Therefore, the method has a vital function on human health by timely and effectively removing the hand and foot cutin.
At present, the cutin removing products on the market comprise cutin removing cream, jelly, washing and protecting products and the like, are mostly used for treating facial cutin, and mostly contain corrosive and irritant chemical components such as ethanol, salicylic acid and the like. There are few and few exfoliating products for the elbows and feet.
The ointment for softening and removing cutin, which is prepared by experiment, selects an oil frying method to extract effective components in raw materials, and prepares the ointment by burning, heating and discharging pills. Compared with the problem that some plasters may cause allergy, the plaster is added with folium artemisiae argyi and safflower to play the role of antianaphylaxis; after the plaster is formed, the toxicity in the plaster is removed by adopting a cold water soaking mode, so that the sensitization of the plaster is reduced to the minimum. In addition, banana peel is added into the plaster, so that the plaster has the effect of moistening skin while removing cutin; the added eggplant stalk and fig white juice play a main role to achieve the purpose of removing cutin. Finally, the plaster with the effects of softening and removing cutin, moistening skin, resisting allergy, promoting local blood circulation and the like is prepared. The plaster has simple preparation process, easily obtained and cheap raw materials, is convenient to use, and provides a new choice for softening and removing cutin for the fast-paced living habits of modern people.
Disclosure of Invention
Aiming at the defects of the prior art, the inventor provides a preparation method of the plaster for softening and removing cutin through long-term technical operation and practical exploration. The plaster for softening and removing the cutin, which is prepared by the invention, does not contain chemical components such as an antibacterial agent, a preservative and the like, is natural and environment-friendly, has mild and non-irritant product performance, and has multiple effects of softening and removing the cutin, moistening the skin, resisting allergy, promoting local blood circulation and the like.
Although the effects of the raw materials adopted by the invention such as eggplant stalks and banana peels are well known, the raw materials only exist in a plurality of partial prescriptions and wonderful life, the medicinal values of the raw materials are really researched and combined, and the raw materials are developed into preparation products convenient for daily use but are rarely recorded. The eggplant stalk and the banana peel are kitchen garbage which is mostly discarded in daily life, the invention can change waste into valuable, uses low-cost raw materials, exerts the advantages of the raw materials through scientific compatibility and simple processing process, eliminates the toxic and side effects of the raw materials, is insist for use, has certain treatment effect on skin dehydration caused by daily work, even cuticle thickening and skin cracking caused by fungal dermatopathy, and is suitable for being used by patients in daily family life for a long time.
Specifically, the invention relates to the following technical scheme:
the process flow comprises the following steps: pretreatment of raw materials → preparation of medicinal oil → oil refining → adding safflower → fire upper and lower pill → adding fig white juice → removing fire toxin → adding heat sense agent and finished product
The preparation of the plaster for softening and removing the cutin comprises the following steps:
(1) pretreatment of raw materials
Selecting fresh eggplant stalks and banana peels, cleaning, blanching, airing and cutting into blocks for later use so as to be beneficial to the extraction of effective components in the subsequent steps;
selecting fresh fig white juice, and refrigerating for later use;
selecting folium Artemisiae Argyi with high quality and no mildew for use;
selecting safflower with superior quality and without mildew, pulverizing, and sieving with 80 mesh sieve;
selecting high-quality yellow lead, sieving with 100 mesh sieve, parching with slow fire, removing water vapor, parching when yellow lead changes from orange yellow to deep red, taking out in time, and cooling;
selecting sesame oil with superior quality for later use.
The mass ratio of the needed raw materials is as follows: eggplant stalk: banana peel: yellow lead: folium artemisiae argyi: safflower: fig white juice is 25:20:20:9:3:1: 0.4.
(2) Preparation of medicinal oil
Accurately weighing a certain amount of sesame oil, eggplant stalk, banana peel and folium artemisiae argyi according to a certain proportion, respectively, heating the sesame oil in a pot, frying the sesame oil in the pot after the sesame oil is slightly heated, fishing out the eggplant stalk and the banana peel when the sesame oil is fried to be dark brown on the surface and the banana peel is golden inside, then adding the folium artemisiae argyi for frying, fishing out the folium artemisiae argyi when the sesame oil is fried to be dark brown, and collecting the obtained medicinal oil.
