CN102302598A - Composition for treating skin ulcer and application thereof - Google Patents
Composition for treating skin ulcer and application thereof Download PDFInfo
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- CN102302598A CN102302598A CN 201110271647 CN201110271647A CN102302598A CN 102302598 A CN102302598 A CN 102302598A CN 201110271647 CN201110271647 CN 201110271647 CN 201110271647 A CN201110271647 A CN 201110271647A CN 102302598 A CN102302598 A CN 102302598A
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- potassium salt
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- 206010040943 Skin Ulcer Diseases 0.000 title claims abstract description 61
- 231100000019 skin ulcer Toxicity 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 20
- 239000005017 polysaccharide Substances 0.000 claims abstract description 20
- 150000004676 glycans Chemical class 0.000 claims abstract description 18
- 239000000284 extract Substances 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims description 28
- 229940079593 drug Drugs 0.000 claims description 22
- 229920001661 Chitosan Polymers 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 15
- 159000000000 sodium salts Chemical class 0.000 claims description 12
- 208000025865 Ulcer Diseases 0.000 claims description 11
- 231100000397 ulcer Toxicity 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 9
- 229920002101 Chitin Polymers 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 6
- -1 ethoxyl Chemical group 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 4
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 4
- 206010056340 Diabetic ulcer Diseases 0.000 claims description 4
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 4
- 229940054190 hydroxypropyl chitosan Drugs 0.000 claims description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- 229940072056 alginate Drugs 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000972672 Phellodendron Species 0.000 abstract 1
- 241000411851 herbal medicine Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 18
- 206010052428 Wound Diseases 0.000 description 14
- 208000027418 Wounds and injury Diseases 0.000 description 14
- 210000000416 exudates and transudate Anatomy 0.000 description 9
- 230000001737 promoting effect Effects 0.000 description 9
- 239000012153 distilled water Substances 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 206010053615 Thermal burn Diseases 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000035617 depilation Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a composition for treating skin ulcer. The composition is characterized by consisting of fine powder or extracts of phellodendron, swordlike atractylodes rhizome, Chinese angelica and the like which serve as Chinese herbal medicines and hydroscopic polysaccharides.
Description
Technical field
The present invention relates to a kind of compositions and application thereof of treating skin ulcer, particularly relating to a kind of is the compositions and the application thereof of processing according to composition of prescription with Traditional Chinese medical theory, belongs to the field of Chinese medicines.
Background technology
Chronic skin ulcer is a disease common in the dermatosis, and usually the course of disease is longer, and therapeutic advance is slow, and patient's body and spirit are all brought very big misery, and patient's quality of life is caused very big influence.Diabetics and lower limb vascular property disease patient are the group of people at high risks of chronic skin ulcer.Paathogenic factor skin ulcer by different can be divided into traumatic infection ulcer, pressure ulcer, venous ulcer, diabetic ulcer etc., and heavier ulcer performance wound surface exudate is more, and foreign odor is arranged, and bacterial infection is heavier, long-term disunion.
The main method of chronic skin ulcer treatment is to carry out Surgery Treatment (like local debridement and infection medication etc.) and the measure of local promotion wound healing that systemic drug is treated (as using antibiotic and using Chinese medicine etc.), wound surface.Promote that the method for surface wound healing is more, like the use of growth-factor medication, physiotherapys such as laser, the local use external application of Chinese medicine etc.Determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is stressed in treatment by Chinese herbs, is main with heat-clearing and toxic substances removing how, is equipped with promoting flow of QI and blood, putrefaction-removing granulation-promoting medicine, and wound surface is had certain curative effect.But because chronic skin ulcer is intractable, clinical efficacy is unsatisfactory generally.
Summary of the invention
The purpose of this invention is to provide compositions and application thereof that the treatment skin ulcer of skin ulcer is held back in a kind of clearing away heat-damp and promoting diuresis detoxifcation, promoting blood circulation to disperse blood clots and relieves pain, putrefaction-removing granulation-promoting, to overcome the deficiency of prior art.
