CN102380123A - Collagen membrane medical dressing and preparation method thereof - Google Patents
Collagen membrane medical dressing and preparation method thereof Download PDFInfo
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- CN102380123A CN102380123A CN2011102924369A CN201110292436A CN102380123A CN 102380123 A CN102380123 A CN 102380123A CN 2011102924369 A CN2011102924369 A CN 2011102924369A CN 201110292436 A CN201110292436 A CN 201110292436A CN 102380123 A CN102380123 A CN 102380123A
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Abstract
The invention discloses a collagen membrane medical dressing, which is prepared in the way that: 1swung dash10 parts of sodium carboxymethylcellulose and 15swung dash150 parts of deionized water are mixed in a reaction bulb into the transparent thick state; 0.05swung dash0.5 part of resina draconis and 0.2swung dash2 parts of polyvidon are mixed and prepared into solid dispersoid through a liquation method; 0.05swung dash0.5 part of collagen and 0.1swung dash1 part of starch are added into 1swung dash5 parts of glutaraldehyde solution, are stirred to dissolve at 20 swung dash30 DEG C, then are mixed with the prepared sodium carboxymethylcellulose solution, and are stirred at 30swung dash50 DEG C, so a pasty mixed liquor is prepared for standby application; and 0.05swung dash0.5 part of pseudo-ginseng and 0.25swung dash2.5 parts of solid dispersion are added into the pasty mixed liquor, and are uniformly mixed at 30swung dash50 DEG C, the pH of the pasty mixed liquor is controlled between 6swung dash8, the pasty mixed liquor is poured into a die to form, and is dried in a drying oven, and the collagen membrane medical dressing product is produced only after the dyestripping.
Description
Technical field
The present invention relates to a kind of medical dressing technology of preparing, more particularly, relate to a kind of collagen protein new medical dressing and preparation method thereof, belong to medical technical field.
Background technology
Along with the high speed development of modern science and technology, the research of medical dressing has obtained gratifying progress, has occurred the medical dressing material of a lot of structures differences, complete function, but has been main with traditional plant class medical dressing still in the market.
Medical dressing can play the temporary protection wound, prevents wound infection, impelling wound healing, and use also a kind of comparatively easily medical material.So its kind also emerges in an endless stream, probably have following several types: 1, conventional medical dressing, like natural gauze, cotton pad, synthetic fibers etc., this type medical dressing is through passive covering and absorb Wound exudate, for wound surface provides protective effect effectively.Though have the simple advantage of process of manufacture, still have following defective: permeability is too big, make the wound surface dehydration easily; And the adhesion wound surface, the wound cicatrix is obvious, is prone to cause the damage of secondary mechanical property during replacing; And along with the minimizing of natural resources, the cost of gauze is also increasing gradually.2, poly film class medical dressing, like poly film, hydrogel etc., it can make the gas with oxygen and steam freely pass through.But this type medical dressing absorbs the ability of wound sepage, and its cost is also higher relatively.3, biological activity type medical dressing, like polysaccharide medical dressing, alginate medical dressing, this is that one type of natural fiber that extract in the natural seaweed plant is as medical dressing.Though it has the ability of quick and powerful absorption wound fluid, most of products do not have autohension, and are opaque, be inconvenient to observe wound surface, and relative cost are higher.4, natural nano type medical dressing, like the nanometer silver medical dressing, it is a kind of noble metal silver medical dressing of natural environmental-protective, adopts high-tech nanotechnology to be prepared from, and has superpower broad-spectrum bactericidal capacity, and has no drug resistance.
In above-mentioned several kinds of different types of medical dressing, the three kinds of medical dressing in front all have pluses and minuses separately, though the 4th kind of dressing has advantage for three kinds than the front, because people will consider many factors when selecting a kind of desirable dressing.Wound fluid that if can absorbing redundant is that wound healing is created a good environment; Has good permeability, the shielding abnormal flavour; Can intercept external environment graininess foreign body, comprise microorganism infiltrations such as antibacterial; Noresidue during replacing can not cause property mechanical damage once more; Be prone to use comfortable and economic dispatch.So it is comprehensive; Main flow medical dressing on the market still adopts tradition type medical dressing now, and is poor but it has with skin-friendliness, slow to wound healing; Be prone to cause shortcomings such as secondary mechanical property damage when changing dressings, and its cost increases gradually along with the minimizing of natural resources.