(3) Oil refining
After the medicinal oil is prepared, oil is refined by slow fire, and when the medicinal oil is dripped into water and is not dispersed and beaded, the oil refining is finished.
(4) Adding safflower
Weighing the treated fine safflower powder according to the proportion in the step (1), slowly adding the fine safflower powder into the refined medicinal oil while stirring, and uniformly stirring.
(5) Huoshengwan pill
Adding Plumbum Preparatium with slow fire when the temperature of the medicinal oil rises to 290 deg.C, slowly adding Plumbum Preparatium under stirring, and stirring to thicken into paste.
(6) White juice added with fig
When the temperature of the decocted plaster is reduced to about 50 ℃, the fig white juice is weighed according to the mass ratio in the step (1) and added into the plaster, and the fig white juice is slowly added while stirring and is uniformly stirred.
(7) Removing fire toxin
Pouring the decocted plaster into cold water to remove water-soluble irritant substances. During operation, the wood bar is used for stirring continuously to form a belt shape, so as to be beneficial to cooling. When the water is hot, cold water is changed, the water is taken out after condensation, the mixture is repeatedly kneaded and pressed to be made into block masses, the block masses are soaked in the cold water for 5-7 days, the water is changed for 1-2 times every day to dissolve most of fire toxin, and the block masses are fished out and placed in a cool place to slowly fade the residual parts.
(8) Heating agent and finished product
After the fire toxin is removed, heating the plaster until the plaster is melted, adding a proper amount of thermal agent, quickly coating the prepared plaster on a mudflat and plaster cloth, applying a liner, and independently packaging.
The product using method comprises the following steps:
before use, moistening skin with warm water, and air drying; the plaster is applied to the dead skin. It is recommended to apply the plaster once a day, and the daily application is ensured to be more than 12 hours, and the heat-sensitive agent loses heat and the plaster is not torn off too early. Continuous application generally has effects from the third and fourth days, and the cutin is softened and a small part begins to fall off slowly. The plaster should be cleaned each time it is removed.
The plaster for softening and removing cutin has the following specific functions of plant raw materials:
the eggplant stalk is persistent calyx of Solanum melongena of Solanaceae, has effects of softening cutin, relieving pain and swelling, clearing heat and promoting blood circulation, and resisting aging, and has good effect in removing dead skin of foot. The eggplant stalk contains various vitamins, saponin, calcium element, phosphorus element and other components, and can remove dead skin and supplement the nutritional requirement of skin.
The banana peel is the peel of banana of Musaceae, has effects of moistening skin, improving hemorrhoid and hematochezia, is usually used for external application to improve dry and rough skin and prevent skin aging, and can also be used for oral administration to treat oral inflammation, etc. The banana peel contains protein, saccharides and potassium, calcium, magnesium, iron, zinc and other elements, and can be used as potential resources and raw materials; the banana peel essence can inhibit the growth of bacteria and fungi.
The folium Artemisiae Argyi is dried leaf of Artemisia princeps Pampanini belonging to Compositae, contains organic components such as flavonoids, triterpenes, eudesmane, tannin and polysaccharide, and has antibacterial, antiinflammatory, antiallergic, antioxidant, and immunity regulating effects.
The Carthami flos is dried flower of Carthamus tinctorius L of Carthamus of Compositae, contains flavonoids and fatty oil as main chemical components, and has effects of promoting blood circulation, dredging channels, resisting inflammation, and relieving pain.
Sesame oil, also known as sesame oil, contains various nutrients such as vitamin E, linoleic acid, iron, calcium, etc. Sesame oil is used as base oil for preparing the plaster, and the plaster has the advantages of less foam during boiling and convenience for operation; the prepared black plaster has bright color, sticky property and good quality.
The fig white juice is juice of fig of Moraceae, contains abundant protease and plant alkaloid, has weak corrosive effect, can remove wart on skin, and can be used for treating dermatoses such as verruca plana, dermatitis, and tinea pedis, but is easy to sensitize. In the preparation process, the applicant finds that the allergenicity of the fig white juice can be well eliminated by using the folium artemisiae argyi and the fig white juice together, and the influence of plant alkali in the fig white juice on skin color can be eliminated by preparing the folium artemisiae argyi and the fig white juice at high temperature and matching with other oily extraction components in the formula, so that the beneficial effect of exfoliating is only kept.
