CN103656731A - Medical chitosan dressing - Google Patents
Medical chitosan dressing Download PDFInfo
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- CN103656731A CN103656731A CN201310662924.3A CN201310662924A CN103656731A CN 103656731 A CN103656731 A CN 103656731A CN 201310662924 A CN201310662924 A CN 201310662924A CN 103656731 A CN103656731 A CN 103656731A
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- parts
- dressing
- chitosan
- medical chitosan
- medical
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000004014 plasticizer Substances 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 8
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 230000002421 anti-septic effect Effects 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 229960003405 ciprofloxacin Drugs 0.000 claims description 4
- 230000000873 masking effect Effects 0.000 claims description 4
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 4
- 229960000282 metronidazole Drugs 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229930189077 Rifamycin Natural products 0.000 claims description 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 229940014041 hyaluronate Drugs 0.000 claims description 2
- -1 hydroxypropyl Chemical group 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229960003292 rifamycin Drugs 0.000 claims description 2
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 claims description 2
- 235000015424 sodium Nutrition 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 3
- 229940054190 hydroxypropyl chitosan Drugs 0.000 abstract description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract description 5
- 230000029663 wound healing Effects 0.000 abstract description 3
- 230000023597 hemostasis Effects 0.000 abstract description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000000025 haemostatic effect Effects 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a medical chitosan dressing, and a preparation method thereof. The medical chitosan dressing is characterized in comprising following raw materials, by weight, 25 to 40 parts of chitosan, 15 to 25 parts of hydroxypropyl chitosan, 5 to 15 parts of sodium hyaluronate, 1 to 5 parts of an antibacterial agent, 2 to 8 parts of a calming anti-inflammatory agent, and 2 to 10 parts of a plasticizer. The medical chitosan dressing is suitable for medical hemostasis, antibiosis and antiphlogosis, and promoting of wound healing.
Description
Technical field
The present invention relates to a kind of medical dressing, be specifically related to a kind of medical chitosan combine dressing and preparation method thereof.
Background technology
Chitin, chitosan and derivant thereof have the effects such as hemostasis, pain relieving, inhibition growth of microorganism, and these healings for wound surface have positive meaning.The effect of the wound healing of chitin, chitosan and derivant is at present proved by numerous scholars' institute.
Find after deliberation, the mechanism that chitosan promotes wound healing mainly: (1) is accelerated PMN cell and is exuded to wound district; (2) accelerate to ooze out, to form silk fabric fibrin and to activate fibroblast, move to wound district; (3) stimulating expression of macrophage moves; (4) stimulate fibroblast proliferation and III type collagen fiber to produce.
At present the put into production bleeding-stopping dressing ubiquity haemostatic effect of clinical use of industry is undesirable, and the problem such as the laminating degree of skin is poor, therefore still await further improving and improve its haemostatic effect and with the stickiness of skin histology.
Summary of the invention
First object of the present invention is to provide a kind of medical chitosan combine dressing, comprises the raw material of following weight portion: 25 ~ 40 parts of chitosans, 15 ~ 25 parts of hydroxypropyl chitosans, 5 ~ 15 parts of hyaluronate sodiums, 1 ~ 5 part of antibacterial, 2 ~ 8 parts of calm antiinflammatory, 2 ~ 10 parts of plasticizers.
Above-mentioned antibacterial is nanometer silver inorganic antiseptic, nano zine oxide or Ammonium biphosphate.
Above-mentioned calm antiinflammatory is ciprofloxacin, rifamycin or metronidazole.
Above-mentioned plasticizer is glycerol, sorbitol, ethylene glycol, mannose or Polyethylene Glycol.
Above-mentioned dressing is powdery or membranaceous.
Second object of the present invention is to provide a kind of preparation method of medical chitosan combine dressing, wherein, the preparation of above-mentioned powdery dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in agitator and stir 10 ~ 20 min, mix homogeneously bottling.
The preparation of above-mentioned membranaceous dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, be stirred to abundant dissolving; Add plasticizer, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Above-mentioned heated at constant temperature temperature is 80 ~ 110 ℃, and be 15 ~ 30 min heat time heating time.
Products material of the present invention is easily buied, and preparation method is simple, and haemostatic effect is positive.
the specific embodiment:
Below in conjunction with concrete case study on implementation, the present invention is described in further detail:
Embodiment 1:
By chitosan 40 kg, hydroxypropyl chitosan 15 kg, hyaluronate sodium 15 kg, nanometer silver inorganic antiseptic 5 kg, ciprofloxacin 8 kg, are placed in agitator and stir 10 ~ 20 min, mix homogeneously bottling.
Embodiment 2:
Take in proportion chitosan 40 kg, hydroxypropyl chitosan 15 kg, hyaluronate sodium 15 kg, nanometer silver inorganic antiseptic 5 kg, ciprofloxacin 8 kg, are placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, are stirred to abundant dissolving; Add analytical pure level ethylene glycol 10 kg, continue to stir and heated at constant temperature 15 ~ 30 min at 80 ~ 110 ℃; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Embodiment 3:
By chitosan 30 kg, hydroxypropyl chitosan 20 kg, hyaluronate sodium 12 kg, nano zine oxide 5 kg, metronidazole 8 kg, are placed in agitator and stir 10 ~ 20 min, mix homogeneously bottling.
