CN102380123B - Collagen membrane medical dressing and preparation method thereof - Google Patents
Collagen membrane medical dressing and preparation method thereof Download PDFInfo
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- CN102380123B CN102380123B CN2011102924369A CN201110292436A CN102380123B CN 102380123 B CN102380123 B CN 102380123B CN 2011102924369 A CN2011102924369 A CN 2011102924369A CN 201110292436 A CN201110292436 A CN 201110292436A CN 102380123 B CN102380123 B CN 102380123B
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Abstract
The invention discloses a collagen membrane medical dressing, which is prepared in the way that: 1swung dash10 parts of sodium carboxymethylcellulose and 15swung dash150 parts of deionized water are mixed in a reaction bulb into the transparent thick state; 0.05swung dash0.5 part of resina draconis and 0.2swung dash2 parts of polyvidon are mixed and prepared into solid dispersoid through a liquation method; 0.05swung dash0.5 part of collagen and 0.1swung dash1 part of starch are added into 1swung dash5 parts of glutaraldehyde solution, are stirred to dissolve at 20 swung dash30 DEG C, then are mixed with the prepared sodium carboxymethylcellulose solution, and are stirred at 30swung dash50 DEG C, so a pasty mixed liquor is prepared for standby application; and 0.05swung dash0.5 part of pseudo-ginseng and 0.25swung dash2.5 parts of solid dispersion are added into the pasty mixed liquor, and are uniformly mixed at 30swung dash50 DEG C, the pH of the pasty mixed liquor is controlled between 6swung dash8, the pasty mixed liquor is poured into a die to form, and is dried in a drying oven, and the collagen membrane medical dressing product is produced only after the dyestripping.
Description
Technical field
The present invention relates to a kind of medical dressing technology of preparing, more particularly, relate to a kind of collagen protein Medical dressing and preparation method thereof, belong to medical technical field.
Background technology
Along with the high speed development of modern science and technology, the research of medical dressing has obtained gratifying progress, has occurred that a lot of structures are different, the medical dressing material of complete function, but in the market still take traditional plant medical dressing as main.
Medical dressing can play the temporary protection wound, prevents wound infection, to impel wound healing, and use also a kind of medical material comparatively easily.So its kind also emerges in an endless stream, following a few class is arranged probably: 1, conventional medical dressing, as natural gauze, cotton pad, synthetic fibers etc., this class medical dressing is by passive covering and absorb Wound exudate, for wound surface provides protective effect effectively., although have the simple advantage of process of manufacture, still have following defect: permeability is too large, easily make the wound surface dehydration; And the adhesion wound surface, the wound cicatrix is obvious, easily causes the secondary mechanical damage during replacing; And along with the minimizing of natural resources, the cost of gauze is also increasing gradually.2, poly film class medical dressing, as poly film, hydrogel etc., it can make the gas with oxygen and steam freely pass through.But this class medical dressing absorbs the ability of wound sepage, and its cost is also relatively high.3, biological activity type medical dressing, as polysaccharide medical dressing, alginate medical dressing, this is a class from the natural fiber that extract in the natural seaweed plant as medical dressing.Although it has the ability of quick and powerful absorbing wound exudate, most products does not have autohension, and is opaque, be inconvenient to observe wound surface, and relative cost is higher.4, natural nano type medical dressing, as the nanometer silver medical dressing, it is a kind of noble silver medical dressing of natural environmental-protective, adopts high-tech nanotechnology to be prepared from, and has superpower broad-spectrum bactericidal capacity, and has no drug resistance.
In above-mentioned several different types of medical dressing, three kinds of fronts medical dressing all has pluses and minuses separately, though the 4th kind of dressing has advantage than three kinds of fronts, because people can consider factors when selecting a kind of desirable dressing.If absorb unnecessary wound fluid, for wound healing is created a good environment; Has good permeability, the shielding abnormal flavour; Can intercept external environment graininess foreign body, comprise the microorganism infiltrations such as antibacterial; Noresidue during replacing, can not cause property mechanical damage again; Easily use comfortable and economic dispatch.So comprehensive, main flow medical dressing on market still adopts traditional class medical dressing now, and is poor but it has with skin-friendliness, slow to wound healing, easily cause the shortcomings such as secondary mechanical damage while changing dressings, and its cost increases gradually along with the minimizing of natural resources.
