CN105726399A - Preparation method of biological dressings for repairing scars - Google Patents
Preparation method of biological dressings for repairing scars Download PDFInfo
- Publication number
- CN105726399A CN105726399A CN201610140676.XA CN201610140676A CN105726399A CN 105726399 A CN105726399 A CN 105726399A CN 201610140676 A CN201610140676 A CN 201610140676A CN 105726399 A CN105726399 A CN 105726399A
- Authority
- CN
- China
- Prior art keywords
- preparation
- powder
- alginate
- cicatrix
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The invention discloses a preparation method of biological dressings for repairing scars.The preparation method includes: weighing raw materials according to the weight, and well mixing in a reactor; pouring the evenly-mixed mixture into a film-making die, flattening through scraping, sufficiently drying, and removing the die to obtain a medicine-stored layer; compositing the medicine-stored layer with base cloth through binder, and using an intensive-puncturing micro-pore machine to puncture the composite material; cutting the punctured composite material into required shapes, and sealing and sterilizing to obtain the biological dressings.The biological dressings prepared by the method have the advantages that the biological dressings made of traditional Chinese medicine materials are low in irritation, free of toxic and side effects and good in biocompatibility; by the reasonable combination of the traditional Chinese medicine materials, the biological dressings can resist interference of external factors such as bacteria and viruses, promote skin absorption, fade pigment and the scars, and the like and is safe, mild and free of toxic and side effects.
Description
Technical field
The invention belongs to medical bio field of new, relate to a kind of preparation method repairing biological dressing for cicatrix.
Technical background
After skin is damaged or is cut open, normal physiological healing reaction can cause the formation of cicatrix.The agglutination of described skin is formed inflammation phase, granulation (granulation) formation stages and matrix remodeling (matrixremodeling) stage by three phases.In first stage, inflammatory reaction occur, produce the biochemical reaction of a succession of (cascade), these biochemical reaction cause that vasodilation, exudate are filled with wound and damage location swelling.Neutrophil migration, to damage field, causes the release of phospholipase A2 (PLA2) and the generation of prostaglandin, thus causing the damage of cell and tissue.In second stage, Factor of Macrophage (cytokines) is to promote the formation of granulation tissue, thus producing granulation.This new tissue is made up of together with new blood vessel and blood supply new epithelial tissue.In three phases, in wound site inside and around, fibroblast proliferation also produces collagen (collagen), elastin laminin (elastin) and other organization component, thus carrying out matrix remodeling.Loose cicatrix represents frequent but excessive healing reaction.Clinically, loose cicatrix is protruding, redness and frequent tuberosity.Loose cicatrix can occur in all skin areas, but modal occurs from the region that skin is thicker.Generally, within several weeks of burn, wound closure, wound infection, histanoxia and other traumatic skin damage, show the cicatrix of hypertrophy.The collagen found in such cicatrix is high turbulence, and forms vortex shape arrangement rather than normal parallel direction arrangement, and this causes hardening and exceeds normal skin surface.The people of skin scar exception faces on health and psychological problem, and these problems are generally relevant to real emotion and financial expenses.Therefore, the formation treating and preventing cicatrix is still a kind of important demand not being solved.Current carry out therapeutic choice range for intervention procedure and surgical operation, compare surgical operation, select the most cicatrix patients carrying out treating to prefer to use non-intervention technology, because the overall compliance of this technology is higher, its process is automatic control, and pain is less.
Biological dressing is the Novel wound reparation and protection material that grow up in repair in trauma " moistening healing " theoretical basis proposed such as Winter.Compared with traditional dressing, biological dressing has reduction and infects, improves wound healing quality, alleviate the misery of patient and facilitate the advantages such as medical personnel's operation, therefore obtains the favor of people.At present, dressing that is that China market has independent intellectual property right and that repair for cicatrix is also little, is almost blank.Therefore, study the novel dressing for cicatrix reparation and preparation method, be extremely important.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that a kind of preparation method repairing biological dressing for cicatrix.
It is an object of the invention to be achieved through the following technical solutions: a kind of preparation method repairing biological dressing for cicatrix, this preparation method comprises the following steps: by weight, weighs Fibrin Glue 30-50 part, chitosan 10-40 part, Herba Pogostemonis powder 10-20 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) powder 10-20 part, accumulated snow grass meal 14-21 part, Herba Portulacae powder 16-21 part, Radix Paeoniae Rubra powder 10-20 part, Radix Scrophulariae powder 10-20 part, alginate 3-12 part, glycyrrhizic acid dipotassium 6-10 part, hyaluronate sodium 10-14 part, emulsifying agent 8-12 part and water 30-40 part and is placed in reactor and stirs；The mixture of mix homogeneously is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Biological dressing prepared by the method by the present invention that the method have the advantages that adopts Chinese medicine formula, and zest is little, has no side effect, and has good biocompatibility.By rational compatibility, be not only sufficient to the interference of opposing extraneous factor (such as antibacterial, virus), promote the effects such as skin absorption, desalination pigment, desalination cicatrix, safety, gentle, have no side effect.