Finding after deliberation, is that the film that the collagen protein of 150KD is processed has good mechanical tenacity and flexibility by mean molecule quantity; In addition, collagen protein contains a large amount of aminoacid, and their composition is identical with human body skin, good biocompatibility; Wherein a kind of aminoacid of uniqueness---the hydroxyl proline is proved to be pure article collagen protein, and biologically active can promote the cell growth and form new collagen fiber; These character have been given it and have been used for the unique distinction of medical material.Therefore, researching and developing a kind of collagen film medical dressing with antiinflammatory, hemostatic function to be applied to field of medicaments, is task of the present invention place.
Summary of the invention
To the existing weak point of above-mentioned existing medical dressing, provide a kind of is raw material with the collagen protein to the object of the invention, is added with the novel collagen film medical dressing of Radix Notoginseng, Sanguis Draxonis Chinese medicine ingredients just; And the method for preparing that a kind of this collagen film medical dressing is provided, collagen film medical dressing of the present invention and human body skin have excellent biological compatibility, give birth to body function property, cell adapted property and hemostasis, antiinflammatory, the effect of antibiotic effect; Its preparation technology is simple, and is easy to operate, and material therefor is easy to get.
Basic thought of the present invention is: through changing the raw material sources of medical dressing, promptly from animal fiber---Corii Sus domestica, extract the natural collagen protein that mean molecule quantity is 150KD, and be that carrier is prepared into novel medical dressing with the sodium carboxymethyl cellulose.In addition, for improving the suitability of this dressing, Radix Notoginseng, Sanguis Draxonis have been added.Contain a series of active component such as dencichine, Radix Notoginseng flavone, aminoacid, trace element because of Radix Notoginseng, have antiinflammatory bacteriostatic drug effect; Sanguis Draxonis has good hemostatic function, can further strengthen the hemagglutinative function of collagen protein.Be the making of difference with conventional medical dressing, the present invention does film forming form with medical dressing, and adopts the cohesiveness of the starch reinforcing membrane of highly branched chain.When using dressing, film just can directly be affixed on the wound like this; Ingredient collagen protein and human body skin have the good compatibility in its film, have both helped the performance of Radix Notoginseng, Sanguis Draxonis drug effect, cause the secondary injury in the time of can avoiding more change dressings again.
For realizing the foregoing invention purpose, the technical scheme that the present invention's employing is made up of following technical measures realizes.
Collagen film medical dressing provided by the invention is a raw material with the collagen protein, Radix Notoginseng, Sanguis Draxonis Chinese medicine ingredients in addition, its composition of raw materials component by weight and/or volume metering be:
0.05～0.5 part of collagen protein
1～10 part of sodium carboxymethyl cellulose
1～5 part of glutaraldehyde solution
0.1～1 part of starch
0.05～0.5 part of Radix Notoginseng
0.05～0.5 part of Sanguis Draxonis
0.2～2 part of polyvinylpyrrolidone (PVP)
15～150 parts of deionized waters.
Wherein collagen protein, sodium carboxymethyl cellulose, starch, Radix Notoginseng, Sanguis Draxonis, polyvinylpyrrolidone (PVP) are solid powder, and weight portion is with the gram metering; Glutaraldehyde solution, deionized water parts by volume are measured with milliliter.
In the technique scheme, said collagen protein is from animal fiber---Corii Sus domestica, extract through series of steps such as defat, enzymolysis, dryings, and its mean molecule quantity is 150KD.