A kind of compositions of treating skin ulcer is characterized in that being made up of the fine powder of Cortex Phellodendri, Rhizoma Atractylodis, Radix Angelicae Sinensis crude drug or extracts of bulk drugs and water-absorbing polysaccharide; Described water-absorbing polysaccharide is the kind or multiple in hyaluroni or potassium salt, sanlose or potassium salt, carboxymethyl chitosan sodium salt or potassium salt, carboxymethyl chitin sodium salt or potassium salt, succinyl-chitosan sodium salt or potassium salt, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin, Chitofilmer, chitosan, chitosan quaternary ammonium salt, alginate, the chondroitin sulfate.
The compositions of above-mentioned treatment skin ulcer is in the medicine of preparation treatment skin ulcer, decubital ulcer, diabetic ulcer etc. or the application in medical dressing or the medical apparatus and instruments.
The compositions of treatment skin ulcer of the present invention; Wherein Cortex Phellodendri has the effect of heat clearing and damp drying, eliminating fire and detoxication; Rhizoma Atractylodis have the effect of removing dampness; Radix Angelicae Sinensis have enrich blood, the effect of promoting blood circulation and stopping pain, water absorption property polysaccharide has the effect of absorptive tissue transudate and putrefaction-removing granulation-promoting, therefore the treatment that is used for skin ulcer of the compositions of treatment skin ulcer of the present invention has clearing away heat-damp and promoting diuresis detoxifcation, promoting blood circulation to disperse blood clots and relieves pain, putrefaction-removing granulation-promoting and holds back the skin ulcer effect; Healing and reparation for ulcer wound surface have significant curative effect, have the important use exploitation and are worth.
The specific embodiment
Embodiment 1
The preparation of treatment skin ulcer compositions A: take by weighing Cortex Phellodendri 15g, Rhizoma Atractylodis 5g, Radix Angelicae Sinensis 10g, water-absorbing polysaccharide chitosan 55g and chondroitin sulfate 15g respectively; Grind into fine powder respectively; Pack in the plastic bottle, irradiation sterilization gets powdery treatment skin ulcer compositions A.
Embodiment 2
The preparation of treatment skin ulcer compositions B: take by weighing Cortex Phellodendri 30g, Rhizoma Atractylodis 20g, Radix Angelicae Sinensis 20g, water-absorbing polysaccharide carboxymethyl chitosan sodium salt 30g respectively, grind into fine powder respectively, in the plastic bottle of packing into, irradiation sterilization gets powdery treatment skin ulcer compositions B.
Embodiment 3
The preparation of treatment skin ulcer compositions C: take by weighing Cortex Phellodendri 80g, Rhizoma Atractylodis 50g, Radix Angelicae Sinensis 50g respectively, put into the beaker of 2000ml, add the distilled water of 1000ml, soak 1 hour post-heating and decoct extraction 40 minutes; Leach extracting solution, add the distilled water of 500ml in the medicinal residues once more, decoct and extracted 30 minutes; Leach extracting solution, merge extracted twice liquid, the centrifugal 20min of 3500rpm; Get centrifuged supernatant and be evaporated to 300ml in 55 ℃, add water-absorbing polysaccharide hydroxypropyl chitosan 20g, stir; Pack in the vial,, get gel treatment skin ulcer compositions C in 121 ℃ of moist heat sterilization 25min.
Embodiment 4
The preparation of treatment skin ulcer compositions D: take by weighing Cortex Phellodendri 60g, Rhizoma Atractylodis 30g, Radix Angelicae Sinensis 80g respectively, put into the beaker of 2000ml, add the distilled water of 1000ml, soak 1 hour post-heating and decoct extraction 40 minutes; Leach extracting solution, add the distilled water of 500ml in the medicinal residues once more, decoct and extracted 30 minutes; Leach extracting solution, merge extracted twice liquid, the centrifugal 20min of 3500rpm; Get centrifuged supernatant and be evaporated to 300ml in 55 ℃, add water-absorbing polysaccharide carboxymethyl chitin sodium salt 30g, stir; Pack in the vial,, get paste treatment skin ulcer compositions D in 121 ℃ of moist heat sterilization 25min.