Detailed description of the invention
Embodiment 1
A kind of preparation method repairing biological dressing for cicatrix, this preparation method comprises the following steps: by weight, weighs Fibrin Glue 30 parts, chitosan 10 parts, 10 parts of Herba Pogostemonis powder, 10 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) powder, accumulated snow grass meal 14 parts, 16 parts of Herba Portulacae powder, 10 parts of Radix Paeoniae Rubra powder, 10 parts of Radix Scrophulariae powder, alginate 3 parts, glycyrrhizic acid dipotassium 6 parts, hyaluronate sodium 10 parts, emulsifying agent 8 parts and 30 parts of water and is placed in reactor and stirs；The mixture of mix homogeneously is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Embodiment 2
A kind of preparation method repairing biological dressing for cicatrix, this preparation method comprises the following steps: by weight, weighs Fibrin Glue 50 parts, chitosan 40 parts, 20 parts of Herba Pogostemonis powder, 20 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) powder, accumulated snow grass meal 21 parts, 21 parts of Herba Portulacae powder, 20 parts of Radix Paeoniae Rubra powder, 20 parts of Radix Scrophulariae powder, alginate 12 parts, glycyrrhizic acid dipotassium 10 parts, hyaluronate sodium 14 parts, emulsifying agent 12 parts and 40 parts of water and is placed in reactor and stirs；The mixture of mix homogeneously is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Embodiment 3
A kind of preparation method repairing biological dressing for cicatrix, this preparation method comprises the following steps: by weight, weighs Fibrin Glue 40 parts, chitosan 20 parts, 15 parts of Herba Pogostemonis powder, 15 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) powder, accumulated snow grass meal 18 parts, 18 parts of Herba Portulacae powder, 15 parts of Radix Paeoniae Rubra powder, 15 parts of Radix Scrophulariae powder, alginate 8 parts, glycyrrhizic acid dipotassium 8 parts, hyaluronate sodium 12 parts, emulsifying agent 10 parts and 35 parts of water and is placed in reactor and stirs；The mixture of mix homogeneously is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Claims (5)
1. the preparation method repairing biological dressing for cicatrix, it is characterized in that this preparation method comprises the following steps: by weight, weigh Fibrin Glue 30-50 part, chitosan 10-40 part, Herba Pogostemonis powder 10-20 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) powder 10-20 part, accumulated snow grass meal 14-21 part, Herba Portulacae powder 16-21 part, Radix Paeoniae Rubra powder 10-20 part, Radix Scrophulariae powder 10-20 part, alginate 3-12 part, glycyrrhizic acid dipotassium 6-10 part, hyaluronate sodium 10-14 part, emulsifying agent 8-12 part and water 30-40 part and be placed in reactor and stir；The mixture of mix homogeneously is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
2. according to claim 1 a kind of for cicatrix repair biological dressing preparation method, it is characterised in that: described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
3. according to claim 1 a kind of for cicatrix repair biological dressing preparation method, it is characterised in that: described binding agent is pressure sensitive adhesive.
4. according to claim 1 a kind of for cicatrix repair biological dressing preparation method, it is characterised in that: described alginate is potassium alginate, sodium alginate or calcium alginate.