Find after deliberation, the film of being made by the mean molecule quantity collagen protein that is 150KD has good mechanical tenacity and flexibility; In addition, collagen protein contains a large amount of aminoacid, and their composition is identical with human body skin, good biocompatibility; Wherein a kind of aminoacid of uniqueness---the hydroxyl proline is proved to be the sterling collagen protein, has biological activity, energy Promote cell's growth and the new collagen fiber of formation; These character have been given it and have been used for the unique distinction of medical material.Therefore, researching and developing a kind of collagen membrane medical dressing with antiinflammatory, hemostatic function to be applied to field of medicaments, is task of the present invention place.
Summary of the invention
Purpose of the present invention, just for the existing weak point of above-mentioned existing medical dressing, provides a kind of take collagen protein as raw material, is added with the novel collagen film medical dressing of Radix Notoginseng, Sanguis Draxonis Chinese medicine ingredients; And the preparation method that a kind of this collagen membrane medical dressing is provided, collagen membrane medical dressing of the present invention and human body skin have good biocompatibility, give birth to body functional, cell adaptation and hemostasis, antiinflammatory, the effect of antibiotic effect; Its preparation technology is simple, and is easy to operate, and material therefor is easy to get.
Basic thought of the present invention is: by changing the raw material sources of medical dressing, namely from animal fiber---Corii Sus domestica extracts the natural collagen protein that mean molecule quantity is 150KD, take the sodium carboxymethyl cellulose medical dressing novel as carrier is prepared into.In addition,, for improving the suitability of this dressing, Radix Notoginseng, Sanguis Draxonis have been added.Contain a series of active component such as dencichine, Radix Notoginseng flavone, aminoacid, trace element because of Radix Notoginseng, have the antibacterial drug effect of antiinflammatory; Sanguis Draxonis has good hemostatic function, can further strengthen the hemagglutinative function of collagen protein.For the making of difference with conventional medical dressing, the present invention does medical dressing the form of film forming, and adopts the cohesiveness of the starch reinforcing membrane of highly branched chain.When using dressing, film just can directly be affixed on wound like this; In its film, ingredient collagen protein and human body skin have the good compatibility, have both helped the performance of Radix Notoginseng, Sanguis Draxonis drug effect, cause secondary injury in the time of can avoiding again more change dressings.
For achieving the above object, the present invention adopts the technical scheme consist of following technical measures to realize.
Collagen membrane medical dressing provided by the invention, take collagen protein as raw material, Radix Notoginseng, Sanguis Draxonis Chinese medicine ingredients in addition, its composition of raw materials component by weight and/or volume metering be:
0.05～0.5 part of collagen protein
1～10 part of sodium carboxymethyl cellulose
1～5 part of glutaraldehyde solution
0.1～1 part of starch
0.05～0.5 part of Radix Notoginseng
0.05～0.5 part of Sanguis Draxonis
0.2～2 part of polyvinylpyrrolidone (PVP)
15～150 parts of deionized waters.
Wherein collagen protein, sodium carboxymethyl cellulose, starch, Radix Notoginseng, Sanguis Draxonis, polyvinylpyrrolidone (PVP) are solid powder, and weight portion measures with gram; Glutaraldehyde solution, deionized water parts by volume are measured with milliliter.
In technique scheme, described collagen protein is from animal fiber---Corii Sus domestica, extract through series of steps such as defat, enzymolysis, dryings, and its mean molecule quantity is 150KD.