Embodiment 5
The preparation of treatment skin ulcer compositions E: take by weighing Cortex Phellodendri 80g, Rhizoma Atractylodis 60g, Radix Angelicae Sinensis 60g respectively, put into the beaker of 2000ml, add the distilled water of 1000ml; Soak 1 hour post-heating and decoct extraction 40 minutes, leach extracting solution, add the distilled water of 500ml in the medicinal residues once more; Decoct and extract 30min, leach extracting solution, merge extracted twice liquid; The centrifugal 20min of 3500rpm gets centrifuged supernatant and is evaporated to 500ml in 55 ℃, through the small-sized spray drier spray drying; Make the powdered extract of crude drug, add water-absorbing polysaccharide sodium carboxymethyl cellulose 60g and chitosan quaternary ammonium salt 20g, mix homogeneously; Pack in the plastic bottle, irradiation sterilization gets powdery treatment skin ulcer compositions E.
Embodiment 6
The preparation of treatment skin ulcer composition F: take by weighing Cortex Phellodendri 60g, Rhizoma Atractylodis 50g, Radix Angelicae Sinensis 90g respectively, put into the beaker of 2000ml, add the distilled water of 1000ml, soak 1 hour post-heating and extracted 40 minutes; Leach extracting solution, add the distilled water of 500ml in the medicinal residues once more, decoct and extracted 30 minutes; Leach extracting solution, merge extracted twice liquid, the centrifugal 20min of 3500rpm; Get centrifuged supernatant and be evaporated to 500ml in 55 ℃,, make the Powdered extract of crude drug through the small-sized spray drier spray drying; Add powdered water-absorbing polysaccharide succinyl-chitosan sodium salt 70g, mix homogeneously adds 75% ethanol water 15ml and makees wetting agent; Carry out wet granulation through stainless (steel) wire, the back of granulating is dry in 70 ℃ of drying baker internal heating, sieves; The particulate matter that makes is packed in the plastic bottle, irradiation sterilization, graininess treatment skin ulcer composition F.
Embodiment 7
Treat of the promotion healing effect of skin ulcer compositions: get 40 of Wistar rats to rat burn and scald skin ulcer wound surface; Male and female hold concurrently half; Body weight 250～300g; Be divided into 5 groups at random by sex, 8 every group, promptly normal saline matched group, powdery treatment skin ulcer compositions B group, gel treatment skin ulcer compositions C group, paste are treated skin ulcer compositions D group, powdery treatment skin ulcer compositions E group.Before the administration rat back is leaned on the depilation of buttocks spinal column one side, the depilation area is about 4 * 4cm
2The plastic barrel of the long 10cm of experiment employing, the supreme lower bottom cover of diameter 3.5cm being pressed on the depilation district skin, will boil boiled water (100 ℃) and pour the interior height to half of plastic barrel into, keeps for 3 seconds, removes plastic barrel water is removed.Evenly smearing concentration at burn and scald skin histology place is 4.2 * 10
6The escherichia coli culture fluid 0.1ml of individual/ml causes inflammation, makes it to form the open infective wound surface of burn and scald ulcer.Apply normal saline or powder composition B or gel-form composition C or paste composition D or powder composition E according to dividing into groups to infect to execute on the ulcer wound surface at the rat burn and scald respectively after 1 hour, execute the amount of applying and be as the criterion with even flap coverage.Execute every day to apply and be administered once continuous 12 days.Every day observed in detail and write down animal and tried to distinguish the inflammatory reaction of wound surface, exudate, tissue new life and wound healing etc.Experimental result shows; Powdery treatment skin ulcer compositions B group, gel treatment skin ulcer compositions C group, paste treatment skin ulcer compositions D group and four experimental grouies of powdery treatment skin ulcer compositions E group; Wound repair situation after the rat medication all obviously is superior to the normal saline matched group, and experimental group ulcer wound surface slight inflammatory reaction, exudate are few, and wound healing is fast; And the matched group wound surface is red and swollen serious, and exudate is many.Each experimental group wound surface inflammatory reaction, exudate were followed successively by to heavy (many) degree by light (lacking): powdery treatment skin ulcer compositions B group＜powdery treatment skin ulcer compositions E group＜paste treatment skin ulcer compositions D group＜gel treatment skin ulcer compositions C group＜normal saline matched group; Show that treatment skin ulcer compositions has the effect that promotes the ulcer wound surface healing, wound surface slight inflammatory reaction, exudate are few.