The present invention provides the method for preparing of above-mentioned described collagen film medical dressing, comprises following processing step:
(1) with 1～10 weight portion sodium carboxymethyl cellulose, put into the reaction bulb that has agitator and thermometer, add 15～150 parts of deionized waters, under 20～30 ℃ of temperature, stirring, it is transparent thick that it is become;
(2) with the polyethylene of the Sanguis Draxonis of 0.05～0.5 weight portion and 0.2～2 weight portion than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion;
(3) with 0.05～0.5 weight portion collagen protein, 0.1～1 weight portion starch adds in the glutaraldehyde solution of 1～5 parts by volume, evenly stirs down for 20～30 ℃ in temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution for preparing of (1) step is mixed with it again, and continue down to stir 15～30 minutes in 30～50 ℃, it is subsequent use to be mixed with the pasty state mixed liquor;
(4) in the pasty state mixed liquor that prepared of (3) step, add 0.05～0.5 weight portion Radix Notoginseng; 0.25～2.5 weight portion solid dispersion stir under 30～50 ℃ of temperature, and the pH value of control pasty state mixed liquor is between 6～8; Pour die for molding again into; In temperature is dry in 50～80 ℃ the baking oven, 0.5～1 hour drying time, takes off film and promptly obtains collagen film medical dressing product.
In the technique scheme, said collagen protein is from animal fiber---Corii Sus domestica, extract through series of steps such as defat, enzymolysis, dryings, and its mean molecule quantity is 150KD.
In the technique scheme, said fusion method is meant adjuvant polyvinylpyrrolidone and Sanguis Draxonis powder heating and melting (about 80 ℃), stirs, and puts cold curing, and is subsequent use.
In the technique scheme, it is that 5～10% sodium carbonate liquor and/or the acetum of 0.5mol/L are regulated control that the pH value of said control pasty state mixed liquor adopts concentration.
Collagen film medical dressing of the present invention and preparation method thereof has following characteristics and beneficial technical effects:
1, method for preparing of the present invention is simple, and is easy to operate, raw materials used being easy to get, and cost is low; Its functional raw material collagen protein can extract from animal skins such as pig with prior art easily.
2, the inventive method no waste discharge in the preparation process can not pollute, and helps environmental conservation.
3, the collagen film medical dressing of the present invention preparation is made up of the polymer substance in the natural animal, and is nontoxic, tasteless, have no side effect.
4, collagen protein and human body skin have excellent biological compatibility in the collagen film medical dressing of the present invention's preparation, give birth to body function property etc., and not sticking wound causes mechanical damage once more when avoiding changing.
5, be added with Radix Notoginseng, Sanguis Draxonis in the collagen film medical dressing of the present invention's preparation, can play good hemostasis, antiinflammatory, antibiotic, aseptic effect wound surface.
The specific embodiment
Below in conjunction with embodiment the present invention is done further concrete description, but content of the present invention is not limited only to content related among the said embodiment.
Embodiment 1
Sodium carboxymethyl cellulose 1.0 grams are put into the reaction bulb that has agitator and thermometer, add 15 ml deionized water, under 20 ℃, stirring, it is transparent thick that it is become; Than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion the polyethylene of 0.05 cron Sanguis Draxonis and 0.2 gram; With 0.05 gram collagen protein, 0.1 gram starch adds in 2 milliliters the glutaraldehyde solution; 20 ℃ of even down stirrings of temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, continue to stir 25 minutes in 35 ℃, and it is subsequent use to be mixed with the pasty state mixed liquor; In the pasty state mixed liquor that has prepared, add 0.05 gram Radix Notoginseng, 0.25 gram solid dispersion stirs under 35 ℃ of temperature; The sodium carbonate liquor of reuse concentration 5% and the acetum of 0.5mol/L are regulated the pH value of pasty state mixed liquor; PH value being controlled to be 6, pouring die for molding again into, is dry in 50 ℃ the baking oven in temperature; 1.0 hours drying times, take off film and promptly obtain collagen film medical dressing product.
Embodiment 2
Sodium carboxymethyl cellulose 6.0 grams are put into the reaction bulb that has agitator and thermometer, add 60 ml deionized water, under 25 ℃, stirring, it is transparent thick that it is become; Than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion the polyethylene of 0.2 cron Sanguis Draxonis and 1.0 grams; With 0.1 gram collagen protein, 0.2 gram starch adds in 3 milliliters the glutaraldehyde solution; 25 ℃ of even down stirrings of temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, continue to stir 30 minutes in 30 ℃, and it is subsequent use to be mixed with the pasty state mixed liquor; In the pasty state mixed liquor that has prepared, add 0.2 gram Radix Notoginseng, 1.2 gram solid dispersion stir under 30 ℃ of temperature; The sodium carbonate liquor of reuse concentration 5% and the acetum of 0.5mol/L are regulated the pH value of pasty state mixed liquor; PH value being controlled to be 7, pouring die for molding again into, is dry in 60 ℃ the baking oven in temperature; 0.8 hour drying time, take off film and promptly obtain collagen film medical dressing product.