Plumbum preparatium, also known as Plumbum preparatium, contains lead tetroxide as the main ingredient. The plaster has the curative effect of drawing out pus and promoting granulation when being externally used, and the plaster is formed by the reaction of the fire and the medicinal oil.
The thermal inductance agent vanillyl butyl ether is a self-heating agent, can generate certain thermal inductance on local skin by adding a proper amount of the thermal inductance flavoring agent vanillyl butyl ether, promotes blood circulation, and is favorable for the local skin to absorb and utilize effective components contained in eggplant stalks, banana peels, fig white juice, folium artemisiae argyi and safflower.
The invention has the beneficial effects that:
(1) the raw materials are used as effective components, and the effects of softening cutin of eggplant stalks, moistening skin of banana peels and removing dead peels of fig white juice are highlighted by adopting a proper content ratio through experimental optimization. The folium artemisiae argyi and the safflower have the effects of diminishing inflammation, sterilizing, resisting allergy and promoting blood circulation, and the plant raw materials are rich in nutritional ingredients such as protein, vitamins, minerals and the like, so that the requirement of skin on nutrition can be met; the added thermal agent can effectively promote blood circulation, so that the effective components contained in the eggplant stalk, the banana peel, the fig white juice, the folium artemisiae argyi and the safflower are fully absorbed and utilized. The raw materials have synergistic effect, and the effects of softening cutin, moistening skin, resisting allergy and promoting local blood circulation can be realized at one time.
(2) The main raw materials of the experiment select natural components, and effective components are extracted by frying, so that the skin irritation is avoided, and the use is convenient. The obtained plaster can be applied to elbow and foot cutin to achieve the effects of softening cutin and removing dead skin.
(3) Volatile oil, tannin, flavonoid active substances and the like in the folium artemisiae argyi, safflower polysaccharide, flavonoid substances, hydroxyl safflower yellow and the like in the safflower have the effects of softening and removing dead skin as the active ingredients of the main raw materials, and the folium artemisiae argyi and the safflower also have the effects of diminishing inflammation, sterilizing, resisting allergy, promoting blood circulation and the like.
(4) The softening exfoliate plaster product prepared by experiments has the advantages that the main raw materials of eggplant stalks and banana peel are fully utilized, the price is low, the materials are easy to obtain, and the preparation process is simple and easy to operate.
Drawings
FIG. 1 is a diagram of a finished product of a softening and exfoliating plaster prepared by the invention.
FIG. 2 shows the state of the ointment for softening and exfoliating prepared by the present invention in use.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
The plaster for softening and removing the cutin is prepared from the following raw materials in parts by mass: eggplant stalk: banana peel: yellow lead: folium artemisiae argyi: safflower: fig white juice is 25:20:20:9:3:1: 0.4. The preparation method of the plaster for softening and removing the cutin comprises the following steps: weighing sesame oil, eggplant stalk, banana peel and folium artemisiae argyi according to a proportion, putting the sesame oil into a pot, heating, putting the eggplant stalk and the banana peel into the pot after the sesame oil is slightly heated, frying, fishing out the eggplant stalk and the banana peel when the sesame oil is fried to be dark brown on the surface and the banana peel is golden yellow, then adding the folium artemisiae argyi into the pot, frying, fishing out the folium artemisiae argyi when the sesame oil is fried to be dark brown, and collecting the obtained medicinal oil. Refining with slow fire to make the medicinal oil drop into water without dispersion. Weighing the processed fine powder of Carthami flos at a certain proportion, slowly adding into the refined medicinal oil under stirring, heating the oil to 290 deg.C, adding Plumbum Preparatium with slow fire, and stirring to obtain paste. When the temperature of the ointment is reduced to about 50 ℃, the fig white juice is added while stirring. Pouring the decocted plaster into cold water to remove water-soluble irritant substances. During operation, the wood bar is used for stirring continuously to form a belt shape, so as to be beneficial to cooling. When the water is hot, cold water is changed, the water is taken out after condensation, the mixture is repeatedly kneaded and pressed to be made into block masses, the block masses are soaked in the cold water for 5-7 days, the water is changed for 1-2 times every day to dissolve most of fire toxin, and the block masses are fished out and placed in a cool place to slowly fade the residual parts. After the fire toxin is removed, heating the plaster until the plaster is melted, adding a proper amount of thermal agent, quickly spreading the prepared plaster on plaster cloth, applying a liner, and independently packaging.