In embodiment 1 to embodiment 6, the compositions of treatment skin ulcer of the present invention is made up of the fine powder of Cortex Phellodendri, Rhizoma Atractylodis, Radix Angelicae Sinensis crude drug or extracts of bulk drugs and water-absorbing polysaccharide; The percentage by weight of Cortex Phellodendri, Rhizoma Atractylodis, Radix Angelicae Sinensis crude drug and water absorption property polysaccharide is respectively: Cortex Phellodendri 5～50%, Rhizoma Atractylodis 5～50%, Radix Angelicae Sinensis 5～50%, water absorption property polysaccharide 5～80% all can reach same effect; Described crude drug fine powder is meant that crude drug is through grinding or pulverize the fine powder that forms; Described extracts of bulk drugs is meant that crude drug extracts the liquid extract of the crude drug that makes, paste extract or Powdered extract through decocting; Described water-absorbing polysaccharide is a kind or 2 kinds in hyaluroni or potassium salt, sanlose or potassium salt, carboxymethyl chitosan sodium salt or potassium salt, carboxymethyl chitin sodium salt or potassium salt, succinyl-chitosan sodium salt or potassium salt, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin, Chitofilmer, chitosan, chitosan quaternary ammonium salt, alginate, the chondroitin sulfate; All has the polyhydroxy structure in these water-absorbing polysaccharide molecules; Water absorption is strong, and is good with the body tissue affinity, the absorbable tissue transudate; Effect with convergence and promotion wound healing; Existing more research and the application in fields such as repair in trauma, organizational projects is the good raw material of preparation repair in trauma material, all has same effect; The compositions of treatment skin ulcer can be powdery, graininess, paste or gel.
In the treatment skin ulcer compositions of the present invention, Cortex Phellodendri has the effect of heat clearing and damp drying, eliminating fire and detoxication, and Rhizoma Atractylodis have the effect of removing dampness, Radix Angelicae Sinensis have enrich blood, the effect of promoting blood circulation and stopping pain, water absorption property polysaccharide has the effect of absorptive tissue transudate and putrefaction-removing granulation-promoting.Therefore the compositions of treatment skin ulcer of the present invention has clearing away heat-damp and promoting diuresis detoxifcation, promoting blood circulation to disperse blood clots and relieves pain, putrefaction-removing granulation-promoting and holds back the skin ulcer effect.
Embodiment 7 has further verified the functional effect of the compositions of treatment skin ulcer of the present invention; Show through zoopery; The compositions of treatment skin ulcer of the present invention is used for the treatment of skin ulcer, and the healing and the reparation of ulcer wound surface had significant curative effect.The compositions of treatment skin ulcer of the present invention has the important use exploitation and is worth in the medicine for preparing treatment skin ulcer, decubital ulcer, diabetic ulcer etc. or medical dressing or medical apparatus and instruments.
Claims (5)
1. compositions of treating skin ulcer is characterized in that being made up of the fine powder of Cortex Phellodendri, Rhizoma Atractylodis, Radix Angelicae Sinensis crude drug or extracts of bulk drugs and water-absorbing polysaccharide; Described water-absorbing polysaccharide is a kind or 2 kinds in hyaluroni or potassium salt, sanlose or potassium salt, carboxymethyl chitosan sodium salt or potassium salt, carboxymethyl chitin sodium salt or potassium salt, succinyl-chitosan sodium salt or potassium salt, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethyl chitosan, hydroxypropyl chitosan, ethoxyl chitin, Chitofilmer, chitosan, chitosan quaternary ammonium salt, alginate, the chondroitin sulfate.