Embodiment 3
Sodium carboxymethyl cellulose 7.0 grams are put into the reaction bulb that has agitator and thermometer, add 70 ml deionized water, under 30 ℃, stirring, it is transparent thick that it is become; Than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion 0.3 cron Sanguis Draxonis and 1.5 polyethylene; With 0.2 gram collagen protein, 0.5 gram starch adds in 4 milliliters the glutaraldehyde solution; 28 ℃ of even down stirrings of temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, continue to stir 20 minutes in 40 ℃, and it is subsequent use to be mixed with the pasty state mixed liquor; In the pasty state mixed liquor that has prepared, add 0.3 gram Radix Notoginseng, 1.8 gram solid dispersion stir under 40 ℃ of temperature; The sodium carbonate liquor of reuse concentration 5% and the acetum of 0.5mol/L are regulated the pH value of pasty state mixed liquor; PH value being controlled to be 8, pouring die for molding again into, is dry in 65 ℃ the baking oven in temperature; 0.7 hour drying time, take off film and promptly obtain collagen film medical dressing product.
Embodiment 4
Sodium carboxymethyl cellulose 8.0 grams are put into the reaction bulb that has agitator and thermometer, add 80 ml deionized water, under 20 ℃, stirring, it is transparent thick that it is become; Than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion the polyethylene of 0.3 cron Sanguis Draxonis and 2.0 grams; With 0.3 gram collagen protein, 0.4 gram starch adds in 3 milliliters the glutaraldehyde solution; 30 ℃ of even down stirrings of temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, continue to stir 18 minutes in 45 ℃, and it is subsequent use to be mixed with the pasty state mixed liquor; In the pasty state mixed liquor that has prepared, add 0.05 gram Radix Notoginseng, 2.3 gram solid dispersion stir under 45 ℃ of temperature; The sodium carbonate liquor of reuse concentration 5% and the acetum of 0.5mol/L are regulated the pH value of pasty state mixed liquor; PH value being controlled to be 6, pouring die for molding again into, is dry in 68 ℃ the baking oven in temperature; 0.6 hour drying time, take off film and promptly obtain collagen film medical dressing product.
Embodiment 5
Sodium carboxymethyl cellulose 9.0 grams are put into the reaction bulb that has agitator and thermometer, add 100 ml deionized water, under 25 ℃, stirring, it is transparent thick that it is become; Than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion the polyethylene of 0.4 cron Sanguis Draxonis and 0.5 gram; With 0.4 gram collagen protein, 0.8 gram starch adds in 2 milliliters the glutaraldehyde solution; 25 ℃ of even down stirrings of temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, continue to stir 20 minutes in 40 ℃, and it is subsequent use to be mixed with the pasty state mixed liquor; In the pasty state mixed liquor that has prepared, add 0.1 gram Radix Notoginseng, 0.9 gram solid dispersion stirs under 35 ℃ of temperature; The sodium carbonate liquor of reuse concentration 5% and the acetum of 0.5mol/L are regulated the pH value of pasty state mixed liquor; PH value being controlled to be 8, pouring die for molding again into, is dry in 70 ℃ the baking oven in temperature; 0.6 hour drying time, take off film and promptly obtain collagen film medical dressing product.