Example 2
The fig white juice is removed in the preparation process, the mass ratio of the other raw materials and the preparation method are unchanged, and the sesame oil is prepared from the following raw materials in parts by mass: eggplant stalk: banana peel: yellow lead: folium artemisiae argyi: safflower 25:20:20:9:3: 1. The preparation method of the plaster for softening and removing the cutin comprises the following steps: weighing sesame oil, eggplant stalk, banana peel and folium artemisiae argyi according to a proportion, putting the sesame oil into a pot, heating, putting the eggplant stalk and the banana peel into the pot after the sesame oil is slightly heated, frying, fishing out the eggplant stalk and the banana peel when the sesame oil is fried to be dark brown on the surface and the banana peel is golden yellow, then adding the folium artemisiae argyi into the pot, frying, fishing out the folium artemisiae argyi when the sesame oil is fried to be dark brown, and collecting the obtained medicinal oil. Refining with slow fire to make the medicinal oil drop into water without dispersion. Weighing the processed fine powder of Carthami flos at a certain proportion, slowly adding into the refined medicinal oil under stirring, heating the oil to 290 deg.C, adding Plumbum Preparatium with slow fire, and stirring to obtain paste. Pouring the decocted plaster into cold water to remove water-soluble irritant substances. During operation, the wood bar is used for stirring continuously to form a belt shape, so as to be beneficial to cooling. When the water is hot, cold water is changed, the water is taken out after condensation, the mixture is repeatedly kneaded and pressed to be made into block masses, the block masses are soaked in the cold water for 5-7 days, the water is changed for 1-2 times every day to dissolve most of fire toxin, and the block masses are fished out and placed in a cool place to slowly fade the residual parts. After the fire toxin is removed, heating the plaster until the plaster is melted, adding a proper amount of thermal inductance agent, quickly spreading the prepared plaster on plaster cloth, applying a liner, and independently packaging.
Compared with the embodiment 1, the embodiment 2 has the difference that fig white juice is removed in the preparation process, and the mass ratio of the other raw materials and the preparation method are not changed. By comparing actual use experience, patients have no adverse reaction after using the plaster in example 2, but the skin of the applied part is observed to be thicker than the group in example 1 at the same time.
Example 3
The sesame oil is prepared from the following raw materials in parts by mass, wherein folium artemisiae argyi and safflower are removed in the preparation process, the mass ratio of the rest raw materials and the preparation method are unchanged, and the sesame oil is prepared from the following raw materials in parts by mass: eggplant stalk: banana peel: yellow lead: fig white juice is 25:20:20:9: 0.4. The preparation method of the plaster for softening and removing the cutin comprises the following steps: weighing oleum Sesami, eggplant stalk and banana peel according to a certain proportion, heating oleum Sesami in a pot, frying eggplant stalk and banana peel after slight heating, taking out eggplant stalk and banana peel when the fried surface is dark brown and the inner part is golden yellow, and collecting the obtained medicinal oil. Refining with slow fire to make the medicinal oil drop into water without dispersion. Heating the oil to 290 deg.C, adding Plumbum Preparatium with slow fire, and stirring to obtain paste. After the plaster is cooled to 50 ℃, the fig white juice is added while stirring. Pouring the decocted plaster into cold water to remove water-soluble irritant substances. During operation, the wood bar is used for stirring continuously to form a belt shape, so as to be beneficial to cooling. When the water is hot, cold water is changed, the water is taken out after condensation, the mixture is repeatedly kneaded and pressed to be made into block masses, the block masses are soaked in the cold water for 5-7 days, the water is changed for 1-2 times every day to dissolve most of fire toxin, and the block masses are fished out and placed in a cool place to slowly fade the residual parts. After the fire toxin is removed, heating the plaster until the plaster is melted, adding a proper amount of thermal inductance agent, quickly spreading the prepared plaster on plaster cloth, applying a liner, and independently packaging.
Compared with the embodiment 1, the embodiment 3 has the difference that the folium artemisiae argyi and the safflower are removed in the preparation process, and the mass ratio of the rest raw materials and the preparation method are not changed. Through comparison with actual use experience, the skin of the application part of the plaster in the example 3 is obviously thinned after the plaster is used by a patient, but the skin of the application part is ruddy and has a little allergic symptoms.