The invention provides the preparation method of collagen membrane medical dressing described above, comprise following processing step:
(1), with 1～10 weight portion sodium carboxymethyl cellulose, put into the reaction bulb with agitator and thermometer, add 15～150 parts of deionized waters, stirring at 20～30 ℃ of temperature, it is transparent thick that it is become;
(2) Sanguis Draxonis of 0.05～0.5 weight portion is evenly mixed with the PVP (PVP) of 0.2～2 weight portion, adopt fusion method to make solid dispersion;
(3) with 0.05～0.5 weight portion collagen protein, 0.1～1 weight portion starch, add in the glutaraldehyde solution of 1～5 parts by volume, at 20～30 ℃ of lower uniform stirrings of temperature, it fully dissolved; The transparent thick carboxymethylcellulose sodium solution that again (1) step is prepared mixes with it, and continues to stir 15～30 minutes under 30～50 ℃, is mixed with the pasty state mixed liquor standby;
(4) go on foot in the pasty state mixed liquor that has prepared and add 0.05～0.5 weight portion Radix Notoginseng in (3), 0.25～2.5 weight portion solid dispersion, stir at 30～50 ℃ of temperature, and the pH value of control pasty state mixed liquor is between 6～8, pour again die for molding into, be dry in the baking oven of 50～80 ℃ in temperature, 0.5～1 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
In technique scheme, described collagen protein is from animal fiber---Corii Sus domestica, extract through series of steps such as defat, enzymolysis, dryings, and its mean molecule quantity is 150KD.
In technique scheme, described fusion method refers to adjuvant polyvinylpyrrolidone and Sanguis Draxonis powder heating and melting (approximately 80 ℃) are stirred, and lets cool curing, and is standby.
In technique scheme, it is that 5～10% sodium carbonate liquor and/or the acetum of 0.5mol/L are regulated control that the pH value of described control pasty state mixed liquor adopts concentration.
Collagen membrane medical dressing of the present invention and preparation method thereof has following characteristics and useful technique effect:
1, preparation method of the present invention is simple, and is easy to operate, raw materials used being easy to get, and cost is low; Its functional raw material collagen protein can extract from the animal skins such as pig with prior art easily.
2, the inventive method no waste discharge in preparation process, can not pollute, and is conducive to environmental conservation.
3, the collagen membrane medical dressing of the present invention preparation consists of the polymer substance in natural animal, and is nontoxic, tasteless, have no side effect.
4, in the collagen membrane medical dressing of the present invention's preparation, collagen protein and human body skin have good biocompatibility, give birth to body functional etc., and not sticking wound, cause mechanical damage again while avoiding changing.
5, be added with Radix Notoginseng, Sanguis Draxonis in the collagen membrane medical dressing of the present invention's preparation, to wound surface, can play good hemostasis, antiinflammatory, antibiotic, aseptic effect.
The specific embodiment
Below in conjunction with embodiment, the present invention is more specifically described, but content of the present invention is not limited only to content related in described embodiment.
Embodiment 1
Sodium carboxymethyl cellulose 1.0 grams are put into reaction bulb with agitator and thermometer, add 15 ml deionized water, stirring under 20 ℃, it is transparent thick that it is become; 0.05 cron Sanguis Draxonis is evenly mixed with the PVP (PVP) of 0.2 gram, adopt fusion method to make solid dispersion; With 0.05 gram collagen protein, 0.1 gram starch, add in the glutaraldehyde solution of 2 milliliters, at 20 ℃ of lower uniform stirrings of temperature, it is fully dissolved, the transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, in 35 ℃, continues to stir 25 minutes, is mixed with the pasty state mixed liquor standby; Add 0.05 gram Radix Notoginseng in the pasty state mixed liquor that has prepared, 0.25 gram solid dispersion, stir at 35 ℃ of temperature, the acetum of the sodium carbonate liquor of use concentration 5% and 0.5mol/L is regulated the pH value of pasty state mixed liquor again, pH value being controlled to be 6, then pouring die for molding into, is dry in the baking oven of 50 ℃ in temperature, 1.0 hours drying times, take off film and namely obtain the collagen membrane medical dressing product.