Embodiment 6
Sodium carboxymethyl cellulose 10.0 grams are put into the reaction bulb that has agitator and thermometer, add 150 ml deionized water, under 30 ℃, stirring, it is transparent thick that it is become; Than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion the polyethylene of 0.5 cron Sanguis Draxonis and 0.3 gram; With 0.5 gram collagen protein, 1.0 gram starch add in 5 milliliters the glutaraldehyde solution; 23 ℃ of even down stirrings of temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution that will prepare again mixes with it, continue to stir 15 minutes in 50 ℃, and it is subsequent use to be mixed with the pasty state mixed liquor; In the pasty state mixed liquor that has prepared, add 0.5 gram Radix Notoginseng, 0.8 gram solid dispersion stirs under 50 ℃ of temperature; The sodium carbonate liquor of reuse concentration 5% and the acetum of 0.5mol/L are regulated the pH value of pasty state mixed liquor; PH value is controlled to be 7, pours die for molding again into, dry in 80 ℃ baking oven of temperature; 0.5 hour drying time, take off film and promptly obtain collagen film medical dressing product.
Collagen protein medical dressing of the present invention is done film forming form, and adopts the cohesiveness of the starch reinforcing membrane of highly branched chain.When using dressing, film just can directly be affixed on the wound like this; Ingredient collagen protein and human body skin have the good compatibility in its film, have both helped the performance of Radix Notoginseng, Sanguis Draxonis drug effect, cause the secondary injury in the time of can avoiding more change dressings again.
Collagen film medical dressing of the present invention both had excellent biological compatibility with human body skin, gave birth to body function property, cell adapted property and hemostasis, antiinflammatory, the effect of antibiotic effect; And preparation technology is simple, and easy and simple to handle, material therefor is easy to get.But note in experimentation, wanting factors such as account temperature, PH, time, if the film-forming temperature of choosing is too high or overlong time all can be made film forming toughness and mechanical strength and significantly descends to this dressing Effect on Performance.Therefore have only that the control of conditions such as temperature, time just can be made toughness within the specific limits is strong, mechanical strength is high, the collagen film medical dressing of good biocompatibility.
Claims (5)
1. the collagen film medical dressing is characterized in that
With the collagen protein is raw material,
Radix Notoginseng, Sanguis Draxonis in additionChinese medicine ingredients, its composition of raw materials component by weight and/or volume metering be:
0.05～0.5 part of collagen protein
1～10 part of sodium carboxymethyl cellulose
1～5 part of glutaraldehyde solution
0.1～1 part of starch
0.05～0.5 part of Radix Notoginseng
0.05～0.5 part of Sanguis Draxonis
0.2～2 part of polyvinylpyrrolidone (PVP)
15～150 parts of deionized waters.
2. collagen film medical dressing according to claim 1, the mean molecule quantity that it is characterized in that said collagen protein is 150KD.
3. according to the method for preparing of the collagen film medical dressing described in the claim 1-2, its characteristic is comprising following processing step:
(1) with 1～10 weight portion sodium carboxymethyl cellulose, put into the reaction bulb that has agitator and thermometer, add deionized water 15～150 parts by volume, under 20～30 ℃ of temperature, stirring, it is transparent thick that it is become;
(2) with the polyethylene of the Sanguis Draxonis of 0.05～0.5 weight portion and 0.2～2 weight portion than pyrrolidone (PVP) uniform mixing, adopt fusion method to process solid dispersion;
(3) with 0.05～0.5 weight portion collagen protein, 0.1～1 weight portion starch adds in the glutaraldehyde solution of 1～5 parts by volume, evenly stirs down for 20～30 ℃ in temperature it is fully dissolved; The transparent thick carboxymethylcellulose sodium solution for preparing of (1) step is mixed with it again, and continue down to stir 15～30 minutes in 30～50 ℃, it is subsequent use to be mixed with the pasty state mixed liquor;
(4) in the pasty state mixed liquor that prepared of (3) step, add 0.05～0.5 weight portion Radix Notoginseng; 0.25～2.5 weight portion solid dispersion stir under 30～50 ℃ of temperature, and the pH value of control pasty state mixed liquor is between 6～8; Pour die for molding again into; In temperature is dry in 50～80 ℃ the baking oven, 0.5～1 hour drying time, takes off film and promptly obtains collagen film medical dressing product.
4. the method for preparing of collagen film medical dressing according to claim 3, the mean molecule quantity that it is characterized in that said collagen protein is 150KD.
