CN104324411A - Medical natural marine organism dressing - Google Patents
Medical natural marine organism dressing Download PDFInfo
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- CN104324411A CN104324411A CN201410502857.3A CN201410502857A CN104324411A CN 104324411 A CN104324411 A CN 104324411A CN 201410502857 A CN201410502857 A CN 201410502857A CN 104324411 A CN104324411 A CN 104324411A
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Abstract
The invention discloses a medical natural marine organism dressing and a preparation method thereof. The medical natural marine organism dressing includes a base cloth layer and a drug-storage layer. The base cloth layer and the drug-storage layer are bond to each other through a binding agent. The drug-storage layer includes following raw materials, by weight, 15-25 parts of chitosan, 10-20 parts of glucan, 15-25 parts of alginate, 5-15 parts of sodium hyaluronate, 1-5 parts of a nano-silver inorganic antibacterial agent, 2-8 parts of ciprofloxacin and 2-10 parts of plasticizer. The dressing is suitable for medical small-range hemostasis, bacterial-resistance and wound healing promoting and the like.
Description
Technical field
The present invention relates to a kind of medical dressing, be specifically related to a kind of medical natural marine organism dressing and preparation method thereof.
Background technology
Chitosan is that the chitin extensively existed by nature obtains through deacetylation.From 1859, after first Frenchman Rouget obtains chitosan, the premium properties such as the high molecular biological functionality of this natural marine organism and the compatibility, blood compatibility, safety, microbic resolvability are by all trades and professions extensive concern.
Have at medicine and technical field of biology in recent years and apply widely especially, reason is that chitosan has good biological activity, biocompatibility, biological degradability, it can promote wound healing and tissue repair, and the application in novel wound dressing and organizational project enjoys the concern of people.Chitosan all has obvious inhibition to Glanz poplar, negative bacterium.The research of the people such as Allam shows that chitosan all has obvious inhibitory action to bacillus pyocyaneus, staphylococcus aureus, streptococcus pyogenes, staphylococcus epidermidis, escherichia coli and tropical Candida albicans.In addition, chitosan also has the effect of hemostasis and pain relieving, and this healing for wound surface all has positive meaning.
Natural marine organism class bleeding-stopping dressing ubiquity haemostatic effect commercially available is at present undesirable, and the problem such as the laminating degree difference of skin, therefore still await improving further its haemostatic effect and with the problem such as the stickiness of skin histology.
Summary of the invention
First object of the present invention is to provide a kind of medical natural marine organism dressing, comprises base cloth layer and drug storing layer, and it is bonding that base cloth layer and drug storing layer pass through binding agent.
Above-mentioned drug storing layer comprises the raw material of following weight portion: chitosan 15 ~ 25 parts, glucosan 10 ~ 20 parts, alginate 15 ~ 25 parts, hyaluronate sodium 5 ~ 15 parts, nano silver inorganic antimicrobial agent 1 ~ 5 part, ciprofloxacin 2 ~ 8 parts, plasticizer 2 ~ 10 parts.
Above-mentioned base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Above-mentioned binding agent is pressure sensitive adhesive.
Above-mentioned alginate is potassium alginate, sodium alginate or calcium alginate.
Above-mentioned plasticizer is glycerol, sorbitol, mannose or Polyethylene Glycol.
Second object of the present invention is to provide a kind of preparation method of medical natural marine organism dressing: take chitosan, glucosan, alginate, hyaluronate sodium, nano silver inorganic antimicrobial agent and ciprofloxacin in proportion, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add plasticizer, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained drug storing layer; By the drug storing layer for preparing and Ji Bu by Performance of Pressure Sensitive Adhesive compound; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching is cut into required form, packaging after sterilization.
Above-mentioned heated at constant temperature temperature is 55 ~ 70 DEG C, and heat time heating time is 15 ~ 25 min.
The micro-pore diameter on above-mentioned adhesive composite materials surface is 3 mm, every 100 cm
2there are 90 ~ 100 micropores on adhesive composite materials surface.
The preparation method of product of the present invention is simple, stops blooding among a small circle, antibacterial and promotion wound healing effect is remarkable.
detailed description of the invention:
Below in conjunction with concrete case study on implementation, the present invention is described in further detail:
Embodiment 1:
Take chitosan 25 kg in proportion, glucosan 20 kg, alginate 25 kg, hyaluronate sodium 15 kg, nano silver inorganic antimicrobial agent 5 kg, ciprofloxacin 8 kg, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add sorbitol 10 kg, continue stir and at 70 DEG C heated at constant temperature 25 min; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained drug storing layer; By the drug storing layer for preparing and non-woven fabrics by Performance of Pressure Sensitive Adhesive compound; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching is cut into required form, packaging after sterilization.
Embodiment 2:
Take chitosan 20 kg in proportion, Dextran 15 kg, alginate 20 kg, hyaluronate sodium 12 kg, nano silver inorganic antimicrobial agent 5 kg, ciprofloxacin 5 kg, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add Polyethylene Glycol 10 kg, continue stir and at 65 DEG C heated at constant temperature 20 min; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained drug storing layer; By the drug storing layer for preparing and PU waterproof ventilated membrane by Performance of Pressure Sensitive Adhesive compound; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching is cut into required form, packaging after sterilization.