Embodiment 2
Sodium carboxymethyl cellulose 6.0 grams are put into reaction bulb with agitator and thermometer, add 60 ml deionized water, stirring under 25 ℃, it is transparent thick that it is become; 0.2 cron Sanguis Draxonis is evenly mixed with the PVP (PVP) of 1.0 grams, adopt fusion method to make solid dispersion; With 0.1 gram collagen protein, 0.2 gram starch, add in the glutaraldehyde solution of 3 milliliters, at 25 ℃ of lower uniform stirrings of temperature, it is fully dissolved, the transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, in 30 ℃, continues to stir 30 minutes, is mixed with the pasty state mixed liquor standby; Add 0.2 gram Radix Notoginseng in the pasty state mixed liquor that has prepared, 1.2 gram solid dispersion, stir at 30 ℃ of temperature, the acetum of the sodium carbonate liquor of use concentration 5% and 0.5mol/L is regulated the pH value of pasty state mixed liquor again, pH value being controlled to be 7, then pouring die for molding into, is dry in the baking oven of 60 ℃ in temperature, 0.8 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
Embodiment 3
Sodium carboxymethyl cellulose 7.0 grams are put into reaction bulb with agitator and thermometer, add 70 ml deionized water, stirring under 30 ℃, it is transparent thick that it is become; 0.3 cron Sanguis Draxonis is evenly mixed with 1.5 PVP (PVP), adopt fusion method to make solid dispersion; With 0.2 gram collagen protein, 0.5 gram starch, add in the glutaraldehyde solution of 4 milliliters, at 28 ℃ of lower uniform stirrings of temperature, it is fully dissolved, the transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, in 40 ℃, continues to stir 20 minutes, is mixed with the pasty state mixed liquor standby; Add 0.3 gram Radix Notoginseng in the pasty state mixed liquor that has prepared, 1.8 gram solid dispersion, stir at 40 ℃ of temperature, the acetum of the sodium carbonate liquor of use concentration 5% and 0.5mol/L is regulated the pH value of pasty state mixed liquor again, pH value being controlled to be 8, then pouring die for molding into, is dry in the baking oven of 65 ℃ in temperature, 0.7 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
Embodiment 4
Sodium carboxymethyl cellulose 8.0 grams are put into reaction bulb with agitator and thermometer, add 80 ml deionized water, stirring under 20 ℃, it is transparent thick that it is become; 0.3 cron Sanguis Draxonis is evenly mixed with the PVP (PVP) of 2.0 grams, adopt fusion method to make solid dispersion; With 0.3 gram collagen protein, 0.4 gram starch, add in the glutaraldehyde solution of 3 milliliters, at 30 ℃ of lower uniform stirrings of temperature, it is fully dissolved, the transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, in 45 ℃, continues to stir 18 minutes, is mixed with the pasty state mixed liquor standby; Add 0.05 gram Radix Notoginseng in the pasty state mixed liquor that has prepared, 2.3 gram solid dispersion, stir under temperature 45 C, the acetum of the sodium carbonate liquor of use concentration 5% and 0.5mol/L is regulated the pH value of pasty state mixed liquor again, pH value being controlled to be 6, then pouring die for molding into, is dry in the baking oven of 68 ℃ in temperature, 0.6 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
Embodiment 5
Sodium carboxymethyl cellulose 9.0 grams are put into reaction bulb with agitator and thermometer, add 100 ml deionized water, stirring under 25 ℃, it is transparent thick that it is become; 0.4 cron Sanguis Draxonis is evenly mixed with the PVP (PVP) of 0.5 gram, adopt fusion method to make solid dispersion; With 0.4 gram collagen protein, 0.8 gram starch, add in the glutaraldehyde solution of 2 milliliters, at 25 ℃ of lower uniform stirrings of temperature, it is fully dissolved, the transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, in 40 ℃, continues to stir 20 minutes, is mixed with the pasty state mixed liquor standby; Add 0.1 gram Radix Notoginseng in the pasty state mixed liquor that has prepared, 0.9 gram solid dispersion, stir at 35 ℃ of temperature, the acetum of the sodium carbonate liquor of use concentration 5% and 0.5mol/L is regulated the pH value of pasty state mixed liquor again, pH value being controlled to be 8, then pouring die for molding into, is dry in the baking oven of 70 ℃ in temperature, 0.6 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