5. the method for preparing of collagen film medical dressing according to claim 3, the pH value that it is characterized in that said control pasty state mixed liquor is between 6～8; Be that to adopt concentration be that 5～10% sodium carbonate liquor and/or the acetum of 0.5mol/L are regulated control.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872303A (en) * | 2012-10-31 | 2013-01-16 | 贾国平 | Resina draconis application paster as well as preparation and detection methods |
| WO2014101748A1 (en) * | 2012-12-26 | 2014-07-03 | 上海欣吉特生物科技有限公司 | Hemostatic or anticoagulant collagen material |
| CN105903058A (en) * | 2016-05-30 | 2016-08-31 | 山西大学 | Transparent film band-aid containing Chinese medicinal component and preparation method thereof |
| CN105920654A (en) * | 2016-04-27 | 2016-09-07 | 李明华 | Burn dressing applicable to department of burn and having antibacterial effect |
| CN106110389A (en) * | 2016-08-30 | 2016-11-16 | 上海建华精细生物制品有限公司 | A kind of moist dressing of skin wound and its preparation method and application |
| CN106421865A (en) * | 2016-07-29 | 2017-02-22 | 江苏蓝湾生物科技有限公司 | Preparation method of collagen-based dressing with self anti-inflammatory function |
| CN110339390A (en) * | 2019-08-12 | 2019-10-18 | 中国中医科学院中药研究所 | A kind of compounding adhesive bandage and preparation method thereof |
| CN114272434A (en) * | 2021-03-16 | 2022-04-05 | 卫纳塞德(北京)医疗科技有限公司 | Degradable medical cold compress hydrogel and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004005533A2 (en) * | 2002-07-10 | 2004-01-15 | University Of Florida | Sol-gel derived bioactive glass polymer composite |
| CN1994481A (en) * | 2006-10-10 | 2007-07-11 | 辽宁师范大学 | Highly effective Chinese medicine-chitosan compound hemostatic material |
| CN101450223A (en) * | 2007-11-30 | 2009-06-10 | 张博 | Hemostasia material based on chitosan, collagen and sodium cellulose glycolate and preparation method and use thereof |
-
2011
- 2011-09-30 CN CN2011102924369A patent/CN102380123B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004005533A2 (en) * | 2002-07-10 | 2004-01-15 | University Of Florida | Sol-gel derived bioactive glass polymer composite |
| CN1994481A (en) * | 2006-10-10 | 2007-07-11 | 辽宁师范大学 | Highly effective Chinese medicine-chitosan compound hemostatic material |
| CN101450223A (en) * | 2007-11-30 | 2009-06-10 | 张博 | Hemostasia material based on chitosan, collagen and sodium cellulose glycolate and preparation method and use thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872303A (en) * | 2012-10-31 | 2013-01-16 | 贾国平 | Resina draconis application paster as well as preparation and detection methods |
| WO2014101748A1 (en) * | 2012-12-26 | 2014-07-03 | 上海欣吉特生物科技有限公司 | Hemostatic or anticoagulant collagen material |
| CN105920654A (en) * | 2016-04-27 | 2016-09-07 | 李明华 | Burn dressing applicable to department of burn and having antibacterial effect |
| CN105903058A (en) * | 2016-05-30 | 2016-08-31 | 山西大学 | Transparent film band-aid containing Chinese medicinal component and preparation method thereof |
| CN106421865A (en) * | 2016-07-29 | 2017-02-22 | 江苏蓝湾生物科技有限公司 | Preparation method of collagen-based dressing with self anti-inflammatory function |
| CN106110389A (en) * | 2016-08-30 | 2016-11-16 | 上海建华精细生物制品有限公司 | A kind of moist dressing of skin wound and its preparation method and application |
| CN110339390A (en) * | 2019-08-12 | 2019-10-18 | 中国中医科学院中药研究所 | A kind of compounding adhesive bandage and preparation method thereof |
| CN114272434A (en) * | 2021-03-16 | 2022-04-05 | 卫纳塞德(北京)医疗科技有限公司 | Degradable medical cold compress hydrogel and preparation method thereof |
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| CN102380123B (en) | 2013-11-13 |
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