Example 4
The plaster for softening and removing the cutin is prepared from the following raw materials in parts by mass: eggplant stalk: banana peel: yellow lead: folium artemisiae argyi: safflower: the fig white juice is 30:25:20:12:5:1.5: 0.8. The preparation method of the plaster for softening and removing the cutin comprises the following steps: weighing sesame oil, eggplant stalk, banana peel and folium artemisiae argyi according to a proportion, putting the sesame oil into a pot, heating, putting the eggplant stalk and the banana peel into the pot after the sesame oil is slightly heated, frying, fishing out the eggplant stalk and the banana peel when the sesame oil is fried to be dark brown on the surface and the banana peel is golden yellow, then adding the folium artemisiae argyi into the pot, frying, fishing out the folium artemisiae argyi when the sesame oil is fried to be dark brown, and collecting the obtained medicinal oil. Refining with slow fire to make the medicinal oil drop into water without dispersion. Weighing the processed fine powder of Carthami flos at a certain proportion, slowly adding into the refined medicinal oil under stirring, heating the oil to 290 deg.C, adding Plumbum Preparatium with slow fire, and stirring to obtain loose paste. After the ointment is cooled slightly, the fig white juice is added while stirring. Pouring the decocted plaster into cold water to remove water-soluble irritant substances. During operation, the wood bar is used for stirring continuously to form a belt shape, so as to be beneficial to cooling. When the water is hot, cold water is replaced, the mixture is taken out and repeatedly kneaded to be made into loose block mass, the loose block mass is placed in a refrigerator at the temperature of 4 ℃ for cooling for 48 hours, the loose block mass is taken out and heated until the loose block mass is melted, a proper amount of thermal sensation agent is added, the prepared ointment is quickly coated on the ointment cloth, a liner is coated, and the ointment is independently packaged.
Example 4 compared with example 1, the plaster powder prepared under the above conditions is not easy to form lumps, has high humidity and poor adhesion to skin, and cannot be used as a plaster strictly speaking.
The pharmacological experiment result of the medicament of the invention is as follows:
1 skin sensitization test: 10 SD rats with half of each male and female are selected for experiments, the administration dose is 1g/kg, the plaster prepared in the experimental example 1 is pasted on the skin surface of the rat after hair removal, no abnormality of the rat is observed, and the experimental result shows that the medicine has no sensitization effect and the sensitization reaction is 0 grade;
2 skin irritation test: 10 Chinese white rabbits with the weight of 2kg are selected, the male and female rabbits are half in weight, the elbow skin is depilated and then the plaster in the experimental example 1 is pasted and taken down after 12 hours, no skin irritation phenomenon is found in the observation process, no abnormality is found in the pathological histological examination, and the test shows that the medicine has no irritation to the skin.
3 control test: selecting 18 Chinese white rabbits with the weight of about 2kg, dividing the rabbits into 3 groups, wherein each group is half male and female, depilating the elbow skin, respectively applying the ointment prepared in experimental example 1, experimental example 2 and experimental example 3 for 7 days, wherein the ointment is applied once a day and 12 hours each time, and the statistical results are shown in the following table:
example of death Example of sensitization Comprehensive performance
Experimental example 1 group 0 0 No adverse reaction, soft and ruddy skin at the attachment
Experimental example 2 group 0 0 No adverse reaction, and the skin at the attachment part is thicker than that of the group in the experimental example 1
Experimental example 3 group 0 2 The skin of the patch is ruddy but occasionally allergic
Example of clinical test
The plaster prepared in the embodiment 1 of the invention is used as an example for explaining the efficacy, the plaster is externally applied in clinical use, the affected part is cleaned with warm water and dried, the plaster is stuck on the dead skin of the elbow one day for more than 12 hours, and a treatment course is 7 days after continuous sticking. A total of 28 patients, aged 20-68 years, were observed with the following results: the phenomenon of hand elbow skin chap of 28 patients is relieved, and the effective rate is 100%; the phenomenon of skin chapping of the elbows of 21 patients completely disappears, deep dirt on the cleaned skin can be seen, the stratum corneum is recovered to be normal, and the cure rate is 75%; particularly 11 test patients in the age range of 20-30 years old have the skin chapping phenomenon which disappears completely earlier, the cleaned deep dirt and the over-aged cutin of the skin are seen, the cutin is normal, and the cure rate is 100 percent; none of the 28 patients tested developed an allergic reaction.