2. a kind of compositions of treating skin ulcer as claimed in claim 1 is characterized in that the percentage by weight of Cortex Phellodendri, Rhizoma Atractylodis, Radix Angelicae Sinensis crude drug and water absorption property polysaccharide is respectively: Cortex Phellodendri 5～50%, Rhizoma Atractylodis 5～50%, Radix Angelicae Sinensis 5～50%, water absorption property polysaccharide 5～80%.
3. a kind of compositions of treating skin ulcer as claimed in claim 1 is characterized in that described extracts of bulk drugs is meant that crude drug extracts the liquid extract of the crude drug that makes, paste extract or Powdered extract through decocting.
4. a kind of compositions of treating skin ulcer as claimed in claim 1 is characterized in that powdery, graininess, paste or gel.
5. the compositions of the described treatment skin ulcer of claim 1 is in the medicine of preparation treatment skin ulcer, decubital ulcer, diabetic ulcer etc. or the application in medical dressing or the medical apparatus and instruments.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102716474A CN102302598B (en) | 2011-09-15 | 2011-09-15 | Composition for treating skin ulcer and application thereof |
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| CN2011102716474A CN102302598B (en) | 2011-09-15 | 2011-09-15 | Composition for treating skin ulcer and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103550814A (en) * | 2013-10-31 | 2014-02-05 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
| CN103656731A (en) * | 2013-12-10 | 2014-03-26 | 徐广苓 | Medical chitosan dressing |
| CN107496973A (en) * | 2017-09-27 | 2017-12-22 | 广州润虹医药科技股份有限公司 | A kind of quick-acting haemostatic powder chitosan sponge pad adhesive bandage and preparation method thereof |
| CN109260503A (en) * | 2018-09-30 | 2019-01-25 | 振德医疗用品股份有限公司 | A kind of absorbing material and preparation method thereof, the dressing comprising the material |
| WO2019080115A1 (en) * | 2017-10-27 | 2019-05-02 | 江苏奇力康皮肤药业有限公司 | Long-acting sustained-release traditional chinese medicine cold compress for treating skin ulcer |
| CN111096934A (en) * | 2019-08-16 | 2020-05-05 | 华熙生物科技股份有限公司 | Gel for inhibiting acne |
| CN112274571A (en) * | 2020-12-02 | 2021-01-29 | 西安医学院 | Antibacterial hydrogel suitable for diabetic foot ulcer and preparation method thereof |
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Cited By (11)
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| CN103550814A (en) * | 2013-10-31 | 2014-02-05 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
| CN103550814B (en) * | 2013-10-31 | 2014-12-24 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
| CN103656731A (en) * | 2013-12-10 | 2014-03-26 | 徐广苓 | Medical chitosan dressing |
| CN103656731B (en) * | 2013-12-10 | 2016-03-02 | 青岛文创科技有限公司 | A kind of medical chitosan combine dressing |
| CN107496973A (en) * | 2017-09-27 | 2017-12-22 | 广州润虹医药科技股份有限公司 | A kind of quick-acting haemostatic powder chitosan sponge pad adhesive bandage and preparation method thereof |
| CN107496973B (en) * | 2017-09-27 | 2020-10-27 | 广州润虹医药科技股份有限公司 | Chitosan sponge pad band-aid capable of rapidly stopping bleeding and preparation method thereof |
| WO2019080115A1 (en) * | 2017-10-27 | 2019-05-02 | 江苏奇力康皮肤药业有限公司 | Long-acting sustained-release traditional chinese medicine cold compress for treating skin ulcer |
| CN109260503A (en) * | 2018-09-30 | 2019-01-25 | 振德医疗用品股份有限公司 | A kind of absorbing material and preparation method thereof, the dressing comprising the material |
| CN111096934A (en) * | 2019-08-16 | 2020-05-05 | 华熙生物科技股份有限公司 | Gel for inhibiting acne |
| CN111096934B (en) * | 2019-08-16 | 2022-02-08 | 华熙生物科技股份有限公司 | Gel for inhibiting acne |
| CN112274571A (en) * | 2020-12-02 | 2021-01-29 | 西安医学院 | Antibacterial hydrogel suitable for diabetic foot ulcer and preparation method thereof |
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| CN102302598B (en) | 2012-11-28 |
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