CN104491919A - Propolis hemostatic gauze and preparation method thereof - Google Patents

Abstract

The invention discloses a propolis hemostatic gauze. The propolis hemostatic gauze is prepared from the following raw materials in parts by weight: 6-8 parts of propolis, 1-2 parts of carbomer, 6-8 parts of gelatin, 2-4 parts of sodium alginate, 0.3-0.5 part of jojoba oil, 0.1-0.2 part of grape seed oil, 1-2 parts of hydroxyethyl cellulose, 2-4 parts of sodium carboxymethylcellulose, 0.05-0.1 part of D-panthenol, 0.1-0.2 part of polysorbate-80, 1-2 parts of auxiliary materials and 200-250 parts of water. The soluble hemostatic gauze is prepared by taking a natural substance propolis as a main material, has a good hemostatic effect and antisepsis and anti-inflammation effects, and can be used for promoting the healing of wounds, improving the immunity and providing nutritional ingredients needed by the healing of the wounds; and meanwhile, the propolis hemostatic gauze has a simple manufacturing process, is safe and environmentally friendly, has good biocompatibility, is easily absorbed by a human body and has no toxic or side effects.

Description

A kind of propolis hemostatic gauze and preparation method thereof

Technical field

The present invention relates to field of medicaments, be specifically related to a kind of propolis hemostatic gauze and preparation method thereof.

Background technology

Along with the continuous progress of medical skill, new medical material and correlation technique obtain good development.Wherein the development of hemostatic material and improvement be conducive to improving perform the operation out, the problem of oozing of blood, have great importance, become the focus of current field of medicaments research.Traditional hemostatic gauze is generally made up of Cotton Gossypii, linen etc., have that antibacterial bacteriostatic ability, scrim fiber easily cause foreign material repulsion to react affect wound healing, easy and wound tissue adhesion when using, cause the problems such as secondary damage, and the waste treatment processes produced after using is complicated, easy contaminated environment.

Soluble stanching gauze is the good novel hemostatic material of one of development in recent years, has stronger affinity, absorb moisture and dissolve after running into blood water and saline, blocking blood capillary end and reach the object of hemostasis.Soluble stanching gauze also has good histocompatibility, frivolous softness, is convenient to carry out the operations such as coated filling, has high using value and the market demand potential.

Summary of the invention

The object of this invention is to provide a kind of propolis hemostatic gauze, this hemostatic gauze has good water solublity and biocompatibility, is easily absorbed by the body, and has no side effect, anti-inflammation, and haemostatic effect is good.

The present invention is achieved by the following technical solutions:

A kind of propolis hemostatic gauze, it is characterized in that, it is obtained by the raw material of following weight parts:

Propolis 6-8, carbomer 1-2, gelatin 6-8, sodium alginate 2-4, Jojoba oil 0.3-0.5, Oleum Vitis viniferae 0.1-0.2, hydroxyethyl-cellulose 1-2, sodium carboxymethyl cellulose 2-4, D-panthenol 0.05-0.1, Tween-80 0.1-0.2, adjuvant 1-2, water 200-250;

Wherein adjuvant is made up of the raw material of following weight portion:

Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;

The preparation method of adjuvant is:

Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.

Wherein, propolis used is water-soluble bee glue.

A preparation method for propolis hemostatic gauze, is characterized in that, comprises the following steps:

(1) propolis, carbomer, gelatin and Tween-80 are added in the water of 1/3-1/2 amount, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, add Jojoba oil, Oleum Vitis viniferae and adjuvant 40-50 DEG C again, stir 1-2h under same rotating speed, add D-panthenol after cooling, after stirring, obtain component A;

(2) add in the water of surplus by sodium alginate, sodium carboxymethyl cellulose and hydroxyethyl-cellulose, 800-1000r/min stirs 0.5-1h, obtains B component;

(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 50-60% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 1-4m/min;

(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.