Embodiment 3:
Take chitosan 15 kg in proportion, glucosan 10 kg, alginate 15 kg, hyaluronate sodium 10 kg, nano silver inorganic antimicrobial agent 3 kg, ciprofloxacin 5 kg, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add sorbitol 10 kg, continue stir and at 55 DEG C heated at constant temperature 15 min; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained drug storing layer; By the drug storing layer for preparing and PU waterproof ventilated membrane by Performance of Pressure Sensitive Adhesive compound; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching is cut into required form, packaging after sterilization.
Claims (8)
1. a medical natural marine organism dressing, it is characterized in that, comprise base cloth layer and drug storing layer, it is bonding that base cloth layer and drug storing layer pass through binding agent, and described drug storing layer comprises the raw material of following weight portion: chitosan 15 ~ 25 parts, glucosan 10 ~ 20 parts, alginate 15 ~ 25 parts, hyaluronate sodium 5 ~ 15 parts, nano silver inorganic antimicrobial agent 1 ~ 5 part, ciprofloxacin 2 ~ 8 parts, plasticizer 2 ~ 10 parts.
2. medical natural marine organism dressing according to claim 1, is characterized in that, described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
3. medical natural marine organism dressing according to claim 2, is characterized in that, described binding agent is pressure sensitive adhesive.
4. medical natural marine organism dressing according to claim 3, is characterized in that, described alginate is potassium alginate, sodium alginate or calcium alginate.
5. medical natural marine organism dressing according to claim 4, is characterized in that, described plasticizer is glycerol, sorbitol, mannose or Polyethylene Glycol.
6. prepare the method for medical natural marine organism dressing as claimed in claim 5 for one kind, it is characterized in that, take chitosan, glucosan, alginate, hyaluronate sodium, nano silver inorganic antimicrobial agent and ciprofloxacin in proportion, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add plasticizer, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained drug storing layer; By the drug storing layer for preparing and Ji Bu by Performance of Pressure Sensitive Adhesive compound; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching is cut into required form, packaging after sterilization.
7. the method for the medical natural marine organism dressing of preparation according to claim 6, is characterized in that, described heated at constant temperature temperature is 55 ~ 70 DEG C, and heat time heating time is 15 ~ 25 min.
8. the method for the medical natural marine organism dressing of preparation according to claim 7, is characterized in that, the micro-pore diameter on described adhesive composite materials surface is 3 mm, every 100 cm
2there are 90 ~ 100 micropores on adhesive composite materials surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410502857.3A CN104324411A (en) | 2014-09-28 | 2014-09-28 | Medical natural marine organism dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410502857.3A CN104324411A (en) | 2014-09-28 | 2014-09-28 | Medical natural marine organism dressing |
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| CN104324411A true CN104324411A (en) | 2015-02-04 |
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| CN201410502857.3A Pending CN104324411A (en) | 2014-09-28 | 2014-09-28 | Medical natural marine organism dressing |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687087A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of skin-tightening and freckle-removing biological dressing |
| CN105688262A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of scar-removing biological dressing |
| CN105688259A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing for treating bedsores |
| CN105709261A (en) * | 2016-03-14 | 2016-06-29 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing for treating hemorrhoids |
| CN105726399A (en) * | 2016-03-14 | 2016-07-06 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressings for repairing scars |
| CN105770972A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing capable of removing scars |
| CN105770975A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing capable of eliminating vitiligos |
| CN105770974A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of medical biological dressing for haemorrhoids |
| CN105770973A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of medical biological dressing for bedsores |
| CN106563146A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing piece |
| CN106563153A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | A medical functional biological dressing sheet |
| CN106563147A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
| CN106563152A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
| CN106563151A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | A medical functional biological dressing sheet |
| CN107137751A (en) * | 2017-05-20 | 2017-09-08 | 河南福切尔生物科技有限公司 | A kind of medical dressing of the globulin containing wheat germ |
-
2014
- 2014-09-28 CN CN201410502857.3A patent/CN104324411A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106563146A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing piece |
| CN106563151A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | A medical functional biological dressing sheet |
| CN106563152A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
| CN106563147A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
| CN106563153A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | A medical functional biological dressing sheet |
| CN105709261A (en) * | 2016-03-14 | 2016-06-29 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing for treating hemorrhoids |
| CN105770975A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing capable of eliminating vitiligos |
| CN105770974A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of medical biological dressing for haemorrhoids |
| CN105770973A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of medical biological dressing for bedsores |
| CN105770972A (en) * | 2016-03-14 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing capable of removing scars |
| CN105726399A (en) * | 2016-03-14 | 2016-07-06 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressings for repairing scars |
| CN105687087A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of skin-tightening and freckle-removing biological dressing |
| CN105688259A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of biological dressing for treating bedsores |
| CN105688262A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of scar-removing biological dressing |
| CN107137751A (en) * | 2017-05-20 | 2017-09-08 | 河南福切尔生物科技有限公司 | A kind of medical dressing of the globulin containing wheat germ |
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Application publication date: 20150204 |
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