Embodiment 6
Sodium carboxymethyl cellulose 10.0 grams are put into reaction bulb with agitator and thermometer, add 150 ml deionized water, stirring under 30 ℃, it is transparent thick that it is become; 0.5 cron Sanguis Draxonis is evenly mixed with the PVP (PVP) of 0.3 gram, adopt fusion method to make solid dispersion; With 0.5 gram collagen protein, 1.0 gram starch, add in the glutaraldehyde solution of 5 milliliters, at 23 ℃ of lower uniform stirrings of temperature, it is fully dissolved, the transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, in 50 ℃, continues to stir 15 minutes, is mixed with the pasty state mixed liquor standby; Add 0.5 gram Radix Notoginseng in the pasty state mixed liquor that has prepared, 0.8 gram solid dispersion, stir under temperature 50 C, the acetum of the sodium carbonate liquor of use concentration 5% and 0.5mol/L is regulated the pH value of pasty state mixed liquor again, pH value is controlled to be 7, then pours die for molding into, dry in the baking oven of 80 ℃ of temperature, 0.5 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
Collagen protein medical dressing of the present invention is done the form of film forming, and adopts the cohesiveness of the starch reinforcing membrane of highly branched chain.When using dressing, film just can directly be affixed on wound like this; In its film, ingredient collagen protein and human body skin have the good compatibility, have both helped the performance of Radix Notoginseng, Sanguis Draxonis drug effect, cause secondary injury in the time of can avoiding again more change dressings.
Collagen membrane medical dressing of the present invention both had good biocompatibility with human body skin, gave birth to body functional, cell adaptation and hemostasis, antiinflammatory, the effect of antibiotic effect; And preparation technology is simple, and easy and simple to handle, material therefor is easy to get.But note will considering the impact of the factors such as temperature, PH, time on this dressing performance, if the film-forming temperature of choosing is too high or overlong time all can cause the toughness of film and mechanical strength significantly to descend in experimentation.Therefore only have and the conditions such as temperature, time are controlled just to make within the specific limits toughness strong, mechanical strength is high, the collagen membrane medical dressing of good biocompatibility.
Claims (2)
1. a collagen membrane medical dressing, is characterized in that take collagen protein as raw material, Radix Notoginseng, Sanguis Draxonis Chinese medicine ingredients in addition, its composition of raw materials component by weight and/or volume metering be:
0.05～0.5 part of collagen protein
1～10 part of sodium carboxymethyl cellulose
1～5 part of glutaraldehyde solution
0.1～1 part of starch
0.05～0.5 part of Radix Notoginseng
0.05～0.5 part of Sanguis Draxonis
0.2～2 part of polyvinylpyrrolidone (PVP)
15～150 parts of deionized waters
Wherein collagen protein, sodium carboxymethyl cellulose, starch, Radix Notoginseng, Sanguis Draxonis, polyvinylpyrrolidone (PVP) are solid powder, and weight portion measures with gram; Glutaraldehyde solution, deionized water parts by volume are measured with milliliter.
2. collagen membrane medical dressing according to claim 1, the mean molecule quantity that it is characterized in that described collagen protein is 150KD.