Propolis is the resin (natural gum) that Apis gathers from plant spore or trunk, is mixed into palatine gland on it, a kind of colloidal solid thing with aromatic odor that the secretions of wax gland processes.Propolis contains abundant nutritional labeling, mineral and trace element, and has the effects such as good anti-inflammatory, antibacterial, non-oxidizability, antiviral, raising immunity, has effect of pain easing and hemostasis, sterilization antiinflammatory, has certain repair to wound.

Advantage of the present invention is:

The present invention is using natural materials propolis as major ingredient, soluble stanching gauze is obtained in conjunction with the pharmaceutical adjuvant synthesis such as gelatin, sodium alginate, sodium carboxymethyl cellulose composite fibre, there is good hemostatic function, energy anti-inflammation, promotion wound healing, improve immunity, the nutritional labeling needed for wound healing is provided; Simultaneously processing technology simple, safety and environmental protection, good biocompatibility, be easily absorbed by the body and have no side effect.

Detailed description of the invention

Non-limiting examples of the present invention is as follows:

A kind of propolis hemostatic gauze, is prepared from by the component raw material of following weight (kg):

Propolis 7, carbomer 1.5, gelatin 7, sodium alginate 3, Jojoba oil 0.4, Oleum Vitis viniferae 0.15, hydroxyethyl-cellulose 1.5, sodium carboxymethyl cellulose 3, D-panthenol 0.08, Tween-80 0.15, adjuvant 1.5, water 200;

Wherein, adjuvant is made up of the raw material of following weight (kg):

Soybean lecithin 0.8, glycerol 3, Polyethylene Glycol 1.5, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1.5, mannitol 3, chlorhexidine gluconate 1.5, vitamin C 1.5, water 18;

The preparation method of adjuvant:

Soybean lecithin is added to the water 60 DEG C, 1000r/min stirs 1h, then add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition and stir 15min, add all the other raw materials 600r/min after cooling and stir 5min, to obtain final product.

The preparation method of propolis hemostatic gauze comprises the following steps:

(1) propolis, carbomer, gelatin and Tween-80 are added in the water of 1/2 amount, prior to 80 DEG C, 600r/min stirs 0.5h, stir 1h under adding Jojoba oil, Oleum Vitis viniferae and adjuvant 40 DEG C, equally rotating speed again, add D-panthenol after cooling, after stirring, obtain component A;

(2) add in the water of surplus by sodium alginate, sodium carboxymethyl cellulose and hydroxyethyl-cellulose, 1000r/min stirs 1h, obtains B component;

(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 2% citric acid (mass ratio) and 60% ethanol (volume ratio), coagulation bath temperature is 30 DEG C, and spinning speed is 3m/min;

(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.

The hemostatic gauze obtained to the present embodiment is verified:

Haemostatic effect: mice docking experiment, mice docking bleeding time <15s;

Absorbability: mice subcutaneous absorption is tested, can absorb in 3 weeks, reaction without exception completely.

Claims (2)

1. a propolis hemostatic gauze, is characterized in that, it is obtained by the raw material of following weight parts:

Propolis 6-8, carbomer 1-2, gelatin 6-8, sodium alginate 2-4, Jojoba oil 0.3-0.5, Oleum Vitis viniferae 0.1-0.2, hydroxyethyl-cellulose 1-2, sodium carboxymethyl cellulose 2-4, D-panthenol 0.05-0.1, Tween-80 0.1-0.2, adjuvant 1-2, water 200-250;

Described adjuvant is made up of the raw material of following weight portion:

Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;

The preparation method of described adjuvant is:

Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.

2. the preparation method of a kind of propolis hemostatic gauze according to claim 1, is characterized in that, comprise the following steps:

(1) propolis, carbomer, gelatin and Tween-80 are added in the water of 1/3-1/2 amount, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, add Jojoba oil, Oleum Vitis viniferae and adjuvant 40-50 DEG C again, stir 1-2h under same rotating speed, add D-panthenol after cooling, after stirring, obtain component A;

(2) add in the water of surplus by sodium alginate, sodium carboxymethyl cellulose and hydroxyethyl-cellulose, 800-1000r/min stirs 0.5-1h, obtains B component;

(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 50-60% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 1-4m/min;

(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.