Typical example of use
1. The patients are plum, male, and 52 years old, the skin of feet is chapped, the cuticle is thickened, the peeling phenomenon is generated, the cause is unknown, after 1 treatment course, the cuticle is recovered to be normal, and the peeling phenomenon disappears.
2. After the patient takes 1 treatment course, the hand dryness is relieved, and the dry and cracked parts are healed; after 2 treatment courses, the stratum corneum returned to normal.
3. For a symptomatic part, the plaster is applied and used for 1 treatment course every night under the condition of not influencing normal working, the cracked part is completely healed, and the hand dryness is relieved; after 3 courses of treatment, the stratum corneum of the original symptomatic part of the hand was completely restored to normal.

Claims (2)

1. The plaster for softening and removing the cutin of the elbows and the feet is characterized in that active ingredients are prepared from the following raw materials in parts by weight: 23-27 parts of sesame oil, 18-22 parts of eggplant stalk, 18-22 parts of banana peel, 8-10 parts of yellow lead, 2-4 parts of folium artemisiae argyi, 0.8-1.2 parts of safflower and 0.2-0.6 part of fig white juice;
the preparation method of the plaster for softening and removing the cutin of the elbows and the feet comprises the following steps: pretreating raw materials, preparing medicinal oil, refining oil, adding Carthami flos, adding Plumbum Preparatium, adding fructus fici white juice, removing fire toxin, heating the feeling agent, and making into final product;
the raw material pretreatment comprises the following steps: cleaning eggplant stalk and banana peel, blanching, air drying, and cutting into pieces; freezing the fig white juice; the moldy folium artemisiae argyi is kept for later use; pulverizing Carthami flos, and sieving with 80 mesh sieve; sieving Plumbum Preparatium with 100 mesh sieve, parching with slow fire until the Plumbum Preparatium turns deep red from orange yellow, taking out, and cooling; weighing sesame oil for later use;
the preparation of the medicinal oil comprises the following steps: weighing sesame oil, eggplant stems, banana peel and folium artemisiae argyi according to the mass ratio, heating the sesame oil, slightly heating, putting the eggplant stems and the banana peel into the sesame oil, fishing out the sesame oil when the surfaces of the eggplant stems and the banana peel are dark brown and the interior of the eggplant stems and the banana peel is golden yellow, adding the folium artemisiae argyi into the sesame oil, fishing out the sesame oil when the surfaces of the eggplant stems and the banana peel are dark brown;
the oil refining, the safflower adding, the internal heat treating pellet and the fig white juice comprise: oil refining; slowly adding Carthami flos weighed according to a certain proportion into the refined medicinal oil, adding Plumbum Preparatium with slow fire when the temperature of the medicinal oil rises to 290 deg.C, slowly adding Plumbum Preparatium, stirring to thicken into paste; cooling the decocted plaster to 50 deg.C, weighing fructus fici white juice, slowly adding into the plaster while stirring, and stirring well.
2. The plaster for softening and exfoliating the elbows and feet according to claim 1, wherein the mass ratio of the raw materials in the raw material pretreatment step is that the sesame oil: eggplant stalk: banana peel: yellow lead: folium artemisiae argyi: safflower: fig white juice =25:20:20:9:3:1: 0.4.
CN201810134544.5A 2018-02-09 2018-02-09 Plaster for softening and removing cutin and preparation method thereof Expired - Fee Related CN108186818B (en)

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CN102973858B (en) * 2012-11-26 2014-09-17 宋佰慧 Itching-relieving anti-allergy Chinese traditional medicine compound navel patch
CN103767969B (en) * 2014-01-14 2016-06-01 上海海洋大学 A kind of hand lotion obtained by effective constituent in Pericarpium Musae and its preparation method
CN105561079A (en) * 2016-03-20 2016-05-11 张慧 External medicine for treating skin keratosis pilaris
CN106038399B (en) * 2016-06-30 2018-11-13 山东师范大学 A kind of foot film and preparation method thereof of the anti-chap deodorization of anti-inflammatory

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