5. according to claim 1 a kind of for cicatrix repair biological dressing preparation method, it is characterised in that: described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610140676.XA CN105726399A (en) | 2016-03-14 | 2016-03-14 | Preparation method of biological dressings for repairing scars |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610140676.XA CN105726399A (en) | 2016-03-14 | 2016-03-14 | Preparation method of biological dressings for repairing scars |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105726399A true CN105726399A (en) | 2016-07-06 |
Family
ID=56250375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610140676.XA Pending CN105726399A (en) | 2016-03-14 | 2016-03-14 | Preparation method of biological dressings for repairing scars |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105726399A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732937A (en) * | 2022-05-20 | 2022-07-12 | 斯贝福（北京）生物技术有限公司 | Dressing for animal ear cartilage supporting material and preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806855A (en) * | 2005-11-30 | 2006-07-26 | 合肥恒星医疗用品有限公司 | Wet wound dressing containing plant effective ingredient |
| CN101327179A (en) * | 2008-07-31 | 2008-12-24 | 曹智华 | Medicinal cosmetics for treating acne and scar thereof with antianaphylaxis function |
| CN103191462A (en) * | 2012-01-05 | 2013-07-10 | 王伟 | Medical bleeding-stopping and disinfecting biological dressing |
| CN104307028A (en) * | 2014-09-28 | 2015-01-28 | 青岛佰众化工技术有限公司 | A medical natural-marine-organism bleeding-arresting dressing |
| CN104324411A (en) * | 2014-09-28 | 2015-02-04 | 张亚峰 | Medical natural marine organism dressing |
| CN104368035A (en) * | 2013-08-13 | 2015-02-25 | 凌峰 | Biological dressing for eliminating white spots and scars on human body |
| CN104382766A (en) * | 2014-10-23 | 2015-03-04 | 欧霖拱 | Quick-drying type plant scar removal, black removal and restoration membrane |
-
2016
- 2016-03-14 CN CN201610140676.XA patent/CN105726399A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806855A (en) * | 2005-11-30 | 2006-07-26 | 合肥恒星医疗用品有限公司 | Wet wound dressing containing plant effective ingredient |
| CN101327179A (en) * | 2008-07-31 | 2008-12-24 | 曹智华 | Medicinal cosmetics for treating acne and scar thereof with antianaphylaxis function |
| CN103191462A (en) * | 2012-01-05 | 2013-07-10 | 王伟 | Medical bleeding-stopping and disinfecting biological dressing |
| CN104368035A (en) * | 2013-08-13 | 2015-02-25 | 凌峰 | Biological dressing for eliminating white spots and scars on human body |
| CN104307028A (en) * | 2014-09-28 | 2015-01-28 | 青岛佰众化工技术有限公司 | A medical natural-marine-organism bleeding-arresting dressing |
| CN104324411A (en) * | 2014-09-28 | 2015-02-04 | 张亚峰 | Medical natural marine organism dressing |
| CN104382766A (en) * | 2014-10-23 | 2015-03-04 | 欧霖拱 | Quick-drying type plant scar removal, black removal and restoration membrane |
Non-Patent Citations (2)
| Title |
|---|
| 南京中医药大学编著: "《中药大辞典（第二版上册）》", 31 March 2006, 上海科学技术出版社 * |
| 王建新主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732937A (en) * | 2022-05-20 | 2022-07-12 | 斯贝福（北京）生物技术有限公司 | Dressing for animal ear cartilage supporting material and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2731635B1 (en) | Perforated, layered wound treatment material | |
| CN103230617B (en) | Collagen/chitosan micro-nano fiber composite hemostatic membrane material and preparation method thereof | |
| CN109045349A (en) | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes | |
| TWI398275B (en) | Skin wound dressing and manufacturing method thereof | |
| CN104874014A (en) | Preparation method of medical hemostatic occlusion dressing | |
| CN103212108B (en) | Collagen wound healing film and preparation method thereof | |
| CN101502667A (en) | Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof | |
| CN101596207A (en) | Be used for rapid hemostatic Pharmaceutical composition and preparation method | |
| CN105833331A (en) | Preparation method for degradable biological wound dressing and obtained product | |
| CN102380123A (en) | Collagen membrane medical dressing and preparation method thereof | |
| CN105726400A (en) | Preparation method of whitening and skincare biological dressings | |
| CN105561370A (en) | Novel hemostatic material and preparation method thereof | |
| CN105726399A (en) | Preparation method of biological dressings for repairing scars | |
| CN201692121U (en) | Medical fixing plate | |
| CN105688262A (en) | Preparation method of scar-removing biological dressing | |
| CN102038833A (en) | Burn rapid healing Chinese medicine ointment and preparation method thereof | |
| CN106075563A (en) | A kind of preparation method of medical bio base compound hemostatic dressing | |
| CN105688259A (en) | Preparation method of biological dressing for treating bedsores | |
| Zailan et al. | Comparison of Chlorella vulgaris dressing and sodium alginate dressing: an experimental study in rats | |
| CN106540309A (en) | A kind of fibroin albumen stitching thread with promotion wound healing effect and preparation method thereof | |
| RU2686307C2 (en) | Patch comprising onion extract | |
| CN105770972A (en) | Preparation method of biological dressing capable of removing scars | |
| CN105709261A (en) | Preparation method of biological dressing for treating hemorrhoids | |
| CN105770974A (en) | Preparation method of medical biological dressing for haemorrhoids | |
| CN105770973A (en) | Preparation method of medical biological dressing for bedsores |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160706 |