Embodiment 4:
Take in proportion chitosan 30 kg, hydroxypropyl chitosan 20 kg, hyaluronate sodium 12 kg, nano zine oxide 5 kg, metronidazole 8 kg, are placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, are stirred to abundant dissolving; Adding purity is more than 98% mannose 8 kg, continues to stir and heated at constant temperature 15 ~ 30 min at 80 ~ 110 ℃; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
Claims (8)
1. a medical chitosan combine dressing, is characterized in that, comprises the raw material of following weight portion: 25 ~ 40 parts of chitosans, 15 ~ 25 parts of hydroxypropyl chitosans, 5 ~ 15 parts of hyaluronate sodiums, 1 ~ 5 part of antibacterial, 2 ~ 8 parts of calm antiinflammatory, 2 ~ 10 parts of plasticizers.
2. medical chitosan combine dressing according to claim 1, is characterized in that, described antibacterial is nanometer silver inorganic antiseptic, nano zine oxide or Ammonium biphosphate.
3. medical chitosan combine dressing according to claim 2, is characterized in that, described calm antiinflammatory is ciprofloxacin, rifamycin or metronidazole.
4. medical chitosan combine dressing according to claim 3, is characterized in that, described plasticizer is glycerol, sorbitol, ethylene glycol, mannose or Polyethylene Glycol.
5. medical chitosan combine dressing according to claim 4, is characterized in that, described dressing is powdery or membranaceous.
6. a method of preparing medical chitosan combine dressing as claimed in claim 5, it is characterized in that, the preparation of described powdery dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in agitator and stir 10 ~ 20 min, mix homogeneously bottling.
7. a method of preparing medical chitosan combine dressing as claimed in claim 5, it is characterized in that, the preparation of described membranaceous dressing is by following processing step: take in proportion chitosan, alginate, antibacterial and calm antiinflammatory, be placed in reactor, add 1% ~ 1.5% acetic acid aqueous solution, be stirred to abundant dissolving; Add plasticizer, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, struck off, after being dried fully, demoulding.
8. the method for preparing medical chitosan combine dressing according to claim 7, is characterized in that, described heated at constant temperature temperature is 80 ~ 110 ℃, and be 15 ~ 30 min heat time heating time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662924.3A CN103656731B (en) | 2013-12-10 | 2013-12-10 | A kind of medical chitosan combine dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310662924.3A CN103656731B (en) | 2013-12-10 | 2013-12-10 | A kind of medical chitosan combine dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103656731A true CN103656731A (en) | 2014-03-26 |
| CN103656731B CN103656731B (en) | 2016-03-02 |
Family
ID=50296284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310662924.3A Expired - Fee Related CN103656731B (en) | 2013-12-10 | 2013-12-10 | A kind of medical chitosan combine dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103656731B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104262750A (en) * | 2014-09-18 | 2015-01-07 | 苏州经贸职业技术学院 | Anti-bacterial polymer material and preparation method thereof |
| CN104288826A (en) * | 2014-09-26 | 2015-01-21 | 张明 | Medical rapid chitosan haemostatic wound dressing |
| CN104307029A (en) * | 2014-09-29 | 2015-01-28 | 张亚丽 | Medical natural biological dressing |
| CN104307026A (en) * | 2014-09-26 | 2015-01-28 | 张明 | Novel hemostatic dressing |
| CN104497345A (en) * | 2015-01-06 | 2015-04-08 | 王健 | Preparation method of hyaluronic acid-chitosan degradable dressing |
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
| CN112480485A (en) * | 2020-12-25 | 2021-03-12 | 荣成万盈水产科技有限公司 | Preparation method of hydroxypropyl chitosan composite preservative film |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107224604A (en) * | 2017-06-20 | 2017-10-03 | 中国海洋大学 | A kind of preparation method of chitosan-based compound sponge as wound dressing |
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- 2013-12-10 CN CN201310662924.3A patent/CN103656731B/en not_active Expired - Fee Related
Patent Citations (6)
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| CN1867364A (en) * | 2003-09-08 | 2006-11-22 | Fmc生物聚合物联合股份有限公司 | Gelled biopolymer based foam |
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| US20080114096A1 (en) * | 2006-11-09 | 2008-05-15 | Hydromer, Inc. | Lubricious biopolymeric network compositions and methods of making same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104262750A (en) * | 2014-09-18 | 2015-01-07 | 苏州经贸职业技术学院 | Anti-bacterial polymer material and preparation method thereof |
| CN104288826A (en) * | 2014-09-26 | 2015-01-21 | 张明 | Medical rapid chitosan haemostatic wound dressing |
| CN104307026A (en) * | 2014-09-26 | 2015-01-28 | 张明 | Novel hemostatic dressing |
| CN104307029A (en) * | 2014-09-29 | 2015-01-28 | 张亚丽 | Medical natural biological dressing |
| CN104497345A (en) * | 2015-01-06 | 2015-04-08 | 王健 | Preparation method of hyaluronic acid-chitosan degradable dressing |
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
| CN112480485A (en) * | 2020-12-25 | 2021-03-12 | 荣成万盈水产科技有限公司 | Preparation method of hydroxypropyl chitosan composite preservative film |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103656731B (en) | 2016-03-02 |
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Address after: 510000, 502, No. 2, South Cloud Road, Guangzhou, Guangdong, Luogang District Patentee after: Guangzhou Yanghe Biotechnology Co., Ltd. Address before: 510599 Guangdong Guangzhou Tianhe District Guangyuan East Road No. 2193 in the era of the New World Center North Tower 1101-1102 Patentee before: Guangzhou Bio Science & Technology Co., Ltd. |
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