3. the method for preparing collagen membrane medical dressing described in claim 1 is characterized in that the method comprises by following steps to form:
(1), with 1～10 weight portion sodium carboxymethyl cellulose, put into the reaction bulb with agitator and thermometer, add deionized water 15～150 parts by volume, stirring at 20～30 ℃ of temperature, it is transparent thick that it is become;
(2) Sanguis Draxonis of 0.05～0.5 weight portion is evenly mixed with the PVP (PVP) of 0.2～2 weight portion, adopt fusion method to make solid dispersion;
(3) with 0.05～0.5 weight portion collagen protein, 0.1～1 weight portion starch, add in the glutaraldehyde solution of 1～5 parts by volume, at 20～30 ℃ of lower uniform stirrings of temperature, it fully dissolved; The transparent thick carboxymethylcellulose sodium solution that again (1) step is prepared mixes with it, and continues to stir 15～30 minutes under 30～50 ℃, is mixed with the pasty state mixed liquor standby;
(4) go on foot in the pasty state mixed liquor that has prepared and add 0.05～0.5 weight portion Radix Notoginseng in (3), 0.25～2.5 weight portion solid dispersion, stir at 30～50 ℃ of temperature, and the pH value of control pasty state mixed liquor is between 6～8, pour again die for molding into, be dry in the baking oven of 50～80 ℃ in temperature, 0.5～1 hour drying time, take off film and namely obtain the collagen membrane medical dressing product.
Wherein collagen protein, sodium carboxymethyl cellulose, starch, Radix Notoginseng, Sanguis Draxonis, polyvinylpyrrolidone (PVP) are solid powder, and weight portion measures with gram; Glutaraldehyde solution, deionized water parts by volume are measured with milliliter.
4. the preparation method of collagen membrane medical dressing according to claim 3, the mean molecule quantity that it is characterized in that described collagen protein is 150KD.
5. the preparation method of collagen membrane medical dressing according to claim 3 is characterized in that the pH value of described control pasty state mixed liquor is between 6～8: be that to adopt concentration be that 5～10% sodium carbonate liquor and/or the acetum of 0.5mol/L are regulated control.
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| CN102872303B (en) * | 2012-10-31 | 2014-06-25 | 贾国平 | Resina draconis application paster as well as preparation and detection methods |
| CN103030831B (en) * | 2012-12-26 | 2014-06-25 | 上海欣吉特生物科技有限公司 | Hemostatic or anticoagulant collagen material |
| CN105920654A (en) * | 2016-04-27 | 2016-09-07 | 李明华 | Burn dressing applicable to department of burn and having antibacterial effect |
| CN105903058B (en) * | 2016-05-30 | 2020-11-10 | 山西大学 | Preparation method of transparent film band-aid containing traditional Chinese medicine components |
| CN106421865A (en) * | 2016-07-29 | 2017-02-22 | 江苏蓝湾生物科技有限公司 | Preparation method of collagen-based dressing with self anti-inflammatory function |
| CN106110389A (en) * | 2016-08-30 | 2016-11-16 | 上海建华精细生物制品有限公司 | A kind of moist dressing of skin wound and its preparation method and application |
| CN110339390A (en) * | 2019-08-12 | 2019-10-18 | 中国中医科学院中药研究所 | A kind of compounding adhesive bandage and preparation method thereof |
| CN114272434A (en) * | 2021-03-16 | 2022-04-05 | 卫纳塞德(北京)医疗科技有限公司 | Degradable medical cold compress hydrogel and preparation method thereof |
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| CN1994481A (en) * | 2006-10-10 | 2007-07-11 | 辽宁师范大学 | Highly effective Chinese medicine-chitosan compound hemostatic material |
| CN101450223A (en) * | 2007-11-30 | 2009-06-10 | 张博 | Hemostasia material based on chitosan, collagen and sodium cellulose glycolate and preparation method and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1994481A (en) * | 2006-10-10 | 2007-07-11 | 辽宁师范大学 | Highly effective Chinese medicine-chitosan compound hemostatic material |
| CN101450223A (en) * | 2007-11-30 | 2009-06-10 | 张博 | Hemostasia material based on chitosan, collagen and sodium cellulose glycolate and preparation method and use thereof |
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